This is a demo store. No orders will be fulfilled.

首页   400-620-6333
  • 登录
  • 注册
  • 英文站
切换导航
我的购物车
搜索
高级搜索
菜单
登录
设置
྾

维生素A酸

维生素A代谢产物。干细胞分化。
40篇引用文献 COA COA
有货

库存信息

关闭

库存信息

关闭

库存信息

关闭

库存信息

关闭

库存信息

关闭

库存信息

关闭
货号 (SKU) 包装规格 是否现货 价格 数量
R106320-500mg
 500mg 现货 Stock Image
R106320-1g
 1g 现货 Stock Image
R106320-5g
 5g 现货 Stock Image
R106320-10g
 10g 现货 Stock Image
R106320-25g
 25g 期货 Stock Image
R106320-100g
 100g 现货 Stock Image
大包装询价 收藏夹 比较  SDS下载  DATASHEET  质量标准
查看相关系列
Autophagy (2848) Cell Cycle (7376) Cell Cycle/DNA Damage (2603) Endogenous Metabolite (978) Metabolic Enzyme/Protease (4889) PPAR (154) RAR/RXR (76) Vitamin D Related/Nuclear Receptor (908) 代谢物 (8911) 光谱试剂 (247) 再生医学研究试剂 (17) 脂质代谢 (4331)
main product photo

基本描述

别名 3,7-二甲基-9-(2,6,6-三甲基环己烯)-2,4,6,8-全反式壬四烯酸 | 维他命A酸 | 维甲酸 | 维A酸 | 视黄酸
英文别名 (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid | TRETINOIN COMPONENT OF ZIANA | Tretinoina (INN-Spanish) | Avita (0.025% gel) | Retinoate | Tretinoina [INN-Spanish] | b-Retinoic acid | Tretinoin [USAN:USP:INN:
规格或纯度 Moligand™, ≥98%
英文名称 Retinoic acid
生化机理 全−反式−视黄酸（ATRA）是视黄酸受体（RAR）和视黄醇类 X 受体（RXR）的配体。所结合的RAR和RXR可作为调节正常细胞和恶性细胞的生长和分化的转录因子。细胞色素P450（CYP）可催化ATRA的4-羟基化。视黄酸可使胚胎干细胞成为神经元。
储存温度 -20°C储存,充氩
运输条件 超低温冰袋运输
备注 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍

视黄酸(RA)是一种类视黄醇，具有广泛的生物学作用。可调节正常和转化细胞的分化和增殖，可能会影响癌基因。全反式视黄酸(ATRA)是维生素A最直接相关的活性代谢产品。视黄酸可作为一种信号分子，经由核受体调节中枢神经系统的区域分化。1 nm浓度（1 µM带来最大分化）的视黄酸可诱导一种人早幼粒细胞白血病细胞系形态和功能上的终末分化，代表其可能参与特定造血细胞的分化。视黄酸还可通过调节神经元细胞表面肽生长因子受体的表达，间接影响神经元分化。
此外，视黄酸等类视黄醇可抑制人黑素瘤细胞的增殖并刺激酪氨酸酶活性，[4]还抑制黑色素细胞的细胞基底黏附和迁移。ATRA在哺乳动物血管系统形成中起重要作用，尤其是可以调节组织血管生成过程中的内皮细胞增殖和血管重塑。
应用：
视黄酸（RA）已用于胚胎干细胞至运动神经元的分化。
它已用于非洲爪蟾外胚层至胰腺的分化。
它还用于研究由RARα (视黄酸受体α)引起的表观遗传学调控。
它已用于研究原初精原细胞向精母细胞转化的RA信号转导。

Retinoic acid (RA), a retinoid, exerts a broad range of biological effects. It plays a role in regulating cellular differentiation and proliferation in both normal and transformed cells, potentially influencing oncogenes. All-trans retinoic acid (ATRA) is regarded as the most pertinent and functionally active metabolite of Vitamin-A. RA may serve as a type of signal molecule through a nuclear receptor to regulate regional differentiation in the central nervous system. Moreover, at a concentration of 1 nM (with maximal differentiation at 1 µM), RA induces morphological and functional terminal differentiation in a cell line of human promyelocyte leukemia, indicating its potential involvement in the differentiation of specific hematopoietic cells. Additionally, RA can indirectly impact neuronal differentiation by modifying the expression of neuronal cell surface receptors to peptide growth factors. Furthermore, RA and other retinoids can also inhibit cellular proliferation and stimulate tyrosinase activity in a human melanoma cell line, while also inhibiting cell-substrate adhesion and motility in melanocytes. ATRA plays a vital role in the formation of the mammalian vascular system. Specifically, it regulates endothelial cell proliferation and vascular remodeling throughout tissue angiogenesis.

纯度 ≥98%

产品属性

ALogP 6.3

关联靶点（人）

RARG Tclin 视黄酸受体γ(Retinoic acid receptor gamma) (44 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
RXRG Tclin 视黄酸受体 RXR-γ(Retinoic acid receptor RXR-gamma) (2 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
RXRB Tclin 视黄酸受体 RXR-β(Retinoic acid receptor RXR-beta) (3 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
RORB Tchem 核受体ROR-β(Nuclear receptor ROR-beta) (3 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
RXRA Tclin 视黄酸受体 RXR-alpha(Retinoic acid receptor RXR-alpha) (4 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
PIN1 Tchem 肽基脯氨酰顺反异构酶NIMA相互作用1(Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1) (3 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
RARB Tclin 视黄酸受体β(Retinoic acid receptor beta) (44 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
RARA Tclin 视黄酸受体α(Retinoic acid receptor alpha) (31 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
NR2C2 Tchem 核受体亚家族 2 C 组成员 2(Nuclear receptor subfamily 2 group C member 2) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
APP Tclin 淀粉样β蛋白A4(Amyloid-beta A4 protein) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
PPARD Tchem 过氧化物酶体增殖激活受体δ(Peroxisome proliferator-activated receptor delta) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
PDE5A Tclin Phosphodiesterase 5A (5113 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
EGFR Tclin Epidermal growth factor receptor erbB1 (33727 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
F2 Tclin Thrombin (11687 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CA2 Tclin Carbonic anhydrase II (17698 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HMGCR Tclin HMG-CoA reductase (2475 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NR3C1 Tclin Glucocorticoid receptor (14987 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
INSR Tclin Insulin receptor (5558 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PGR Tclin Progesterone receptor (8562 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRB2 Tclin Beta-2 adrenergic receptor (11824 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRB1 Tclin Beta-1 adrenergic receptor (6630 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AR Tclin Androgen Receptor (11781 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
RARA Tclin Retinoic acid receptor alpha (1324 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
VDR Tclin Vitamin D receptor (26531 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ACE Tclin Angiotensin-converting enzyme (1423 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DRD2 Tclin Dopamine D2 receptor (23596 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TYR Tclin Tyrosinase (717 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CNR1 Tclin Cannabinoid CB1 receptor (20913 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DRD4 Tchem Dopamine D4 receptor (7907 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HRH2 Tclin Histamine H2 receptor (5428 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRA1D Tclin Alpha-1d adrenergic receptor (4171 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR1B Tclin Serotonin 1b (5-HT1b) receptor (2801 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR2C Tclin Serotonin 2c (5-HT2c) receptor (11471 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADORA1 Tclin Adenosine A1 receptor (17603 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CALCR Tclin Calcitonin receptor (2215 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PTGS2 Tclin Cyclooxygenase-2 (13999 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HRH1 Tclin Histamine H1 receptor (7573 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRA1B Tclin Alpha-1b adrenergic receptor (2912 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PPARG Tclin Peroxisome proliferator-activated receptor gamma (15191 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AVPR1A Tclin Vasopressin V1a receptor (5412 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
OPRD1 Tclin Delta opioid receptor (15096 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
OPRK1 Tclin Kappa opioid receptor (16155 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
KCNH2 Tclin HERG (29587 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR4 Tclin Serotonin 4 (5-HT4) receptor (2068 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PDE3A Tclin Phosphodiesterase 3A (3309 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

