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寡霉素

ATP合酶抑制剂
10篇引用文献 COA COA
    级别和纯度:
  • ≥90%
有货

库存信息

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库存信息

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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
O399693-1mg
 1mg 现货 Stock Image
O399693-5mg
 5mg 现货 Stock Image
O399693-25mg
 25mg 现货 Stock Image
大包装询价 收藏夹 比较  SDS下载  DATASHEET  质量标准
查看相关系列
Anti-infection (2804) Antibiotic (2632) ATP Synthase (14) Fungal (1689) Glucose Metabolism (3713) 膜转运体 (1142) 膜转运器/离子通道 (1829)
main product photo

基本描述

英文别名 Oligomycin a, b, c mixture | Oligomycin Complex
规格或纯度 ≥90%
英文名称 Oligomycin
生化机理 大环内酯类抗生素；抑制线粒体 ATP 酶和磷酸基转移。阻断质子通道（F o 亚基）。大环内酯类抗生素。
储存温度 避光,-20°C储存,充氩
运输条件 超低温冰袋运输
备注 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍

Oligomycin is a macrolide that acts as a specific inhibitor of the mitochondrial ATP-synthase and blocks oxidative phosphorylation. The compound is a mixture of isomers A ,B , and C .Cancer cell studies show that Oligomycin does not activate the hypoxia-induced factor, however, it enhances the bioenergetic adaptation of heterogeneous bioenergetically organized cells. Oligomycin has been shown to decreased the cyclin D1 protein expression levels

Oligomycin is a macrolide that acts as a specific inhibitor of the mitochondrial ATP-synthase and blocks oxidative phosphorylation. The compound is a mixture of isomers A ,B , and C .Cancer cell studies show that Oligomycin does not activate the hypoxia-induced factor, however, it enhances the bioenergetic adaptation of heterogeneous bioenergetically organized cells. Oligomycin has been shown to decreased the cyclin D1 protein expression levels
A specific inhibitor of the mitochondrial ATP-synthase.
纯度 ≥90%

关联靶点（其它种属）

Pseudomonas aeruginosa (123386 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Klebsiella pneumoniae (43867 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Staphylococcus aureus (210822 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Acinetobacter baumannii (41033 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Escherichia coli (133304 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Cryptococcus neoformans (21258 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Candida albicans (78123 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Kcnk9 Potassium channel subfamily K member 9 (8 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

EC号 MFCD01779388
分子类型 小分子
IIUPAC Name (1S,4E,5'R,6R,6'R,7S,8R,10S,11S,12R,14S,15R,16S,18E,20E,22S,25R,27S,28R,29S)-22-ethyl-7,11,14,15-tetrahydroxy-6'-[(2S)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethylspiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-oxane]-3,9,13-trione
INCHI 1S/C45H74O11/c1-12-34-17-15-13-14-16-27(4)42(51)44(11,53)43(52)32(9)40(50)31(8)39(49)30(7)38(48)26(3)18-21-37(47)54-41-29(6)35(20-19-34)55-45(33(41)10)23-22-25(2)36(56-45)24-28(5)46/h13-15,17-18,21,25-36,38,40-42,46,48,50-51,53H,12,16,19-20,22-24H2,1-11H3/b14-13+,17-15+,21-18+/t25-,26-,27+,28+,29+,30-,31-,32-,33-,34-,35-,36-,38+,40+,41+,42-,44+,45-/m1/s1
InChi Key MNULEGDCPYONBU-WMBHJXFZSA-N
Smiles CCC1CCC2C(C(C(C3(O2)CCC(C(O3)CC(C)O)C)C)OC(=O)C=CC(C(C(C(=O)C(C(C(C(=O)C(C(C(CC=CC=C1)C)O)(C)O)C)O)C)C)O)C)C
Isomeric SMILES CC[C@H]\1CC[C@@H]2[C@@H]([C@@H]([C@H]([C@@]3(O2)CC[C@H]([C@H](O3)C[C@H](C)O)C)C)OC(=O)/C=C/[C@H]([C@@H]([C@H](C(=O)[C@H]([C@@H]([C@H](C(=O)[C@@]([C@@H]([C@H](C/C=C/C=C1)C)O)(C)O)C)O)C)C)O)C)C
分子量 791.07(for Oligomycin A)
Beilstein号 7615308
Reaxy-Rn 25435774
Reaxys-RN link address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25435774&ln=

化学和物理性质

溶解性 Soluble in EtOH, acetone (50 mg/ml), DMSO (300 mg/ml), ethanol, and methanol. Insoluble in water
敏感性 对湿度敏感;对光敏感
熔点 84-100°C
分子量 791.100 g/mol
XLogP3 7.100
氢键供体数Hydrogen Bond Donor Count 5
氢键受体数Hydrogen Bond Acceptor Count 11
可旋转键计数Rotatable Bond Count 3
精确质量Exact Mass 790.523 Da
单同位素质量Monoisotopic Mass 790.523 Da
拓扑极表面积Topological Polar Surface Area 180.000 Ų
重原子数Heavy Atom Count 56
形式电荷Formal Charge 0
复杂度Complexity 1390.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 18
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 3
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 3
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

