Determine the necessary mass, volume, or concentration for preparing a solution.
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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab175484-100μg
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100μg |
10
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$59.90
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Ab175484-1mg
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1mg |
4
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$279.90
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Ab175484-5mg
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5mg |
1
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$739.90
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Ab175484-10mg
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10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$1,189.90
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Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Cabiralizumab (anti-CSF1R) - Primary antibody, specific to CSF1R, >95%, high purity, Human IgG4SP, Antibody of colony stimulating factor 1 receptor |
|---|---|
| Synonyms | C FMS antibody | CD 115 antibody | CD115 antibody | CD115 antigen antibody | CFMS antibody | Colony stimulating factor 1 receptor antibody | Colony stimulating factor I receptor antibody | CSF 1 R antibody | CSF 1R antibody | CSF-1 receptor antibody | CSF |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Host species | Human |
| Specificity | CSF1R |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | ANTAGONIST |
| Mechanism of action | Antibody of colony stimulating factor 1 receptor |
| Product Description |
Cabiralizumab (anti-CSF1R) is an anti-CSF1R monoclonal antibody (MAb). Cabiralizumab (anti-CSF1R) enhances T cell infiltration and antitumor T cell immune responses. Cabiralizumab (anti-CSF1R) inhibits the activation of osteoclasts and blocks bone destruction, and can be used in the research of rheumatoid arthritis (RA). Cabiralizumab (anti-CSF1R) can combine with Nivolumab (anti-PD-1) for lung cancer research. |
| Isotype | Human IgG4SP |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 26.1kDa (Light Chain) & 51.7kDa (Heavy Chain), under reducing conditions; 188.5 kDa, under non-reducing conditions. |
| Purification Method | Protein A purified |
| Purity | >95% |
| Shape | Liquid |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 1613144-80-1 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
Cabiralizumab (anti-CSF1R) (Ab175484) - ELISA
Immobilized Hu-CSF1R-his at 2 μg/mL can bind Cabiralizumab (anti-CSF1R) (Ab175484) with the EC₅₀ of 21.57 ng/mL.
Cabiralizumab (anti-CSF1R) (Ab175484) - SEC
The purity of Cabiralizumab (anti-CSF1R) (Ab175484) is more than 95% verified by HPLC.
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Mar 29, 2024 | Ab175484 | |
| Certificate of Analysis | Mar 29, 2024 | Ab175484 | |
| Certificate of Analysis | Mar 29, 2024 | Ab175484 |