Agtr2 Angiotensin II type 2 (AT-2) receptor (803 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mc4r Melanocortin receptor 4 (1205 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Ltc4s Leukotriene C4 synthase (1 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Sigmar1 Sigma opioid receptor (160 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Npy1r Neuropeptide Y receptor type 1 (8 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Cruzipain (33337 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Cckar Cholecystokinin A receptor (90 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Ppard Peroxisome proliferator-activated receptor delta (358 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Abcb1b P-glycoprotein 1 (174 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Nos2 Nitric oxide synthase, inducible (3573 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mapk1 MAP kinase ERK2 (650 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mmp2 Matrix metalloproteinase-2 (12 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Hdac6 Histone deacetylase 6 (222 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Tdo2 Tryptophan 2,3-dioxygenase (8 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mmp9 Matrix metalloproteinase 9 (38 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Abcb1a P-glycoprotein 3 (492 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Pseudomonas aeruginosa (123386 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Klebsiella pneumoniae (43867 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Staphylococcus aureus (210822 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Acinetobacter baumannii (41033 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Escherichia coli (133304 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Saccharomyces cerevisiae (19171 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Plasmodium falciparum (966862 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Cryptococcus neoformans (21258 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Candida albicans (78123 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Human gammaherpesvirus 4 (1538 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Oryctolagus cuniculus (11301 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mus musculus (284745 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Cricetinae gen. sp. (3197 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
F9 (77 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MDCK (10148 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
N2a (708 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
P19 (309 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
RAW264.7 (28094 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
S91 (48 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
3LLD122 (4 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
H4 (48 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
lef Anthrax lethal factor (7585 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Hamster (598 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GCN5 Histone acetyltransferase GCN5 (89 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Luciferin 4-monooxygenase (66902 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
pfk 6-phospho-1-fructokinase (7870 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
BCHE Cholinesterase (8742 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Trachea (5 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Ido1 Indoleamine 2,3-dioxygenase 1 (313 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TGR Thioredoxin glutathione reductase (28579 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mapt Microtubule-associated protein tau (6 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

PubChem SID 504758832
EC号 206-129-0
分子类型 小分子
IIUPAC Name (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid
INCHI 1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+
InChi Key SHGAZHPCJJPHSC-YCNIQYBTSA-N
Smiles CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C
Isomeric SMILES CC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C/C(=O)O)/C)/C
分子量 300.44
Beilstein号 2057223
Reaxy-Rn 2508066
Reaxys-RN link address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2508066&ln=

化学和物理性质

溶解性 Soluble in ethanol, acetate, dimethyl formamide, dimethyl sulfoxide, chloroform, methanol, acetone and dichloromethane. Insoluble in water and ether.
密度 1.011
敏感性 对空气、光线敏感
熔点 180-181°C
分子量 300.400 g/mol
XLogP3 6.300
氢键供体数Hydrogen Bond Donor Count 1
氢键受体数Hydrogen Bond Acceptor Count 2
可旋转键计数Rotatable Bond Count 5
精确质量Exact Mass 300.209 Da
单同位素质量Monoisotopic Mass 300.209 Da
拓扑极表面积Topological Polar Surface Area 37.300 Ų
重原子数Heavy Atom Count 22
形式电荷Formal Charge 0
复杂度Complexity 567.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 0
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 4
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 4
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

象形图 GHS07,   GHS08
信号词 危险
危险声明

H315: 引起皮肤刺激

H319: 引起严重眼睛刺激

H335: 可能引起呼吸道刺激

H360: 可能损害生育力或未出生的孩子
预防措施声明

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾

P264: 处理后要彻底洗手。

P271: 仅在室外或通风良好的地方使用。

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P321: 特殊处理（请参阅此标签上的...）。

P302+P352: 如皮肤沾染：用水充分清洗。

P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。

P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。

P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。

P405: 密闭存放

P403+P233: 存放在通风良好的地方。保持容器密闭。

P501: 将内容物/容器处理到。。。

P203: 使用前，获取、阅读并遵守所有安全说明。

P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。

P318: 如果暴露或担心，请就医。

P337+P317: 如果眼睛刺激持续：寻求医疗帮助。

P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。

P319: 如果你感到不适，请寻求医疗帮助。
WGK Germany 2
RTECS VH6475000
Merck Index 8165
个人防护装备 dust mask type N95 (US),Eyeshields,Gloves

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到22个结果

批号(Lot Number) 证书类型 货号
L2111129 分析证书 R106320
B2521595 分析证书 R106320
B2528662 分析证书 R106320
B2528663 分析证书 R106320
G2530050 分析证书 R106320
G2516045 分析证书 R106320
C2503089 分析证书 R106320
G2517061 分析证书 R106320
I2509595 分析证书 R106320
I2509596 分析证书 R106320
C2429737 分析证书 R106320
L2420138 分析证书 R106320
K2215765 分析证书 R106320
K2215886 分析证书 R106320
K2215888 分析证书 R106320
K2215889 分析证书 R106320
K2215890 分析证书 R106320
D2418103 分析证书 R106320
I2405135 分析证书 R106320
L2103038 分析证书 R106320
G2315039 分析证书 R106320
F2406031 分析证书 R106320

显示更多⌵

技术文档和文章

类器官新用途
Categories: 技术文章
探索主题:
类器官
New Uses for Organoids
Categories: 技术文章
探索主题:
Organoids
New Uses for Organoids
Categories: 技术文章
探索主题:
Organoids
New Uses for Organoids
Categories: 技术文章
探索主题:
Organoids
Hedgehog信号通路
Categories: 技术文章
探索主题:
Hedgehog信号通路
Hedgehog Signaling
Categories: 技术文章
探索主题:
Hedgehog Signaling
Hh信号通路
Categories: 技术文章
探索主题:
Hh信号通路
Hedgehog Signaling
Categories: 技术文章
探索主题:
Hedgehog Signaling

