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PF 04217903 mesylate - ≥98%(HPLC), high purity , CAS No.956906-93-7

Grade & Purity:

≥98%(HPLC)

Cas Number: 956906-93-7
Molecular Weight: 468.49
PubChem CID: 24852079

In stock

Item Number

P288839

Grouped product items
SKU	Size	Availability	Price
P288839-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$79.90
P288839-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$125.90
P288839-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$209.90
P288839-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$376.90
P288839-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$677.90

Highly selective MET inhibitor

View related series

c-Met/HGFR (76) Protein Tyrosine Kinase/RTK (1314) Receptor Tyrosine Kinase (1260)

Synonyms	2-(4-{1-[(quinolin-6-yl)methyl]-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl}-1H-pyrazol-1-yl)ethan-1-ol; methanesulfonic acid \| PF-04217903 methanesulfonate \| CS-0845 \| methanesulfonic acid;2-[4-[3-(quinolin-6-ylmethyl)triazolo[4,5-b]pyrazin-5-yl]pyrazol-1-yl]e
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	Highly selective, high affinity MET inhibitor (Ki= 6-7 nM against wild type c-Met). Displays >1000-fold selectivity for c-Met over a panel of 208 kinases.
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	PF-04217903 methanesulfonate is a potent ATP-competitive inhibitor of c-Met kinase (Ki of 4.8 nM for human c-Met). Application： PF-04217903 has been used as tyrosine-protein kinase Met (C-Met) selective inhibitor in Madin-Darby Canine kidney (MDCK) cells[1] and NT2D1 non-seminoma cells.

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Quinolines and derivatives
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Quinolines and derivatives
Alternative Parents	Pyridines and derivatives Pyrazines Benzenoids Triazoles Sulfonyls Pyrazoles Organosulfonic acids Methanesulfonates Heteroaromatic compounds Alkanesulfonic acids Azacyclic compounds Alkanolamines Primary alcohols Organic oxides Hydrocarbon derivatives
Molecular Framework	Not available
Substituents	Quinoline - Pyrazine - Pyridine - Benzenoid - Azole - Methanesulfonate - Pyrazole - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Organosulfonic acid - Sulfonyl - 1,2,3-triazole - Alkanesulfonic acid - Heteroaromatic compound - Alkanolamine - Azacycle - Organic oxygen compound - Organic oxide - Alcohol - Organonitrogen compound - Organooxygen compound - Organosulfur compound - Primary alcohol - Hydrocarbon derivative - Organic nitrogen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as quinolines and derivatives. These are compounds containing a quinoline moiety, which consists of a benzene ring fused to a pyrimidine ring to form benzo[b]azabenzene.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

IUPAC Name	methanesulfonic acid;2-[4-[3-(quinolin-6-ylmethyl)triazolo[4,5-b]pyrazin-5-yl]pyrazol-1-yl]ethanol
INCHI	InChI=1S/C19H16N8O.CH4O3S/c28-7-6-26-12-15(9-22-26)17-10-21-18-19(23-17)27(25-24-18)11-13-3-4-16-14(8-13)2-1-5-20-16;1-5(2,3)4/h1-5,8-10,12,28H,6-7,11H2;1H3,(H,2,3,4)
InChIKey	HBEMHKVWZJTVOC-UHFFFAOYSA-N
Smiles	CS(=O)(=O)O.C1=CC2=C(C=CC(=C2)CN3C4=NC(=CN=C4N=N3)C5=CN(N=C5)CCO)N=C1
Isomeric SMILES	CS(=O)(=O)O.C1=CC2=C(C=CC(=C2)CN3C4=NC(=CN=C4N=N3)C5=CN(N=C5)CCO)N=C1
PubChem CID	24852079
Molecular Weight	468.49

Solubility	Solvent:DMSO, Max Conc. mg/mL: 46.85, Max Conc. mM: 100
Sensitivity	Moisture sensitive
Molecular Weight	468.500 g/mol
XLogP3
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	5
Exact Mass	468.133 Da
Monoisotopic Mass	468.133 Da
Topological Polar Surface Area	170.000 Å²
Heavy Atom Count	33
Formal Charge	0
Complexity	617.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

PF 04217903 mesylate - ≥98%(HPLC), high purity , CAS No.956906-93-7

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