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槲皮素 3-D-半乳糖苷

34篇引用文献 COA COA
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货号 (SKU) 包装规格 是否现货 价格 数量
Q123379-10mg
 10mg 现货 Stock Image
Q123379-50mg
 50mg 期货 Stock Image
Q123379-250mg
 250mg 现货 Stock Image
大包装询价 收藏夹 比较  SDS下载  DATASHEET  质量标准
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Anti-infection (2804) Apoptosis (7108) Fungal (1689) Influenza Virus (253) NF-κB (756) Virus (3767)
main product photo

基本描述

别名 槲皮素2-D-半乳糖苷 | 3,3',4',5,7-五羟基黄酮3-D-半乳糖苷
英文别名 Hyperin | 3,3',4',5,7-Pentahydroxyflavone 3-D-galactoside | Quercetin 3-D-galactoside
规格或纯度 Moligand™, ≥97%(HPLC)
英文名称 Quercetin 3-D-galactoside
生化机理 防止过氧化物诱导的对细胞的氧化伤害，清除活性氧和提高抗氧化酶的活性，特别是，过氧化氢酶和谷胱甘肽过氧化物酶
储存温度 2-8°C储存,充氩
运输条件 冰袋运输
产品介绍

Hyperoside (Hyperin) 是一种 NF-κB 抑制剂，从 Hypericum monogynum 中发现。Hyperoside 具有抗肿瘤、抗真菌、抗炎症、抗病毒和抗氧化的活性，并能诱导细胞凋亡。

应用
金丝桃苷可被用于：可发高效液相色谱-质谱法测定大鼠血浆样品经蛋白质沉淀和液-液萃取处理后的金丝桃苷；通过HPLC结合二极管阵列检测（DAD）对用于中药的 罗布麻 和 刺五加 植物样品中的金丝桃苷、异槲皮苷和刺五加苷 E进行多残留分析；从 S天山花楸 叶样品中用离子液体真空微波辅助提取（ILVMAE）芦丁、金丝桃苷和橙皮苷，并随后用HPLC定量；使用高效液相色谱结合分光光度检测(HPLC-UV)同时检测和定量山楂花和叶提取物样品中的牡荆素、芦丁、金丝桃苷和槲皮素。

Hyperoside is a NF-κB inhibitor, found from Hypericum monogynum. Hyperoside shows anti-tumor, antifungal, anti-inflammatory, anti-viral, and anti-oxidative activities, and can induce apoptosis.
纯度 ≥97%(HPLC)

关联靶点（人）

HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TYR Tclin Tyrosinase (717 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADORA1 Tclin Adenosine A1 receptor (17603 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
OPRD1 Tclin Delta opioid receptor (15096 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
OPRK1 Tclin Kappa opioid receptor (16155 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
XDH Tclin Xanthine dehydrogenase (1038 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AKR1B1 Tclin Aldose reductase (1404 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
FABP4 Tchem Fatty acid binding protein adipocyte (764 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
POLB Tchem DNA polymerase beta (23632 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GLA Tclin Alpha-galactosidase A (5444 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AMY2A Tclin Pancreatic alpha-amylase (74 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GBA1 Tclin Beta-glucocerebrosidase (14647 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GAA Tclin Lysosomal alpha-glucosidase (35701 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
RNASEL Tchem RNase L (193 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
EPHX2 Tchem Epoxide hydratase (3844 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HL-60 (67320 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HT-29 (80576 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MCF7 (126967 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
A549 (127892 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HepG2 (196354 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
A2780 (11979 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HeLa (62764 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ABCG2 Tchem ATP-binding cassette sub-family G member 2 (4927 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
KDM4E Tchem Lysine-specific demethylase 4D-like (40243 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
LMNA Tbio Prelamin-A/C (36751 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MBNL1 Tbio Muscleblind-like protein 1 (34431 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
BAZ2B Tchem Bromodomain adjacent to zinc finger domain protein 2B (56204 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLCO2B1 Tchem Solute carrier organic anion transporter family member 2B1 (580 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CDK5 Tchem Cyclin-dependent kinase 5/CDK5 activator 1 (3697 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

