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芝麻素, CYP4F2 抑制剂
有货
库存信息
| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| S425032-1ml |
1ml |
现货  |
|
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基本描述
| 英文别名 | 11-Hydroxy-1-undecene | 5,5'-(1S,3aR,4S,6aR)-tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diylbis(1,3-benzodioxole) | Sezamin | 1,3-Benzodioxole, 5,5'-(tetrahydro-1H,3H-furo(3,4-c)furan-1,4-diyl)bis-, (1S-(1alpha,3a alpha,4alpha,6a alpha))- | 1,3-Benzodioxole, 5 |
|---|---|
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Sesamin |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 作用机制 | CYP4F2 抑制剂 |
| 产品介绍 |
不易溶于火油，须先溶于丙酮中，再加入火油。溶于丙酮、氯仿、乙醇等。微溶于乙醚、石油醚。 |
关联靶点（人）
CYP4F2
Tchem
叶绿醌ω-羟化酶 CYP4F2(Phylloquinone omega-hydroxylase CYP4F2)
(0 活性数据)
VDR
Tclin
Vitamin D receptor
(26531 活性数据)
PLK1
Tchem
Serine/threonine-protein kinase PLK1
(28605 活性数据)
SI
Tchem
Sucrase-isomaltase
(84 活性数据)
CYP1A2
Tchem
Cytochrome P450 1A2
(26471 活性数据)
CYP2C9
Tchem
Cytochrome P450 2C9
(32119 活性数据)
CYP2C19
Tchem
Cytochrome P450 2C19
(29246 活性数据)
Daoy
(570 活性数据)
MCF7
(126967 活性数据)
SH-SY5Y
(11521 活性数据)
HEK293
(82097 活性数据)
HEp-2
(3859 活性数据)
HepG2
(196354 活性数据)
KB
(17409 活性数据)
HeLa
(62764 活性数据)
GMNN
Tbio
Geminin
(128009 活性数据)
CBX1
Tbio
Chromobox protein homolog 1
(92434 活性数据)
TARDBP
Tchem
TAR DNA-binding protein 43
(40113 活性数据)
关联靶点（其它种属）
Ttr
Transthyretin (14 活性数据)
Hdac6
Histone deacetylase 6 (222 活性数据)
Gaa
Acidic alpha-glucosidase (551 活性数据)
Mycobacterium tuberculosis (203094 活性数据)
Plasmodium falciparum (966862 活性数据)
RAW (181 活性数据)
rep
Replicase polyprotein 1ab (378 活性数据)
Txnrd1
Thioredoxin reductase 1, cytoplasmic (45279 活性数据)
Nfe2l2
Nuclear factor erythroid 2-related factor 2 (214 活性数据)
NS1
Nonstructural protein 1 (33327 活性数据)
Liver microsome (341 活性数据)
SARS-CoV-2 (38078 活性数据)
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
名称和识别符
| EC号 | 612-029-1 |
|---|---|
| 分子类型 | 小分子 |
| IIUPAC Name | 5-[(3S,3aR,6S,6aR)-3-(1,3-benzodioxol-5-yl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-6-yl]-1,3-benzodioxole |
| INCHI | 1S/C20H18O6/c1-3-15-17(25-9-23-15)5-11(1)19-13-7-22-20(14(13)8-21-19)12-2-4-16-18(6-12)26-10-24-16/h1-6,13-14,19-20H,7-10H2/t13-,14-,19+,20+/m0/s1 |
| InChi Key | PEYUIKBAABKQKQ-AFHBHXEDSA-N |
| Smiles | C1C2C(COC2C3=CC4=C(C=C3)OCO4)C(O1)C5=CC6=C(C=C5)OCO6 |
| Isomeric SMILES | C1[C@H]2[C@H](CO[C@@H]2C3=CC4=C(C=C3)OCO4)[C@H](O1)C5=CC6=C(C=C5)OCO6 |
| 关联CAS | 81602-22-4,7076-24-6,607-80-7 |
| MeSH Entry Terms | asarinin;epi-sesamin;episesamin;sesamin;sesamin, (1R-(1alpha,3aalpha,4alpha,6aalpha))-isomer;sesamin, (1R-(1alpha,3aalpha,4beta,6aalpha))-isomer |
| 分子量 | 354.35 |
| Reaxy-Rn | 96112 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=96112&ln= |
化学和物理性质
| 敏感性 | 对热敏感 |
|---|---|
| 比旋光度 | 67° (C=1,CHCl3) |
| 熔点 | 123°C |
| 分子量 | 354.400 g/mol |
| XLogP3 | 2.700 |
| 氢键供体数Hydrogen Bond Donor Count | 0 |
| 氢键受体数Hydrogen Bond Acceptor Count | 6 |
| 可旋转键计数Rotatable Bond Count | 2 |
| 精确质量Exact Mass | 354.11 Da |
| 单同位素质量Monoisotopic Mass | 354.11 Da |
| 拓扑极表面积Topological Polar Surface Area | 55.400 Ų |
| 重原子数Heavy Atom Count | 26 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 482.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 4 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
安全和危险性（GHS）
| 信号词 | Warning |
|---|---|
| 危险声明 |
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H302: 吞食有害 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 |
| WGK Germany | 3 |
| Merck Index | 8470 |
| 个人防护装备 | Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter |
