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c-Met/HGFR

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Items 1-12 of 121

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  1. , Vascular endothelial growth factor receptor inhibitor
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    Foretinib (GSK1363089), Vascular endothelial growth factor receptor inhibitor
    Cas Number: 849217-64-7
    Formula:  C34H34F2N4O6        Molecular Weight: 632.65
    IUPAC Name:  1-N'-[3-fluoro-4-[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxyphenyl]-1-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
    SMILES:  COC1=CC2=C(C=CN=C2C=C1OCCCN3CCOCC3)OC4=C(C=C(C=C4)NC(=O)C5(CC5)C(=O)NC6=CC=C(C=C6)F)F
    InChIKey: CXQHYVUVSFXTMY-UHFFFAOYSA-N
    InChI:  InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-show more
    Synonyms: 81FH7VK1C4 | Foretinib [USAN:INN] | N-(3-FLUORO-4-((6-METHOXY-7-(3-(MORPHOLIN-4-YL)PROPOXY)QUINOLIN-4-YL)OXY) PHENYL)...
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    PF 04217903 mesylate
      Grade & Purity: 
    • ≥98%(HPLC)
    Cas Number: 956906-93-7        Compound CID:  24852079
    Formula:  C20H20N8O4S        Molecular Weight: 468.49
    IUPAC Name:  methanesulfonic acid;2-[4-[3-(quinolin-6-ylmethyl)triazolo[4,5-b]pyrazin-5-yl]pyrazol-1-yl]ethanol
    SMILES:  CS(=O)(=O)O.C1=CC2=C(C=CC(=C2)CN3C4=NC(=CN=C4N=N3)C5=CN(N=C5)CCO)N=C1
    InChIKey: HBEMHKVWZJTVOC-UHFFFAOYSA-N
    InChI:  InChI=1S/C19H16N8O.CH4O3S/c28-7-6-26-12-15(9-22-26)17-10-21-18-19(23-17)27(25-24-18)11-13-3-4-16-14(8-13)2-1-5-20-16;1-5(2,3)4/h1-5,8-10,12,28H,6-7,11show more
    Synonyms: 2-(4-{1-[(quinolin-6-yl)methyl]-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl}-1H-pyrazol-1-yl)ethan-1-ol; methanesulfonic ac...
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    SJF 8240
      Grade & Purity: 
    • ≥98%(HPLC)
    Cas Number: 2230821-68-6        Compound CID:  135175904
    Formula:  C₅₈H₆₅F₂N₇O₁₁S        Molecular Weight: 1106.25
    SMILES:  COC1=CC2=C(N=CC=C2OC3=C(C=C(C=C3)NC(C4(C(NC5=CC=C(C=C5)F)=O)CC4)=O)F)C=C1OCCCOCCCOCCC(N[C@@H](C(C)(C)C)C(N6C[C@@H](C[C@H]6C(NCC7=CC=C(C8=C(N=CS8)C)C=Cshow more
    InChIKey: SCUZPTNDZHEHLB-ZWUDBOSPSA-N
    Synonyms: N-(3-Fluoro-4-((7-(3-(3-(3-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3...
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  4. , Hepatocyte growth factor receptor inhibitor
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    MK-2461, Hepatocyte growth factor receptor inhibitor
    Cas Number: 917879-39-1
    Formula:  C24H25N5O5S        Molecular Weight: 495.55
    IUPAC Name:  14-[[[(2R)-1,4-dioxan-2-yl]methyl-methylsulfamoyl]amino]-5-(1-methylpyrazol-4-yl)-2-oxo-7-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,9,12,14-heptshow more
    SMILES:  CN1C=C(C=N1)C2=CC3=C(C=CC4=C(C3=O)C=C(C=C4)NS(=O)(=O)N(C)CC5COCCO5)N=C2
    InChIKey: JGEBLDKNWBUGRZ-HXUWFJFHSA-N
    InChI:  InChI=1S/C24H25N5O5S/c1-28-13-18(12-26-28)17-9-22-23(25-11-17)6-4-16-3-5-19(10-21(16)24(22)30)27-35(31,32)29(2)14-20-15-33-7-8-34-20/h3-6,9-13,20,27H,show more
    Synonyms: SCHEMBL93526 | NCGC00346695-05 | CCG-264723 | FT-0631528 | NSC800795 | NSC-800795 | EX-A1566 | SY003220 | UNII-4200RD...