NA Neuraminidase (1107 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mapk1 MAP kinase ERK2 (650 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Hdac6 Histone deacetylase 6 (222 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Ptpn1 Protein-tyrosine phosphatase 1B (270 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
pol Human immunodeficiency virus type 1 integrase (9041 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Gaa Acidic alpha-glucosidase (551 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Streptococcus pneumoniae (31063 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Enterococcus (1748 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Pseudomonas aeruginosa (123386 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Klebsiella pneumoniae (43867 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Staphylococcus aureus (210822 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Acinetobacter baumannii (41033 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Escherichia coli (133304 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Entamoeba histolytica (2676 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Cryptococcus neoformans (21258 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Candida albicans (78123 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Candida parapsilosis (8521 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Giardia intestinalis (1290 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mus musculus (284745 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Dengue virus (413 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MDCK (10148 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
RAW264.7 (28094 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
C2C12 (756 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
pfk 6-phospho-1-fructokinase (7870 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Aorta (2975 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mapt Microtubule-associated protein tau (6 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
fba Putative fructose-1,6-bisphosphate aldolase (15559 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

PubChem SID 488195240
EC号 207-580-6
分子类型 小分子
IIUPAC Name 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one
INCHI 1S/C21H20O12/c22-6-13-15(27)17(29)18(30)21(32-13)33-20-16(28)14-11(26)4-8(23)5-12(14)31-19(20)7-1-2-9(24)10(25)3-7/h1-5,13,15,17-18,21-27,29-30H,6H2/t13-,15+,17+,18-,21+/m1/s1
InChi Key OVSQVDMCBVZWGM-DTGCRPNFSA-N
Smiles C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)OC4C(C(C(C(O4)CO)O)O)O)O)O
Isomeric SMILES C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O[C@H]4[C@@H]([C@H]([C@H]([C@H](O4)CO)O)O)O)O)O
分子量 464.38
Beilstein号 5784795

化学和物理性质

密度 1.87
敏感性 对空气敏感；对热敏感
熔点 233 °C
分子量 464.400 g/mol
XLogP3 0.400
氢键供体数Hydrogen Bond Donor Count 8
氢键受体数Hydrogen Bond Acceptor Count 12
可旋转键计数Rotatable Bond Count 4
精确质量Exact Mass 464.095 Da
单同位素质量Monoisotopic Mass 464.095 Da
拓扑极表面积Topological Polar Surface Area 207.000 Ų
重原子数Heavy Atom Count 33
形式电荷Formal Charge 0
复杂度Complexity 758.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 5
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

