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红景天苷

15篇引用文献 COA COA
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货号 (SKU) 包装规格 是否现货 价格 数量
S101157-20mg
 20mg 现货 Stock Image
S101157-100mg
 100mg 现货 Stock Image
S101157-250mg
 250mg 期货 Stock Image
S101157-1g
 1g 现货 Stock Image
大包装询价 收藏夹 比较  SDS下载  DATASHEET  质量标准
查看相关系列
Amino Acid/Protein Metabolism (4559) Apoptosis (7108) Atg and Atg-related Protein (255) Metabolic Enzyme/Protease (4889) MTOR (146) PI3K/Akt/mTOR (764) Prolyl Endopeptidase (PREP) (9) 分子标准品 (13)
main product photo

基本描述

别名 红景天甙 | 红景天素 | 酪醇 a-(β-D-吡喃葡萄糖苷) | 对羟基苯基吡喃葡萄糖苷 | 2-(4-羟基苯基)乙基-β−D-吡喃葡萄糖苷 | (2R,3S,4S,5R,6R)-2-(羟甲基)-6-(4-羟基苯乙氧基)四氢-2H-吡喃-3,4,5-三醇
英文别名 2-(4-Hydroxyphenyl)ethyl beta-D-glucopyranoside | SALIDROSIDE (USP-RS) | NCGC00256072-01 | Tox21_113565 | NCGC00257931-01 | A800725 | NSC 741643 | s2396 | (2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-[2-(4-hydroxyphenyl)ethoxy]tetrahydropyran-3,4,5-triol | AKOS00
规格或纯度 分析标准品, Moligand™, ≥98%(HPLC)
英文名称 Salidroside
生化机理 皂苷是酪醇的 8-O-β-D-葡萄糖苷，是红景天的主要生物活性成分，主要存在于植物根部。它是在酪氨酸代谢过程中生物合成的，酪醇的葡萄糖基化是最后一步。据报道，它具有神经保护作用，是红景天抗抑郁和抗焦虑作用的主要成分之一。
储存温度 避光
运输条件 常规运输
产品介绍

红景天苷 (Rhodioloside) 是一种脯氨酰内肽酶 (prolyl endopeptidase) 抑制剂。红景天苷可通过激活 mTOR 信号缓解肿瘤恶病质小鼠模型中的恶病质症状。红景天苷还能通过增强 PINK1/Parkin 介导的线粒体自噬来保护多巴胺能神经元。

Salidroside (Rhodioloside) is a prolyl endopeptidase inhibitor. Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling. Salidroside protects dopaminergic neurons by enhancing PINK1/Parkin-mediated mitophagy.
纯度 ≥98%(HPLC)

关联靶点（人）

MAOB Tclin 胺氧化酶[含黄素]B(Amine oxidase [flavin-containing] B) (2 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
MAOA Tclin Monoamine oxidase A (11911 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MAOB Tclin Monoamine oxidase B (8835 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HUVEC (11049 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HeLa (62764 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MDA-MB-231 (73002 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
L02 (4864 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

Hdac6 Histone deacetylase 6 (222 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mus musculus (284745 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PC-12 (7051 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
L929 (3802 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
C2C12 (756 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
rnhA Ribonuclease HI (16 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MOVAS-1 (14 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

PubChem SID 504757437
分子类型 小分子
IIUPAC Name (2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-[2-(4-hydroxyphenyl)ethoxy]oxane-3,4,5-triol
INCHI 1S/C14H20O7/c15-7-10-11(17)12(18)13(19)14(21-10)20-6-5-8-1-3-9(16)4-2-8/h1-4,10-19H,5-7H2/t10-,11-,12+,13-,14-/m1/s1
InChi Key ILRCGYURZSFMEG-RKQHYHRCSA-N
Smiles C1=CC(=CC=C1CCOC2C(C(C(C(O2)CO)O)O)O)O
Isomeric SMILES C1=CC(=CC=C1CCO[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O)O
PubChem CID 159278
分子量 300.31

