This is a demo store. No orders will be fulfilled.

首页   400-620-6333
  • 登录
  • 注册
  • 英文站
切换导航
我的购物车
搜索
高级搜索
菜单
登录
设置
྾

普卡酶素

DNA和RNA聚合酶抑制剂。DNA结合转录抑制剂。
2篇引用文献 COA COA
有货

库存信息

关闭

库存信息

关闭

库存信息

关闭
货号 (SKU) 包装规格 是否现货 价格 数量
P113149-1mg
 1mg 现货 Stock Image
P113149-5mg
 5mg 现货 Stock Image
P113149-25mg
 25mg 现货 Stock Image
大包装询价 收藏夹 比较  SDS下载  DATASHEET  质量标准
查看相关系列
Amino Acid/Protein Metabolism (4559) Antibiotic (2632) Bacterial (5911) Cell Cycle (7376) Cell Cycle/DNA Damage (2603) DNA/RNA Synthesis (362)
main product photo

基本描述

别名 光辉酶素,金霉酸 | 普卡霉素 | 光辉霉素
英文别名 Mithramycin A | Aurlelic acid | DB06810 | PA-144 | MITHRAMYCINA | MITHRAMYCIN | BDBM50547623 | Plicamycin [USAN:USP:INN:BAN] | PLICAMYCIN [USAN] | D00468 | Antibiotic LA 7017 | Mithramycinum | Mitramycine | plicamycin | Aureolic acid | CCRIS 5629 | NJWSNN
规格或纯度 Moligand™, ≥95%
英文名称 Plicamycin
生化机理 抗癌抗生素。抑制转录和蛋白质合成。与原生染色质中的 DNA 结合。DNA 和 RNA 聚合酶抑制剂，DNA 结合转录抑制剂（Sp1 和 Sp3）。具有抗肿瘤活性。
储存温度 -20°C储存,充氩
运输条件 超低温冰袋运输
备注 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍

Mithramycin A is an antibiotic DNA/RNA polymerase and DNA binding transcriptional inhibitor observed to facilitate TNF-α and Fas-ligand induced apoptosis. As a DNA binding transcriptional inhibitor, mithramycin A binds to GC rich sequences located in the minor groove of DNA and is noted to be reversible and Mg2+ dependent. Additionally reported to a block transcriptional activation of the SV40 promoter via competitive binding against Sp1 transcription factor to GC rich areas in the early promoter. Mithramycin A is noted to supress TNF-α induced expression of fractalkine (CX3CL1) mRNA in a dose-dependent manner and to act as an effective differentiation agent of HL60 promyelocytic leukemia cellsA polymerase inhibitor that binds to GC rich sequences located in the minor groove of DNA;DNA binding fluorescent dye. Until 2000 it was used to reduce high levels of plasma calcium; Used as an antineoplastic agent

Mithramycin A is an antibiotic DNA/RNA polymerase and DNA binding transcriptional inhibitor observed to facilitate TNF-α and Fas-ligand induced apoptosis. As a DNA binding transcriptional inhibitor, mithramycin A binds to GC rich sequences located in the minor groove of DNA and is noted to be reversible and Mg2+ dependent. Additionally reported to a block transcriptional activation of the SV40 promoter via competitive binding against Sp1 transcription factor to GC rich areas in the early promoter. Mithramycin A is noted to supress TNF-α induced expression of fractalkine (CX3CL1) mRNA in a dose-dependent manner and to act as an effective differentiation agent of HL60 promyelocytic leukemia cells
A polymerase inhibitor that binds to GC rich sequences located in the minor groove of DNA;DNA binding fluorescent dye. Until 2000 it was used to reduce high levels of plasma calcium; Used as an antineoplastic agent
纯度 ≥95%

