This is a demo store. No orders will be fulfilled.

首页   400-620-6333
  • 登录
  • 注册
  • 英文站
切换导航
我的购物车
搜索
高级搜索
菜单
登录
设置
྾

东莨菪碱

31篇引用文献 COA COA
有货

库存信息

关闭

库存信息

关闭

库存信息

关闭
货号 (SKU) 包装规格 是否现货 价格 数量
P303845-10mg
 10mg 现货 Stock Image
P303845-25mg
 25mg 现货 Stock Image
P303845-100mg
 100mg 现货 Stock Image
大包装询价 收藏夹 比较  SDS下载  DATASHEET  质量标准
查看相关系列
Class A GPCR (8201) Endogenous Metabolite (978) GPCR/G Protein (3179) Metabolic Enzyme/Protease (4889) Natural Products (12) 代谢物 (8911) 分析对照品 (2)
main product photo

基本描述

别名 (-)-东莨菪碱 | 9-甲基-3-氧杂-9-氮杂三环[3.3.1.02,4]壬烷-7-醇 (-)-ALPHA-(羟甲基)苯乙酸酯
英文别名 Hyoscine | Scopine (-)-tropate | Scopine tropate
规格或纯度 分析标准品
英文名称 Scopolamine
储存温度 2-8°C储存,避光,充氩
运输条件 冰袋运输
产品介绍

Scopolamine 是高亲和力的 (nM 级别) 毒蕈碱 (muscarinic) 拮抗剂。Scopolamine 可逆抑制 5-HT3 受体反应，IC50 为 2.09 μM

Product Describtion:

Scopolamine (Skopolamin) is a tropane alkaloid derived from plants of the nightshade family, specifically Hyoscyamus niger and Atropa belladonna, with anticholinergic, antiemetic and antivertigo properties.


Product Application:

Scopolamine is an acetylcholine antagonist. Used in treatment of motion sickness; antiemetic; antispasmodic; mydriatic; preanesthetic medicant.

关联靶点（人）

CHRM3 Tclin 毒蕈碱乙酰胆碱受体 M3(Muscarinic acetylcholine receptor M3) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
CHRM4 Tclin 毒蕈碱乙酰胆碱受体 M4(Muscarinic acetylcholine receptor M4) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
CHRM2 Tclin 毒蕈碱乙酰胆碱受体 M2(Muscarinic acetylcholine receptor M2) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
CHRM1 Tclin 毒蕈碱乙酰胆碱受体 M1(Muscarinic acetylcholine receptor M1) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

名称和识别符

PubChem SID 504762274
分子类型 小分子
IIUPAC Name [(1R,2R,4S,5S)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-yl] (2S)-3-hydroxy-2-phenylpropanoate
INCHI 1S/C17H21NO4/c1-18-13-7-11(8-14(18)16-15(13)22-16)21-17(20)12(9-19)10-5-3-2-4-6-10/h2-6,11-16,19H,7-9H2,1H3/t11?,12-,13-,14+,15-,16+/m1/s1
InChi Key STECJAGHUSJQJN-USLFZFAMSA-N
Smiles CN1C2CC(CC1C3C2O3)OC(=O)C(CO)C4=CC=CC=C4
Isomeric SMILES CN1[C@@H]2CC(C[C@H]1[C@H]3[C@@H]2O3)OC(=O)[C@H](CO)C4=CC=CC=C4
PubChem CID 3000322
分子量 303.35

化学和物理性质

溶解性 Chloroform (Slightly), DMSO (Sparingly), Ethanol (Slightly), Methanol (Slightly)；Soluble in MeCN
敏感性 对光线和湿度敏感
闪点(℃) 232.2ºC
沸点 460.3ºC at 760 mmHg
熔点 59ºC
分子量 303.350 g/mol
XLogP3 0.900
氢键供体数Hydrogen Bond Donor Count 1
氢键受体数Hydrogen Bond Acceptor Count 5
可旋转键计数Rotatable Bond Count 5
精确质量Exact Mass 303.147 Da
单同位素质量Monoisotopic Mass 303.147 Da
拓扑极表面积Topological Polar Surface Area 62.300 Ų
重原子数Heavy Atom Count 22
形式电荷Formal Charge 0
复杂度Complexity 418.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 5
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

