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31篇引用文献 
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东莨菪碱
有货
库存信息
| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| P424411-1ml |
1ml |
现货  |
|
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基本描述
| 英文别名 | scopolamine | Hyoscine | (-)-Hyoscine | 51-34-3 | Scopine (-)-tropate | Scopine tropate | (-)-Scopolamine | 6,7-Epoxytropine tropate | Hyosol | Atrochin | Atroquin | Isopto Hyoscine | Skopolamin | Transderm-Scop | l-Scopolamine | Epoxytropine tropate | Scopolamine hydrobromide | 6-beta,7- |
|---|---|
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | Plexonal |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
Scopolamine 是高亲和力的 (nM 级别) 毒蕈碱 (muscarinic) 拮抗剂。Scopolamine 可逆抑制 5-HT3 受体反应，IC50 为 2.09 μM Product Describtion: Scopolamine (Skopolamin) is a tropane alkaloid derived from plants of the nightshade family, specifically Hyoscyamus niger and Atropa belladonna, with anticholinergic, antiemetic and antivertigo properties. Product Application: Scopolamine is an acetylcholine antagonist. Used in treatment of motion sickness; antiemetic; antispasmodic; mydriatic; preanesthetic medicant. |
关联靶点（人）
CHRM3
Tclin
毒蕈碱乙酰胆碱受体 M3(Muscarinic acetylcholine receptor M3)
(0 活性数据)
CHRM4
Tclin
毒蕈碱乙酰胆碱受体 M4(Muscarinic acetylcholine receptor M4)
(0 活性数据)
CHRM2
Tclin
毒蕈碱乙酰胆碱受体 M2(Muscarinic acetylcholine receptor M2)
(0 活性数据)
CHRM1
Tclin
毒蕈碱乙酰胆碱受体 M1(Muscarinic acetylcholine receptor M1)
(0 活性数据)
名称和识别符
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | [(1R,2R,4S,5S)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-yl] (2S)-3-hydroxy-2-phenylpropanoate |
| INCHI | 1S/C17H21NO4/c1-18-13-7-11(8-14(18)16-15(13)22-16)21-17(20)12(9-19)10-5-3-2-4-6-10/h2-6,11-16,19H,7-9H2,1H3/t11?,12-,13-,14+,15-,16+/m1/s1 |
| InChi Key | STECJAGHUSJQJN-USLFZFAMSA-N |
| Smiles | CN1C2CC(CC1C3C2O3)OC(=O)C(CO)C4=CC=CC=C4 |
| Isomeric SMILES | CN1[C@@H]2CC(C[C@H]1[C@H]3[C@@H]2O3)OC(=O)[C@H](CO)C4=CC=CC=C4 |
| PubChem CID | 3000322 |
| 分子量 | 303.35 |
化学和物理性质
| 闪点(℃) | 232.2ºC |
|---|---|
| 沸点 | 460.3ºC at 760 mmHg |
| 熔点 | 59ºC |
| 分子量 | 303.350 g/mol |
| XLogP3 | 0.900 |
| 氢键供体数Hydrogen Bond Donor Count | 1 |
| 氢键受体数Hydrogen Bond Acceptor Count | 5 |
| 可旋转键计数Rotatable Bond Count | 5 |
| 精确质量Exact Mass | 303.147 Da |
| 单同位素质量Monoisotopic Mass | 303.147 Da |
| 拓扑极表面积Topological Polar Surface Area | 62.300 Ų |
| 重原子数Heavy Atom Count | 22 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 418.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 5 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
安全和危险性（GHS）
| 象形图 | GHS06 |
|---|---|
| 信号词 | 危险 |
| 危险声明 |
H300: 吞咽致命 H310: 与皮肤接触致命 H330: 吸入致命 |
| 预防措施声明 |
P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P262: 不要进入眼睛、皮肤或衣服。 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P271: 仅在室外或通风良好的地方使用。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P284: 如果通风不良，请佩戴呼吸防护装置。 P320: 迫切需要特殊治疗（请参阅此标签上的...）。 P321: 特殊处理（请参阅此标签上的...）。 P330: 漱口 P302+P352: 如皮肤沾染：用水充分清洗。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P361+P364: 立即脱掉所有沾染的衣服，清洗后方可重新使用。 P405: 密闭存放 P403+P233: 存放在通风良好的地方。保持容器密闭。 P501: 将内容物/容器处理到。。。 P301+P316: 如果吞咽：立即寻求紧急医疗救助。 P316: 立即寻求紧急医疗救助。 |
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
此产品的引用文献
引用文献
