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补骨脂素
有货
库存信息
| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| P425374-1ml |
1ml |
现货  |
|
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基本描述
| 别名 | 制斑素 |
|---|---|
| 英文别名 | 7H-Furo(3,2-g)(1)benzopyran-7-one | BRD-K47264279-001-01-4 | DTXSID00216205 | 6-hydroxy-5-benzofuranacrylic Acid deta-lacton | Furo[2'.3':7.6]coumarin | HY-N0053 | P2077 | 6,7-Furanocoumarin | BCP04177 | Furo(2',3',7,6)coumarin | Psoralen,(S) | 2-Propenoi |
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | Psoralen |
| 生化机理 | 光毒性植物毒素；当被紫外线激活时，补骨脂素会诱导 DNA 中的链间交联。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
有增加皮肤黑色素的作用，适用于白癜风。此外，尚可用于斑秃及牛皮癣。 Photochemical reagent for the investigation of nucleic acid structure and function. |
关联靶点（人）
CYP2A6
Tchem
细胞色素 P450 2A6(Cytochrome P450 2A6)
(1 活性数据)
TOP2A
Tclin
DNA topoisomerase II alpha
(6317 活性数据)
MAOA
Tclin
Monoamine oxidase A
(11911 活性数据)
ACHE
Tclin
Acetylcholinesterase
(18204 活性数据)
MAOB
Tclin
Monoamine oxidase B
(8835 活性数据)
CYP1A1
Tchem
Cytochrome P450 1A1
(1169 活性数据)
CYP2D6
Tclin
Cytochrome P450 2D6
(33882 活性数据)
NFKB1
Tclin
Nuclear factor NF-kappa-B p105 subunit
(1459 活性数据)
BACE1
Tchem
Beta-secretase 1
(15641 活性数据)
CYP2C9
Tchem
Cytochrome P450 2C9
(32119 活性数据)
CYP2C19
Tchem
Cytochrome P450 2C19
(29246 活性数据)
CYP3A4
Tclin
Cytochrome P450 3A4
(53859 活性数据)
CYP2A6
Tchem
Cytochrome P450 2A6
(2861 活性数据)
CYP2B6
Tchem
Cytochrome P450 2B6
(1338 活性数据)
HL-60
(67320 活性数据)
HT-29
(80576 活性数据)
K562
(73714 活性数据)
LoVo
(4724 活性数据)
A549
(127892 活性数据)
HCT-116
(91556 活性数据)
HEK293
(82097 活性数据)
HepG2
(196354 活性数据)
SIRT1
Tchem
NAD-dependent deacetylase sirtuin 1
(3505 活性数据)
HSD17B10
Tchem
Endoplasmic reticulum-associated amyloid beta-peptide-binding protein
(20669 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | 期刊 | PubMed Id | doi | Assay Aladdin ID |
|---|
KDM4E
Tchem
Lysine-specific demethylase 4D-like
(40243 活性数据)
CBX1
Tbio
Chromobox protein homolog 1
(92434 活性数据)
USP1
Tchem
Ubiquitin carboxyl-terminal hydrolase 1
(22556 活性数据)
关联靶点（其它种属）
Hdac6
Histone deacetylase 6 (222 活性数据)
Nannizzia gypsea (2039 活性数据)
Helicobacter pylori (3113 活性数据)
Pseudomonas aeruginosa (123386 活性数据)
Salmonella typhimurium (15756 活性数据)
Shigella flexneri (1836 活性数据)
Micrococcus luteus (7463 活性数据)
Staphylococcus aureus (210822 活性数据)
Staphylococcus epidermidis (22802 活性数据)
Escherichia coli (133304 活性数据)
Bacillus subtilis (32866 活性数据)
Trypanosoma brucei brucei (13300 活性数据)
Plasmodium falciparum (966862 活性数据)
Candida albicans (78123 活性数据)
Trichophyton rubrum (3646 活性数据)
Caenorhabditis elegans (1055 活性数据)
Human immunodeficiency virus (3636 活性数据)
B16 (5829 活性数据)
Ehrlich (1318 活性数据)
B16-F10 (4610 活性数据)
lef
Anthrax lethal factor (7585 活性数据)
