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Dostarlimab (anti-PD-1) - Primary antibody, specific to PDCD1, >95%, high purity, Human IgG4SP, Antibody of programmed cell death 1 (CD279), Antibody of programmed cell death 1 (CD279)

COA COA
    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Cynomolgus monkey,Human
  • Isotype: Human IgG4SP
  • Conjugation: Unconjugated
In stock
Item Number
Ab175513
Grouped product items
SKU Size
Availability
 Price Qty
Ab175513-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$79.90
Ab175513-1mg
1mg
5
$379.90
Ab175513-5mg
5mg
1
$989.90
Ab175513-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,589.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

View related series
Click to view target information: PDCD1
Accession#:Q15116 (38) Gene ID:5133 (38) PD1 (37) PDCD1 (39) programmed cell death 1 (CD279) Antibody (8)

Basic Description

Product Name Dostarlimab (anti-PD-1) - Primary antibody, specific to PDCD1, >95%, high purity, Human IgG4SP, Antibody of programmed cell death 1 (CD279)
Synonyms CD279 antibody | CD279 antigen antibody | hPD 1 antibody | hPD l antibody | hPD-1 antibody | hSLE1 antibody | PD 1 antibody | PD-1 antibody | PD1 antibody | PDCD 1 antibody | PDCD1 antibody | PDCD1_HUMAN antibody | Programmed cell death 1 antibody | Progr
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity PDCD1
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type ANTAGONIST
Mechanism of action Antibody of programmed cell death 1 (CD279)
Product Description

Dostarlimab (anti-PD-1) is a humanized anti-PD-1 monoclonal antibody. Dostarlimab (anti-PD-1) binds with high affinity to human PD-1 and competitively inhibits its interaction with its ligands, PD-L1 and PD-L2, with IC50s of 1.8 and 1.5 nM, respectively[1].

Product Properties

Isotype Human IgG4SP
Light Chain Type kappa
SDS-PAGE 26.6 kDa (Light Chain) & 50.8 kDa (Heavy Chain), under reducing conditions; 180.0 kDa, under non-reducing conditions.
Purification Method Protein A purified
Purity >95%
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 2022215-59-2

Associated Targets(Human)

PDCD1 Tclin Programmed cell death protein 1 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
PDCD1 Tclin Programmed cell death protein 1 (14 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Dostarlimab (anti-PD-1) (Ab175513) - ELISA
Immobilized Human PDCD1/PD-1/CD279-his at 2 μg/mL can bind Dostarlimab (anti-PD-1) (Ab175513) with the EC₅₀ of 12.16 ng/mL.

Dostarlimab (anti-PD-1) (Ab175513) - SEC
The purity of Dostarlimab (anti-PD-1) (Ab175513) is more than 95% verified by HPLC.

Dostarlimab (anti-PD-1) (Ab175513) - ELISA
Immobilized Recombinant Human PD-1 Protein (rp176241) at 1.0 μg/mL can bind Dostarlimab (anti-PD-1) (Ab175513) with the EC50 of 32.41 ng/mL.

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number Certificate Type Date Item
ZJ23F1202182 Certificate of Analysis Dec 22, 2023 Ab175513
ZJ23F1202181 Certificate of Analysis Dec 22, 2023 Ab175513

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