化学和物理性质

密度 1.46
敏感性 对光线敏感
分子量 300.300 g/mol
XLogP3 -0.600
氢键供体数Hydrogen Bond Donor Count 5
氢键受体数Hydrogen Bond Acceptor Count 7
可旋转键计数Rotatable Bond Count 5
精确质量Exact Mass 300.121 Da
单同位素质量Monoisotopic Mass 300.121 Da
拓扑极表面积Topological Polar Surface Area 120.000 Ų
重原子数Heavy Atom Count 21
形式电荷Formal Charge 0
复杂度Complexity 306.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 5
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

象形图 GHS07
信号词 Warning

质检证书（CoA,COO,BSE/TSE 和分析图谱)

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批号(Lot Number) 证书类型 货号
C2202383 分析证书 S101157
K2301498 分析证书 S101157
H2501742 分析证书 S101157
H2501741 分析证书 S101157
H2330634 分析证书 S101157
A2513545 分析证书 S101157
A2513553 分析证书 S101157
A2513546 分析证书 S101157
K2224768 分析证书 S101157
G2408399 分析证书 S101157
G2408400 分析证书 S101157
G2408401 分析证书 S101157
H2330554 分析证书 S101157
K2224769 分析证书 S101157
G2215460 分析证书 S101157
G1817039 分析证书 S101157
C2202382 分析证书 S101157