象形图 GHS06
信号词 危险
危险声明

H300+H310+H330: 吞咽，皮肤接触或吸入会致命。
预防措施声明

P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。

P262: 不要进入眼睛、皮肤或衣服。

P264: 处理后要彻底洗手。

P270: 使用本产品时，请勿进食、饮水或吸烟。

P271: 仅在室外或通风良好的地方使用。

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P284: 如果通风不良，请佩戴呼吸防护装置。

P320: 迫切需要特殊治疗（请参阅此标签上的...）。

P321: 特殊处理（请参阅此标签上的...）。

P330: 漱口

P302+P352: 如皮肤沾染：用水充分清洗。

P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。

P361+P364: 立即脱掉所有沾染的衣服，清洗后方可重新使用。

P405: 密闭存放

P403+P233: 存放在通风良好的地方。保持容器密闭。

P501: 将内容物/容器处理到。。。

P301+P316: 如果吞咽：立即寻求紧急医疗救助。

P316: 立即寻求紧急医疗救助。

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到33个结果

批号(Lot Number) 证书类型 货号
E2515601 分析证书 P303845
E2515602 分析证书 P303845
E2515603 分析证书 P303845
B2506482 分析证书 P303845
B2506483 分析证书 P303845
B2506484 分析证书 P303845
K2412623 分析证书 P303845
K2412624 分析证书 P303845
K2412649 分析证书 P303845
H2412243 分析证书 P303845
H2412245 分析证书 P303845
F2403186 分析证书 P303845
F2403187 分析证书 P303845
F2403188 分析证书 P303845
B2423234 分析证书 P303845
B24232350 分析证书 P303845
B2423236 分析证书 P303845
K2314545 分析证书 P303845
K2314585 分析证书 P303845
K2314586 分析证书 P303845
B2427584 分析证书 P303845
H2330536 分析证书 P303845
H2330537 分析证书 P303845
I2322138 分析证书 P303845
E2325794 分析证书 P303845
E2325749 分析证书 P303845
E2325760 分析证书 P303845
E2325769 分析证书 P303845
E2325770 分析证书 P303845
E2325798 分析证书 P303845
H2218485 分析证书 P303845
H2218719 分析证书 P303845
H2218720 分析证书 P303845

