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BHQ880 (anti-DKK1) - Primary antibody, specific to DKK1, >95% (SDS-PAGE&SEC), high purity, Human IgG1

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Cynomolgus monkey,Human,Mouse
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
Ab177877
Grouped product items
SKU Size
Availability
Price Qty
Ab177877-100μg
100μg
10
$109.90
Ab177877-1mg
1mg
4
$519.90
Ab177877-5mg
5mg
1
$1,399.90
Ab177877-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,239.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<0.01EU/μg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name BHQ880 (anti-DKK1) - Primary antibody, specific to DKK1, >95% (SDS-PAGE&SEC), high purity, Human IgG1
Synonyms Dickkopf-1 | Dkk-1 | hDkk-1 | SK
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity DKK1
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Recombinant, Validated
Product Description

BHQ880 (anti-DKK1) is a humanized monoclonal antibody targeting Wnt antagonist Dickkopf-1 (DKK1). It binds to and inhibits DKK1, enhancing signaling through the Wnt pathway, which result in osteoblast differentiation and activation within the bone matrix and the reversal of tumor-induced osteolytic disease.

Product Properties

Isotype Human IgG1
Light Chain Type lambda
SDS-PAGE 27.2 kDa (Light Chain) & 49.6 kDa (Heavy Chain), under reducing conditions; 190.3 kDa, under non-reducing conditions.
Purification Method Protein A purified
Purity >95% (SDS-PAGE&SEC)
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

DKK1 Tchem Dickkopf-related protein 1 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
DKK1 Tchem Dickkopf-related protein 1 (93 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

BHQ880 (anti-DKK1) (Ab177877) - Flow Cytometry
Flow Cytometry analysis of HepG2 cells labelling DKK1 (red) with BHQ880 (anti-DKK1) (Ab177877). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

BHQ880 (anti-DKK1) (Ab177877) - SEC
The purity of BHQ880 (anti-DKK1) (Ab177877) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0404124 Certificate of Analysis Apr 03, 2024 Ab177877
ZJ24F0404123 Certificate of Analysis Apr 03, 2024 Ab177877
ZJ24F0404122 Certificate of Analysis Apr 03, 2024 Ab177877

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