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H5B14 (anti-RON) - Primary antibody, specific to MST1R, Human IgG1

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Human,Mouse
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
Ab209909
Grouped product items
SKU Size
Availability
Price Qty
Ab209909-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$109.90
Ab209909-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$509.90
Ab209909-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,399.90
Ab209909-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,299.90

Purity≥95% (SDS-PAGE&SEC-HPLC); Endotoxin Level<1.0 EU/mg; Human IgG1; CHO; ELISA, Flow Cytometry, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name H5B14 (anti-RON) - Primary antibody, specific to MST1R, Human IgG1
Synonyms c met related tyrosine kinase antibody | CD136 antibody | CD136 antigen antibody | CDw136 antibody | Macrophage stimulating 1 receptor (c met related tyrosine kinase) antibody | Anti-MSPR/RON/CD136 Antibody | CDw136 | NPCA3 | CD136 | SEA | RON | soluble R
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Biochemical and Physiological Mechanisms Receptor for macrophage stimulating protein (MSP). Has a tyrosine-protein kinase activity. Post-translational: Proteolytic processing yields the two subunits. Phosphorylated in response to ligand binding.
Host species Human
Specificity MST1R
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Product Description

H5B14 (anti-RON) is a neutralizing human monoclonal antibody-drug conjugate that targets RON binding to its ligand, macrophage-stimulating protein (MSP). It has an strong potential in treatment of chronic liver inflammation and also in autoimmune diseases.

Product Properties

Isotype Human IgG1
Light Chain Type kappa
SDS-PAGE 156.7 kDa
Purification Method Protein A purified
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

MST1R Tchem Macrophage-stimulating protein receptor (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

H5B14 (anti-RON) (Ab209909) - Flow Cytometry
Flow Cytometry analysis of A431 cells labelling RON (red) with H5B14 (anti-RON) (Ab209909) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

H5B14 (anti-RON) (Ab209909) - Flow Cytometry
Flow Cytometry analysis of HT-29 cells labelling RON (red) with H5B14 (anti-RON) (Ab209909) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

H5B14 (anti-RON) (Ab209909) - SEC
The purity of H5B14 (anti-RON) (Ab209909) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Solution Calculators

Reviews

Customer Reviews

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