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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab209753-100μg
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100μg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$109.90
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Ab209753-1mg
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1mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$509.90
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Ab209753-5mg
|
5mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$1,399.90
|
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Ab209753-10mg
|
10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$2,299.90
|
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Purity≥95% (SDS-PAGE&SEC-HPLC); Endotoxin Level<1.0 EU/mg; Human IgG1; CHO; ELISA, Flow Cytometry, Functional assay, Animal Model; Unconjugated
| Product Name | Genzyme patent anti-CXCR3 (anti-CXCR3) - Primary antibody, specific to CXCR3, Human IgG1 |
|---|---|
| Synonyms | C-X-C chemokine receptor type 3 antibody | CD 183 antibody | CD182 antibody | CD183 antibody | Chemokine (C X C motif) receptor 3 antibody | Anti-CXCR3/GPR9/CD183 Antibody | CMKAR3 | CKR-L2 | Chemokine (C X C) receptor 3 antibody | Chemokine CXC Motif Rec |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Biochemical and Physiological Mechanisms | Receptor for CXCL9, CXCL10 and CXCL11 and mediates the proliferation of human mesangial cells (HMC). Isoform 2 is a receptor for CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the growth of human microvascular endothelial |
| Host species | Human |
| Specificity | CXCR3 |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Product Description |
Genzyme patent anti-CXCR3 (anti-CXCR3) is a monoclonal antibody binds to Chemokine (C-X-C motif) receptor 3 (CXCR3, also known as G protein-coupled receptor 9 (GPR9)). It has the potentially to be used in the treatment of diabetes mellitus type I (T1D). |
| Isotype | Human IgG1 |
|---|---|
| Light Chain Type | kappa |
| Purification Method | Protein A purified |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Genzyme patent anti-CXCR3 (anti-CXCR3) (Ab209753) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CXCR3 with Genzyme patent anti-CXCR3 (anti-CXCR3) (Ab209753) conjugated with biotin (right panel) compared with Human IgG (Biotin) (Ab180314) - Isotype Control (left panel) and detected with SA-PE (rp156150).
Genzyme patent anti-CXCR3 (anti-CXCR3) (Ab209753) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CXCR3 (red) with Genzyme patent anti-CXCR3 (anti-CXCR3) (Ab209753) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, Human IgG (Biotin) (Ab180314). Black - Unlabelled control, cells without incubation with primary antibody.
Genzyme patent anti-CXCR3 (anti-CXCR3) (Ab209753) - ELISA
Immobilized Recombinant N-hCXCR3-Fc protein at 2.0 μg/mL can bind Genzyme patent anti-CXCR3 (anti-CXCR3) (Ab209753), with the EC₅₀ of 38.23 ng/mL.
Genzyme patent anti-CXCR3 (anti-CXCR3) (Ab209753) - SEC
The purity of Genzyme patent anti-CXCR3 (anti-CXCR3) (Ab209753) is more than 95% verified by HPLC.