关联靶点（人）

A673 (619 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DU-145 (51482 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PANC-1 (6144 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PC-3 (62116 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
A549 (127892 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HCT-116 (91556 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Prostatic carcinoma cell (85 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
LNCaP (8286 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HeLa (62764 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DMS-114 (15429 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
U-118-MG (352 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ES8 (149 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ES7 (149 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
EWSR1 Tbio Friend leukemia integration 1 transcription factor (Proto-oncogene Fli-1)/RNA-binding protein EWS (19 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TC-32 (111 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
VCaP (1078 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

PubChem SID 504757537
分子类型 小分子
IIUPAC Name (2S,3S)-2-[(2S,4R,5R,6R)-4-[(2S,4R,5S,6R)-4-[(2S,4S,5R,6R)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-5-hydroxy-6-methyloxan-2-yl]oxy-5-hydroxy-6-methyloxan-2-yl]oxy-3-[(1S,3S,4R)-3,4-dihydroxy-1-methoxy-2-oxopentyl]-6-[(2S,4R,5R,6R)-4-[(2S,4R,5S,6R)-4,5-dihydroxy-6-methyloxan-2-yl]oxy-5-hydroxy-6-methyloxan-2-yl]oxy-8,9-dihydroxy-7-methyl-3,4-dihydro-2H-anthracen-1-one
INCHI 1S/C52H76O24/c1-18-29(72-34-14-30(43(58)21(4)68-34)73-33-13-28(54)42(57)20(3)67-33)12-26-10-25-11-27(49(66-9)48(63)41(56)19(2)53)50(47(62)39(25)46(61)38(26)40(18)55)76-36-16-31(44(59)23(6)70-36)74-35-15-32(45(60)22(5)69-35)75-37-17-52(8,65)51(64)24(7)71-37/h10,12,19-24,27-28,30-37,41-45,49-51,53-61,64-65H,11,13-17H2,1-9H3/t19-,20-,21-,22-,23-,24-,27+,28-,30-,31-,32-,33+,34+,35+,36+,37+,41+,42-,43-,44-,45+,49+,50+,51-,52+/m1/s1
InChi Key CFCUWKMKBJTWLW-BKHRDMLASA-N
Smiles CC1C(C(CC(O1)OC2CC(OC(C2O)C)OC3=CC4=CC5=C(C(=O)C(C(C5)C(C(=O)C(C(C)O)O)OC)OC6CC(C(C(O6)C)O)OC7CC(C(C(O7)C)O)OC8CC(C(C(O8)C)O)(C)O)C(=C4C(=C3C)O)O)O)O
Isomeric SMILES C[C@@H]1[C@H]([C@@H](C[C@@H](O1)O[C@@H]2C[C@@H](O[C@@H]([C@H]2O)C)OC3=CC4=CC5=C(C(=O)[C@H]([C@@H](C5)[C@@H](C(=O)[C@H]([C@@H](C)O)O)OC)O[C@H]6C[C@H]([C@@H]([C@H](O6)C)O)O[C@H]7C[C@H]([C@H]([C@H](O7)C)O)O[C@H]8C[C@]([C@@H]([C@H](O8)C)O)(C)O)C(=C4C(=C3C)O)O)O)O
UN Number 2811
分子量 1085.15
Beilstein号 5236667
Reaxy-Rn 24710368
Reaxys-RN link address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24710368&ln=

化学和物理性质

溶解性 Soluble in phosphate buffered saline (1 mg/ml), ethanol, ethyl acetate, lower alcohols, and acetone. Insoluble in water.
密度 1.48
敏感性 对光线和湿度敏感
熔点 170-175°C
分子量 1085.100 g/mol
XLogP3 0.600
氢键供体数Hydrogen Bond Donor Count 11
氢键受体数Hydrogen Bond Acceptor Count 24
可旋转键计数Rotatable Bond Count 15
精确质量Exact Mass 1084.47 Da
单同位素质量Monoisotopic Mass 1084.47 Da
拓扑极表面积Topological Polar Surface Area 358.000 Ų
重原子数Heavy Atom Count 76
形式电荷Formal Charge 0
复杂度Complexity 1940.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 25
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