| 1. Leilei Pan, Shuifeng Xiao, Zichao Xu, Wenping Li, Long Zhao, Ling Zhang, Ruirui Qi, Junqin Wang, Yiling Cai. (2024) Orexin-A attenuated motion sickness through modulating neural activity in hypothalamus nuclei. BRITISH JOURNAL OF PHARMACOLOGY, [PMID:38129941] [10.1111/bph.16307] |
| 2. Xi Zhu, Yangjing Lv, Miaoliang Fan, Jianan Guo, Yujia Zhang, Bianbian Gao, Changjun Zhang, Yuanyuan Xie. (2023) Exploration of the novel phthalimide-hydroxypyridinone derivatives as multifunctional drug candidates against Alzheimer’s disease. BIOORGANIC CHEMISTRY, 141 (106817). [PMID:37690318] [10.1016/j.bioorg.2023.106817] |
| 3. Changjun Zhang, Yujia Zhang, Yangjing Lv, Jianan Guo, Bianbian Gao, Yi Lu, Anjie Zang, Xi Zhu, Tao Zhou, Yuanyuan Xie. (2023) Chromone-based monoamine oxidase B inhibitor with potential iron-chelating activity for the treatment of Alzheimer’s disease. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, [PMID:36519319] [10.1080/14756366.2022.2134358] |
| 4. Jingru Zheng, Yuanhong Gao, Jie Ding, Na Sun, Songyi Lin. (2022) Antarctic krill peptides improve scopolamine-induced memory impairment in mice. Food Bioscience, 49 (101987). [10.1016/j.fbio.2022.101987] |
| 5. Wang Yue, Wu Xinyan, Yang Kailin, Liu Qing, Jiang Baoping, Yang Runmei, Xiao Peigen, He Chunnian. (2022) Integrating network pharmacology analysis and pharmacodynamic evaluation for exploring the active components and molecular mechanism of moutan seed coat extract to improve cognitive impairment. Frontiers in Pharmacology, 13 [PMID:36034803] [10.3389/fphar.2022.952876] |
| 6. Chuansheng Yao, Xiaoying Jiang, Rui Zhao, Zhichao Zhong, Jiamin Ge, Junlong Zhu, Xiang-Yang Ye, Yuanyuan Xie, Zhen Liu, Tian Xie, Renren Bai. (2022) HDAC1/MAO-B dual inhibitors against Alzheimer’s disease: Design, synthesis and biological evaluation of N-propargylamine-hydroxamic acid/o-aminobenzamide hybrids. BIOORGANIC CHEMISTRY, 122 (105724). [PMID:35305483] [10.1016/j.bioorg.2022.105724] |
| 7. Yue Zhao, Zhiqiang Lu, Xiaomeng Xu, Na Sun, Songyi Lin. (2022) Sea Cucumber-Derived Peptide Attenuates Scopolamine-Induced Cognitive Impairment by Preventing Hippocampal Cholinergic Dysfunction and Neuronal Cell Death. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 70 (2): (567–576). [PMID:34989228] [10.1021/acs.jafc.1c07232] |
| 8. Zhiqiang Lu, Xiaomeng Xu, Dongmei Li, Na Sun, Songyi Lin. (2021) Comprehensive Analysis of Mouse Hippocampal Lysine Acetylome Mediated by Sea Cucumber Peptides Preventing Memory Impairment. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 69 (41): (12333–12343). [PMID:34633809] [10.1021/acs.jafc.1c05155] |
| 9. Min Wang, Longji Fang, Tongtong Liu, Xuejie Chen, Yan Zheng, Yilong Zhang, Shiming Chen, Zeng Li. (2021) Discovery of 7-O-1, 2, 3-triazole hesperetin derivatives as multi-target-directed ligands against Alzheimer's disease. CHEMICO-BIOLOGICAL INTERACTIONS, 342 (109489). [PMID:33905740] [10.1016/j.cbi.2021.109489] |
| 10. Yilei Song, Xiangyu Wang, Xingrong Wang, Jianze Wang, Qiulian Hao, Jifu Hao, Xueqin Hou. (2021) Osthole-Loaded Nanoemulsion Enhances Brain Target in the Treatment of Alzheimer’s Disease via Intranasal Administration. Oxidative Medicine and Cellular Longevity, 2021 (8844455). [PMID:33564364] [10.1155/2021/8844455] |
