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SIRP alpha/CD172a Rat mAb - Primary antibody, specific to SIRP alpha/CD172a, Rat IgG1

COA COA
    Application:
  • Animal Model
  • Blocking
  • Flow Cytometry
  • Functional Assay
  • IP
  • WB
  • Host species: Rat
  • Reactive species: Mouse
  • Isotype: Rat IgG1
  • Clone Number: P84
  • Conjugation: Unconjugated
In stock
Item Number
Ab127636
Grouped product items
SKU Size
Availability
 Price Qty
Ab127636-10μg
10μg
5
$29.90
Ab127636-50μg
50μg
2
$69.90
Ab127636-100μg
100μg
1
$99.90
Ab127636-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$219.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

mAb (P84); Rat anti Mouse SIRP alpha/CD172a Antibody; in vivo SIRPα blocking, in vitro SIRPα blocking, WB, IP, Flow; Unconjugated

View related series
Click to view target information: SIRPA
Accession#: P97797 (8) CD172a (9) Flow Cytometry (1158) Gene ID: 19261 (8) SIRP alpha (3) Sirpa (8)

Basic Description

Product Name SIRP alpha/CD172a Rat mAb - Primary antibody, specific to SIRP alpha/CD172a, Rat IgG1
Synonyms Bit | SIRP | SHP-1 | Ptpns1 | Idd13.2 | BIT | BITbrain-immunoglobulin-like molecule with tyrosine-based activation motifs | Brain Ig-like molecule with tyrosine-based activation motifs | CD172 antigen-like family member A | CD172a antigen | CD172a | Inhib
Specifications & Purity Carrier Free, ExactAb™, Azide Free, Validated, ≥95%(SDS-PAGE), See COA
Host species Rat
Specificity SIRP alpha/CD172a
Immunogen Mouse brain membrane protein
Conjugation Unconjugated
Grade Azide Free, Carrier Free, ExactAb™, Validated
Product Description

Rat anti Mouse SIRP alpha/CD172a Antibody, Monoclonal (P84), could be used for in vivo SIRPα blocking, in vitro SIRPα blocking, WB, IP, Flow and so on.

Application:

in vivo SIRPα blocking: Use at an assay dependent concentration. 

in vitro SIRPα blocking: Use at an assay dependent concentration. 

WB: Use at an assay dependent concentration. 

IP: Use at an assay dependent concentration. 

Flow: Use at an assay dependent concentration. 
Protein Function
Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.

Product Properties

Isotype Rat IgG1
Light Chain Type kappa
SDS-PAGE 150 kDa
Purification Method Protein A purified
Shape Liquid
Concentration See COA
Storage Temp Store at 2-8°C,Do not freeze
Shipped In Wet ice
Stability And Storage Shipped at 4°C. Store at 4°C long term (12 months). Do not freeze. Upon receipt, it is recommended to aliquot.

Associated Targets(Human)

SIRPA Tbio Tyrosine-protein phosphatase non-receptor type substrate 1 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Images

SIRP alpha/CD172a Rat mAb (Ab127636) - Flow Cytometry
Two-color flow cytometric analysis of SIRP alpha/CD172a expression on mouse bone marrow cells. C57BL/6 mouse bone marrow cells were stained with CD11b Rat mAb (APC) (Ab178881) and either Rat IgG Isotype Control Antibody (Biotin) (Ab180310; Left panel) or SIRP alpha/CD172a Rat mAb (Ab127636; Right panel) at 0.5 μg/mL. Two-color flow cytometric dot plots showing the correlated expression of CD11b versus SIRP alpha/CD172a (or Isotype control staining) were derived from gated events with the forward and side light-scatter characteristics of viable mononuclear cells.

Application

Application Dilution info
WB

Use at an assay dependent concentration.
IP

Use at an assay dependent concentration.
Flow Cytometry

Use at an assay dependent concentration.
in vivo SIRPα blocking

Use at an assay dependent concentration
in vitro SIRPα blocking

Use at an assay dependent concentration

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

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