象形图 GHS07
信号词 警告
危险声明

H302: 吞食有害

H361: 怀疑破坏生育力或未出生的孩子
预防措施声明

P264: 处理后要彻底洗手。

P270: 使用本产品时，请勿进食、饮水或吸烟。

P330: 漱口

P301+P312: 如误吞咽：如感觉不适，呼叫急救中心/医生。

P308+P313: 如接触到或有疑虑：求医/就诊。

P501: 将内容物/容器处理到。。。
WGK Germany 3
RTECS PZ2800000
个人防护装备 dust mask type N95 (US),Eyeshields,Faceshields,Gloves

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到8个结果

批号(Lot Number) 证书类型 货号
J2523005 分析证书 P113149
J2510048 分析证书 P113149
I2419126 分析证书 P113149
E2225243 分析证书 P113149
E2225244 分析证书 P113149
E2225253 分析证书 P113149
L2109072 分析证书 P113149
L2109073 分析证书 P113149

此产品的引用文献

如何在您的发表作品中引用阿拉丁的产品和网站? 引用文献检索

引用文献

1. Lin RK, Hsu CH, Wang YC.  (2007)  Mithramycin A inhibits DNA methyltransferase and metastasis potential of lung cancer cells..  Anticancer Drugs,  18  (10): (1157-64).  [PMID:17893516]
2. BROWN JH, KENNEDY BJ.  (1965)  MITHRAMYCIN IN THE TREATMENT OF DISSEMINATED TESTICULAR NEOPLASMS..  N Engl J Med,  272  (111-8).  [PMID:14224214]
3. Ryu H, Lee J, Hagerty SW, Soh BY, McAlpin SE, Cormier KA, Smith KM, Ferrante RJ.  (2006)  ESET/SETDB1 gene expression and histone H3 (K9) trimethylation in Huntington's disease..  Proc Natl Acad Sci USA,  103  (50): (19176-81).  [PMID:17142323]
4. Rodriguez-Paredes M, Martinez de Paz A, Simó-Riudalbas L, Sayols S, Moutinho C, Moran S, Villanueva A, Vázquez-Cedeira M, Lazo PA, Carneiro F et al..  (2014)  Gene amplification of the histone methyltransferase SETDB1 contributes to human lung tumorigenesis..  Oncogene,  33  (21): (2807-13).  [PMID:23770855]
5. Jones Jr DE, Cui DM, Miller DM.  (1995)  Expression of beta-galactosidase under the control of the human c-myc promoter in transgenic mice is inhibited by mithramycin..  Oncogene,  10  (12): (2323-30).  [PMID:7784080]
6. Yan X et al..  (2020)  VIP Induces Changes in the F-/G-Actin Ratio of Schlemm's Canal Endothelium via LRRK2 Transcriptional Regulation..  Invest Ophthalmol Vis Sci,  61  (6): (45).  [PMID:32572455]
7. Huang C et al..  (2020)  Drug-Eluting Stent Targeting Sp-1-Attenuated Restenosis by Engaging YAP-Mediated Vascular Smooth Muscle Cell Phenotypic Modulation..  J Am Heart Assoc,  9  (e014103).  [PMID:31880978]
8. Zhang H et al..  (2020)  Sp4 controls constitutive expression of neuronal serine racemase and NF-E2-related factor-2 mediates its induction by valproic acid..  Biochim Biophys Acta Gene Regul Mech,  1863  (9): (194597).  [PMID:32603878]
9. Zhou Q et al..  (2020)  The reciprocal interaction between tumor cells and activated fibroblasts mediated by TNF-a/IL-33/ST2L signaling promotes gastric cancer metastasis..  Oncogene,  39  (7): (1414-1428).  [PMID:31659258]
10. Yamaguchi R et al..  (2018)  Transcription factor specificity protein 1 modulates TGFß1/Smad signaling to negatively regulate SIGIRR expression by human M1 macrophages stimulated with substance P..  Cytokine,  108  (24-36).  [PMID:29558695]
11. Guo J et al..  (2019)  AKT methylation by SETDB1 promotes AKT kinase activity and oncogenic functions..  Nat Cell Biol,  21  (2): (226-237).  [PMID:30692625]