此产品的引用文献

如何在您的发表作品中引用阿拉丁的产品和网站? 引用文献检索

引用文献

1. Zhou TB et al..  (2014)  Effect of all-trans retinoic acid treatment on prohibitin and renin-angiotensin-aldosterone system expression in hypoxia-induced renal tubular epithelial cell injury..  J Renin Angiotensin Aldosterone Syst,  15  (3): (243-9).  [PMID:25031298]
2. Dolce LG et al..  (2019)  Myosin Va interacts with the exosomal protein spermine synthase..  Biosci Rep,  39  (3): [PMID:30733278]
3. Maina MB et al..  (2018)  The involvement of tau in nucleolar transcription and the stress response..  Acta Neuropathol Commun,  6  (70).  [PMID:30064522]
4. Maria Rodriguez-Guzman,Juan A Montero,Elena Santesteban,Yolanda Gañan,Domingo Macias,Juan M Hurle.  (2006-10-31)  Tendon-muscle crosstalk controls muscle bellies morphogenesis, which is mediated by cell death and retinoic acid signaling..  Developmental biology,  302  ((1)): (267-280).  [PMID:17070795]
5. Jing Yuan,Ronald L Johnson,Ruili Huang,Jennifer Wichterman,Hongying Jiang,Karen Hayton,David A Fidock,Thomas E Wellems,James Inglese,Christopher P Austin,Xin-zhuan Su.  (2009-09-08)  Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum..  Nature chemical biology,  5  ((10)): (765-771).  [PMID:19734910]
6. Vineet Agrawal,Scott A Johnson,Janet Reing,Li Zhang,Stephen Tottey,Gang Wang,Karen K Hirschi,Susan Braunhut,Lorraine J Gudas,Stephen F Badylak.  (2009-12-08)  Epimorphic regeneration approach to tissue replacement in adult mammals..  Proceedings of the National Academy of Sciences of the United States of America,  107  ((8)): (3351-3355).  [PMID:19966310]
7. Palle J Pedersen,Sidsel K Adolph,Arun K Subramanian,Ahmad Arouri,Thomas L Andresen,Ole G Mouritsen,Robert Madsen,Mogens W Madsen,Günther H Peters,Mads H Clausen.  (2010-04-22)  Liposomal formulation of retinoids designed for enzyme triggered release..  Journal of medicinal chemistry,  53  ((9)): (3782-3792).  [PMID:20405849]
8. Zebin Xia,Lulu Farhana,Ricardo G Correa,Jayanta K Das,David J Castro,Jinghua Yu,Robert G Oshima,John C Reed,Joseph A Fontana,Marcia I Dawson.  (2011-05-10)  Heteroatom-substituted analogues of orphan nuclear receptor small heterodimer partner ligand and apoptosis inducer (E)-4-[3-(1-Adamantyl)-4-hydroxyphenyl]-3-chlorocinnamic acid..  Journal of medicinal chemistry,  54  ((11)): (3793-3816).  [PMID:21548569]
9. Hongyun Li,Genevieve Evin,Andrew F Hill,Ya Hui Hung,Ashley I Bush,Brett Garner.  (2011-11-23)  Dissociation of ERK signalling inhibition from the anti-amyloidogenic action of synthetic ceramide analogues..  Clinical science (London, England : 1979),  122  ((9)): (409-419).  [PMID:22103431]
10. Michael J Surace,Liwu Li.  (2013-07-26)  Potent suppression of arginase 1 expression in murine macrophages by low dose endotoxin..  American journal of clinical and experimental immunology,  2  ((1)): (117-123).  [PMID:23885329]
11. Yan Wang,DE-Jian Qian,Wen-Yu Zhong,Jun-Hong Lu,Xiang-Kai Guo,Yi-Lin Cao,Ju Liu.  (2014-06-20)  TGF-β1 induces the formation of vascular-like structures in embryoid bodies derived from human embryonic stem cells..  Experimental and therapeutic medicine,  8  ((1)): (52-58).  [PMID:24944596]
12. Donald J Vander Griend,Ivan V Litvinov,John T Isaacs.  (2014-06-21)  Conversion of androgen receptor signaling from a growth suppressor in normal prostate epithelial cells to an oncogene in prostate cancer cells involves a gain of function in c-Myc regulation..  International journal of biological sciences,  10  ((6)): (627-642).  [PMID:24948876]
13. Stefano Bartesaghi,Stefan Hallen,Li Huang,Per-Arne Svensson,Remi A Momo,Simonetta Wallin,Eva K Carlsson,Anna Forslöw,Patrick Seale,Xiao-Rong Peng.  (2014-11-13)  Thermogenic activity of UCP1 in human white fat-derived beige adipocytes..  Molecular endocrinology (Baltimore, Md.),  29  ((1)): (130-139).  [PMID:25389910]
14. Yeon Jeong Jang,Hyun Jung Koo,Eun-Hwa Sohn,Se Chan Kang,Dong-Kwon Rhee,Suhkneung Pyo.  (2015-06-19)  Theobromine inhibits differentiation of 3T3-L1 cells during the early stage of adipogenesis via AMPK and MAPK signaling pathways..  Food & function,  6  ((7)): (2365-2374).  [PMID:26085110]
15. Xiaoshuai Li,Zhengwei Yuan,Xiaowei Wei,Hui Li,Guifeng Zhao,Jiaoning Miao,Di Wu,Bo Liu,Songying Cao,Dong An,Wei Ma,Henan Zhang,Weilin Wang,Qiushi Wang,Hui Gu.  (2016-02-20)  Application potential of bone marrow mesenchymal stem cell (BMSCs) based tissue-engineering for spinal cord defect repair in rat fetuses with spina bifida aperta..  Journal of materials science. Materials in medicine,  27  ((4)): (77-77).  [PMID:26894267]
16. Weili Wu,Lixia Fan,Zeqing Bao,Yu Zhang,Yuexia Peng,Min Shao,Yuke Xiang,Xiaomin Zhang,Qin Wang,Liang Tao.  (2017-04-17)  The cytoplasmic translocation of Cx32 mediates cisplatin resistance in ovarian cancer cells..  Biochemical and biophysical research communications,  487  ((2)): (292-299).  [PMID:28412364]
17. Swanand Koli,Ayan Mukherjee,Kudumula Venkata Rami Reddy.  (2017-04-27)  Retinoic acid triggers c-kit gene expression in spermatogonial stem cells through an enhanceosome constituted between transcription factor binding sites for retinoic acid response element (RARE), spleen focus forming virus proviral integration oncogene (SPFI1) (PU.1) and E26 transformation-specific (ETS)..  Reproduction, fertility, and development,  29  ((3)): (521-543).  [PMID:28442062]
18. Hannah M Komar,Gregory Serpa,Claire Kerscher,Erin Schwoegl,Thomas A Mace,Ming Jin,Ming-Chen Yang,Ching-Shih Chen,Mark Bloomston,Michael C Ostrowski,Phil A Hart,Darwin L Conwell,Gregory B Lesinski.  (2017-05-13)  Inhibition of Jak/STAT signaling reduces the activation of pancreatic stellate cells in vitro and limits caerulein-induced chronic pancreatitis in vivo..  Scientific reports,  7  ((1)): (1787-1787).  [PMID:28496202]