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  5. , Hepatocyte growth factor receptor inhibitor
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    SGX-523, Hepatocyte growth factor receptor inhibitor
    Cas Number: 1022150-57-7        Compound CID:  24779724
    Formula:  C18H13N7S        Molecular Weight: 359.42
    IUPAC Name:  6-[[6-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl]quinoline
    SMILES:  CN1C=C(C=N1)C2=NN3C(=NN=C3SC4=CC5=C(C=C4)N=CC=C5)C=C2
    InChIKey: BCZUAADEACICHN-UHFFFAOYSA-N
    InChI:  InChI=1S/C18H13N7S/c1-24-11-13(10-20-24)16-6-7-17-21-22-18(25(17)23-16)26-14-4-5-15-12(9-14)3-2-8-19-15/h2-11H,1H3
    Synonyms: 6-((6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)thio)quinoline | AKOS025117577 | NCGC00263163-0...
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  6. , Inhibitor of MET proto-oncogene; receptor tyrosine kinase
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    PHA-665752, Inhibitor of MET proto-oncogene; receptor tyrosine kinase
    Cas Number: 477575-56-7
    Formula:  C32H34Cl2N4O4S        Molecular Weight: 641.61
    IUPAC Name:  (3Z)-5-[(2,6-dichlorophenyl)methylsulfonyl]-3-[[3,5-dimethyl-4-[(2R)-2-(pyrrolidin-1-ylmethyl)pyrrolidine-1-carbonyl]-1H-pyrrol-2-yl]methylidene]-1H-ishow more
    SMILES:  CC1=C(NC(=C1C(=O)N2CCCC2CN3CCCC3)C)C=C4C5=C(C=CC(=C5)S(=O)(=O)CC6=C(C=CC=C6Cl)Cl)NC4=O
    InChIKey: OYONTEXKYJZFHA-SSHUPFPWSA-N
    InChI:  InChI=1S/C32H34Cl2N4O4S/c1-19-29(35-20(2)30(19)32(40)38-14-6-7-21(38)17-37-12-3-4-13-37)16-24-23-15-22(10-11-28(23)36-31(24)39)43(41,42)18-25-26(33)8-show more
    Synonyms: PHA-665752 hydrate | (3Z)-5-{[(2,6-dichlorophenyl)methane]sulfonyl}-3-[(3,5-dimethyl-4-{[(2R)-2-(pyrrolidin-1-ylmethy...
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  7. , Inhibitor of MER proto-oncogene; tyrosine kinase
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    BMS-794833, Inhibitor of MER proto-oncogene; tyrosine kinase
    Cas Number: 1174046-72-0
    Formula:  C23H15ClF2N4O3        Molecular Weight: 468.84
    IUPAC Name:  N-[4-(2-amino-3-chloropyridin-4-yl)oxy-3-fluorophenyl]-5-(4-fluorophenyl)-4-oxo-1H-pyridine-3-carboxamide
    SMILES:  C1=CC(=CC=C1C2=CNC=C(C2=O)C(=O)NC3=CC(=C(C=C3)OC4=C(C(=NC=C4)N)Cl)F)F
    InChIKey: PDYXPCKITKHFOZ-UHFFFAOYSA-N
    InChI:  InChI=1S/C23H15ClF2N4O3/c24-20-19(7-8-29-22(20)27)33-18-6-5-14(9-17(18)26)30-23(32)16-11-28-10-15(21(16)31)12-1-3-13(25)4-2-12/h1-11H,(H2,27,29)(H,28,show more
    Synonyms: SCHEMBL13770016 | J-690046 | HY-10497 | AC-32814 | BDBM50146164 | BMS 794833 | 1174046-72-0 | SMR004702756 | metatini...
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  8. , Hepatocyte growth factor receptor inhibitor
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    PF-04217903, Hepatocyte growth factor receptor inhibitor
      Grade & Purity: 
    • ≥98%
    Cas Number: 956905-27-4
    Formula:  C19H16N8O        Molecular Weight: 372.38
    IUPAC Name:  2-[4-[3-(quinolin-6-ylmethyl)triazolo[4,5-b]pyrazin-5-yl]pyrazol-1-yl]ethanol
    SMILES:  C1=CC2=C(C=CC(=C2)CN3C4=NC(=CN=C4N=N3)C5=CN(N=C5)CCO)N=C1
    InChIKey: PDMUGYOXRHVNMO-UHFFFAOYSA-N
    InChI:  InChI=1S/C19H16N8O/c28-7-6-26-12-15(9-22-26)17-10-21-18-19(23-17)27(25-24-18)11-13-3-4-16-14(8-13)2-1-5-20-16/h1-5,8-10,12,28H,6-7,11H2
    Synonyms: 2-(4-(3-(quinolin-6-ylmethyl)-3H-[1,2,3]triazolo[4,5-b]pyrazin-5-yl)-1H-pyrazol-1-yl)ethanol | 2-[4-[1-(Quinolin-6-yl...
