Determine the necessary mass, volume, or concentration for preparing a solution.
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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab177924-100μg
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100μg |
10
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$109.90
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Ab177924-1mg
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1mg |
4
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$519.90
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Ab177924-5mg
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5mg |
1
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$1,399.90
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Ab177924-10mg
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10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$2,239.90
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Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | IMC-EB10 (anti-FLT3) - Primary antibody, specific to FLT3, >95%, high purity, Human IgG1, INHIBITOR of Tyrosine-protein kinase receptor FLT3 inhibitor |
|---|---|
| Synonyms | EC 2.7.10.1 | Fetal liver kinase-2 | FL cytokine receptor | FLK-2 | FLT-3 | Fms-like tyrosine kinase 3 | Stem cell tyrosine kinase 1 | STK-1 |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Host species | Human |
| Specificity | FLT3 |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | INHIBITOR |
| Mechanism of action | INHIBITOR of Tyrosine-protein kinase receptor FLT3 inhibitor |
| Product Description |
IMC-EB10 (anti-FLT3) is a fully human IgG1 monoclonal antibody, targeting the FLT3 tyrosine kinase receptor (CD135) with potential antineoplastic activity. It binds to FLT3 and blocks FLT3 ligand binding to FLT3 and subsequent FLT3 phosphorylation, which may result in the inhibition of FLT3-mediated signal transduction pathways. |
| Isotype | Human IgG1 |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 26.7 kDa (Light Chain) & 50.9 kDa (Heavy Chain), under reducing conditions; 191.9 kDa, under non-reducing conditions. |
| Purification Method | Protein A purified |
| Purity | >95% |
| Shape | Liquid |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IMC-EB10 (anti-FLT3) (Ab177924) - Flow
Human FLT3 HEK293 cells were stained with IMC-EB10 (anti-FLT3) (Ab177924) and negative control protein respectively, washed and then followed by PE and analyzed with FACS, EC
₅₀
for this effect is 110 nM.
IMC-EB10 (anti-FLT3) (Ab177924) - SEC
The purity of IMC-EB10 (anti-FLT3) (Ab177924) is more than 95% verified by HPLC.
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Jun 21, 2024 | Ab177924 | |
| Certificate of Analysis | Jun 21, 2024 | Ab177924 | |
| Certificate of Analysis | Jun 21, 2024 | Ab177924 |