19. Tsutomu Motohashi,Masahiro Nishioka,Daisuke Kitagawa,Norito Kawamura,Natsuki Watanabe,Takanori Wakaoka,Toshihiko Kadoya,Takahiro Kunisada.  (2017-07-12)  Galectin-1 enhances the generation of neural crest cells..  The International journal of developmental biology,  61  ((6-7)): (407-413).  [PMID:28695960]
20. Nikolas S Kappy,Shaohua Chang,William M Harris,Michael Plastini,Telisha Ortiz,Ping Zhang,Joshua P Hazelton,Jeffrey P Carpenter,Spencer A Brown.  (2017-12-19)  Human adipose-derived stem cell treatment modulates cellular protection in both in vitro and in vivo traumatic brain injury models..  The journal of trauma and acute care surgery,  84  ((5)): (745-751).  [PMID:29251705]
21. Bing Chen,Lu Jiang,Meng-Ling Zhong,Jian-Feng Li,Ben-Shang Li,Li-Jun Peng,Yu-Ting Dai,Bo-Wen Cui,Tian-Qi Yan,Wei-Na Zhang,Xiang-Qin Weng,Yin-Yin Xie,Jing Lu,Rui-Bao Ren,Su-Ning Chen,Jian-Da Hu,De-Pei Wu,Zhu Chen,Jing-Yan Tang,Jin-Yan Huang,Jian-Qing Mi,Sai-Juan Chen.  (2017-12-28)  Identification of fusion genes and characterization of transcriptome features in T-cell acute lymphoblastic leukemia..  Proceedings of the National Academy of Sciences of the United States of America,  115  ((2)): (373-378).  [PMID:29279377]
22. Ryusuke Sawada,Michio Iwata,Yasuo Tabei,Haruka Yamato,Yoshihiro Yamanishi.  (2018-01-11)  Predicting inhibitory and activatory drug targets by chemically and genetically perturbed transcriptome signatures..  Scientific reports,  8  ((1)): (156-156).  [PMID:29317676]
23. Susanne Höing,Ting-Yu Yeh,Matthias Baumann,Nancy E Martinez,Peter Habenberger,Lea Kremer,Hannes C A Drexler,Philipp Küchler,Peter Reinhardt,Axel Choidas,Mia-Lisa Zischinsky,Gunther Zischinsky,Swaran Nandini,Aaron P Ledray,Stephanie A Ketcham,Lydia Reinhardt,Masin Abo-Rady,Michael Glatza,Stephen J King,Peter Nussbaumer,Slava Ziegler,Bert Klebl,Trina A Schroer,Hans R Schöler,Herbert Waldmann,Jared Sterneckert.  (2018-02-06)  Dynarrestin, a Novel Inhibitor of Cytoplasmic Dynein..  Cell chemical biology,  25  ((4)): (357-369).  [PMID:29396292]
24. Eric M Kernfeld,Ryan M J Genga,Kashfia Neherin,Margaret E Magaletta,Ping Xu,René Maehr.  (2018-06-10)  A Single-Cell Transcriptomic Atlas of Thymus Organogenesis Resolves Cell Types and Developmental Maturation..  Immunity,  48  ((6)): (1258-1270).  [PMID:29884461]
25. Alejo R Gianotti,Raúl G Ferreyra,Mario R Ermácora.  (2018-10-05)  Binding properties of sterol carrier protein 2 (SCP2) characterized using Laurdan..  Biochimica et biophysica acta. Proteins and proteomics,  1866  ((11)): (1143-1152).  [PMID:30282612]
26. Olaia F Vila,Sebastien G M Uzel,Stephen P Ma,Damian Williams,Joseph Pak,Roger D Kamm,Gordana Vunjak-Novakovic.  (2019-03-15)  Quantification of human neuromuscular function through optogenetics..  Theranostics,  9  ((5)): (1232-1246).  [PMID:30867827]
27. Michael Telias,Bristol Denlinger,Zachary Helft,Casey Thornton,Billie Beckwith-Cohen,Richard H Kramer.  (2019-03-17)  Retinoic Acid Induces Hyperactivity, and Blocking Its Receptor Unmasks Light Responses and Augments Vision in Retinal Degeneration..  Neuron,  102  ((3)): (574-586).  [PMID:30876849]
28. Silvia-E Glont,Evangelia K Papachristou,Ashley Sawle,Kelly A Holmes,Jason S Carroll,Rasmus Siersbaek.  (2019-04-11)  Identification of ChIP-seq and RIME grade antibodies for Estrogen Receptor alpha..  PloS one,  14  ((4)): (e0215340-e0215340).  [PMID:30970003]
29. Nikola Kolundzic,Preeti Khurana,Liani Devito,Matthew Donne,Carl Hobbs,Jakob Jeriha,Xuan Fei Colin Cornelius Wong,John A E Common,Ellen Birgitte Lane,Sandrine Dubrac,Robert Gruber,Matthias Schmuth,Theodora M Mauro,Dusko Ilic.  (2019-05-20)  Induced pluripotent stem cell line heterozygous for p.R2447X mutation in filaggrin: KCLi002-A..  Stem cell research,  38  (101462-101462).  [PMID:31103941]
30. Hanna Schmidt,Peter Braubach,Carolin Schilpp,Robin Lochbaum,Kathrin Neuland,Kristin Thompson,Danny Jonigk,Manfred Frick,Paul Dietl,Oliver H Wittekindt.  (2019-07-03)  IL-13 Impairs Tight Junctions in Airway Epithelia..  International journal of molecular sciences,  20  ((13)): [PMID:31262043]
31. Chih-Hao Yang,Adrian Di Antonio,Gregory W Kirschen,Parul Varma,Jenny Hsieh,Shaoyu Ge.  (2020-01-30)  Circuit Integration Initiation of New Hippocampal Neurons in the Adult Brain..  Cell reports,  30  ((4)): (959-968).  [PMID:31995766]
32. Larry A Cogburn,Nares Trakooljul,Xiaofei Wang,Laura E Ellestad,Tom E Porter.  (2020-02-02)  Transcriptome analyses of liver in newly-hatched chicks during the metabolic perturbation of fasting and re-feeding reveals THRSPA as the key lipogenic transcription factor..  BMC genomics,  21  ((1)): (109-109).  [PMID:32005146]
33. Adeleh Taei,Azam Samadian,Zahra Ghezel-Ayagh,Sepideh Mollamohammadi,Sharif Moradi,Tahereh Kiani,Ehsan Janzamin,Zahra Farzaneh,Yaser Tahamtani,Thomas Braun,Seyedeh-Nafiseh Hassani,Hossein Baharvand.  (2020-05-25)  Suppression of p38-MAPK endows endoderm propensity to human embryonic stem cells..  Biochemical and biophysical research communications,  527  ((3)): (811-817).  [PMID:32446562]
34. Ke Zhang,Dan-Ya Wu,Hui Zheng,Yao Wang,Qiao-Ran Sun,Xin Liu,Li-Yan Wang,Wen-Jing Xiong,Qiujun Wang,James D P Rhodes,Kai Xu,Lijia Li,Zili Lin,Guang Yu,Weikun Xia,Bo Huang,Zhenhai Du,Yao Yao,Kim A Nasmyth,Robert J Klose,Yi-Liang Miao,Wei Xie.  (2020-06-25)  Analysis of Genome Architecture during SCNT Reveals a Role of Cohesin in Impeding Minor ZGA..  Molecular cell,  79  ((2)): (234-250).  [PMID:32579944]
