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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab209909-100μg
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100μg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$109.90
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Ab209909-1mg
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1mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$509.90
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Ab209909-5mg
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5mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$1,399.90
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Ab209909-10mg
|
10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$2,299.90
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Purity≥95% (SDS-PAGE&SEC-HPLC); Endotoxin Level<1.0 EU/mg; Human IgG1; CHO; ELISA, Flow Cytometry, Functional assay, Animal Model; Unconjugated
| Product Name | H5B14 (anti-RON) - Primary antibody, specific to MST1R, Human IgG1 |
|---|---|
| Synonyms | c met related tyrosine kinase antibody | CD136 antibody | CD136 antigen antibody | CDw136 antibody | Macrophage stimulating 1 receptor (c met related tyrosine kinase) antibody | Anti-MSPR/RON/CD136 Antibody | CDw136 | NPCA3 | CD136 | SEA | RON | soluble R |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Biochemical and Physiological Mechanisms | Receptor for macrophage stimulating protein (MSP). Has a tyrosine-protein kinase activity. Post-translational: Proteolytic processing yields the two subunits. Phosphorylated in response to ligand binding. |
| Host species | Human |
| Specificity | MST1R |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Product Description |
H5B14 (anti-RON) is a neutralizing human monoclonal antibody-drug conjugate that targets RON binding to its ligand, macrophage-stimulating protein (MSP). It has an strong potential in treatment of chronic liver inflammation and also in autoimmune diseases. |
| Isotype | Human IgG1 |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 156.7 kDa |
| Purification Method | Protein A purified |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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H5B14 (anti-RON) (Ab209909) - Flow Cytometry
Flow Cytometry analysis of A431 cells labelling RON (red) with H5B14 (anti-RON) (Ab209909) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
H5B14 (anti-RON) (Ab209909) - Flow Cytometry
Flow Cytometry analysis of HT-29 cells labelling RON (red) with H5B14 (anti-RON) (Ab209909) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
H5B14 (anti-RON) (Ab209909) - SEC
The purity of H5B14 (anti-RON) (Ab209909) is more than 95% verified by HPLC.
Starting at $109.90