BALB/3T3 (534 活性数据)
rep
Replicase polyprotein 1ab (378 活性数据)
Bursaphelenchus xylophilus (372 活性数据)
Panagrellus redivivus (38 活性数据)
SARS-CoV-2 (38078 活性数据)
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
名称和识别符
| EC号 | 200-639-7 |
|---|---|
| 分子类型 | 小分子 |
| IIUPAC Name | furo[3,2-g]chromen-7-one |
| INCHI | 1S/C11H6O3/c12-11-2-1-7-5-8-3-4-13-9(8)6-10(7)14-11/h1-6H |
| InChi Key | ZCCUUQDIBDJBTK-UHFFFAOYSA-N |
| Smiles | C1=CC(=O)OC2=CC3=C(C=CO3)C=C21 |
| Isomeric SMILES | C1=CC(=O)OC2=CC3=C(C=CO3)C=C21 |
| 分子量 | 186.16 |
| Beilstein号 | 152784 |
| Reaxy-Rn | 152784 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=152784&ln= |
化学和物理性质
| 敏感性 | 对热和光线敏感 |
|---|---|
| 熔点 | 163 °C |
| 分子量 | 186.160 g/mol |
| XLogP3 | 2.300 |
| 氢键供体数Hydrogen Bond Donor Count | 0 |
| 氢键受体数Hydrogen Bond Acceptor Count | 3 |
| 可旋转键计数Rotatable Bond Count | 0 |
| 精确质量Exact Mass | 186.032 Da |
| 单同位素质量Monoisotopic Mass | 186.032 Da |
| 拓扑极表面积Topological Polar Surface Area | 39.400 Ų |
| 重原子数Heavy Atom Count | 14 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 284.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
安全和危险性（GHS）
| 象形图 | GHS07 |
|---|---|
| 信号词 | 警告 |
| 危险声明 |
H302: 吞食有害 H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P271: 仅在室外或通风良好的地方使用。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P330: 漱口 P302+P352: 如皮肤沾染：用水充分清洗。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P405: 密闭存放 P403+P233: 存放在通风良好的地方。保持容器密闭。 P501: 将内容物/容器处理到。。。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P301+P317: 如果被吞咽：请寻求医疗帮助。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。 |
| WGK Germany | 3 |
| RTECS | LV0944000 |
| Merck Index | 7928 |
| 个人防护装备 | dust mask type N95 (US),Eyeshields,Gloves |
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
技术文档和文章
DNA Damage and Repair
Categories: 技术文章
DNA Damage and Repair
Categories: 技术文章
DNA Damage and Repair
Categories: 技术文章
DNA Damage and Repair
Categories: 技术文章
此产品的引用文献
引用文献
| 1. Baofei Yan, Xian Zheng, Yun Wang, Jingwen Yang, Xingyu Zhu, Mengmeng Qiu, Kexin Xia, Yongan Wang, Mian Li, Sipan Li, Xinai Ma, Jianjun Xie, Fengtao Li, Tingming Fu, Wei Li. (2023) Liposome-Based Silibinin for Mitigating Nonalcoholic Fatty Liver Disease: Dual Effects via Parenteral and Intestinal Routes. ACS Pharmacology & Translational Science, [PMID:38093834] [10.1021/acsptsci.3c00210] |
| 2. Liangliang Han, Libo Zhang, Yuedong He, Lijing Liao, Junde Li, Sheng Xu, Yucheng Zhao, Xiaohong Bian, Yuanzheng Xia. (2023) Three carbon-/oxygen-prenyltransferases responsible for furanocoumarin synthesis in Angelica dahurica. INDUSTRIAL CROPS AND PRODUCTS, 200 (116814). [10.1016/j.indcrop.2023.116814] |