35. Anna Shcherbina,Jacqueline Larouche,Paula Fraczek,Benjamin A Yang,Lemuel A Brown,James F Markworth,Carolina H Chung,Mehwish Khaliq,Kanishka de Silva,Jeongmoon J Choi,Mohammad Fallahi-Sichani,Sriram Chandrasekaran,Young C Jang,Susan V Brooks,Carlos A Aguilar.  (2020-07-30)  Dissecting Murine Muscle Stem Cell Aging through Regeneration Using Integrative Genomic Analysis..  Cell reports,  32  ((4)): (107964-107964).  [PMID:32726628]
36. Yuki Kiyokawa,Masahiro Sato,Hirofumi Noguchi,Emi Inada,Yoko Iwase,Naoko Kubota,Tadashi Sawami,Miho Terunuma,Takeyasu Maeda,Haruaki Hayasaki,Issei Saitoh.  (2020-09-06)  Drug-Induced Naïve iPS Cells Exhibit Better Performance than Primed iPS Cells with Respect to the Ability to Differentiate into Pancreatic β-Cell Lineage..  Journal of clinical medicine,  9  ((9)): [PMID:32887316]
37. Zahida Yesmin Roly,Rasoul Godini,Martin A Estermann,Andrew T Major,Roger Pocock,Craig A Smith.  (2020-10-04)  Transcriptional landscape of the embryonic chicken Müllerian duct..  BMC genomics,  21  ((1)): (688-688).  [PMID:33008304]
38. Benjamin D Pope,Curtis R Warren,Madeleine O Dahl,Christina V Pizza,Douglas E Henze,Nina R Sinatra,Grant M Gonzalez,Huibin Chang,Qihan Liu,Aaron L Glieberman,John P Ferrier,Chad A Cowan,Kevin Kit Parker.  (2020-10-10)  Fattening chips: hypertrophy, feeding, and fasting of human white adipocytes in vitro..  Lab on a chip,  20  ((22)): (4152-4165).  [PMID:33034335]
39. Rachel R Besser,Annie C Bowles,Ahmad Alassaf,Daniel Carbonero,Renata Maciel,Mario Saporta,Ashutosh Agarwal.  (2020-12-08)  A Chemically Defined Common Medium for Culture of C2C12 Skeletal Muscle and Human Induced Pluripotent Stem Cell Derived Spinal Spheroids..  Cellular and molecular bioengineering,  13  ((6)): (605-619).  [PMID:33281990]
40. Georgina L K McDonald,Mengdi Wang,Chrissy L Hammond,Dylan J M Bergen.  (2021-03-07)  Pharmacological Manipulation of Early Zebrafish Skeletal Development Shows an Important Role for Smad9 in Control of Skeletal Progenitor Populations..  Biomolecules,  11  ((2)): [PMID:33668680]
41. Lin Wang,Jingzheng Li,Hu Zhou,Weidao Zhang,Jing Gao,Ping Zheng.  (2021-09-24)  A novel lncRNA Discn fine-tunes replication protein A (RPA) availability to promote genomic stability..  Nature communications,  12  ((1)): (5572-5572).  [PMID:34552092]
42. Anne N T Strehlow,Jun Z Li,Richard M Myers.  (2006-12-26)  Wild-type huntingtin participates in protein trafficking between the Golgi and the extracellular space..  Human molecular genetics,  16  ((4)): (391-409).  [PMID:17189290]
43. Magda A Meester-Smoor,Anco C Molijn,Yixian Zhao,Nicole A Groen,Cora A H Groffen,Merel Boogaard,Diny van Dalsum-Verbiest,Gerard C Grosveld,Ellen C Zwarthoff.  (2007-01-24)  The MN1 oncoprotein activates transcription of the IGFBP5 promoter through a CACCC-rich consensus sequence..  Journal of molecular endocrinology,  38  ((1-2)): (113-125).  [PMID:17242174]
44. Stanley Shapiro,Annie Heremans,David A Mays,Amber L Martin,Marisol Hernandez-Medina,Stephan Lanes.  (2011-05-10)  Use of topical tretinoin and the development of noncutaneous adverse events: evidence from a systematic review of the literature..  Journal of the American Academy of Dermatology,  65  ((6)): (1194-1201).  [PMID:21550137]
45. Prashanth Kumar Bajpe,Guus J J E Heynen,Lorenza Mittempergher,Wipawadee Grernrum,Iris A de Rink,Wouter Nijkamp,Roderick L Beijersbergen,Rene Bernards,Sidong Huang.  (2013-06-19)  The corepressor CTBP2 is a coactivator of retinoic acid receptor/retinoid X receptor in retinoic acid signaling..  Molecular and cellular biology,  33  ((16)): (3343-3353).  [PMID:23775127]
46. Vidya Subramanian,Aprotim Mazumder,Lauren E Surface,Vincent L Butty,Paul A Fields,Allison Alwan,Lillian Torrey,Kevin K Thai,Stuart S Levine,Mark Bathe,Laurie A Boyer.  (2013-08-31)  H2A.Z acidic patch couples chromatin dynamics to regulation of gene expression programs during ESC differentiation..  PLoS genetics,  9  ((8)): (e1003725-e1003725).  [PMID:23990805]
47. Rie Saba,Quan Wu,Yumiko Saga.  (2014-03-01)  CYP26B1 promotes male germ cell differentiation by suppressing STRA8-dependent meiotic and STRA8-independent mitotic pathways..  Developmental biology,  389  ((2)): (173-181).  [PMID:24576537]
48. Thibaud Cherbuin,Mohammad Mehdi Movahednia,Wei Seong Toh,Tong Cao.  (2014-10-07)  Investigation of human embryonic stem cell-derived keratinocytes as an in vitro research model for mechanical stress dynamic response..  Stem cell reviews,  11  ((3)): (460-473).  [PMID:25283762]
49. Neda Bayat,Somayeh Ebrahimi-Barough,Mohammad Mehdi Mokhtari Ardakan,Arman Ai,Ahmadreza Kamyab,Hamideh Babaloo,Jafar Ai.  (2015-12-22)  Differentiation of Human Endometrial Stem Cells into Schwann Cells in Fibrin Hydrogel as 3D Culture..  Molecular neurobiology,  53  ((10)): (7170-7176).  [PMID:26687182]
50. Weiluan Chen,Johanna Clauser,Anja Lena Thiebes,Donnacha J McGrath,Peter E McHugh,Ulrich Steinseifer,Stefan Jockenhoevel,Wim E Hennink,Robbert Jan Kok.  (2016-11-20)  Selection and fabrication of a non-woven polycarbonate urethane cover for a tissue engineered airway stent..  International journal of pharmaceutics,  514  ((1)): (255-262).  [PMID:27863670]
51. Ken Suzawa,Kazuhiko Shien,Huang Peng,Masakiyo Sakaguchi,Masami Watanabe,Shinsuke Hashida,Yuho Maki,Hiromasa Yamamoto,Shuta Tomida,Junichi Soh,Hiroaki Asano,Kazunori Tsukuda,Yasutomo Nasu,Hiromi Kumon,Shinichiro Miyoshi,Shinichi Toyooka.  (2016-12-25)  Distant Bystander Effect of REIC/DKK3 Gene Therapy Through Immune System Stimulation in Thoracic Malignancies..  Anticancer research,  37  ((1)): (301-307).  [PMID:28011506]
