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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab182999-100μg
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100μg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$189.90
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Ab182999-1mg
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1mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$909.90
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Ab182999-5mg
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5mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$2,279.90
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Ab182999-10mg
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10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$3,649.90
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Purity≥90% (SDS-PAGE&SEC-HPLC); Endotoxin Level<1.0 EU/mg; Human IgG1-REM; CHO; ELISA, Flow Cytometry, Functional assay, Animal Model; Unconjugated
| Product Name | Izalontamab (anti-EGFR&HER3) - Primary antibody, specific to EGFR&ERBB3, Human IgG1 |
|---|---|
| Synonyms | Avian erythroblastic leukemia viral (v erb b) oncogene homolog antibody | Cell growth inhibiting protein 40 antibody | Cell proliferation inducing protein 61 antibody | EGF R antibody | EGFR antibody | EGFR_HUMAN antibody | Epidermal growth factor recepto |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥90%(SDS-PAGE&SEC-HPLC), See COA |
| Biochemical and Physiological Mechanisms | EGFR: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacel |
| Host species | Human |
| Specificity | EGFR&ERBB3 |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Product Description |
Izalontamab (anti-EGFR&HER3) is a bispecific anti-EGFR/HER3 monoclonal antibody with high selectivity for EGFR/HER3 heterodimer. Izalontamab (anti-EGFR&HER3) can be used for the research of cancer. |
| Isotype | Human IgG1 |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 197.22 kDa |
| Purification Method | Protein A purified |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 2559704-24-2 |
Izalontamab (anti-EGFR&HER3) (Ab182999) - Flow Cytometry
Flow Cytometry analysis of A431 cells labelling EGFR&HER3 (red) with Izalontamab (anti-EGFR&HER3) (Ab182999) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Izalontamab (anti-EGFR&HER3) (Ab182999) - Flow Cytometry
Flow Cytometry analysis of MCF7 cells labelling EGFR&HER3 (red) with Izalontamab (anti-EGFR&HER3) (Ab182999) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Izalontamab (anti-EGFR&HER3) (Ab182999) - ELISA
Immobilized Recombinant Human EGFR protein (rp176273) at 1.0 μg/mL can bind Izalontamab (anti-EGFR&HER3) (Ab182999) with the EC50 of 23.2 ng/mL.
Izalontamab (anti-EGFR&HER3) (Ab182999) - ELISA
Immobilized Recombinant Human ErbB3/HER3 protein (rp170123) at 1.0 μg/mL can bind Izalontamab (anti-EGFR&HER3) (Ab182999) with the EC50 of 50.02 ng/mL.
Izalontamab (anti-EGFR&HER3) (Ab182999) - SEC
The purity of Izalontamab (anti-EGFR&HER3) (Ab182999) is more than 95% verified by HPLC.
Starting at $89.90