象形图 GHS07
信号词 警告
危险声明

H302: 吞食有害
预防措施声明

P264: 处理后要彻底洗手。

P270: 使用本产品时，请勿进食、饮水或吸烟。

P330: 漱口

P301+P312: 如误吞咽：如感觉不适，呼叫急救中心/医生。

P501: 将内容物/容器处理到。。。
WGK Germany 3
RTECS DJ3009200

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引用文献

1. Liu Xinru, Ma Qianwei, Sun Yongjun, Ju Wenming, Kumrungsee Thanutchaporn, Zhou Zhongkai, Wang Lijuan, Cao Ruge.  (2023)  Effects of Processings and Complexation on Solubility, Antioxidant and Antibacterial Properties of Buckwheat Polyphenols.  Food and Bioprocess Technology,  (1-13).  [10.1007/s11947-023-03217-8]
2. Linzi Li, Xueying Lei, Lin Chen, Ya Ma, Jun Luo, Xuebo Liu, Xinglian Xu, Guanghong Zhou, Xianchao Feng.  (2024)  Protective mechanism of quercetin compounds against acrylamide-induced hepatotoxicity.  Food Science and Human Wellness,  13  (225).  [10.26599/FSHW.2022.9250019]
3. Huiqun Fan, Mingshun Chen, Taotao Dai, Lizhen Deng, Chengmei Liu, Wei Zhou, Jun Chen.  (2023)  Phenolic compounds profile of Amomum tsaoko Crevost et Lemaire and their antioxidant and hypoglycemic potential.  Food Bioscience,  52  (102508).  [10.1016/j.fbio.2023.102508]
4. Zhixin Xiao, Min Liu, Wentao Bi, David Da Yong Chen.  (2023)  Ionic liquid as hydrogen bond acceptor in the extraction of nutritional natural products.  FOOD CHEMISTRY,  412  (135589).  [PMID:36736187] [10.1016/j.foodchem.2023.135589]
5. Zhixu Chen, Jincai Wang, Jiaming Yuan, Zhen Wang, Zhengchao Tu, Jacques Crommen, Wenhui Luo, Jialiang Guo, Tingting Zhang, Zhengjin Jiang.  (2023)  Rapid screening of neuraminidase inhibitors using an at-line nanofractionation platform involving parallel oseltamivir-sensitive/resistant neuraminidase bioassays.  JOURNAL OF CHROMATOGRAPHY A,  1687  (463693).  [PMID:36516530] [10.1016/j.chroma.2022.463693]
6. Qi Dong, Na Hu, Huilan Yue, Honglun Wang, Yue Wei.  (2022)  Rapid screening of α-glucosidase inhibitors in Hypericum perforatum L. using bio-affinity chromatography coupled with UPLC/MS.  BIOMEDICAL CHROMATOGRAPHY,  37  (2): (e5536).  [PMID:36264709] [10.1002/bmc.5536]
7. Yuan Pan, Hui-Wen Gu, Yi Lv, Xiao-Li Yin, Ying Chen, Wanjun Long, Haiyan Fu, Yuanbin She.  (2022)  Untargeted metabolomic analysis of Chinese red wines for geographical origin traceability by UPLC-QTOF-MS coupled with chemometrics.  FOOD CHEMISTRY,  394  (133473).  [PMID:35716498] [10.1016/j.foodchem.2022.133473]
8. Liangmei Rao, Yifu Zhu, Zhongshu Duan, Ting Xue, Xuemin Duan, Yangping Wen, Annamalai Senthil Kumar, Weiming Zhang, Jingkun Xu, Akbar Hojjati-Najafabadi.  (2022)  Lotus seedpods biochar decorated molybdenum disulfide for portable, flexible, outdoor and inexpensive sensing of hyperin.  CHEMOSPHERE,  301  (134595).  [PMID:35427664] [10.1016/j.chemosphere.2022.134595]
9. Jie Zhao, Lin Huang, Renjie Li, Zhuangwei Zhang, Jin Chen, Hongjin Tang.  (2022)  Insights from multi-spectroscopic analysis and molecular modeling to understand the structure–affinity relationship and the interaction mechanism of flavonoids with gliadin.  Food & Function,  13  (9): (5061-5074).  [PMID:35404372] [10.1039/D1FO03816H]
10. Liuying Zhu, Wenting Li, Zeyuan Deng, Hongyan Li, Bing Zhang.  (2020)  The Composition and Antioxidant Activity of Bound Phenolics in Three Legumes, and Their Metabolism and Bioaccessibility of Gastrointestinal Tract.  Foods,  9  (12): (1816).  [PMID:33297502] [10.3390/foods9121816]
11. Hongjin Tang, Lin Huang, Dongsheng Zhao, Chunyong Sun, Ping Song.  (2020)  Interaction mechanism of flavonoids on bovine serum albumin: Insights from molecular property-binding affinity relationship.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  239  (118519).  [PMID:32480277] [10.1016/j.saa.2020.118519]
