| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| T107400-50mg |
50mg |
期货  |
|
| 别名 | 雷公藤甲素 |
|---|---|
| 英文别名 | PG 490 | HY-32735 | NSC839303 | NSC-839303 | CAS-5611-51-8 | SCHEMBL413634 | MLS000759410 | NCGC00163411-02 | BSPBio_001595 | Triptolid | NCGC00163411-01 | (5bS,6aS,7aS,8R,8aR,9aS,9bS,10aS,10bS)-8-Hydroxy-8a-isopropyl-10b-methyl-1,5,5b,6,6a,8,8a,9a,9b,10b |
| 规格或纯度 | ≥98% |
| 英文名称 | Triptolide |
| 生化机理 | 抑制XBP的DNA依赖性ATPase活性并诱导抑制RNA聚合酶II（RNAPII）介导的转录（IC50 = 200 nM）。相对于RNAPI和RNAPIII具有选择性。阻止HeLa细胞中的RNA合成（IC50 = 62 nM）；在60个癌细胞系中表现出有效的抗增殖活性（平均IC50 = 12 nM），并通过阻断TNF-α介导的c-IAP1和c-IAP2诱导细胞凋亡。还显示出免疫抑制和抗炎活性。 |
| 储存温度 | 2-8°C储存 |
| 运输条件 | 冰袋运输 |
| 产品介绍 |
雷公藤甲素是一个具有多种生物活性的二萜内酯，可溶于二甲基亚砜.来源于中药雷公藤的根 |
| 纯度 | ≥98% |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| PubChem SID | 504756646 |
|---|---|
| 分子类型 | 小分子 |
| IIUPAC Name | (1S,2S,4S,5S,7R,8R,9S,11S,13S)-8-hydroxy-1-methyl-7-propan-2-yl-3,6,10,16-tetraoxaheptacyclo[11.7.0.02,4.02,9.05,7.09,11.014,18]icos-14(18)-en-17-one |
| INCHI | 1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11-,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1 |
| InChi Key | DFBIRQPKNDILPW-CIVMWXNOSA-N |
| Smiles | CC(C)C12C(O1)C3C4(O3)C5(CCC6=C(C5CC7C4(C2O)O7)COC6=O)C |
| Isomeric SMILES | CC(C)[C@@]12[C@@H](O1)[C@H]3[C@@]4(O3)[C@]5(CCC6=C([C@@H]5C[C@H]7[C@]4([C@@H]2O)O7)COC6=O)C |
| PubChem CID | 107985 |
| 分子量 | 360.4 |
| Reaxy-Rn | 1692435 |
| 溶解性 | 溶于DMSO, 最高浓度 (mg/mL): 7.21, 最高浓度(mM): 20 |
|---|---|
| 密度 | 1.48 |
| 敏感性 | 对热敏感 |
| 熔点 | 229 °C |
| 分子量 | 360.400 g/mol |
| XLogP3 | 0.200 |
| 氢键供体数Hydrogen Bond Donor Count | 1 |
| 氢键受体数Hydrogen Bond Acceptor Count | 6 |
| 可旋转键计数Rotatable Bond Count | 1 |
| 精确质量Exact Mass | 360.157 Da |
| 单同位素质量Monoisotopic Mass | 360.157 Da |
| 拓扑极表面积Topological Polar Surface Area | 84.100 Ų |
| 重原子数Heavy Atom Count | 26 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 819.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 9 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 1. Lin Jingpan, Gao Lu, Lin Yanke, Wang Shuai, Yang Zemin, Ren Shujing, Chen Min, Wu Baojian. (2021) Pharmacokinetics-Based Chronoefficacy of Semen Strychni and Tripterygium Glycoside Tablet Against Rheumatoid Arthritis. Frontiers in Pharmacology, 12 [PMID:34108880] [10.3389/fphar.2021.673263] |
| 2. Zhao Huan, Tong Yongbin, Lu Danyi, Wu Baojian. (2020) Circadian clock regulates hepatotoxicity of Tripterygium wilfordii through modulation of metabolism. JOURNAL OF PHARMACY AND PHARMACOLOGY, 72 (12): (1854-1864). [PMID:32478421] [10.1111/jphp.13299] |
| 3. Lin Yanke, Wang Shuai, Zhou Ziyue, Guo Lianxia, Yu Fangjun, Wu Baojian. (2019) Bmal1 regulates circadian expression of cytochrome P450 3a11 and drug metabolism in mice. Communications Biology, 2 (1): (1-11). [PMID:31633069] [10.1038/s42003-019-0607-z] |
| 4. Caili Huang, Tao Zeng, Jiawen Li, Lishan Tan, Xiulong Deng, Yanchao Pan, Qi Chen, Aiqing Li, Jianqiang Hu. (2019) Folate Receptor-Mediated Renal-Targeting Nanoplatform for the Specific Delivery of Triptolide to Treat Renal Ischemia/Reperfusion Injury. ACS Biomaterials Science & Engineering, 5 (6): (2877–2886). [PMID:33405591] [10.1021/acsbiomaterials.9b00119] |
| 5. Bailing Ma, Mi Lu, Bo-Yang Yu, Jiangwei Tian. (2018) A galactose-mediated targeting nanoprobe for intracellular hydroxyl radical imaging to predict drug-induced liver injury. RSC Advances, 8 (39): (22062-22068). [PMID:35541760] [10.1039/C8RA01424H] |
| 6. Yanrong Zhu, Lichen Yao, Yilei Guo, Jing Zhang, Yufeng Xia, Zhifeng Wei, Yue Dai. (2024) Bergenin attenuates triptolide-caused premature ovarian failure in mice based on the antioxidant activity. REPRODUCTIVE TOXICOLOGY, (108608). [PMID:38735593] [10.1016/j.reprotox.2024.108608] |
| 7. Huahui Zeng, Man Li, Zhirong Wang, Tianqi Wang, Zhenqiang Zhang, Xiangxiang Wu. (2024) Disulfide bond-based oxidation-responsive triptolide-loaded nanodrug for inflammation-targeted treatment of collagen-induced arthritis. Applied Materials Today, 40 (102350). [10.1016/j.apmt.2024.102350] |
| 8. Meizhen Yin, Xinying Zhang, Tongguang Zhang, Zhiqiang Bao, Zhihui He. (2024) Folic Acid-Targeted Mixed Pluronic Micelles for Delivery of Triptolide. Polymers, 16 (24): (3485). [PMID:39771337] [10.3390/polym16243485] |
| 9. Abudureheman Bahatibieke, Jianming Zhao, Danping Fan, Zixiang Zhou, Junfei Li, Xing Wang, Hongyan Zhao, Tianyang Wang, Ziyuan Fang, Yajie Xie, Cheng Huang, Cheng Xiao, Yudong Zheng. (2025) Sea-Island Micelle Structured Hydrogel Scaffold: A Dual-Action Approach to Combat Cartilage Damage under RA Conditions. ACS Applied Materials & Interfaces, [PMID:39746184] [10.1021/acsami.4c16005] |
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