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IMC-EB10 (anti-FLT3) - Primary antibody, specific to FLT3, >95%, high purity, Human IgG1, INHIBITOR of Tyrosine-protein kinase receptor FLT3 inhibitor, INHIBITOR of Tyrosine-protein kinase receptor FLT3 inhibitor

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Cynomolgus monkey,Human
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
Ab177924
Grouped product items
SKU Size
Availability
Price Qty
Ab177924-100μg
100μg
10
$109.90
Ab177924-1mg
1mg
4
$519.90
Ab177924-5mg
5mg
1
$1,399.90
Ab177924-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,239.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name IMC-EB10 (anti-FLT3) - Primary antibody, specific to FLT3, >95%, high purity, Human IgG1, INHIBITOR of Tyrosine-protein kinase receptor FLT3 inhibitor
Synonyms EC 2.7.10.1 | Fetal liver kinase-2 | FL cytokine receptor | FLK-2 | FLT-3 | Fms-like tyrosine kinase 3 | Stem cell tyrosine kinase 1 | STK-1
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity FLT3
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type INHIBITOR
Mechanism of action INHIBITOR of Tyrosine-protein kinase receptor FLT3 inhibitor
Product Description

IMC-EB10 (anti-FLT3) is a fully human IgG1 monoclonal antibody, targeting the FLT3 tyrosine kinase receptor (CD135) with potential antineoplastic activity. It binds to FLT3 and blocks FLT3 ligand binding to FLT3 and subsequent FLT3 phosphorylation, which may result in the inhibition of FLT3-mediated signal transduction pathways.

Product Properties

Isotype Human IgG1
Light Chain Type kappa
SDS-PAGE 26.7 kDa (Light Chain) & 50.9 kDa (Heavy Chain), under reducing conditions; 191.9 kDa, under non-reducing conditions.
Purification Method Protein A purified
Purity >95%
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

FLT3 Tclin Receptor-type tyrosine-protein kinase FLT3 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
FLT3 Tclin Tyrosine-protein kinase receptor FLT3 (13481 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
FLT3 Tclin VHL/FLT3 (13 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

IMC-EB10 (anti-FLT3) (Ab177924) - Flow
Human FLT3 HEK293 cells were stained with IMC-EB10 (anti-FLT3) (Ab177924) and negative control protein respectively, washed and then followed by PE and analyzed with FACS, EC ₅₀ for this effect is 110 nM.

IMC-EB10 (anti-FLT3) (Ab177924) - SEC
The purity of IMC-EB10 (anti-FLT3) (Ab177924) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0607184 Certificate of Analysis Jun 21, 2024 Ab177924
ZJ24F0607183 Certificate of Analysis Jun 21, 2024 Ab177924
ZJ24F0607182 Certificate of Analysis Jun 21, 2024 Ab177924

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