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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab177886-100μg
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100μg |
10
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$79.90
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Ab177886-1mg
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1mg |
4
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$359.90
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Ab177886-5mg
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5mg |
1
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$929.90
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Ab177886-10mg
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10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$1,489.90
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Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG2; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Astegolimab (anti-IL-1RL1) - Primary antibody, specific to IL1RL1, >95%, high purity, Human IgG2, INHIBITOR of IL-33 receptor (ST2) inhibitor |
|---|---|
| Synonyms | EC 3.2.2.6 | Protein ST2 |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Host species | Human |
| Specificity | IL1RL1 |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | INHIBITOR |
| Mechanism of action | INHIBITOR of IL-33 receptor (ST2) inhibitor |
| Product Description |
Astegolimab (anti-IL-1RL1) is a human IgG2 monoclonal antibody that blocks IL-33 signaling by targeting ST2, the IL-33 receptor. Astegolimab (anti-IL-1RL1) has the potential for chronic obstructive pulmonary disease (COPD) research. |
| Isotype | Human IgG2 |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 26.1 kDa (Light Chain) & 51.9 kDa (Heavy Chain), under reducing conditions; 189.3kDa, under non-reducing conditions. |
| Purification Method | Protein A purified |
| Purity | >95% |
| Shape | Liquid |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 2173054-79-8 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
Astegolimab (anti-IL-1RL1) (Ab177886) - ELISA
Immobilized Human-ST2-ECD-his at 2 μg/mL can bind Astegolimab (anti-IL-1RL1) (Ab177886) with the EC₅₀ of 28.29 ng/mL.
Astegolimab (anti-IL-1RL1) (Ab177886) - SEC
The purity of Astegolimab (anti-IL-1RL1) (Ab177886) is more than 95% verified by HPLC.
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Apr 03, 2024 | Ab177886 | |
| Certificate of Analysis | Apr 03, 2024 | Ab177886 | |
| Certificate of Analysis | Apr 03, 2024 | Ab177886 |
Starting at $69.90
Starting at $69.90
Starting at $69.90