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Astegolimab (anti-IL-1RL1) - Primary antibody, specific to IL1RL1, >95%, high purity, Human IgG2, INHIBITOR of IL-33 receptor (ST2) inhibitor, INHIBITOR of IL-33 receptor (ST2) inhibitor

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Cynomolgus monkey,Human,Mouse
  • Isotype: Human IgG2
  • Conjugation: Unconjugated
In stock
Item Number
Ab177886
Grouped product items
SKU Size
Availability
Price Qty
Ab177886-100μg
100μg
10
$79.90
Ab177886-1mg
1mg
4
$359.90
Ab177886-5mg
5mg
1
$929.90
Ab177886-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,489.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG2; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Astegolimab (anti-IL-1RL1) - Primary antibody, specific to IL1RL1, >95%, high purity, Human IgG2, INHIBITOR of IL-33 receptor (ST2) inhibitor
Synonyms EC 3.2.2.6 | Protein ST2
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity IL1RL1
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type INHIBITOR
Mechanism of action INHIBITOR of IL-33 receptor (ST2) inhibitor
Product Description

Astegolimab (anti-IL-1RL1) is a human IgG2 monoclonal antibody that blocks IL-33 signaling by targeting ST2, the IL-33 receptor. Astegolimab (anti-IL-1RL1) has the potential for chronic obstructive pulmonary disease (COPD) research.

Product Properties

Isotype Human IgG2
Light Chain Type kappa
SDS-PAGE 26.1 kDa (Light Chain) & 51.9 kDa (Heavy Chain), under reducing conditions; 189.3kDa, under non-reducing conditions.
Purification Method Protein A purified
Purity >95%
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 2173054-79-8

Associated Targets(Human)

IL1RL1 Tbio Interleukin-1 receptor-like 1 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Images

Astegolimab (anti-IL-1RL1) (Ab177886) - ELISA
Immobilized Human-ST2-ECD-his at 2 μg/mL can bind Astegolimab (anti-IL-1RL1) (Ab177886) with the EC₅₀ of 28.29 ng/mL.

Astegolimab (anti-IL-1RL1) (Ab177886) - SEC
The purity of Astegolimab (anti-IL-1RL1) (Ab177886) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0404101 Certificate of Analysis Apr 03, 2024 Ab177886
ZJ24F0404102 Certificate of Analysis Apr 03, 2024 Ab177886
ZJ24F0404103 Certificate of Analysis Apr 03, 2024 Ab177886

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