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Recombinant Human IFN-alpha-2B Protein

COA COA
  • 表达系统: 酵母
  • Accession #: P01563
  • 蛋白标签: No tag
  • 生物活性: Fully biologically active when compared to standard. The specific activity determined by an anti-viral assay is no less than 1.6 × 10^8 IU/mg.
  • 内毒素水平: <0.1 EU/μg
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货号 (SKU) 包装规格 是否现货 价格 数量
rp156087-10μg
 10μg 现货 Stock Image
rp156087-100μg
 100μg 现货 Stock Image
rp156087-500μg
 500μg 期货 Stock Image
rp156087-1mg
 1mg 期货 Stock Image
大包装询价 收藏夹 比较  SDS下载  DATASHEET  质量标准
查看相关系列
点击查看蛋白信息: IFNA2
Accession#:P01563 (3) Gene ID:3440 (3) IFN-alpha-2B (1) IFNA2 (3)
main product photo

基本描述

产品名称 Recombinant Human IFN-alpha-2B Protein
别名 重组人 IFN-alpha-2B 蛋白
英文别名 IFN-alpha-2 | Interferon alpha-A | LeIF A
规格或纯度 无动物源, Carrier Free, 生物活性, ActiBioPure™, ≥98%(SDS-PAGE&HPLC)
产品介绍

干扰素（IFN）以其在宿主防御机制中的关键作用而闻名。Ⅰ型干扰素包括IFN-alpha 家族，IFN-beta， -omega，-kappa 和 Limitin/IFN-zeta，对调节病毒感染的免疫应答具有重要意义。Ⅱ型干扰素组仅包括干扰素γ。IFN-γ是一种多功能细胞因子，具有抗增殖、免疫调节和促炎症作用，对免疫应答的许多方面都很重要。Ⅲ型干扰素家族包括IL-29/IFN-lambda 1， IL-28A/IFN-lambda 2， IL-28B/IFN-lambda 3， and IFN-lambda 4。与Ⅰ型干扰素类似，Ⅲ型干扰素具有抗病毒、抗增殖和免疫调节作用。

IFN-αs are proteins secreted by leukocyte. They are mainly involved in innate immune response against viral infection. The IFN-α family has 13 subtypes and 23 different variants. The individual proteins have molecular masses between 19-26 kDa and consist of proteins with lengths of 156-166 and 172 amino acids. All IFN-α subtypes possess a common conserved sequence region between amino acid positions 115-151 while the amino-terminal ends are variable. Many IFN-alpha subtypes differ in their sequences at only one or two positions. Naturally occurring variants also include proteins truncated by 10 amino acids at the carboxy-terminal end.
生物活性 Fully biologically active when compared to standard. The specific activity determined by an anti-viral assay is no less than 1.6 × 10^8 IU/mg.
内毒素水平 <0.1 EU/μg
表达系统 酵母
种属 人(Human)
氨基酸 24-188 aa
序列 CDLPQTHSLG SRRTLMLLAQ MRRISLFSCL KDRHDFGFPQ EEFGNQFQKA ETIPVLHEMI QQIFNLFSTK DSSAAWDETL LDKFYTELYQ QLNDLEACVI QGVGVTETPL MKEDSILAVR KYFQRITLYL KEKKYSPCAW EVVRAEIMRS FSLSTNLQES LRSKE
纯度 ＞98% ( SDS-PAGE and HPLC)
蛋白标签 No tag
蛋白长度 Full length protein
无载体 Yes
无动物源 Yes
Accession # P01563
来源 重组表达
预测分子量 19.3 kDa

储存与运输

物理形态 冻干(Lyophilized)
储存缓冲液 Lyophilized from a 0.2 µm filtered solution in 1×PBS, pH 7.4, with 0.02 % Tween-20.
复溶 We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存温度 -20°C储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution. Upon delivery aliquot. Avoid freeze/thaw cycle.
分子类型 蛋白质

图片

Recombinant Human IFN-alpha-2B Protein (rp156087)-Protein Bioactivity
Fully biologically active when compared to standard. The specific activity determined by an anti-viral assay is no less than 1.6×10⁸ IU/mg.

Recombinant Human IFN-alpha-2B Protein (rp156087)-SDS-PAGE
Recombinant Human IFN-alpha-2B Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining. Showing a single band at 19.3 kDa under reducing conditions and 16.2 kDa under non-reducing conditions.

