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Gankyrin Mouse mAb - Primary antibody, specific to Gankyrin, Mouse IgG1

COA COA
    Application:
  • WB
  • Host species: Mouse
  • Reactive species: Human,Pig
  • Isotype: Mouse IgG1
  • Clone Number: C5
  • Conjugation: Unconjugated
In stock
Item Number
Ab104742
Grouped product items
SKU Size
Availability
 Price Qty
Ab104742-10μl
10μl
10
$66.90
Ab104742-50μl
50μl
4
$189.90
Ab104742-100μl
100μl
2
$289.90
Ab104742-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,449.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

mAb (C5); Mouse anti Human Gankyrin Antibody; WB; Unconjugated

View related series
Click to view target information: PSMD10
Accession#:O75832 (2) Gankyrin (2) Gene ID:5716 (2) PSMD10 (2)

Basic Description

Product Name Gankyrin Mouse mAb - Primary antibody, specific to Gankyrin, Mouse IgG1
Synonyms 26S proteasome non-ATPase regulatory subunit 10 antibody | 26S proteasome regulatory subunit p28 antibody | Ankyrin repeat protein antibody | dJ889N15.2 antibody | Gankyrin antibody | Hepatocellular carcinoma-associated protein p28 II antibody | p28 antib
Specifications & Purity Carrier Free, ExactAb™, Azide Free, Validated, High Performance, See COA
Host species Mouse
Specificity Gankyrin
Immunogen Recombinant PSMD10 expressed in E.coli (1-226).
Positive Control WB: A549, MCF7 and HeLa cell lysates.
Conjugation Unconjugated
Grade Azide Free, Carrier Free, ExactAb™, High Performance, Validated
Product Description

Mouse anti Human Gankyrin Antibody, Monoclonal (C5), could be used for WB and so on.
Application:
WB: 0.01-2 µg/mL
Protein Function:
Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Acts as an proto-oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2 to p53/TP53 and the mono- and polyubiquitination of p53/TP53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S proteasome. Involved in p53-independent apoptosis. Involved in regulation of NF-kappa-B by retaining it in the cytoplasm. Binds to the NF-kappa-B component RELA and accelerates its XPO1/CRM1-mediated nuclear export.

Product Properties

Isotype Mouse IgG1
Light Chain Type kappa
SDS-PAGE 150 kDa
Purification Method Protein A purified + Protein G purified
Shape Liquid
Concentration See COA
Storage Temp Store at -20°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at 4℃ short term (1-2 weeks). Store at -20℃ long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

PSMD10 Tbio 26S proteasome non-ATPase regulatory subunit 10 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Gankyrin Mouse mAb (Ab104742) - Western Blot
All lanes: Gankyrin Mouse mAb (Ab104742) at 1/2000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Mouse IgG H&L (HRP) (Ab138040) at 1/20000 dilution

Predicted band size: 24 kDa
Observed band size: 25 kDa
Exposure time: 4.8 s


Application

Application Dilution info
WB

0.01-2 µg/mL

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0404091 Certificate of Analysis Apr 02, 2024 Ab104742
ZJ24F0404090 Certificate of Analysis Apr 02, 2024 Ab104742
ZJ24F0404089 Certificate of Analysis Apr 02, 2024 Ab104742

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