显示更多⌵

可替换产品

  1. 2,2'-二辛可宁酸二钾盐水合物
    2,2'-二辛可宁酸二钾盐水合物
    • ≥98%

    ¥29.90

  2. 氯丁泼尼
    氯丁泼尼

    ¥1,256.90

  3. 东莨菪碱
    东莨菪碱
    • 10mM in DMSO

    ¥720.90

此产品的引用文献

如何在您的发表作品中引用阿拉丁的产品和网站? 引用文献检索

引用文献

1. Leilei Pan, Shuifeng Xiao, Zichao Xu, Wenping Li, Long Zhao, Ling Zhang, Ruirui Qi, Junqin Wang, Yiling Cai.  (2024)  Orexin-A attenuated motion sickness through modulating neural activity in hypothalamus nuclei.  BRITISH JOURNAL OF PHARMACOLOGY,  [PMID:38129941] [10.1111/bph.16307]
2. Xi Zhu, Yangjing Lv, Miaoliang Fan, Jianan Guo, Yujia Zhang, Bianbian Gao, Changjun Zhang, Yuanyuan Xie.  (2023)  Exploration of the novel phthalimide-hydroxypyridinone derivatives as multifunctional drug candidates against Alzheimer’s disease.  BIOORGANIC CHEMISTRY,  141  (106817).  [PMID:37690318] [10.1016/j.bioorg.2023.106817]
3. Changjun Zhang, Yujia Zhang, Yangjing Lv, Jianan Guo, Bianbian Gao, Yi Lu, Anjie Zang, Xi Zhu, Tao Zhou, Yuanyuan Xie.  (2023)  Chromone-based monoamine oxidase B inhibitor with potential iron-chelating activity for the treatment of Alzheimer’s disease.  JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY,  [PMID:36519319] [10.1080/14756366.2022.2134358]
4. Jingru Zheng, Yuanhong Gao, Jie Ding, Na Sun, Songyi Lin.  (2022)  Antarctic krill peptides improve scopolamine-induced memory impairment in mice.  Food Bioscience,  49  (101987).  [10.1016/j.fbio.2022.101987]
5. Wang Yue, Wu Xinyan, Yang Kailin, Liu Qing, Jiang Baoping, Yang Runmei, Xiao Peigen, He Chunnian.  (2022)  Integrating network pharmacology analysis and pharmacodynamic evaluation for exploring the active components and molecular mechanism of moutan seed coat extract to improve cognitive impairment.  Frontiers in Pharmacology,  13  [PMID:36034803] [10.3389/fphar.2022.952876]
6. Chuansheng Yao, Xiaoying Jiang, Rui Zhao, Zhichao Zhong, Jiamin Ge, Junlong Zhu, Xiang-Yang Ye, Yuanyuan Xie, Zhen Liu, Tian Xie, Renren Bai.  (2022)  HDAC1/MAO-B dual inhibitors against Alzheimer’s disease: Design, synthesis and biological evaluation of N-propargylamine-hydroxamic acid/o-aminobenzamide hybrids.  BIOORGANIC CHEMISTRY,  122  (105724).  [PMID:35305483] [10.1016/j.bioorg.2022.105724]
7. Yue Zhao, Zhiqiang Lu, Xiaomeng Xu, Na Sun, Songyi Lin.  (2022)  Sea Cucumber-Derived Peptide Attenuates Scopolamine-Induced Cognitive Impairment by Preventing Hippocampal Cholinergic Dysfunction and Neuronal Cell Death.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  70  (2): (567–576).  [PMID:34989228] [10.1021/acs.jafc.1c07232]
8. Zhiqiang Lu, Xiaomeng Xu, Dongmei Li, Na Sun, Songyi Lin.  (2021)  Comprehensive Analysis of Mouse Hippocampal Lysine Acetylome Mediated by Sea Cucumber Peptides Preventing Memory Impairment.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  69  (41): (12333–12343).  [PMID:34633809] [10.1021/acs.jafc.1c05155]
9. Min Wang, Longji Fang, Tongtong Liu, Xuejie Chen, Yan Zheng, Yilong Zhang, Shiming Chen, Zeng Li.  (2021)  Discovery of 7-O-1, 2, 3-triazole hesperetin derivatives as multi-target-directed ligands against Alzheimer's disease.  CHEMICO-BIOLOGICAL INTERACTIONS,  342  (109489).  [PMID:33905740] [10.1016/j.cbi.2021.109489]
10. Yilei Song, Xiangyu Wang, Xingrong Wang, Jianze Wang, Qiulian Hao, Jifu Hao, Xueqin Hou.  (2021)  Osthole-Loaded Nanoemulsion Enhances Brain Target in the Treatment of Alzheimer’s Disease via Intranasal Administration.  Oxidative Medicine and Cellular Longevity,  2021  (8844455).  [PMID:33564364] [10.1155/2021/8844455]
