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Cabiralizumab (anti-CSF1R) - Primary antibody, specific to CSF1R, >95%, high purity, Human IgG4SP, Antibody of colony stimulating factor 1 receptor, Antibody of colony stimulating factor 1 receptor

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Cynomolgus monkey,Human
  • Isotype: Human IgG4SP
  • Conjugation: Unconjugated
In stock
Item Number
Ab175484
Grouped product items
SKU Size
Availability
Price Qty
Ab175484-100μg
100μg
10
$59.90
Ab175484-1mg
1mg
4
$279.90
Ab175484-5mg
5mg
1
$739.90
Ab175484-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,189.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Cabiralizumab (anti-CSF1R) - Primary antibody, specific to CSF1R, >95%, high purity, Human IgG4SP, Antibody of colony stimulating factor 1 receptor
Synonyms C FMS antibody | CD 115 antibody | CD115 antibody | CD115 antigen antibody | CFMS antibody | Colony stimulating factor 1 receptor antibody | Colony stimulating factor I receptor antibody | CSF 1 R antibody | CSF 1R antibody | CSF-1 receptor antibody | CSF
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity CSF1R
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type ANTAGONIST
Mechanism of action Antibody of colony stimulating factor 1 receptor
Product Description

Cabiralizumab (anti-CSF1R) is an anti-CSF1R monoclonal antibody (MAb). Cabiralizumab (anti-CSF1R) enhances T cell infiltration and antitumor T cell immune responses. Cabiralizumab (anti-CSF1R) inhibits the activation of osteoclasts and blocks bone destruction, and can be used in the research of rheumatoid arthritis (RA). Cabiralizumab (anti-CSF1R) can combine with Nivolumab (anti-PD-1) for lung cancer research.

Product Properties

Isotype Human IgG4SP
Light Chain Type kappa
SDS-PAGE 26.1kDa (Light Chain) & 51.7kDa (Heavy Chain), under reducing conditions; 188.5 kDa, under non-reducing conditions.
Purification Method Protein A purified
Purity >95%
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 1613144-80-1

Associated Targets(Human)

CSF1R Tclin Macrophage colony-stimulating factor 1 receptor (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Cabiralizumab (anti-CSF1R) (Ab175484) - ELISA
Immobilized Hu-CSF1R-his at 2 μg/mL can bind Cabiralizumab (anti-CSF1R) (Ab175484) with the EC₅₀ of 21.57 ng/mL.

Cabiralizumab (anti-CSF1R) (Ab175484) - SEC
The purity of Cabiralizumab (anti-CSF1R) (Ab175484) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0303759 Certificate of Analysis Mar 29, 2024 Ab175484
ZJ24F0303758 Certificate of Analysis Mar 29, 2024 Ab175484
ZJ24F0303757 Certificate of Analysis Mar 29, 2024 Ab175484

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