| 11. Jianan Guo, Zhisheng Mi, Xiaoying Jiang, Changjun Zhang, Zili Guo, Linzi Li, Jinping Gu, Tao Zhou, Renren Bai, Yuanyuan Xie. (2021) Design, synthesis and biological evaluation of potential anti-AD hybrids with monoamine oxidase B inhibitory and iron-chelating effects. BIOORGANIC CHEMISTRY, 108 (104564). [PMID:33353806] [10.1016/j.bioorg.2020.104564] |
| 12. Xu Yi, Zhang Shuai, Sun Qiang, Wang Xu-Qiao, Chai Ya-Ni, Mishra Chandan, Chandra Shah Ram, Ai Jing. (2020) Cholinergic Dysfunction Involvement in Chronic Cerebral Hypoperfusion-Induced Impairment of Medial Septum–dCA1 Neurocircuit in Rats. Frontiers in Cellular Neuroscience, 14 [PMID:33132852] [10.3389/fncel.2020.586591] |
| 13. Shuangshuang Liu, Yue Li, Fan Yi, Qing Liu, Naihong Chen, Xiaoli He, Chunnian He, Peigen Xiao. (2020) Resveratrol oligomers from Paeonia suffruticosa protect mice against cognitive dysfunction by regulating cholinergic, antioxidant and anti-inflammatory pathways. JOURNAL OF ETHNOPHARMACOLOGY, 260 (112983). [PMID:32442589] [10.1016/j.jep.2020.112983] |
| 14. Huimin Wu, Longfei Lin, Xueying Du, Lingling Zhang, Xingbin Yin, Xiaoxv Dong, Xiaofeng Hao, Like Xie, Changhai Qu, Jian Ni. (2020) Study on the potential effective ingredients of Xiaosheng prescription for dry eye disease. BIOMEDICINE & PHARMACOTHERAPY, 127 (110051). [PMID:32428832] [10.1016/j.biopha.2020.110051] |
| 15. Zhijie Bao, Penglin Zhang, Jin Chen, Jie Gao, Songyi Lin, Na Sun. (2020) Egg yolk phospholipids reverse scopolamine–induced spatial memory deficits in mice by attenuating cholinergic damage. Journal of Functional Foods, 69 (103948). [10.1016/j.jff.2020.103948] |
| 16. Xiaomeng Xu, Rong Liang, Dongmei Li, Chengyao Jiang, Songyi Lin. (2020) Evaluation of sea cucumber peptides-assisted memory activity and acetylation modification in hippocampus of test mice based on scopolamine-induced experimental animal model of memory disorder. Journal of Functional Foods, 68 (103909). [10.1016/j.jff.2020.103909] |
| 17. Huihong Zeng, Huan Li, Mengzhen Yue, Ying Fan, Jiaoqi Cheng, Xincheng Wu, Rui Xu, Wuping Yang, Manjun Li, Jiahui Tang, Hongping Chen, Bohai Kuang, Guangqin Fan, Qingxian Zhu, Lijian Shao. (2020) Isoprenaline protects intestinal stem cells from chemotherapy-induced damage. BRITISH JOURNAL OF PHARMACOLOGY, 177 (3): (687-700). [PMID:31648381] [10.1111/bph.14883] |
| 18. Yu-Min Xu, Xin-Chen Wang, Ting-Ting Xu, Hong-Ying Li, Shang-Yan Hei, Na-Chuan Luo, Hong Wang, Wei Zhao, Shu-Huan Fang, Yun-Bo Chen, Li Guan, Yong-Qi Fang, Shi-Jie Zhang, Qi Wang, Wei-Xiong Liang. (2019) Kai Xin San ameliorates scopolamine-induced cognitive dysfunction. Neural Regeneration Research, 14 (5): ( 794–804). [PMID:30688265] [10.4103/1673-5374.249227] |
| 19. Jing Zhang, Jun Wang, Gui-Sheng Zhou, Ya-Jie Tan, Hui-Juan Tao, Jia-Qian Chen, Zong-Jin Pu, Jia-Yan Ma, Wen She, An Kang, Yue Zhu, Pei Liu, Zhen-Hua Zhu, Xu-Qin Shi, Yu-Ping Tang, Jin-Ao Duan. (2019) Studies of the Anti-amnesic Effects and Mechanisms of Single and Combined Use of Donepezil and Ginkgo Ketoester Tablet on Scopolamine-Induced Memory Impairment in Mice. Oxidative Medicine and Cellular Longevity, 2019 (8636835). [PMID:30911351] [10.1155/2019/8636835] |
| 20. Sun Kaiyue, Bai Yuting, Zhao Rong, Guo Zijiao, Su Xiang, Li Peiqi, Yang Pengyu. (2019) Neuroprotective effects of matrine on scopolamine-induced amnesia via inhibition of AChE/BuChE and oxidative stress. METABOLIC BRAIN DISEASE, 34 (1): (173-181). [PMID:30406376] [10.1007/s11011-018-0335-y] |