11. Jianan Guo, Zhisheng Mi, Xiaoying Jiang, Changjun Zhang, Zili Guo, Linzi Li, Jinping Gu, Tao Zhou, Renren Bai, Yuanyuan Xie.  (2021)  Design, synthesis and biological evaluation of potential anti-AD hybrids with monoamine oxidase B inhibitory and iron-chelating effects.  BIOORGANIC CHEMISTRY,  108  (104564).  [PMID:33353806] [10.1016/j.bioorg.2020.104564]
12. Xu Yi, Zhang Shuai, Sun Qiang, Wang Xu-Qiao, Chai Ya-Ni, Mishra Chandan, Chandra Shah Ram, Ai Jing.  (2020)  Cholinergic Dysfunction Involvement in Chronic Cerebral Hypoperfusion-Induced Impairment of Medial Septum–dCA1 Neurocircuit in Rats.  Frontiers in Cellular Neuroscience,  14  [PMID:33132852] [10.3389/fncel.2020.586591]
13. Shuangshuang Liu, Yue Li, Fan Yi, Qing Liu, Naihong Chen, Xiaoli He, Chunnian He, Peigen Xiao.  (2020)  Resveratrol oligomers from Paeonia suffruticosa protect mice against cognitive dysfunction by regulating cholinergic, antioxidant and anti-inflammatory pathways.  JOURNAL OF ETHNOPHARMACOLOGY,  260  (112983).  [PMID:32442589] [10.1016/j.jep.2020.112983]
14. Huimin Wu, Longfei Lin, Xueying Du, Lingling Zhang, Xingbin Yin, Xiaoxv Dong, Xiaofeng Hao, Like Xie, Changhai Qu, Jian Ni.  (2020)  Study on the potential effective ingredients of Xiaosheng prescription for dry eye disease.  BIOMEDICINE & PHARMACOTHERAPY,  127  (110051).  [PMID:32428832] [10.1016/j.biopha.2020.110051]
15. Zhijie Bao, Penglin Zhang, Jin Chen, Jie Gao, Songyi Lin, Na Sun.  (2020)  Egg yolk phospholipids reverse scopolamine–induced spatial memory deficits in mice by attenuating cholinergic damage.  Journal of Functional Foods,  69  (103948).  [10.1016/j.jff.2020.103948]
16. Xiaomeng Xu, Rong Liang, Dongmei Li, Chengyao Jiang, Songyi Lin.  (2020)  Evaluation of sea cucumber peptides-assisted memory activity and acetylation modification in hippocampus of test mice based on scopolamine-induced experimental animal model of memory disorder.  Journal of Functional Foods,  68  (103909).  [10.1016/j.jff.2020.103909]
17. Huihong Zeng, Huan Li, Mengzhen Yue, Ying Fan, Jiaoqi Cheng, Xincheng Wu, Rui Xu, Wuping Yang, Manjun Li, Jiahui Tang, Hongping Chen, Bohai Kuang, Guangqin Fan, Qingxian Zhu, Lijian Shao.  (2020)  Isoprenaline protects intestinal stem cells from chemotherapy-induced damage.  BRITISH JOURNAL OF PHARMACOLOGY,  177  (3): (687-700).  [PMID:31648381] [10.1111/bph.14883]
18. Yu-Min Xu, Xin-Chen Wang, Ting-Ting Xu, Hong-Ying Li, Shang-Yan Hei, Na-Chuan Luo, Hong Wang, Wei Zhao, Shu-Huan Fang, Yun-Bo Chen, Li Guan, Yong-Qi Fang, Shi-Jie Zhang, Qi Wang, Wei-Xiong Liang.  (2019)  Kai Xin San ameliorates scopolamine-induced cognitive dysfunction.  Neural Regeneration Research,  14  (5): ( 794–804).  [PMID:30688265] [10.4103/1673-5374.249227]
19. Jing Zhang, Jun Wang, Gui-Sheng Zhou, Ya-Jie Tan, Hui-Juan Tao, Jia-Qian Chen, Zong-Jin Pu, Jia-Yan Ma, Wen She, An Kang, Yue Zhu, Pei Liu, Zhen-Hua Zhu, Xu-Qin Shi, Yu-Ping Tang, Jin-Ao Duan.  (2019)  Studies of the Anti-amnesic Effects and Mechanisms of Single and Combined Use of Donepezil and Ginkgo Ketoester Tablet on Scopolamine-Induced Memory Impairment in Mice.  Oxidative Medicine and Cellular Longevity,  2019  (8636835).  [PMID:30911351] [10.1155/2019/8636835]
20. Sun Kaiyue, Bai Yuting, Zhao Rong, Guo Zijiao, Su Xiang, Li Peiqi, Yang Pengyu.  (2019)  Neuroprotective effects of matrine on scopolamine-induced amnesia via inhibition of AChE/BuChE and oxidative stress.  METABOLIC BRAIN DISEASE,  34  (1): (173-181).  [PMID:30406376] [10.1007/s11011-018-0335-y]