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
技术文档和文章
JAK/STAT抑制剂
Categories: 技术文章
JAK/STAT Inhibitors
Categories: 技术文章
JAK/STAT 抑制剂
Categories: 技术文章
JAK/STAT Inhibitors
Categories: 技术文章
此产品的引用文献
引用文献
| 1. Hui Du, Shiwen Tong, Ge Kuang, Xia Gong, Ningman Jiang, Xian Yang, Hao Liu, Nana Li, Yao Xie, Yang Xiang, Jiashi Guo, Zhenhan Li, Yinglin Yuan, Shengwang Wu, Jingyuan Wan. (2023) Sesamin Protects against APAP-Induced Acute Liver Injury by Inhibiting Oxidative Stress and Inflammatory Response via Deactivation of HMGB1/TLR4/NFκB Signal in Mice. Journal of Immunology Research, 2023 (1116841). [PMID:37663051] [10.1155/2023/1116841] |
| 2. Liumin Huang, Jun Li, Yanlan Bi, Yanhui Xu, Yanmei Wang, Jian Wang, Dan Peng. (2021) Simultaneous determination of α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, sesamin, sesamolin, sesamol, and asarinin in sesame oil by normal-phase high performance liquid chromatography. JOURNAL OF FOOD COMPOSITION AND ANALYSIS, 104 (104132). [10.1016/j.jfca.2021.104132] |
| 3. Zhenzhen Xia, Tian Yi, Yan Liu. (2020) Rapid and nondestructive determination of sesamin and sesamolin in Chinese sesames by near-infrared spectroscopy coupling with chemometric method. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 228 (117777). [PMID:31727518] [10.1016/j.saa.2019.117777] |
| 4. Yan Liu, Zhenzhen Xia, Liyun Yao, Yang Wu, Yan Li, Shan Zeng, Hao Li. (2019) Discriminating geographic origin of sesame oils and determining lignans by near-infrared spectroscopy combined with chemometric methods. JOURNAL OF FOOD COMPOSITION AND ANALYSIS, 84 (103327). [10.1016/j.jfca.2019.103327] |
| 5. Deng Shuang, Zhou Jian-Lin, Fang Hong-Song, Nie Zhi-Gang, Chen Sen, Peng Hao. (2018) Sesamin Protects the Femoral Head From Osteonecrosis by Inhibiting ROS-Induced Osteoblast Apoptosis in Rat Model. Frontiers in Physiology, 9 (1787). [PMID:30618801] [10.3389/fphys.2018.01787] |
| 6. Ke Li, Xia Gong, Ge Kuang, Rong Jiang, Jingyuan Wan, Bin Wang. (2016) Sesamin protects against renal ischemia reperfusion injury by promoting CD39-adenosine-A2AR signal pathway in mice. American Journal of Translational Research, 8 (5): ( 2245–2254). [PMID:27347331] |
| 7. Qiang Li, Yuan Jiang, Shouyin Jiang, Yulin Li, Libing Jiang, Jian-an Wang. (2016) Sesamin Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Inhibition of TLR4 Signaling Pathways. INFLAMMATION, 39 (1): (467-472). [PMID:26468152] [10.1007/s10753-015-0270-6] |
| 8. Li Ma, Xia Gong, Ge Kuang, Rong Jiang, Rongchun Chen, Jingyuan Wan. (2015) Sesamin ameliorates lipopolysaccharide/d-galactosamine-induced fulminant hepatic failure by suppression of Toll-like receptor 4 signaling in mice. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 461 (230). [PMID:25866179] [10.1016/j.bbrc.2015.03.154] |
| 9. Mengyun Dong, Tianliang Zhang, Xueli Liang, Xinyi Cheng, Fuyan Shi, Hang Yuan, Fengxiang Zhang, Qiqi Jiang, Xia Wang. (2024) Sesamin alleviates lipid accumulation induced by oleic acid via PINK1/Parkin-mediated mitophagy in HepG2 cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 708 (149815). [PMID:38531220] [10.1016/j.bbrc.2024.149815] |
| 10. Tao Chen, Peng Liu, Yu Ge, Xiaoting Lei, Zhenzong Fan, Xiaoyu Zhu, Yangping Wen, Hassan Karimi-Maleh, Xiaoqiang Wang. (2025) XGBoost algorithm-guided synthesis of violet phosphorus/MoAlB-MBene nanozyme for portable wireless intelligent sensing of sesamol in different varieties of sesame seeds. CHEMICAL ENGINEERING JOURNAL, 506 (160080). [10.1016/j.cej.2025.160080] |