12. J Xu,W F Ding,K K Shao,X D Wang,G H Wang,H Q Li,H M Wang.  (2012-02-03)  Transcription of promoter from the human APRIL gene regulated by Sp1 and NF-kB..  Neoplasma,  59  ((3)): (341-347).  [PMID:22296504]
13. Pei-Ming Yang,Pei-Jie Lin,Ching-Chow Chen.  (2012-03-16)  CD1d induction in solid tumor cells by histone deacetylase inhibitors through inhibition of HDAC1/2 and activation of Sp1..  Epigenetics,  7  ((4)): (390-399).  [PMID:22419072]
14. Cristina Zuccato,Laura Breda,Francesca Salvatori,Giulia Breveglieri,Sara Gardenghi,Nicoletta Bianchi,Eleonora Brognara,Ilaria Lampronti,Monica Borgatti,Stefano Rivella,Roberto Gambari.  (2012-03-31)  A combined approach for β-thalassemia based on gene therapy-mediated adult hemoglobin (HbA) production and fetal hemoglobin (HbF) induction..  Annals of hematology,  91  ((8)): (1201-1213).  [PMID:22460946]
15. Yasuhito Ohsaka,Hoyoku Nishino.  (2012-04-03)  Cooling-increased phospho-β-arrestin-1 and β-arrestin-1 expression levels in 3T3-L1 adipocytes..  Cryobiology,  65  ((1)): (12-20).  [PMID:22465333]
16. Luz E Núñez,Stephen E Nybo,Javier González-Sabín,María Pérez,Nuria Menéndez,Alfredo F Braña,Khaled A Shaaban,Min He,Francisco Morís,José A Salas,Jürgen Rohr,Carmen Méndez.  (2012-05-15)  A novel mithramycin analogue with high antitumor activity and less toxicity generated by combinatorial biosynthesis..  Journal of medicinal chemistry,  55  ((12)): (5813-5825).  [PMID:22578073]
17. Wei-feng Zhao,Hong-bo Wang,Bo Xie,Li-juan Hu,Li-hua Xu,Bo-hua Kuang,Man-zhi Li,Xing Zhang.  (2012-06-12)  Sp1 and Sp3 are involved in the full transcriptional activity of centromere protein H in human nasopharyngeal carcinoma cells..  The FEBS journal,  279  ((15)): (2714-2726).  [PMID:22682030]
18. Mary Zhang,Aarti Mathur,Yuwei Zhang,Sichuan Xi,Scott Atay,Julie A Hong,Nicole Datrice,Trevor Upham,Clinton D Kemp,R Taylor Ripley,Gordon Wiegand,Itzak Avital,Patricia Fetsch,Haresh Mani,Daniel Zlott,Robert Robey,Susan E Bates,Xinmin Li,Mahadev Rao,David S Schrump.  (2012-07-04)  Mithramycin represses basal and cigarette smoke-induced expression of ABCG2 and inhibits stem cell signaling in lung and esophageal cancer cells..  Cancer research,  72  ((16)): (4178-4192).  [PMID:22751465]
19. Jiansheng Lu,Yihua Ma,Jianjia Liang,Yingying Xing,Tao Xi,Yuanyuan Lu.  (2012-07-14)  Aureolic acids from a marine-derived Streptomyces sp. WBF16..  Microbiological research,  167  ((10)): (590-595).  [PMID:22789867]
20. G Gopisetty,J Xu,D Sampath,H Colman,V K Puduvalli.  (2012-09-05)  Epigenetic regulation of CD133/PROM1 expression in glioma stem cells by Sp1/myc and promoter methylation..  Oncogene,  32  ((26)): (3119-3129).  [PMID:22945648]
21. Tsung-I Hsu,Mei-Chun Wang,Szu-Yu Chen,Shih-Ting Huang,Yu-Min Yeh,Wu-Chou Su,Wen-Chang Chang,Jan-Jong Hung.  (2012-09-08)  Betulinic acid decreases specificity protein 1 (Sp1) level via increasing the sumoylation of sp1 to inhibit lung cancer growth..  Molecular pharmacology,  82  ((6)): (1115-1128).  [PMID:22956772]