| 3. Yujie Lu, Man Zhang, Jin Zhang, Min Jiang, Gang Bai. (2023) Psoralen prevents the inactivation of estradiol and treats osteoporosis via covalently targeting HSD17B2. JOURNAL OF ETHNOPHARMACOLOGY, 311 (116426). [PMID:36997132] [10.1016/j.jep.2023.116426] |
| 4. Ying-Hui He, Xiao-Fei Shang, Hai-Xin Li, An-Ping Li, Chen Tang, Bao-Qi Zhang, Zhi-Jun Zhang, Rui Wang, Yue Ma, Sha-Sha Du, Yong-Mei Hu, Tian-Lin Wu, Wen-Bin Zhao, Cheng-Jie Yang, Ying-Qian Liu. (2021) Antifungal Activity and Action Mechanism Study of Coumarins from Cnidium monnieri Fruit and Structurally Related Compounds. CHEMISTRY & BIODIVERSITY, 18 (12): (e2100633). [PMID:34643056] [10.1002/cbdv.202100633] |
| 5. Li Huxiao, Xu Jianrong, Li Xiaotian, Hu Yi, Liao Yue, Zhou Wei, Song Zhongchen. (2021) Anti-inflammatory activity of psoralen in human periodontal ligament cells via estrogen receptor signaling pathway. Scientific Reports, 11 (1): (1-12). [PMID:33888745] [10.1038/s41598-021-85145-1] |
| 6. Chen Feng, Bai Min, Cao Xiaowen, Xue Jing, Zhao Yue, Wu Na, Wang Lei, Zhang Dexin, Zhao Yongxi. (2021) Cellular macromolecules-tethered DNA walking indexing to explore nanoenvironments of chromatin modifications. Nature Communications, 12 (1): (1-12). [PMID:33785750] [10.1038/s41467-021-22284-z] |
| 7. Yuling Chen, Rong Wang, Zilin Chen. (2018) Sensitive determination of psoralen and isopsoralen in Fructus Psoraleae by online solid phase microextraction with a porphyrin-based porous organic polymer modified capillary. Analytical Methods, 11 (1): (29-35). [10.1039/C8AY01885E] |
| 8. Li Xiaotian, Yu Chunbo, Hu Yi, Xia Xinyi, Liao Yue, Zhang Jing, Chen Huiwen, Lu Weili, Zhou Wei, Song Zhongchen. (2018) New Application of Psoralen and Angelicin on Periodontitis With Anti-bacterial, Anti-inflammatory, and Osteogenesis Effects. Frontiers in Cellular and Infection Microbiology, 8 [PMID:29922598] [10.3389/fcimb.2018.00178] |
| 9. Sun Yujing, Wang Yihua, Zhang Le, Ye Xingqian, Guo Jingtong. (2024) Furanocoumarin profiles and inhibitory effects on cytochrome P450 activity of whole citrus fruit. Food Quality and Safety, [10.1093/fqsafe/fyae038] |
| 10. Kai Tian, Jiang Zhu, Xinghui Qiu. (2024) Metabolism of Furanocoumarins by Three Recombinant CYP9A Proteins From the Polyphagous Cotton Bollworm Helicoverpa armigera. ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY, 117 (3): (e70004). [PMID:39494619] [10.1002/arch.70004] |
| 11. Zaiwei Fan, Jianyuan Gao, Yikun Chen, Qirui Chen, Qingshan Peng, Jiadi Le, Yiming Li, Chunhui Chen, Haihong Jiang, Jun Tao, Yang Zhou. (2025) Psoralen remodels the articular cartilage microenvironment by pharmacologically regulating the Nrf2 pathway in osteoarthritis treatment. INTERNATIONAL IMMUNOPHARMACOLOGY, 149 (114221). [PMID:39914283] [10.1016/j.intimp.2025.114221] |