52. Nesrin Tüysüz,Louis van Bloois,Stieneke van den Brink,Harry Begthel,Monique M A Verstegen,Luis J Cruz,Lijian Hui,Luc J W van der Laan,Jeroen de Jonge,Robert Vries,Eric Braakman,Enrico Mastrobattista,Jan J Cornelissen,Hans Clevers,Derk Ten Berge.  (2017-03-07)  Lipid-mediated Wnt protein stabilization enables serum-free culture of human organ stem cells..  Nature communications,  8  (14578-14578).  [PMID:28262686]
53. Farnaz Ghorbani,Ali Zamanian,Hanieh Nojehdehian.  (2017-05-24)  Effects of pore orientation on in-vitro properties of retinoic acid-loaded PLGA/gelatin scaffolds for artificial peripheral nerve application..  Materials science & engineering. C, Materials for biological applications,  77  (159-172).  [PMID:28532017]
54. Estela J Jauregui,Debra Mitchell,Traci Topping,Cathryn A Hogarth,Michael D Griswold.  (2018-06-15)  Retinoic acid receptor signaling is necessary in steroidogenic cells for normal spermatogenesis and epididymal function..  Development (Cambridge, England),  145  ((13)): [PMID:29899137]
55. Lide Arana,Laura Bayón-Cordero,Laura Isabel Sarasola,Miren Berasategi,Sandra Ruiz,Itziar Alkorta.  (2019-03-23)  Solid Lipid Nanoparticles Surface Modification Modulates Cell Internalization and Improves Chemotoxic Treatment in an Oral Carcinoma Cell Line..  Nanomaterials (Basel, Switzerland),  9  ((3)): [PMID:30897724]
56. Mi-Yeon Yu,Ji Eun Kim,Saram Lee,Jin Woo Choi,Yong Chul Kim,Seung Seok Han,Hajeong Lee,Ran Hui Cha,Jung Pyo Lee,Jae Wook Lee,Dong Ki Kim,Yon Su Kim,Seung Hee Yang.  (2019-11-08)  Krüppel-like factor 15 is a key suppressor of podocyte fibrosis under rotational force-driven pressure..  Experimental cell research,  386  ((1)): (111706-111706).  [PMID:31697927]
57. Mairéad Flynn,Laura Whitton,Gary Donohoe,Ciaran G Morrison,Derek W Morris.  (2019-12-24)  Altered gene regulation as a candidate mechanism by which ciliopathy gene SDCCAG8 contributes to schizophrenia and cognitive function..  Human molecular genetics,  29  ((3)): (407-417).  [PMID:31868218]
58. Zhiwei Lu,Yuhua Xie,Huanwei Huang,Kaiju Jiang,Bin Zhou,Fengchao Wang,Ting Chen.  (2020-01-04)  Hair follicle stem cells regulate retinoid metabolism to maintain the self-renewal niche for melanocyte stem cells..  eLife,  9  [PMID:31898934]
59. Nandini Kasarpalkar,Barnali Deb,Prashant Kumar,Vikrant M Bhor.  (2020-06-12)  The Role of Integrin α4β7 Signaling in Human Immunodeficiency Virus-1 Pathogenesis and Viral Entry in Primary CD4+ T Cells As Revealed by Comparative Phosphoproteomic Signatures..  Omics : a journal of integrative biology,  24  ((7)): (437-450).  [PMID:32522079]
60. Vartika Mishra,Diane B Re,Virginia Le Verche,Mariano J Alvarez,Alessandro Vasciaveo,Arnaud Jacquier,Paschalis-Tomas Doulias,Todd M Greco,Monica Nizzardo,Dimitra Papadimitriou,Tetsuya Nagata,Paola Rinchetti,Eduardo J Perez-Torres,Kristin A Politi,Burcin Ikiz,Kevin Clare,Manuel E Than,Stefania Corti,Harry Ischiropoulos,Francesco Lotti,Andrea Califano,Serge Przedborski.  (2020-11-06)  Systematic elucidation of neuron-astrocyte interaction in models of amyotrophic lateral sclerosis using multi-modal integrated bioinformatics workflow..  Nature communications,  11  ((1)): (5579-5579).  [PMID:33149111]
61. Jakob Morgenstern,Thomas Fleming,Elisabeth Kliemank,Maik Brune,Peter Nawroth,Andreas Fischer.  (2021-01-23)  Quantification of All-Trans Retinoic Acid by Liquid Chromatography-Tandem Mass Spectrometry and Association with Lipid Profile in Patients with Type 2 Diabetes..  Metabolites,  11  ((1)): [PMID:33478094]
62. Yaxin Zhao, Chao Wang, Bohang Zou, Lin Fu, Shushan Ren, Xiangyu Zhang.  (2023)  Design and Evaluation of Tretinoin Fatty Acid Vesicles for the Topical Treatment of Psoriasis.  MOLECULES,  28  (23): (7868).  [PMID:38067597] [10.3390/molecules28237868]
63. Shan Gao, Meng Liu, Dongzhu Liu, Xinru Kong, Yuelin Fang, Yingying Li, Hang Wu, Jianbo Ji, Xiaoye Yang, Guangxi Zhai.  (2023)  Biomimetic biomineralization nanoplatform-mediated differentiation therapy and phototherapy for cancer stem cell inhibition and antitumor immunity activation.  Asian Journal of Pharmaceutical Sciences,  18  (100851).  [PMID:37915760] [10.1016/j.ajps.2023.100851]
64. Kaili Wang, Hao Chen, Si Qin, Shuhui Chen, Qian Zhang, Jiali Chen, Donghua Di, Guangyue Su, Yue Yuan.  (2023)  Co-delivery of pirfenidone and siRNA in ZIF-based nanoparticles for dual inhibition of hepatic stellate cell activation in liver fibrotic therapy.  COLLOIDS AND SURFACES B-BIOINTERFACES,  231  (113567).  [PMID:37797465] [10.1016/j.colsurfb.2023.113567]
65. Sanli Zhang, Yan Yu, Mingyue Sheng, Xun Chen, Qi Wu, Junping Kou, Gangling Chen.  (2023)  Ruscogenin timing administration mitigates cerebral ischemia-reperfusion injury through regulating circadian genes and activating Nrf2 pathway.  PHYTOMEDICINE,  120  (155028).  [PMID:37659295] [10.1016/j.phymed.2023.155028]
66. Li Xiang, Xin Wang, Qiangqiang Jiao, Yaru Shao, Rui Luo, Jie Zhang, Xiaotong Zheng, Shaobing Zhou, Yuping Chen.  (2023)  Selective inhibition of glycolysis in hepatic stellate cells and suppression of liver fibrogenesis with vitamin A-derivative decorated camptothecin micelles.  Acta Biomaterialia,  168  (497).  [PMID:37507035] [10.1016/j.actbio.2023.07.035]
67. Si Qin, Xuening Du, Kaili Wang, Da Wang, Jiani Zheng, Haiyan Xu, Xiuyan Wei, Yue Yuan.  (2023)  Vitamin A-modified ZIF-8 lipid nanoparticles for the therapy of liver fibrosis.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,  642  (123167).  [PMID:37356511] [10.1016/j.ijpharm.2023.123167]