22. Carolina Vizcaíno,Sylvia Mansilla,Luz-Elena Núñez,Carmen Méndez,José A Salas,Francisco Morís,José Portugal.  (2012-09-18)  Novel mithramycins abrogate the involvement of protein factors in the transcription of cell cycle control genes..  Biochemical pharmacology,  84  ((9)): (1133-1142).  [PMID:22981341]
23. Guojun Wang,Pallab Pahari,Madan K Kharel,Jing Chen,Haining Zhu,Steven G Van Lanen,Jürgen Rohr.  (2012-09-22)  Cooperation of two bifunctional enzymes in the biosynthesis and attachment of deoxysugars of the antitumor antibiotic mithramycin..  Angewandte Chemie (International ed. in English),  51  ((42)): (10638-10642).  [PMID:22997042]
24. S Min,L Li,M Zhang,Y Zhang,X Liang,Y Xie,Q He,Y Li,J Sun,Q Liu,X Jiang,Y Zhang,Y Che,R Yang.  (2012-10-05)  TGF-β-associated miR-27a inhibits dendritic cell-mediated differentiation of Th1 and Th17 cells by TAB3, p38 MAPK, MAP2K4 and MAP2K7..  Genes and immunity,  13  ((8)): (621-631).  [PMID:23034448]
25. Chun-Wei Hsu,Chia-Feng Kuo,Show-Mei Chuang,Ming-Hon Hou.  (2012-10-26)  Elucidation of the DNA-interacting properties and anticancer activity of a Ni(II)-coordinated mithramycin dimer complex..  Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine,  26  ((1)): (1-12).  [PMID:23097078]
26. Marina Isshiki,Haruka Ohta,Hiroomi Tamura.  (2013-02-02)  Coffee reduces SULT1E1 expression in human colon carcinoma Caco-2 cells..  Biological & pharmaceutical bulletin,  36  ((2)): (299-304).  [PMID:23370358]
27. M Jin,A Ande,A Kumar,S Kumar.  (2013-03-23)  Regulation of cytochrome P450 2e1 expression by ethanol: role of oxidative stress-mediated pkc/jnk/sp1 pathway..  Cell death & disease,  4  (e554-e554).  [PMID:23519123]
28. Bhavana Chhunchha,Eri Kubo,Prerna Singh,Dhirendra P Singh.  (2018-09-15)  Sumoylation-deficient Prdx6 repairs aberrant Sumoylation-mediated Sp1 dysregulation-dependent Prdx6 repression and cell injury in aging and oxidative stress..  Aging,  10  ((9)): (2284-2315).  [PMID:30215601]
29. Valentina Sica,Jose Manuel Bravo-San Pedro,Valentina Izzo,Jonathan Pol,Sandra Pierredon,David Enot,Sylvère Durand,Noélie Bossut,Alexis Chery,Sylvie Souquere,Gerard Pierron,Evangelia Vartholomaiou,Naoufal Zamzami,Thierry Soussi,Allan Sauvat,Laura Mondragón,Oliver Kepp,Lorenzo Galluzzi,Jean-Claude Martinou,Holger Hess-Stumpp,Karl Ziegelbauer,Guido Kroemer,Maria Chiara Maiuri.  (2019-04-18)  Lethal Poisoning of Cancer Cells by Respiratory Chain Inhibition plus Dimethyl α-Ketoglutarate..  Cell reports,  27  ((3)): (820-834).  [PMID:30995479]
30. Han Cai,Bingying Liu,Huarong Wang,Guanghong Sun,Lizhao Feng,Ziqi Chen,Jiaqi Zhou,Jiawei Zhang,Tuo Zhang,Meina He,Tingting Yang,Qirui Guo,Zhen Teng,Qiliang Xin,Bo Zhou,Hua Zhang,Guoliang Xia,Chao Wang.  (2019-07-10)  SP1 governs primordial folliculogenesis by regulating pregranulosa cell development in mice..  Journal of molecular cell biology,  12  ((3)): (230-244).  [PMID:31282930]
