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Volociximab (anti-Integrin α5β1) - Primary antibody, specific to ITGA5; ITGB1, Human IgG4SP, Antibody of integrin α5β1;Antibody of integrin; alpha 5 subunit (fibronectin receptor; alpha polypeptide), Antibody of integrin α5β1;Antibody of integrin; alpha 5 subunit (fibronectin receptor; alpha polypeptide)

COA COA
    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Human
  • Isotype: Human IgG4SP
  • Conjugation: Unconjugated
In stock
Item Number
Ab175701
Grouped product items
SKU Size
Availability
 Price Qty
Ab175701-100μg
100μg
10
$79.90
Ab175701-1mg
1mg
4
$389.90
Ab175701-5mg
5mg
1
$1,149.90
Ab175701-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,939.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

View related series
Click to view target information: ITGB1 Click to view target information: ITGA5
Accession#:P05556 (3) Accession#:P08648 (2) CD29 (3) CD49 (5) CD49e (1) Gene ID:3678 (2) Gene ID:3688 (3) Integrin alpha 5 (2) Integrin beta 1 (3) ITGA5 (2) ITGB1 (4)

Basic Description

Product Name Volociximab (anti-Integrin α5β1) - Primary antibody, specific to ITGA5; ITGB1, Human IgG4SP, Antibody of integrin α5β1;Antibody of integrin; alpha 5 subunit (fibronectin receptor; alpha polypeptide)
Synonyms M200 | Eos 200-4 | ITGA5 | CD49 antigen-like family member E antibody | CD49e antibody | Fibronectin receptor subunit alpha antibody | Fibronectin receptor, alpha subunit antibody | FNRA antibody | Integrin alpha 5 (fibronectin receptor alpha) antibody |
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity ITGA5; ITGB1
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type ANTAGONIST
Mechanism of action Antibody of integrin α5β1;Antibody of integrin; alpha 5 subunit (fibronectin receptor; alpha polypeptide)
Product Description

Volociximab is a chimeric human/murine IgG4 antibody IIA1 targeting integrin α5β1. Integrin α5β1 is a major fibronectin receptor involved in angiogenesis. Volociximab (anti-Integrin α5β1)) has antiangiogenic and antitumor activities and inhibits the proliferation of human umbilical vein vascular endothelial cells (HUVECs).
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Product Properties

Isotype Human IgG4SP
Light Chain Type kappa
SDS-PAGE 26.6 kDa (Light Chain) & 51.8 kDa (Heavy Chain), under reducing conditions; 190.8 kDa, under non-reducing conditions.
Purification Method Protein A purified
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS 558480-40-3

Associated Targets(Human)

ITGB1 Tclin Integrin beta-1 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
ITGA5 Tbio Integrin alpha-5 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
ITGB1 Tclin Fibronectin receptor beta (8 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ITGA5 Tbio Fibronectin receptor alpha (13 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ITGB1 Tclin Integrin alpha-4/beta-1 (2269 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ITGB1 Tclin Integrin alpha-5/beta-1 (686 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ITGB1 Tclin Integrin alpha-V/beta-1 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ITGB1 Tclin Integrin alpha2/beta1 (69 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ITGB1 Tclin Integrin alpha1/beta1 complex (6 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ITGB1 Tclin Integrin alpha-10/Integrin beta-1 (1 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ITGB1 Tclin ITGA6-ITGB1 complex (1 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Volociximab (anti-Integrin α5β1) (Ab175701) - ELISA
Immobilized Human Integrin α5β1 Protein at 2.0 μg/mL can bind Volociximab (anti-Integrin α5β1) (Ab175701) with the EC ₅₀ of 9.58 ng/mL.

Volociximab (anti-Integrin α5β1) (Ab175701) - SEC
The purity of Volociximab (anti-Integrin α5β1) (Ab175701) is more than 95% verified by HPLC.

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0708319 Certificate of Analysis Jul 16, 2024 Ab175701
ZJ24F0708318 Certificate of Analysis Jul 16, 2024 Ab175701
ZJ24F0708317 Certificate of Analysis Jul 16, 2024 Ab175701

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