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    CEP-40783
      Grade & Purity: 
    • ≥98%
    Cas Number: 1437321-24-8
    Formula:  C31H26F2N4O6        Molecular Weight: 588.6
    IUPAC Name:  N-[4-(6,7-dimethoxyquinolin-4-yl)oxy-3-fluorophenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
    SMILES:  CC(C)N1C=C(C(=O)N(C1=O)C2=CC=C(C=C2)F)C(=O)NC3=CC(=C(C=C3)OC4=C5C=C(C(=CC5=NC=C4)OC)OC)F
    InChIKey: FKCWHHYUMFGOPY-UHFFFAOYSA-N
    InChI:  InChI=1S/C31H26F2N4O6/c1-17(2)36-16-22(30(39)37(31(36)40)20-8-5-18(32)6-9-20)29(38)35-19-7-10-26(23(33)13-19)43-25-11-12-34-24-15-28(42-4)27(41-3)14-2show more
    Synonyms: AS-35141 | N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)-3-fluorophenyl)-3-(4-fluorophenyl)-1-isopropyl-2,4-dioxo-1,2,3,4-te...
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    NVP-BVU972
      Grade & Purity: 
    • ≥98%
    Cas Number: 1185763-69-2
    Formula:  C20H16N6        Molecular Weight: 340.38
    IUPAC Name:  6-[[6-(1-methylpyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]methyl]quinoline
    SMILES:  CN1C=C(C=N1)C2=NN3C(=NC=C3CC4=CC5=C(C=C4)N=CC=C5)C=C2
    InChIKey: RNCNPRCUHHDYPC-UHFFFAOYSA-N
    InChI:  InChI=1S/C20H16N6/c1-25-13-16(11-23-25)19-6-7-20-22-12-17(26(20)24-19)10-14-4-5-18-15(9-14)3-2-8-21-18/h2-9,11-13H,10H2,1H3
    Synonyms: NCGC00346689-02 | (.+/-.)-2-Ethyloxirane | Allylglycide ether | BDBM50146169 | MLS006010964 | AS-56284 | C71592 | RNC...
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  11. , Hepatocyte growth factor receptor inhibitor
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    LY2801653, Hepatocyte growth factor receptor inhibitor
    Cas Number: 1206799-15-6
    Formula:  C30H22F2N6O3        Molecular Weight: 552.53
    IUPAC Name:  N-[3-fluoro-4-[1-methyl-6-(1H-pyrazol-4-yl)indazol-5-yl]oxyphenyl]-1-(4-fluorophenyl)-6-methyl-2-oxopyridine-3-carboxamide
    SMILES:  CC1=CC=C(C(=O)N1C2=CC=C(C=C2)F)C(=O)NC3=CC(=C(C=C3)OC4=C(C=C5C(=C4)C=NN5C)C6=CNN=C6)F
    InChIKey: QHADVLVFMKEIIP-UHFFFAOYSA-N
    InChI:  InChI=1S/C30H22F2N6O3/c1-17-3-9-23(30(40)38(17)22-7-4-20(31)5-8-22)29(39)36-21-6-10-27(25(32)12-21)41-28-11-18-16-35-37(2)26(18)13-24(28)19-14-33-34-1show more
    Synonyms: 2,2'-Dithiobis[benzothiazole] | SCHEMBL2716 | s7014 | NSC800788 | NSC-800788 | CCG-270011 | LY 2801653 | BDBM50172078...
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    7-Methoxy-1-tetralone
      Grade & Purity: 
    • ≥99%
    Cas Number: 6836-19-7        EC Number: 229-916-0
    Formula:  C11H12O2        Molecular Weight: 176.21
    IUPAC Name:  7-methoxy-3,4-dihydro-2H-naphthalen-1-one
    SMILES:  COC1=CC2=C(CCCC2=O)C=C1
    InChIKey: GABLTKRIYDNDIN-UHFFFAOYSA-N
    InChI:  InChI=1S/C11H12O2/c1-13-9-6-5-8-3-2-4-11(12)10(8)7-9/h5-7H,2-4H2,1H3
    Synonyms: 7-methoxy-3,4-dihydro-2H-naphthalen-1-one | 7-methoxytetralone | 7-methoxy-tetralone | HY-W001925 | 7-methoxy-1,2,3,4...
