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Briquilimab (anti-CD117) - Primary antibody, specific to KIT, Human IgG1(N297Q)

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Human
  • Isotype: Human IgG1(N297Q)
  • Conjugation: Unconjugated
In stock
Item Number
Ab182958
Grouped product items
SKU Size
Availability
Price Qty
Ab182958-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$69.90
Ab182958-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$349.90
Ab182958-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$879.90
Ab182958-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,399.90

Purity≥95% (SDS-PAGE&SEC); Endotoxin Level≤1.0EU/mg; Human IgG1-N297Q; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Briquilimab (anti-CD117) - Primary antibody, specific to KIT, Human IgG1(N297Q)
Synonyms C Kit antibody | c-Kit antibody | c-Kit Ligand antibody | CD117 antibody | Kit antibody | Kit Ligand antibody | KIT oncogene antibody | KIT proto oncogene receptor tyrosine kinase antibody | KIT_HUMAN antibody | Mast cell growth factor receptor antibody |
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Biochemical and Physiological Mechanisms Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration a
Host species Human
Specificity KIT
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Product Description

Briquilimab (anti-CD117) is a non-toxic humanized monoclonal antibody targeting CD117 (c-Kit) to deplete hematopoietic stem cell (HSC). Briquilimab (anti-CD117) has safety to clear host marrow niche space to enable sufficient donor HSC engraftment and immune reconstitution as primary method of severe combined immunodeficiency (SCID).

Product Properties

Isotype Human IgG1(N297Q)
Light Chain Type kappa
SDS-PAGE 145.58 kDa
Purification Method Protein A purified
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 2574591-89-0

Associated Targets(Human)

KIT Tclin Mast/stem cell growth factor receptor Kit (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
KIT Tclin Stem cell growth factor receptor (10667 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KIT Tclin VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT) (10 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KIT Tclin VHL/KIT (4 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Briquilimab (anti-CD117) (Ab182958) - Flow Cytometry
Flow Cytometry analysis of HEL cells labelling CD117 (red) with Briquilimab (anti-CD117) (Ab182958) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Briquilimab (anti-CD117) (Ab182958) - SEC
The purity of Briquilimab (anti-CD117) (Ab182958) is more than 95% verified by HPLC.

Briquilimab (anti-CD117) (Ab182958) - ELISA
Immobilized Recombinant Human CD117/c-kit protein (rp181606) at 1.0 μg/mL can bind Briquilimab (anti-CD117) (Ab182958) with the EC₅₀ of 13.14 ng/mL.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

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