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HDAC4 Mouse mAb - Primary antibody, specific to HDAC4, Mouse IgG2a

1 Citations COA COA
    Application:
  • IP
  • WB
  • Host species: Mouse
  • Reactive species: Human,Monkey,Mouse,Rat
  • Isotype: Mouse IgG2a
  • Clone Number: 4A3-H7-C6
  • Conjugation: Unconjugated
In stock
Item Number
Ab107057
Grouped product items
SKU Size
Availability
 Price Qty
Ab107057-10μl
10μl
2
$66.90
Ab107057-50μl
50μl
1
$189.90
Ab107057-100μl
100μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$279.90
Ab107057-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,599.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

mAb (4A3-H7-C6); Mouse anti Human HDAC4 Antibody; WB, IP; Unconjugated

View related series
Click to view target information: HDAC4
Accession#:P56524 (2) Gene ID:9759 (2) HDAC4 (2)

Basic Description

Product Name HDAC4 Mouse mAb - Primary antibody, specific to HDAC4, Mouse IgG2a
Synonyms AHO3 antibody | BDMR antibody | EC 3.5.1.98 antibody | HA6116 antibody | HD 4 antibody | HD4 antibody | HDAC 4 antibody | HDAC A antibody | HDAC4 antibody | HDAC4_HUMAN antibody | HDACA antibody | Histone deacetylase 4 antibody | Histone Deacetylase A ant
Specifications & Purity ExactAb™, Validated, 1.0 mg/mL
Host species Mouse
Specificity HDAC4
Immunogen Recombinant protein of human HDAC4 (AA 11-125)
Positive Control WB: Jurkat, NIH/3T3 and C6 cell lysates. IP: HeLa lysates.
Conjugation Unconjugated
Grade ExactAb™, Validated
Product Description

Mouse anti Human HDAC4 Antibody, Monoclonal antibody(4A3-H7-C6), could be used for WB, IP and so on.
Application:
WB: 1/500-1/1000
IP: 1/20
Protein Function
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D.
Post-translational
Phosphorylated by CaMK4 at Ser-246, Ser-467 and Ser-632. Phosphorylation at other residues is required for the interaction with 14-3-3. Sumoylation on Lys-559 is promoted by the E3 SUMO-protein ligase RANBP2, and prevented by phosphorylation by CaMK4.

Product Properties

Isotype Mouse IgG2a
Light Chain Type kappa
SDS-PAGE 150 kDa
Purification Method Protein G purified
Shape Liquid
Concentration 1.0 mg/mL
Storage Temp Store at -20°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

HDAC4 Tclin Histone deacetylase 4 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
HDAC4 Tclin Histone deacetylase 4 (2328 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HDAC4 Tclin Cereblon/Histone deacetylase 4 (8 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

HDAC4 Mouse mAb (Ab107057) - Western Blot
All lanes: HDAC4 Mouse mAb (Ab107057) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Mouse IgG H&L (HRP) (Ab179001) at 1/20000 dilution

Predicted band size: 119 kDa
Observed band size: 134 kDa
Exposure time: 60.0 s

HDAC4 Mouse mAb (Ab107057) - Western Blot
All lanes: HDAC4 Mouse mAb (Ab107057) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Mouse IgG H&L (HRP) (Ab179001) at 1/20000 dilution

Predicted band size: 119 kDa
Observed band size: 134 kDa
Exposure time: 30.0 s

HDAC4 Mouse mAb (Ab107057) - Western Blot
Immunoprecipitation analysis of HDAC4 in HeLa lysates using HDAC4 Mouse mAb (Ab107057)

Application

Application Dilution info
WB

1/500-1/1000
IP

1/20

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number Certificate Type Date Item
ZJ24F0404334 Certificate of Analysis Apr 10, 2024 Ab107057
ZJ24F0404335 Certificate of Analysis Apr 10, 2024 Ab107057

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Citations of This Product

How to Cite Aladdin Scientific Products?
1. Ling Y, Li Y, Zhu R, Qian J, Liu J, Gao W, Meng C, Miao J, Xiong B, Qiu X, Ling C, Dai H, Zhang Y..  (2019)  Hydroxamic Acid Derivatives of β-Carboline/Hydroxycinnamic Acid Hybrids Inducing Apoptosis and Autophagy through the PI3K/Akt/mTOR Pathways..  J Nat Prod,  82  (6): (1442-1450). 

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