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Pembrolizumab (anti-PD-1), 程序性细胞死亡 1 (CD279) 抗体

COA COA
    应用:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • 宿主种属: 人(Human)
  • 种属反应性: 人(Human), 食蟹猴(Cynomolgus monkey)
  • 亚型: Human IgG4SP
  • 偶联: Unconjugated
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货号 (SKU) 包装规格 是否现货 价格 数量
P411997-100μg
 100μg 现货 Stock Image
P411997-1mg
 1mg 现货 Stock Image
P411997-5mg
 5mg 现货 Stock Image
P411997-10mg
 10mg 期货 Stock Image
大包装询价 收藏夹 比较  SDS下载  DATASHEET  质量标准
查看相关系列
点击查看靶蛋白信息: PDCD1
Accession#:Q15116 (39) Gene ID:5133 (39) Immunology/Inflammation (1938) PD-1/PD-L1 (58) PD1 (37) PDCD1 (40) programmed cell death 1 (CD279) Antibody (8)
main product photo

基本信息

产品名称 Pembrolizumab (anti-PD-1), 程序性细胞死亡 1 (CD279) 抗体
别名 帕博利珠单抗(抗 PD-1)
英文别名 1374853-91-4 | 1-butyl-4-propylpiperazine;ethane;1-[hex-5-enyl(2-methyltetradecyl)amino]tetradecan-2-ol;3-[[(8E,10E)-2-methylhexadeca-8,10-dienyl]-[(9E,11E)-2-methylhexadeca-9,11-dienyl]amino]propane-1-thiol
规格或纯度 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属 人(Human)
特异性 PDCD1
应用 ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
种属反应性 人(Human),食蟹猴(Cynomolgus monkey)
偶联 Unconjugated
作用类型 抑制剂
作用机制 程序性细胞死亡 1 (CD279) 抗体

产品属性

抗体类型 Primary antibody
克隆类型 重组抗体
Format Whole IgG
亚型 Human IgG4SP
轻链亚型 kappa
SDS-PAGE 146 kDa
纯化方法 Protein A purified
纯度 >95%
来源 CHO supernatant
物理外观 Liquid
储存缓冲液 Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂 No
浓度 见COA
储存温度 -80℃储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息 1374853-91-4
分子类型 抗体

关联靶点（人）

PDCD1 Tclin 程序性细胞死亡蛋白 1(Programmed cell death protein 1) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
PDCD1 Tclin Programmed cell death protein 1 (14 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

图片

Pembrolizumab (anti-PD-1) (P411997) - Flow Cytometry
Flow Cytometry analysis of PHA-stimulated (3 days) human peripheral blood mononuclear lymphocytes labelling PD-1 (red) with Pembrolizumab (anti-PD-1) (P411997). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Pembrolizumab (anti-PD-1) (P411997) - SEC
The purity of Pembrolizumab (anti-PD-1) (P411997) is more than 95% verified by HPLC.

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到6个结果

批号(Lot Number) 证书类型 货号
ZJ23F0900991 分析证书 P411997
ZJ25F0318908 分析证书 P411997
ZJ25F0318907 分析证书 P411997
ZJ25F0318906 分析证书 P411997
ZJ24F0707872 分析证书 P411997
ZJ23F0900990 分析证书 P411997

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引用文献

1. Janakiram M, Abadi YM, Sparano JA, Zang X.  (2012)  T cell coinhibition and immunotherapy in human breast cancer..  Discov Med,  14  (77): (229-36).  [PMID:23114578]
2. Greaves P, Gribben JG.  (2013)  The role of B7 family molecules in hematologic malignancy..  Blood,  121  (5): (734-44).  [PMID:23223433]
3. Tang PA, Heng DY.  (2013)  Programmed death 1 pathway inhibition in metastatic renal cell cancer and prostate cancer..  Curr Oncol Rep,  15  (2): (98-104).  [PMID:23263823]
4. Hamid O, Robert C, Daud A, Hodi FS, Hwu WJ, Kefford R, Wolchok JD, Hersey P, Joseph RW, Weber JS et al..  (2013)  Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma..  N Engl J Med,  369  (2): (134-44).  [PMID:23724846]
5. Nghiem PT, Bhatia S, Lipson EJ, Kudchadkar RR, Miller NJ, Annamalai L, Berry S, Chartash EK, Daud A, Fling SP et al..  (2016)  PD-1 Blockade with Pembrolizumab in Advanced Merkel-Cell Carcinoma..  N Engl J Med,  374  (26): (2542-52).  [PMID:27093365]
6. Paz-Ares L, Luft A, Vicente D, Tafreshi A, Gümüş M, Mazières J, Hermes B, Çay Şenler F, Csőszi T, Fülöp A et al..  (2018)  Pembrolizumab plus Chemotherapy for Squamous Non-Small-Cell Lung Cancer..  N Engl J Med,  379  (21): (2040-2051).  [PMID:30280635]
7. Rini BI, Plimack ER, Stus V, Gafanov R, Hawkins R, Nosov D, Pouliot F, Alekseev B, Soulières D, Melichar B et al..  (2019)  Pembrolizumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma..  N Engl J Med,  380  (12): (1116-1127).  [PMID:30779529]
8. Saada-Bouzid E, Peyrade F, Guigay J.  (2019)  Immunotherapy in recurrent and or metastatic squamous cell carcinoma of the head and neck..  Curr Opin Oncol,  31  (3): (146-151).  [PMID:30893146]

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