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Molecule Type
  1. Small molecule 77 items
  2. Unknown 6 items
  3. Antibody 5 items
  4. Antibody drug conjugate 1 item
Target
  1. MET 54 items
  2. AXL 14 items
  3. KDR 13 items
  4. MST1R 11 items
  5. MERTK 11 items
  6. TEK 8 items
  7. FLT3 7 items
  8. NTRK2 7 items
  9. EGFR 6 items
  10. NQO2 6 items
  11. NTRK1 6 items
  12. GPR84 5 items
  13. ERBB2 5 items
  14. DDR1 4 items
  15. TYRO3 4 items
  16. BCR 4 items
  17. FLT1 4 items
  18. ABL1 4 items
  19. ALK 4 items
  20. KIT 4 items
  21. NTRK3 4 items
  22. ERBB4 3 items
  23. EPHB6 3 items
  24. RET 3 items
  25. ROS1 3 items
  26. FLT4 3 items
  27. SLK 3 items
  28. PDGFRB 3 items
  29. TIE1 3 items
  30. JAK2 3 items
  31. CSF1R 2 items
  32. SRC 2 items
  33. HMOX2 2 items
  34. HGF 2 items
  35. FGFR1 2 items
  36. PTK2B 2 items
  37. EIF5B 2 items
  38. SMO 2 items
  39. PDGFRA 2 items
  40. LTK 2 items
  41. ABL2 2 items
  42. OPA1 2 items
  43. CYP3A4 1 item
  44. CDK7 1 item
  45. EPHA2 1 item
  46. EPHA4 1 item
  47. EPHA8 1 item
  48. EPHB1 1 item
  49. EPHB4 1 item
  50. EPHA5 1 item
  51. DDR2 1 item
  52. EPHA1 1 item
  53. EPHA3 1 item
  54. PTK6 1 item
  55. SRMS 1 item
  56. STK10 1 item
  57. FRK 1 item
  58. EPHA6 1 item
  59. EPHA7 1 item
  60. EPHB2 1 item
  61. HIPK4 1 item
  62. FGFR2 1 item
  63. FGFR3 1 item
  64. PRKACG 1 item
  65. TNK1 1 item
  66. PLK4 1 item
  67. PIP4K2C 1 item
  68. RIPK2 1 item
  69. MKNK2 1 item
  70. MAP2K2 1 item
  71. MAP3K13 1 item
  72. MAP3K19 1 item
  73. LCK 1 item
  74. MAP3K12 1 item
  75. MAP4K5 1 item
  76. LYN 1 item
  77. BLK 1 item
  78. AURKC 1 item
  79. HCK 1 item
  80. MAP2K1 1 item
  81. MAP2K5 1 item
  82. MUSK 1 item
Antibody Type
  1. Primary antibody 6 items
Application
  1. Animal Model 6 items
  2. ELISA 6 items
  3. Flow Cytometry 6 items
  4. Functional Assay 6 items
Species reactivity（Reacts with)
  1. Human 6 items
  2. Cynomolgus monkey 4 items
  3. Mouse 2 items
  4. Rat 1 item
Host species
  1. Human 6 items
Clonality
  1. Recombinant 6 items
Conjugation
  1. Unconjugated 5 items
  2. MC-VC-PAB-MMAE 1 item
Isotype
  1. Human IgG1 4 items
  2. Human IgG2SA 1 item
  3. Human IgG4SP 1 item
Physical Form
  1. Liquid 6 items
  2. Solid 4 items
Purity
  1. ≥98% 47 items
  2. ≥99% 18 items
  3. ≥97% 6 items
  4. ≥95%(SDS-PAGE&SEC-HPLC) 5 items
  5. ≥96% 2 items
  6. ≥98%(HPLC) 2 items
  7. ≥90%(SDS-PAGE&SEC-HPLC) 1 item
  8. ≥95% 1 item
  9. ≥99%(GC) 1 item
  10. ≥99.5%(GC) 1 item
Source
  1. CHO supernatant 5 items
Grade
  1. Moligand™ 52 items
  2. Animal Free 6 items
  3. Azide Free 6 items
  4. Carrier Free 6 items
  5. ExactAb™ 6 items
  6. Low Endotoxin 6 items
  7. Recombinant 6 items
  8. Validated 6 items
  9. analytical standard 1 item
  10. AR 1 item
  11. CP 1 item
  12. Standard for GC 1 item
Action Type
  1. INHIBITOR 57 items
  2. AGONIST 3 items
  3. ACTIVATOR 1 item
  4. ANTAGONIST 1 item
Price
  1. $0.00 - $500.00 109 items
  2. $500.00 - $1,000.00 7 items
  3. $1,000.00 - $1,500.00 4 items
  4. $2,000.00 - $2,500.00 1 item
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