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Lesabelimab (anti-PD-L1) - Primary antibody, specific to CD274, Human IgG1

COA COA
    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Human
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
Ab182969
Grouped product items
SKU Size
Availability
 Price Qty
Ab182969-100μg
100μg
10
$89.90
Ab182969-1mg
1mg
4
$419.90
Ab182969-5mg
5mg
1
$1,089.90
Ab182969-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,749.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet
View related series
Click to view target information: CD274
Accession#:Q9NZQ7 (26) B7-H1 (7) Flow Cytometry (1158) Gene ID:29126 (26) PD-L1 (22)

Basic Description

Product Name Lesabelimab (anti-PD-L1) - Primary antibody, specific to CD274, Human IgG1
Synonyms B7 H antibody | B7 H1 antibody | B7 homolog 1 antibody | B7-H1 antibody | B7H antibody | B7H1 antibody | CD 274 antibody | CD-274 antibody | CD274 antibody | CD274 antigen antibody | CD274 molecule antibody | MGC142294 antibody | MGC142296 antibody | OTTH
Specifications & Purity RUO, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity CD274
Conjugation Unconjugated
Grade Animal Free, RUO
Product Description

Lesabelimab (anti-PD-L1) is an immunoglobulin G1-kappa anti-CD274 monoclonal antibody. CD274 is an immune checkpoint ligand, represses antitumour immunity through the interaction with PDCD1 receptor.
Purity
≥95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Product Properties

Isotype Human IgG1
Light Chain Type kappa
SDS-PAGE 25.8 kDa (Light Chain) & 49.1 kDa (Heavy Chain), under reducing conditions; 195.9 kDa, under non-reducing conditions.
Purification Method Protein A purified
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 2475402-56-1

Associated Targets(Human)

CD274 Tclin Programmed cell death 1 ligand 1 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Lesabelimab (anti-PD-L1) (Ab182969) - Flow Cytometry
Flow Cytometry analysis of 500 ng/mL Ionomycin (I139530) and 10 ng/mL PMA (P408905) co-stimulated Jurkat cells (24h) labelling PD-L1 (red) with Lesabelimab (anti-PD-L1) (Ab182969). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Lesabelimab (anti-PD-L1) (Ab182969) - ELISA
Immobilized Recombinant Human PD-L1 protein (rp169666) at 1.0 μg/mL can bind Lesabelimab (anti-PD-L1) (Ab182969) with the EC₅₀ of 172.4 ng/mL.

Lesabelimab (anti-PD-L1) (Ab182969) - SEC
The purity of Lesabelimab (anti-PD-L1) (Ab182969) is more than 95% verified by HPLC.

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0606995 Certificate of Analysis Jun 19, 2024 Ab182969
ZJ24F0606994 Certificate of Analysis Jun 19, 2024 Ab182969
ZJ24F0606993 Certificate of Analysis Jun 19, 2024 Ab182969

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