68. Chongzhi Wu, Fu Zhang, Bowen Li, Zhiyao Li, Xin Xie, Yong Huang, Zhuo Yao, Yuan Chen, Yuan Ping, Weidong Pan.  (2023)  A Self-Assembly Nano-Prodrug for Combination Therapy in Triple-Negative Breast Cancer Stem Cells.  Small,  (2301600).  [PMID:37328445] [10.1002/smll.202301600]
69. Qiao Lu, Xueyang Gong, Guangtao Jia, Jingliang Wu, Siwei Liu, Ke Song, Guixiang Tian.  (2023)  A pH‑responsive hyaluronic acid nano‑vehicle co‑encapsulating doxorubicin and all‑trans retinoic acid for the inhibition of hepatic stellate cell‑induced tumor growth and metastasis.  Molecular Medicine Reports,  28  (2): (1-11).  [PMID:37326031] [10.3892/mmr.2023.13029]
70. Qi Wenxia, Wang Shenglan, Yang Heng, Luo Tingting, Zhao Feng, Han Jingtian, Zhang Jing.  (2023)  An albumin-based nanosystem for cocktail therapy of breast cancer amplifies the therapeutic efficacy of combination chemotherapy with photodynamic therapy.  JOURNAL OF MATERIALS SCIENCE,  58  (21): (8952-8968).  [10.1007/s10853-023-08590-5]
71. Sheng Mingyue, Chen Xun, Yu Yan, Wu Qi, Kou Junping, Chen Gangling.  (2023)  Rev-erbα agonist SR9009 protects against cerebral ischemic injury through mechanisms involving Nrf2 pathway.  Frontiers in Pharmacology,  14  [PMID:37063298] [10.3389/fphar.2023.1102567]
72. Naiying Chen, Sicheng Yao, Mingming Li, Qiuyue Wang, Xinxing Sun, Xun Feng, Yang Chen.  (2023)  Nonporous versus Mesoporous Bioinspired Polydopamine Nanoparticles for Skin Drug Delivery.  BIOMACROMOLECULES,  24  (4): (1648–1661).  [PMID:36883261] [10.1021/acs.biomac.2c01431]
73. Shiyang Shen, Teng Li, Jinyi Fan, Quanlin Shao, He Dong, Xiao Xu, Ran Mo.  (2023)  Lipid-polymer hybrid nanoparticle with cell-distinct drug release for treatment of stemness-derived resistant tumor.  Acta Pharmaceutica Sinica B,  13  (1262).  [PMID:36970217] [10.1016/j.apsb.2022.11.009]
74. Hui Jin, Ningning Jiang, Wenshu Xu, Zhongyuan Zhang, Yang Yang, Jingmin Zhang, Hui Xu.  (2022)  Effect of flavonoids from Rhizoma Drynariae on osteoporosis rats and osteocytes.  BIOMEDICINE & PHARMACOTHERAPY,  153  (113379).  [PMID:36076521] [10.1016/j.biopha.2022.113379]
75. Rong Zhang, Wei Jia.  (2022)  Authenticity and traceability of goat milk: Molecular mechanism of β-carotene biotransformation and accessibility.  FOOD CHEMISTRY,  388  (133073).  [PMID:35483296] [10.1016/j.foodchem.2022.133073]
76. Wang Yufeng, Wang Chunxu, Zuo Nan, Yang Hao, Fang Shaohong, Shi Jialan.  (2022)  Extracellular Traps Increase Burden of Bleeding by Damaging Endothelial Cell in Acute Promyelocytic Leukaemia.  Frontiers in Immunology,  13  [PMID:35479063] [10.3389/fimmu.2022.841445]
77. Guohua Yao, Muhammad Muhammad, Jiajiang Zhao, Jianguo Liu, Qing Huang.  (2022)  DFT-based Raman spectral study of astaxanthin geometrical isomers.  Food Chemistry: Molecular Sciences,  4  (100103).  [PMID:35769397] [10.1016/j.fochms.2022.100103]
78. Yupeng Liu, Fangying Yu, Suhuan Dai, Tingting Meng, Yun Zhu, Guoxi Qiu, Lijuan Wen, Xueqing Zhou, Hong Yuan, Fuqiang Hu.  (2021)  All-Trans Retinoic Acid and Doxorubicin Delivery by Folic Acid Modified Polymeric Micelles for the Modulation of Pin1-Mediated DOX-Induced Breast Cancer Stemness and Metastasis.  MOLECULAR PHARMACEUTICS,  18  (11): (3966–3978).  [PMID:34579532] [10.1021/acs.molpharmaceut.1c00220]
79. Hang Hu, Defeng Xu.  (2021)  Co-delivery of docetaxel and retinoic acid by poly (ethylene glycol)-retinoic acid conjugates based micelles for synergistic prostate cancer therapy.  Micro & Nano Letters,  16  (6): (336-343).  [10.1049/mna2.12036]
80. Jiang Ying, Song Hanbing, Jiang Ling, Qiao Yu, Yang Dan, Wang Donghua, Li Ji.  (2020)  Silybin Prevents Prostate Cancer by Inhibited the ALDH1A1 Expression in the Retinol Metabolism Pathway.  Frontiers in Cell and Developmental Biology,  8  (888).  [PMID:32984354] [10.3389/fcell.2020.574394]
81. Ken Zhao, Jie Liu, Gang Dong, Huan Xia, Pingan Wang, Xuan Xiao, Zhen Chen.  (2020)  Preliminary research on the effects and mechanisms of umbilical cord‑derived mesenchymal stem cells in streptozotocin‑induced diabetic retinopathy Corrigendum in /10.3892/ijmm.2020.4708.  INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,  46  (2): (849-858).  [PMID:32626946] [10.3892/ijmm.2020.4623]
82. Chengyan Sun, Ning Jia, Rui Li, Ze Zhang, Yi Zhong, Kun Han.  (2020)  miR-143-3p inhibition promotes neuronal survival in an Alzheimer’s disease cell model by targeting neuregulin-1.  FOLIA NEUROPATHOLOGICA,  58  (1): (10-21).  [PMID:32337953] [10.5114/fn.2020.94002]
83. Hu Hang, Wang Chong, Zhang Rong, Xiao Chen, Lai Chao, Li Zifu, Xu Defeng.  (2020)  Branched worm-like nanoparticles featured with programmed drug release for synergistic castration-resistant prostate cancer therapy.  JOURNAL OF MATERIALS SCIENCE,  55  (16): (6992-7008).  [10.1007/s10853-020-04495-9]
84. Song Lin, Yao Lifen, Zhang Limei, Piao Zhongyuan, Lu Yichan.  (2020)  Schizandrol A protects against Aβ1–42-induced autophagy via activation of PI3K/AKT/mTOR pathway in SH-SY5Y cells and primary hippocampal neurons.  NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY,  393  (9): (1739-1752).  [PMID:31900522] [10.1007/s00210-019-01792-2]
85. Qing-qing Xia, Ling-min Zhang, Ying-ying Zhou, Ya-lin Wu, Jie Li.  (2019)  All-trans-retinoic acid generation is an antidotal clearance pathway for all-trans-retinal in the retina.  Journal of Zhejiang University-SCIENCE B,  20  (12): ( 960–971).  [PMID:31749343] [10.1631/jzus.B1900271]