| 21. Yao Chen, Jie Zhu, Jun Mo, Hongyu Yang, Xueyang Jiang, Hongzhi Lin, Kai Gu, Yuqiong Pei, Liang Wu, Renxiang Tan, Jing Hou, Jingyi Chen, Yang Lv, Yaoyao Bian, Haopeng Sun. (2018) Synthesis and bioevaluation of new tacrine-cinnamic acid hybrids as cholinesterase inhibitors against Alzheimer’s disease. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, [PMID:29278947] [10.1080/14756366.2017.1412314] |
| 22. Liang Meng, Pinjia Meng, Bugang Tang, Qingqing Zhang, Yanji Wang. (2013) Molecularly imprinted photonic hydrogels for fast screening of atropine in biological samples with high sensitivity. FORENSIC SCIENCE INTERNATIONAL, 231 (6). [PMID:23890610] [10.1016/j.forsciint.2013.04.008] |
| 23. Bao-Yuan Hou. (2012) Ameliorative Effects of Curculigoside from Curculigo orchioides Gaertn on Learning and Memory in Aged Rats. MOLECULES, 17 (9): (10108-10118). [PMID:22922281] [10.3390/molecules170910108] |
| 24. Chen Y, Sun J, Fang L, Liu M, Peng S, Liao H, Lehmann J, Zhang Y.. (2012) Tacrine-ferulic acid-nitric oxide (NO) donor trihybrids as potent, multifunctional acetyl- and butyrylcholinesterase inhibitors.. J Med Chem, 55 (9): (4309-4321). [PMID:22512543] [10.1021/jm300106z] |
| 25. Yao H, Uras G, Zhang P, Xu S, Yin Y, Liu J, Qin S, Li X, Allen S, Bai R, Gong Q, Zhang H, Zhu Z, Xu J.. (2021) Discovery of Novel Tacrine-Pyrimidone Hybrids as Potent Dual AChE/GSK-3 Inhibitors for the Treatment of Alzheimer's Disease.. J Med Chem, 64 (11.0): (7483-7506). [PMID:34024109] [10.1021/acs.jmedchem.1c00160] |
| 26. Li Q, Chen Y, Xing S, Liao Q, Xiong B, Wang Y, Lu W, He S, Feng F, Liu W, Chen Y, Sun H.. (2021) Highly Potent and Selective Butyrylcholinesterase Inhibitors for Cognitive Improvement and Neuroprotection.. J Med Chem, 64 (10.0): (6856-6876). [PMID:33973470] [10.1021/acs.jmedchem.1c00167] |
| 27. Liu D, Zhang H, Wang Y, Liu W, Yin G, Wang D, Li J, Shi T, Wang Z.. (2022) Design, synthesis, and biological evaluation of carbamate derivatives of N-salicyloyl tryptamine as multifunctional agents for the treatment of Alzheimer's disease.. Eur J Med Chem, 229 (114044-114044). [PMID:34923430] [10.1016/j.ejmech.2021.114044] |
| 28. Sun X, Wang Y, Lei Z, Yue S, Chen L, Sun J.. (2022) Development of 5-hydroxyl-1-azabenzanthrone derivatives as dual binding site and selective acetylcholinesterase inhibitors.. Eur J Med Chem, 234 (114210-114210). [PMID:35303485] [10.1016/j.ejmech.2022.114210] |
| 29. Zhiqiang Lu, Yuan Gao, Zhijie Bao, Songyi Lin. (2024) A novel neuroprotective peptide against cognitive disorder in mice by regulating hippocampal oxidative stress and synaptic plasticity. Food Bioscience, 61 (104575). [10.1016/j.fbio.2024.104575] |
| 30. Xiaomeng Xu, Jingqi Yang, Zhiqiang Lu, Jie Ding, Songyi Lin. (2024) Folic acid ameliorated the scopolamine-induced memory impairment in mice and the neuroprotective mechanisms. Food Bioscience, 60 (104351). [10.1016/j.fbio.2024.104351] |
| 31. Xin Li, Kai Zheng, Hao Chen, Wei Li. (2024) Ginsenoside Re Regulates Oxidative Stress through the PI3K/Akt/Nrf2 Signaling Pathway in Mice with Scopolamine-Induced Memory Impairments. CURRENT ISSUES IN MOLECULAR BIOLOGY, 46 (10): (11359-11374). [PMID:39451557] [10.3390/cimb46100677] |