31. Waise Quarni,Rinku Dutta,Ryan Green,Sandhyabanu Katiri,Bhaumik Patel,Shyam S Mohapatra,Subhra Mohapatra.  (2019-10-28)  Mithramycin A Inhibits Colorectal Cancer Growth by Targeting Cancer Stem Cells..  Scientific reports,  9  ((1)): (15202-15202).  [PMID:31645574]
32. Yang Zhou,Yunjiang Zhou,Keke Wang,Tao Li,Minda Zhang,Yunjia Yang,Rui Wang,Rong Hu.  (2019-12-01)  ROCK2 Confers Acquired Gemcitabine Resistance in Pancreatic Cancer Cells by Upregulating Transcription Factor ZEB1..  Cancers,  11  ((12)): [PMID:31783584]
33. Ushasree Mrudulakumari Vasudevan,Eun Yeol Lee.  (2020-05-04)  Flavonoids, terpenoids, and polyketide antibiotics: Role of glycosylation and biocatalytic tactics in engineering glycosylation..  Biotechnology advances,  41  (107550-107550).  [PMID:32360984]
34. Takashi Furuta,Tsuyoshi Shuto,Shogo Shimasaki,Yuko Ohira,Mary Ann Suico,Dieter C Gruenert,Hirofumi Kai.  (2008-04-22)  DNA demethylation-dependent enhancement of toll-like receptor-2 gene expression in cystic fibrosis epithelial cells involves SP1-activated transcription..  BMC molecular biology,  9  (39-39).  [PMID:18423053]
35. Wangsheng Wang,Jianneng Li,Yuchun Ge,Wenjiao Li,Qun Shu,Haiyan Guan,Kaiping Yang,Leslie Myatt,Kang Sun.  (2012-02-09)  Cortisol induces aromatase expression in human placental syncytiotrophoblasts through the cAMP/Sp1 pathway..  Endocrinology,  153  ((4)): (2012-2022).  [PMID:22315456]
36. Anastasia Malek,Luz-Elena Núñez,Marco Magistri,Lara Brambilla,Sandra Jovic,Giuseppina M Carbone,Francisco Morís,Carlo V Catapano.  (2012-05-01)  Modulation of the activity of Sp transcription factors by mithramycin analogues as a new strategy for treatment of metastatic prostate cancer..  PloS one,  7  ((4)): (e35130-e35130).  [PMID:22545098]
37. Y Peter Di,Jinming Zhao,Richart Harper.  (2012-06-16)  Cigarette smoke induces MUC5AC protein expression through the activation of Sp1..  The Journal of biological chemistry,  287  ((33)): (27948-27958).  [PMID:22700966]
38. Paula C M Sales,Bryan R G Williams,Aristóbolo M Silva.  (2012-08-10)  Regulation of double-stranded RNA dependent protein kinase expression and attenuation of protein synthesis induced by bacterial toll-like receptors agonists in the absence of interferon..  Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research,  32  ((10)): (495-504).  [PMID:22873641]
39. Eun-Sun Choi,Ji-Youn Jung,Jin-Seok Lee,Jong-Hwan Park,Nam-Pyo Cho,Sung-Dae Cho.  (2012-09-25)  Myeloid cell leukemia-1 is a key molecular target for mithramycin A-induced apoptosis in androgen-independent prostate cancer cells and a tumor xenograft animal model..  Cancer letters,  328  ((1)): (65-72).  [PMID:23000424]
40. Ji-Ae Shin,Ji-Youn Jung,Mi Heon Ryu,Stephen Safe,Sung-Dae Cho.  (2012-09-29)  Mithramycin A inhibits myeloid cell leukemia-1 to induce apoptosis in oral squamous cell carcinomas and tumor xenograft through activation of Bax and oligomerization..  Molecular pharmacology,  83  ((1)): (33-41).  [PMID:23019217]