12. Jie Zhao, Lin Huang, Chunyong Sun, Dongsheng Zhao, Hongjin Tang.  (2020)  Studies on the structure-activity relationship and interaction mechanism of flavonoids and xanthine oxidase through enzyme kinetics, spectroscopy methods and molecular simulations.  FOOD CHEMISTRY,  323  (126807).  [PMID:32330646] [10.1016/j.foodchem.2020.126807]
13. Guo Xiao, Zhang Yongtao, Lu Changhong, Qu Fengxia, Jiang Xianyan.  (2020)  Protective effect of hyperoside on heart failure rats via attenuating myocardial apoptosis and inducing autophagy.  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY,  84  (4): (714-724).  [PMID:31797747] [10.1080/09168451.2019.1685369]
14. Yuhuan Chen, Qiwen Chen, Xiaozhong Wang, Fan Sun, Yawei Fan, Xiaoru Liu, Hongyan Li, Zeyuan Deng.  (2020)  Hemostatic action of lotus leaf charcoal is probably due to transformation of flavonol aglycons from flavonol glycosides in traditional Chinses medicine.  JOURNAL OF ETHNOPHARMACOLOGY,  249  (112364).  [PMID:31678413] [10.1016/j.jep.2019.112364]
15. Na Wang, Jianyao Kou, Lijie Wang, Fei Wang, Kui Lu.  (2019)  Sensitive Electrochemical Determination of Hyperin Based on Electrochemically Activated ZrO2 Nanoparticles-Modified Carbon Paste Electrode.  NANO,  [10.1142/S1793292019500528]
16. Li Wei, He Weiming, Xia Ping, Sun Wei, Shi Ming, Zhou Yao, Zhu Weiwei, Zhang Lu, Liu Buhui, Zhu Jingjing, Zhu Yiye, Zhou Enchao, Sun Minjie, Gao Kun.  (2019)  Total Extracts of Abelmoschus manihot L. Attenuates Adriamycin-Induced Renal Tubule Injury via Suppression of ROS-ERK1/2-Mediated NLRP3 Inflammasome Activation.  Frontiers in Pharmacology,  10  [PMID:31191310] [10.3389/fphar.2019.00567]
17. Nan Yang, Ruixia Qiu, Shuo Yang, Kangning Zhou, Chengtao Wang, Shiyi Ou, Jie Zheng.  (2019)  Influences of stir-frying and baking on flavonoid profile, antioxidant property, and hydroxymethylfurfural formation during preparation of blueberry-filled pastries.  FOOD CHEMISTRY,  287  (167).  [PMID:30857686] [10.1016/j.foodchem.2019.02.053]
18. Yurong Ma, Qingfeng Ban, Jingying Shi, Tiantian Dong, Cai-Zhong Jiang, Qingguo Wang.  (2019)  1-Methylcyclopropene (1-MCP), storage time, and shelf life and temperature affect phenolic compounds and antioxidant activity of ‘Jonagold’ apple.  POSTHARVEST BIOLOGY AND TECHNOLOGY,  150  (71).  [10.1016/j.postharvbio.2018.12.015]
19. Danjing Wan, Yu Han, Farui Li, Hua Mao, Gang Chen.  (2018)  Far infrared-assisted removal of extraction solvent for capillary electrophoretic determination of the bioactive constituents in Plumula Nelumbinis.  ELECTROPHORESIS,  40  (4): (582-586).  [PMID:30488648] [10.1002/elps.201800477]
20. Yu-Mei Zhao, Lv-Huan Wang, Si-Fan Luo, Qi-Qin Wang, Ruin Moaddel, Ting-Ting Zhang, Zheng-Jin Jiang.  (2018)  Magnetic beads-based neuraminidase enzyme microreactor as a drug discovery tool for screening inhibitors from compound libraries and fishing ligands from natural products.  JOURNAL OF CHROMATOGRAPHY A,  1568  (123).  [PMID:30005943] [10.1016/j.chroma.2018.07.031]
21. Yang Huang, Ying Feng, Guangyun Tang, Minyi Li, Tingting Zhang, Marianne Fillet, Jacques Crommen, Zhengjin Jiang.  (2017)  Development and validation of a fast SFC method for the analysis of flavonoids in plant extracts.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,  140  (384).  [PMID:28347593] [10.1016/j.jpba.2017.03.012]
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