86. Chao Guo, Junrong Zhu, Jingwen Wang, Jialin Duan, Shanbo Ma, Ying Yin, Wei Quan, Wei Zhang, Yue Guan, Yi Ding, Aidong Wen, Yingdong Zhang.  (2019)  Neuroprotective effects of protocatechuic aldehyde through PLK2/p-GSK3β/Nrf2 signaling pathway in both in vivo and in vitro models of Parkinson's disease.  Aging-US,  11  (21): ( 9424–9441).  [PMID:31697645] [10.18632/aging.102394]
87. Lihong Ruan, Ningning Jiang, Fengyang Guo, Hui Xu, Jingmin Zhang, Jingchun Sun.  (2019)  The antiresoptive effects of recombinant Lingzhi-8 protein against retinoic acid-induced osteopenia.  EUROPEAN JOURNAL OF PHARMACOLOGY,  863  (172669).  [PMID:31542486] [10.1016/j.ejphar.2019.172669]
88. Lumei Chi, Dan Jiao, Guangxian Nan, Honghua Yuan, Jing Shen, Yu Gao.  (2019)  miR-9-5p attenuates ischemic stroke through targeting ERMP1-mediated endoplasmic reticulum stress.  ACTA HISTOCHEMICA,  121  (151438).  [PMID:31500865] [10.1016/j.acthis.2019.08.005]
89. Cui Huang, Jing Ma, Bai‑Xiang Li, Yan Sun.  (2019)  Wnt1 silencing enhances neurotoxicity induced by paraquat and maneb in SH‑SY5Y cells.  Experimental and Therapeutic Medicine,  18  (5): (3643-3649).  [PMID:31602242] [10.3892/etm.2019.7963]
90. Tingting Luo, Jingtian Han, Feng Zhao, Xiaohong Pan, Baocheng Tian, Xiujuan Ding, Jing Zhang.  (2019)  Redox-sensitive micelles based on retinoic acid modified chitosan conjugate for intracellular drug delivery and smart drug release in cancer therapy.  CARBOHYDRATE POLYMERS,  215  (8).  [PMID:30981373] [10.1016/j.carbpol.2019.03.064]
91. Yanqiu Zhang, Lianjun Peng, Jiahui Chu, Ming Zhang, Lizhu Sun, Bin Zhong, Qiyong Wu.  (2018)  pH and redox dual-responsive copolymer micelles with surface charge reversal for co-delivery of all-trans-retinoic acid and paclitaxel for cancer combination chemotherapy.  International Journal of Nanomedicine,  [PMID:30410335] [10.2147/IJN.S179046]
92. Jia Jiao, Hongshuai Wu, Fanghui Chen, Renjie Chen, Baiwang Sun, Mingliang Wang.  (2018)  Delivery of coumarin-containing all-trans retinoic acid derivatives via targeted nanoparticles encapsulating indocyanine green for chemo/photothermal/photodynamic therapy of breast cancer.  NEW JOURNAL OF CHEMISTRY,  42  (11): (8805-8814).  [10.1039/C8NJ00578H]
93. Yuming Yang, Caixia Yue, Yu Han, Wei Zhang, Aina He, Chunlei Zhang, Ting Yin, Qian Zhang, Jingjing Zhang, Yao Yang, Jian Ni, Jielin Sun, Daxiang Cui.  (2016)  Tumor-Responsive Small Molecule Self-Assembled Nanosystem for Simultaneous Fluorescence Imaging and Chemotherapy of Lung Cancer.  ADVANCED FUNCTIONAL MATERIALS,  26  (47): (8735-8745).  [10.1002/adfm.201601369]
94. Jing Zhang, Jian Han, Xiuli Zhang, Jing Jiang, Maolei Xu, Daolai Zhang, Jingtian Han.  (2015)  Polymeric nanoparticles based on chitooligosaccharide as drug carriers for co-delivery of all-trans-retinoic acid and paclitaxel.  CARBOHYDRATE POLYMERS,  129  (25).  [PMID:26050884] [10.1016/j.carbpol.2015.04.036]
95. Juan Yang, Nana Wu, Jie Peng, Xiaoquan Yang, Jian Guo, Shouwei Yin, Jinmei Wang.  (2015)  Prevention of retinoic acid-induced osteoporosis in mice by isoflavone-enriched soy protein.  JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE,  96  (1): (331-338).  [PMID:25645024] [10.1002/jsfa.7098]
96. Qida Hu, Fu Zhang, Bowen Li, Piaopiao Jin, Junming Huang, Zhuo Yao, Xinyu Zhao, Shiyi Shao, Meng Wang, Yuan Ping, Tingbo Liang.  (2025)  Engineered a Gemcitabine Nano-Prodrug Targeting Desmoplastic Pancreatic Tumor with Dual Enhancement of Penetration Dynamics.  Small,  (2410629).  [PMID:40007057] [10.1002/smll.202410629]
97. Li Xiang, Xianjing Xiang, Qiangqiang Jiao, Yu Luo, Guodong Zeng, Wenhui Zhang, Yuting Qin, Yuping Chen.  (2025)  Inhibition of HSC proliferation and hepatic fibrogenesis with Erythrocyte membrane coated Doxorubicin/Black phosphorus nanosheets.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,  673  (125403).  [PMID:40015579] [10.1016/j.ijpharm.2025.125403]
98. Chunfei Zhong, Xinyan Li, Fan Zhang, Ning Liu, Jiewei Deng, Yunyun Yang, Tiangang Luan.  (2024)  Rapid and sensitive determination of bongkrekic acid with molecularly imprinted polymer-coated wooden-tip electrospray ionization mass spectrometry.  Advances in Sample Preparation,  12  (100137).  [10.1016/j.sampre.2024.100137]
99. Shuxian Dai, Mengting Hu, Wen Zhang, Zhen Lei.  (2025)  Selective colorimetric detection of carbosulfan based on its hydrolysis behavior and Ti3C2/AuPt nanozyme.  ANALYTICA CHIMICA ACTA,  1336  (343519).  [PMID:39788672] [10.1016/j.aca.2024.343519]
100. Li Xiang, Yuting Qin, Lei Li, Xianjing Xiang, Wenhui Zhang, Qiangqiang Jiao, Yaru Shao, Xinqiong Huang, Meichun Wu, Tianle Zhou, Yukang Lin, Yuping Chen.  (2024)  Targeting hyperactive mitochondria in activated HSCs and inhibition of liver fibrogenesis in mice using sorafenib complex micelles.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,  (125058).  [PMID:39653289] [10.1016/j.ijpharm.2024.125058]
101. Yuan Chen, Yi Zhou, Jinhan Cai, Jiayi Xu, Chenwei Hu, Huiyue Chen, Yirui Hong, Nanyi Pan, Yujie Jiang, Chenhui Zhou, Hua Wei, Zhipeng Xu, Lin Liu, Xiang Wu, Wei Cui.  (2024)  The activation of RARα prevents surgery-induced cognitive impairments via the inhibition of neuroinflammation and the restoration of synaptic proteins in elderly mice.  INTERNATIONAL IMMUNOPHARMACOLOGY,  130  (111772).  [PMID:38432148] [10.1016/j.intimp.2024.111772]

溶液计算器

上海阿拉丁生化科技股份有限公司
© 2016 ALADDIN-E.COM . 版权所有,未经授权禁止拷贝本站资料,如有违反,将追究法律责任

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用。

上海工商 危险品化学品经营许可证（带存储）营业执照(三证合一)