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此产品的引用文献

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引用文献

1. Fei Wang, Fan Yang, Jiawei Liu, Quan Bai.  (2023)  Studies on the retention mechanism of solutes in hydrophilic interaction chromatography using stoichiometric displacement theory II. HILIC/RPLC dual-retention mechanism of solutes in hydrophilic interaction chromatography over the entire range of water concentration in mobile phase.  TALANTA,  265  (124858).  [PMID:37385194] [10.1016/j.talanta.2023.124858]
2. Qi Liang, Rongjie Guo, Jia-Ruei Tsao, Yun He, Chenchen Wang, Jiaxuan Jiang, Di Zhang, Taige Chen, Tingting Yue, Kai Hu.  (2023)  Salidroside alleviates oxidative stress in dry eye disease by activating autophagy through AMPK-Sirt1 pathway.  INTERNATIONAL IMMUNOPHARMACOLOGY,  121  (110397).  [PMID:37302369] [10.1016/j.intimp.2023.110397]
3. Yang Rongling, Wang Yu, Zhao Xiangjie, Tong Zheng, Zhu Qianlin, He Xiaoxi, Wang Zhaoyu, Luo Hongzhen, Fang Fang.  (2022)  A facile and efficient synthesis approach of salidroside esters by whole-cell biocatalysts in organic solvents.  Frontiers in Bioengineering and Biotechnology,  10  [PMID:36507279] [10.3389/fbioe.2022.1051117]
4. Jiaqi Li, Yongguang Zhang, Zhimin Yang, Jingxian Zhang, Ren Lin, Daoshu Luo.  (2020)  Salidroside promotes sciatic nerve regeneration following combined application epimysium conduit and Schwann cells in rats.  EXPERIMENTAL BIOLOGY AND MEDICINE,  [PMID:32053008] [10.1177/1535370220906541]
5. Xiaojing SI, Chaolin WANG, Li LI, Daixin YE, Youli WEI, Yaping DING.  (2020)  Preparation of nickel-aluminum hydrotalcite nanosheet-coated carbon nanofibers and their application in the detection of salidroside.  MICROCHEMICAL JOURNAL,  155  (104652).  [10.1016/j.microc.2020.104652]
6. Shasha Chen, Feng Cai, Jirong Wang, Zhouxin Yang, Chi Gu, Guofu Wang, Genxiang Mao, Jing Yan.  (2019)  Salidroside protects SH‑SY5Y from pathogenic α‑synuclein by promoting cell autophagy via mediation of mTOR/p70S6K signaling.  Molecular Medicine Reports,  20  (1): (529-538).  [PMID:31180515] [10.3892/mmr.2019.10285]
7. Jiahong Han, Min Dai, Yan Zhao, Enbo Cai, Lianxue Zhang, Xiaohuan Jia, Nian Sun, Xuan Fei, Hui Shu.  (2020)  Compatibility effects of ginseng and Ligustrum lucidum Ait herb pair on hematopoietic recovery in mice with cyclophosphamide-induced myelosuppression and its material basis.  Journal of Ginseng Research,  44  (291).  [PMID:32148411] [10.1016/j.jgr.2019.01.001]
8. Zhou Fei, Zhao Yajing, Li Maiquan, Xu Tao, Zhang Liuquan, Lu Baiyi, Wu Xiaodan, Ge Zhiwei.  (2017)  Degradation of phenylethanoid glycosides in Osmanthus fragrans Lour. flowers and its effect on anti-hypoxia activity.  Scientific Reports,  7  (1): (1-10).  [PMID:28855701] [10.1038/s41598-017-10411-0]
9. Zhilin Qi, Shimei Qi, Liefeng Ling, Jun Lv, Zunyong Feng.  (2016)  Salidroside attenuates inflammatory response via suppressing JAK2-STAT3 pathway activation and preventing STAT3 transfer into nucleus.  INTERNATIONAL IMMUNOPHARMACOLOGY,  35  (265).  [PMID:27085677] [10.1016/j.intimp.2016.04.004]
10. Yanfen Bai, Hua Yin, Huiping Bi, Yibin Zhuang, Tao Liu, Yanhe Ma.  (2016)  De novo biosynthesis of Gastrodin in Escherichia coli.  METABOLIC ENGINEERING,  35  (138).  [PMID:26804288] [10.1016/j.ymben.2016.01.002]
11. Yibo Feng, Xiaojuan Zhao, Fang Lv, Jinqiu Zhang, Bihua Deng, Yanhong Zhao, Yuanliang Hu, Deyun Wang, Jiaguo Liu, Yu Lu, Ruonan Bo, Zhenguang Liu.  (2015)  Optimization on Preparation Conditions of Salidroside Liposome and Its Immunological Activity on PCV-2 in Mice.  Evidence-based Complementary and Alternative Medicine,  2015  (178128).  [PMID:25878712] [10.1155/2015/178128]
12. Lingyun Xiao, Haifeng Li, Ju Zhang, Fan Yang, Aizhen Huang, Jingjing Deng, Ming Liang, Fangli Ma, Minghua Hu, Zebo Huang.  (2014)  Salidroside Protects Caenorhabditis elegans Neurons from Polyglutamine-Mediated Toxicity by Reducing Oxidative Stress.  MOLECULES,  19  (6): (7757-7769).  [PMID:24918543] [10.3390/molecules19067757]
13. Yanhong Bi, Ruiping Fu, Weiliang Hua, Xinyu Xiong, Chun Zhu, Xiaobao Nie, Zhaoyu Wang.  (2025)  An empirical exploration of the capacity of choline chloride/lactic acid eutectics to extract and stabilize natural polyhydroxy compounds.  FOOD CHEMISTRY,  (143873).  [PMID:40120314] [10.1016/j.foodchem.2025.143873]
14. Zhibin Zhou, Mengzhen Zhao, Huaqiang Fang, Ziyue Lin, Xinrui Zheng, Yi Zhuo, Zimeng Li, Weiming Zhou, Xiaolei Wang.  (2024)  Conductive hydrogel with responsive release of Herbal-Derived carbon dots for neurovascular reconstruction in diabetic critical limb ischemia.  CHEMICAL ENGINEERING JOURNAL,  500  (157265).  [10.1016/j.cej.2024.157265]
15. Jishan Li, Muyang Li, Chenyu Yong, Zhemin Zhou, Laichuang Han, Zhongmei Liu.  (2025)  Reshaping UDP-binding pocket of bacterial sucrose synthase to improve efficiency of UDP-glucose production.  BIORESOURCE TECHNOLOGY,  427  (132396).  [PMID:40090494] [10.1016/j.biortech.2025.132396]

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