41. Pham Thi Thu Huong,Nak Kyun Soung,Jae Hyuk Jang,Hyun Joo Cha-Molstad,Krisada Sakchaisri,Sun Ok Kim,Jun Min Jang,Kyoon Eon Kim,Kyung Sang Lee,Yong Tae Kwon,Raymond Leo Erikson,Jong Seog Ahn,Bo Yeon Kim.  (2012-11-10)  Regulation of CEP131 gene expression by SP1..  Gene,  513  ((1)): (75-81).  [PMID:23137637]
42. Alexa Klettner,Daniel Westhues,Jens Lassen,Sofia Bartsch,Johann Roider.  (2013-02-13)  Regulation of constitutive vascular endothelial growth factor secretion in retinal pigment epithelium/choroid organ cultures: p38, nuclear factor κB, and the vascular endothelial growth factor receptor-2/phosphatidylinositol 3 kinase pathway..  Molecular vision,  19  (281-291).  [PMID:23401656]
43. Robert J Vanner,Marc Remke,Marco Gallo,Hayden J Selvadurai,Fiona Coutinho,Lilian Lee,Michelle Kushida,Renee Head,Sorana Morrissy,Xueming Zhu,Tzvi Aviv,Veronique Voisin,Ian D Clarke,Yisu Li,Andrew J Mungall,Richard A Moore,Yussanne Ma,Steven J M Jones,Marco A Marra,David Malkin,Paul A Northcott,Marcel Kool,Stefan M Pfister,Gary Bader,Konrad Hochedlinger,Andrey Korshunov,Michael D Taylor,Peter B Dirks.  (2014-06-24)  Quiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma..  Cancer cell,  26  ((1)): (33-47).  [PMID:24954133]
44. Keizo Takenaga,Takahiro Ochiya,Hideya Endo.  (2021-03-03)  Inhibition of the invasion and metastasis of mammary carcinoma cells by NBD peptide targeting S100A4 via the suppression of the Sp1/MMP‑14 axis..  International journal of oncology,  58  ((3)): (397-408).  [PMID:33650647]
45. Annapaola Angrisani,Annamaria Di Fiore,Claudia Augusta Di Trani,Simone Fonte,Marialaura Petroni,Ludovica Lospinoso Severini,Fabio Bordin,Laura Belloni,Elisabetta Ferretti,Gianluca Canettieri,Marta Moretti,Enrico De Smaele.  (2021-04-27)  Specific Protein 1 and p53 Interplay Modulates the Expression of the KCTD-Containing Cullin3 Adaptor Suppressor of Hedgehog 2..  Frontiers in cell and developmental biology,  9  (638508-638508).  [PMID:33898425]
46. Danfeng Wang, Min Liu, Yushu Wu, Tianxin Weng, Lu Wang, Yongfang Zhang, Yanna Zhao, Jun Han.  (2022)  Idarubicin/mithramycin-acridine orange combination drugs co-loaded by DNA nanostructures: Different effects of intercalation and groove binding on drug release and cytotoxicity.  JOURNAL OF MOLECULAR LIQUIDS,  355  (118947).  [10.1016/j.molliq.2022.118947]
47. Danfeng Wang, Min Liu, Yushu Wu, Yanna Zhao, Qingpeng Wang, Tianxin Weng, Lu Wang, He Liu, Yongfang Ren, Jun Han.  (2021)  Self-assembled DNA nanotrains for targeted delivery of mithramycin dimers coordinated by different metal ions: Effect of binding affinity on drug loading, release and cytotoxicity.  JOURNAL OF MOLECULAR LIQUIDS,  339  (116722).  [10.1016/j.molliq.2021.116722]

溶液计算器

上海阿拉丁生化科技股份有限公司
© 2016 ALADDIN-E.COM . 版权所有,未经授权禁止拷贝本站资料,如有违反,将追究法律责任

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用。

上海工商 危险品化学品经营许可证（带存储）营业执照(三证合一)