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找到4个结果

批号(Lot Number) 证书类型 货号
ZJ23F0600300 分析证书 rp156087
ZJ25F0319554 分析证书 rp156087
ZJ24F0910188 分析证书 rp156087
ZJ23F0600301 分析证书 rp156087

可替换产品

  1. Recombinant Human IFN-alpha-2/IFNA2 Protein
    Recombinant Human IFN-alpha-2/IFNA2 Protein

    ¥699.90

引用文献

1. Adolf, G R GR, Kalsner, I I, Ahorn, H H, Maurer-Fogy, I I and Cantell, K K..  (1991)  Natural human interferon-alpha 2 is O-glycosylated..  The Biochemical journal,  (1): [PMID:2049076]
2. Oliver, G G, Balbás, P P, Valle, F F, Soberón, X X and Bolívar, F F.. [Cloning of human leukocyte interferon cDNA and a strategy for its production in E. coli]..  Revista latinoamericana de microbiologia,  [PMID:3906813]
3. Streuli, M M, Nagata, S S and Weissmann, C C..  (1980)  At least three human type alpha interferons: structure of alpha 2..  Science (New York, N.Y.),  (19): [PMID:6158094]
4. Allen, G G and Fantes, K H KH..  (1980)  A family of structural genes for human lymphoblastoid (leukocyte-type) interferon..  Nature,  (2): [PMID:6159537]
5. Goeddel, D V DV and 17 more authors..  (1980)  Human leukocyte interferon produced by E. coli is biologically active..  Nature,  (2): [PMID:6159538]
6. and Wetzel, R R..  (1981)  Assignment of the disulphide bonds of leukocyte interferon..  Nature,  (12): [PMID:6162107]
7. Goeddel, D V DV and 9 more authors..  (1981)  The structure of eight distinct cloned human leukocyte interferon cDNAs..  Nature,  (5): [PMID:6163083]
8. Lawn, R M RM and 5 more authors..  (1981)  DNA sequence of a major human leukocyte interferon gene..  Proceedings of the National Academy of Sciences of the United States of America,  [PMID:6170983]
9. Weber, H H and Weissmann, C C..  (1983)  Formation of genes coding for hybrid proteins by recombination between related, cloned genes in E. coli..  Nucleic acids research,  (25): [PMID:6310510]
10. Lee, N N and 7 more authors..  (1995)  Interferon-alpha 2 variants in the human genome..  Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research,  [PMID:7627809]
11. Murgolo, N J NJ and 9 more authors..  (1993)  A homology model of human interferon alpha-2..  Proteins,  [PMID:8234245]
12. Radhakrishnan, R R and 6 more authors..  (1996)  Zinc mediated dimer of human interferon-alpha 2b revealed by X-ray crystallography..  Structure (London, England : 1993),  (15): [PMID:8994971]
13. Klaus, W W, Gsell, B B, Labhardt, A M AM, Wipf, B B and Senn, H H..  (1997)  The three-dimensional high resolution structure of human interferon alpha-2a determined by heteronuclear NMR spectroscopy in solution..  Journal of molecular biology,  (12): [PMID:9417943]
14. Nyman, T A TA, Tölö, H H, Parkkinen, J J and Kalkkinen, N N..  (1998)  Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes..  The Biochemical journal,  (15): [PMID:9425112]
15. Austruy, E E and 7 more authors.. A defective retroviral vector encoding human interferon-alpha2 can transduce human leukemic cell lines..  Cancer gene therapy,  [PMID:9694076]
16. Humphray, S J SJ and 147 more authors..  (2004)  DNA sequence and analysis of human chromosome 9..  Nature,  (27): [PMID:15164053]
17. Sjöblom, Tobias T and 28 more authors..  (2006)  The consensus coding sequences of human breast and colorectal cancers..  Science (New York, N.Y.),  (13): [PMID:16959974]
18. Quadt-Akabayov, Sabine R SR, Chill, Jordan H JH, Levy, Rina R, Kessler, Naama N and Anglister, Jacob J..  (2006)  Determination of the human type I interferon receptor binding site on human interferon-alpha2 by cross saturation and an NMR-based model of the complex..  Protein science : a publication of the Protein Society,  [PMID:17001036]
19. Gull, Iram I, Samra, Zahoor Qadir ZQ, Aslam, Muhammad Shahbaz MS and Athar, Muhammad Amin MA..  (2013)  Heterologous expression, immunochemical and computational analysis of recombinant human interferon alpha 2b..  SpringerPlus,  [PMID:23875128]

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