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Durvalumab (anti-PD-L1) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to B7-H1 / PD-L1 / CD274, >95%, high purity, Human IgG1, INHIBITOR of Programmed cell death 1 ligand 1 inhib, INHIBITOR of Programmed cell death 1 ligand 1 inhibitor

COA COA
    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Cynomolgus monkey,Human,Mouse
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
D412005
Grouped product items
SKU Size
Availability
 Price Qty
D412005-100μg
100μg
10
$39.90
D412005-1mg
1mg
4
$159.90
D412005-5mg
5mg
1
$664.90
D412005-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,196.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<0.01EU/μg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

View related series
Click to view target information: CD274
Accession#:Q9NZQ7 (26) Gene ID:29126 (26) Immunology/Inflammation (1929) PD-1/PD-L1 (59) PD-L1 (22)

Basic Description

Product Name Durvalumab (anti-PD-L1) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to B7-H1 / PD-L1 / CD274, >95%, high purity, Human IgG1, INHIBITOR of Programmed cell death 1 ligand 1 inhib
Synonyms Durvalumab (anti-PD-L1) | MEDI4736 | Durvalumab | MEDI 4736 | Anti-B7-H1 / PD-L1 / CD274 Reference Antibody (durvalumab) | Recombinant Durvalumab Antibody | B7 H antibody | B7 H1 antibody | B7 homolog 1 antibody | B7-H1 antibody | B7H antibody | B7H1 anti
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity B7-H1 / PD-L1 / CD274
Application ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Recombinant, Validated
Action Type INHIBITOR
Mechanism of action INHIBITOR of Programmed cell death 1 ligand 1 inhibitor
Product Description

Durvalumab is an humanized anti-PD-L1 monoclonal antibody, completely blocks the binding of PD-L1 to both PD-1 and CD80, with IC50s of 0.1 and 0.04 nM, respectively.
Purity>95% (SDS-PAGE&SEC)
Endotoxin Level<0.01EU/μg

Product Properties

Antibody Type Primary antibody
Clonality Recombinant
Isotype Human IgG1
Light Chain Type kappa
SDS-PAGE 26.5 kDa (Light Chain) & 52.2 kDa (Heavy Chain), under reducing conditions; 180.0 kDa, under non-reducing conditions.
Purification Method Protein A purified
Purity >95%
Source CHO supernatant
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 1428935-60-7

Associated Targets(Human)

CD274 Tclin Programmed cell death 1 ligand 1 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Durvalumab (anti-PD-L1) (D412005) - Flow Cytometry
Flow Cytometry analysis of PBMC cells labelling PD-L1 (red) with Durvalumab (anti-PD-L1) (D412005) . Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Durvalumab (anti-PD-L1) (D412005) - SEC
The purity of Durvalumab (anti-PD-L1) (D412005) is more than 95% verified by HPLC.

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0404206 Certificate of Analysis Apr 08, 2024 D412005
ZJ24F0404207 Certificate of Analysis Apr 08, 2024 D412005
ZJ24F0404208 Certificate of Analysis Apr 08, 2024 D412005

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