21. Yao Chen, Jie Zhu, Jun Mo, Hongyu Yang, Xueyang Jiang, Hongzhi Lin, Kai Gu, Yuqiong Pei, Liang Wu, Renxiang Tan, Jing Hou, Jingyi Chen, Yang Lv, Yaoyao Bian, Haopeng Sun.  (2018)  Synthesis and bioevaluation of new tacrine-cinnamic acid hybrids as cholinesterase inhibitors against Alzheimer’s disease.  JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY,  [PMID:29278947] [10.1080/14756366.2017.1412314]
22. Liang Meng, Pinjia Meng, Bugang Tang, Qingqing Zhang, Yanji Wang.  (2013)  Molecularly imprinted photonic hydrogels for fast screening of atropine in biological samples with high sensitivity.  FORENSIC SCIENCE INTERNATIONAL,  231  (6).  [PMID:23890610] [10.1016/j.forsciint.2013.04.008]
23. Bao-Yuan Hou.  (2012)  Ameliorative Effects of Curculigoside from Curculigo orchioides Gaertn on Learning and Memory in Aged Rats.  MOLECULES,  17  (9): (10108-10118).  [PMID:22922281] [10.3390/molecules170910108]
24. Chen Y, Sun J, Fang L, Liu M, Peng S, Liao H, Lehmann J, Zhang Y..  (2012)  Tacrine-ferulic acid-nitric oxide (NO) donor trihybrids as potent, multifunctional acetyl- and butyrylcholinesterase inhibitors..  J Med Chem,  55  (9): (4309-4321).  [PMID:22512543] [10.1021/jm300106z]
25. Yao H, Uras G, Zhang P, Xu S, Yin Y, Liu J, Qin S, Li X, Allen S, Bai R, Gong Q, Zhang H, Zhu Z, Xu J..  (2021)  Discovery of Novel Tacrine-Pyrimidone Hybrids as Potent Dual AChE/GSK-3 Inhibitors for the Treatment of Alzheimer's Disease..  J Med Chem,  64  (11.0): (7483-7506).  [PMID:34024109] [10.1021/acs.jmedchem.1c00160]
26. Li Q, Chen Y, Xing S, Liao Q, Xiong B, Wang Y, Lu W, He S, Feng F, Liu W, Chen Y, Sun H..  (2021)  Highly Potent and Selective Butyrylcholinesterase Inhibitors for Cognitive Improvement and Neuroprotection..  J Med Chem,  64  (10.0): (6856-6876).  [PMID:33973470] [10.1021/acs.jmedchem.1c00167]
27. Liu D, Zhang H, Wang Y, Liu W, Yin G, Wang D, Li J, Shi T, Wang Z..  (2022)  Design, synthesis, and biological evaluation of carbamate derivatives of N-salicyloyl tryptamine as multifunctional agents for the treatment of Alzheimer's disease..  Eur J Med Chem,  229  (114044-114044).  [PMID:34923430] [10.1016/j.ejmech.2021.114044]
28. Sun X, Wang Y, Lei Z, Yue S, Chen L, Sun J..  (2022)  Development of 5-hydroxyl-1-azabenzanthrone derivatives as dual binding site and selective acetylcholinesterase inhibitors..  Eur J Med Chem,  234  (114210-114210).  [PMID:35303485] [10.1016/j.ejmech.2022.114210]
29. Zhiqiang Lu, Yuan Gao, Zhijie Bao, Songyi Lin.  (2024)  A novel neuroprotective peptide against cognitive disorder in mice by regulating hippocampal oxidative stress and synaptic plasticity.  Food Bioscience,  61  (104575).  [10.1016/j.fbio.2024.104575]
30. Xiaomeng Xu, Jingqi Yang, Zhiqiang Lu, Jie Ding, Songyi Lin.  (2024)  Folic acid ameliorated the scopolamine-induced memory impairment in mice and the neuroprotective mechanisms.  Food Bioscience,  60  (104351).  [10.1016/j.fbio.2024.104351]
31. Xin Li, Kai Zheng, Hao Chen, Wei Li.  (2024)  Ginsenoside Re Regulates Oxidative Stress through the PI3K/Akt/Nrf2 Signaling Pathway in Mice with Scopolamine-Induced Memory Impairments.  CURRENT ISSUES IN MOLECULAR BIOLOGY,  46  (10): (11359-11374).  [PMID:39451557] [10.3390/cimb46100677]

溶液计算器

上海阿拉丁生化科技股份有限公司
© 2016 ALADDIN-E.COM . 版权所有,未经授权禁止拷贝本站资料,如有违反,将追究法律责任

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用。

上海工商 危险品化学品经营许可证（带存储）营业执照(三证合一)