| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| R106321-250mg |
250mg |
现货  |
|
| 别名 | 维A酸 |
|---|---|
| 英文别名 | (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid | TRETINOIN COMPONENT OF ZIANA | Tretinoina (INN-Spanish) | Avita (0.025% gel) | Retinoate | Tretinoina [INN-Spanish] | b-Retinoic acid | Tretinoin [USAN:USP:INN: |
| 规格或纯度 | Moligand™, 分析标准品 |
| 英文名称 | Retinoic acid |
| 生化机理 | 描述： IC50 值IC50 值：不适用 全反式维甲酸（ATRA）已被广泛用于治疗包括前列腺癌在内的多种癌症：ATRA 能诱导 AR 前列腺癌细胞生长停滞并增加 HOXB13 的表达。EZH2和DNMT3b都通过涉及DNA和组蛋白甲基化修饰的表观遗传机制参与抑制HOXB13的表达[1]。ATRA 可通过降低 EZH2 和 DNMT3b 的表达并减少它们与 HOXB13 启动子的相互作用来上调 HOXB13[1]。体内：早期研究发现，用 ATRA 处理白血病细胞可导致细胞凋亡，这可能是分化过程的继发结果。由于 ATRA 能纠正细胞的异常生长并诱导细胞凋亡，因此在临床前和临床试验中被广泛用于治疗多种癌症类型，包括早期胃癌和前列腺癌。在对 AR? 和 drμg 具有抗药性的 DU145 前列腺癌细胞中，ATRA 被证明能提高细胞对抗癌药物多西他赛的敏感性[1]。全反式维甲酸（ATRA）通过增强 APL 细胞的快速分化和清除 APL 标志性肿瘤蛋白 PML-RARα，诱导 APL 患者的临床缓解[2]。临床试验：不适用 |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 激动剂 |
| 作用机制 | 维甲酸受体激动剂 |
| 产品介绍 |
不溶于水，溶于乙醚、DMSO (25 mg/ml)；微溶于乙醇和氯仿。 |
| ALogP | 6.3 |
|---|
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| EC号 | 206-129-0 |
|---|---|
| 分子类型 | 小分子 |
| IIUPAC Name | (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid |
| INCHI | 1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+ |
| InChi Key | SHGAZHPCJJPHSC-YCNIQYBTSA-N |
| Smiles | CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C |
| Isomeric SMILES | CC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C/C(=O)O)/C)/C |
| 分子量 | 300.44 |
| Beilstein号 | 2057223 |
| Reaxy-Rn | 2508066 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2508066&ln= |
| 密度 | 1.011 |
|---|---|
| 熔点 | 180-181°C |
| 分子量 | 300.400 g/mol |
| XLogP3 | 6.300 |
| 氢键供体数Hydrogen Bond Donor Count | 1 |
| 氢键受体数Hydrogen Bond Acceptor Count | 2 |
| 可旋转键计数Rotatable Bond Count | 5 |
| 精确质量Exact Mass | 300.209 Da |
| 单同位素质量Monoisotopic Mass | 300.209 Da |
| 拓扑极表面积Topological Polar Surface Area | 37.300 Ų |
| 重原子数Heavy Atom Count | 22 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 567.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 4 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 4 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS07, GHS08 |
|---|---|
| 信号词 | 危险 |
| 危险声明 |
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H360: 可能损害生育力或未出生的孩子 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P302+P352: 如皮肤沾染：用水充分清洗。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P405: 密闭存放 P403+P233: 存放在通风良好的地方。保持容器密闭。 P501: 将内容物/容器处理到。。。 P203: 使用前，获取、阅读并遵守所有安全说明。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P318: 如果暴露或担心，请就医。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。 |
| WGK Germany | 2 |
| RTECS | VH6475000 |
| Merck Index | 8165 |
| 个人防护装备 | dust mask type N95 (US),Eyeshields,Gloves |
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