象形图 GHS06,   GHS07,   GHS08
信号词 危险
危险声明

H301: 吞咽会中毒

H302: 吞食有害

H370: 对器官造成损害
预防措施声明

P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。

P264: 处理后要彻底洗手。

P270: 使用本产品时，请勿进食、饮水或吸烟。

P321: 特殊处理（请参阅此标签上的...）。

P330: 漱口

P405: 密闭存放

P501: 将内容物/容器处理到。。。

P301+P316: 如果吞咽：立即寻求紧急医疗救助。

P301+P317: 如果被吞咽：请寻求医疗帮助。

P308+P316: 如果暴露或担心：立即寻求紧急医疗救助。
WGK Germany 3
个人防护装备 dust mask type N95 (US),Eyeshields,Faceshields,Gloves

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到7个结果

批号(Lot Number) 证书类型 货号
K2230613 分析证书 O399693
J2408527 分析证书 O399693
J2408526 分析证书 O399693
G2418008 分析证书 O399693
H2323046 分析证书 O399693
F2306073 分析证书 O399693
H2218101 分析证书 O399693

可替换产品

  1. 寡霉素C
    寡霉素C
    • ≥95%

    ¥9,999.90

  2. 寡霉素A 来源于 淀粉酶产色链霉菌
    寡霉素A 来源于 淀粉酶产色链霉菌

    ¥588.90

  3. 寡霉素
    寡霉素
    • ≥92%

    ¥411.90

此产品的引用文献

如何在您的发表作品中引用阿拉丁的产品和网站? 引用文献检索

引用文献

1. Yao Yuying, Wang Yeru, Zhu Jingru, Guo Zhiqiang, Li Zongqiang, Li Qianru, Liu Su, Wang Yu, Yu Jinghua, Huang Jiadong.  (2023)  A spatially-controlled DNA triangular prism nanomachine for AND-gated intracellular imaging of ATP in acidic microenvironment.  MICROCHIMICA ACTA,  190  (11): (1-9).  [PMID:37837554] [10.1007/s00604-023-06010-8]
2. Zeng Hao, Pan Ting, Zhan Meiling, Hailiwu Renaguli, Liu Baolin, Yang Hua, Li Ping.  (2022)  Suppression of PFKFB3-driven glycolysis restrains endothelial-to-mesenchymal transition and fibrotic response.  Signal Transduction and Targeted Therapy,  7  (1): (1-17).  [PMID:36045132] [10.1038/s41392-022-01097-6]
3. Xinran Shi, Liang Ji, Yuanyuan Hu, Jinyu Gu, Liming Wang, Wenwen Lu, Jiali Meng, Yan Du, Lingzhong Huang, Dongxia Nie, Yanyan Yu.  (2022)  Dual-responsive zeolitic imidazolate framework-90 for the combined detection and intracellular imaging of ATP and ROS.  SENSORS AND ACTUATORS B-CHEMICAL,  363  (131848).  [10.1016/j.snb.2022.131848]
4. Zhuoheng Zhong, Shengzhi Liu, Songling Han, Yaohan Li, Minglei Tao, Amin Liu, Qiang He, Sixue Chen, Criag Dufresne, Wei Zhu, Jingkui Tian.  (2021)  Integrative omic analysis reveals the improvement of alkaloid accumulation by ultraviolet-B radiation and its upstream regulation in Catharanthus roseus.  INDUSTRIAL CROPS AND PRODUCTS,  166  (113448).  [10.1016/j.indcrop.2021.113448]
5. Chen Ying, Li Rui, Zhu Yuqi, Zhong Sixia, Qian Jinjun, Yang Dongqing, Jurczyszyn Artur, Beksac Meral, Gu Chunyan, Yang Ye.  (2020)  Dihydroartemisinin Induces Growth Arrest and Overcomes Dexamethasone Resistance in Multiple Myeloma.  Frontiers in Oncology,  10  (767).  [PMID:32500030] [10.3389/fonc.2020.00767]
6. Mingtong Ye, Sufan Wang, Ting Wan, Rui Jiang, Yun Qiu, Lei Pei, Nengzhi Pang, Yuanling Huang, Yufeng Huang, Zhenfeng Zhang, Lili Yang.  (2017)  Combined Inhibitions of Glycolysis and AKT/autophagy Can Overcome Resistance to EGFR-targeted Therapy of Lung Cancer.  Journal of Cancer,  8  (18): ( 3774–3784).  [PMID:29151965] [10.7150/jca.21035]
7. Changzheng Wang, Hongwei Lv, Wen Yang, Ting Li, Tian Fang, Guishuai Lv, Qin Han, Liwei Dong, Tianyi Jiang, Beige Jiang, Guangshun Yang, Hongyang Wang.  (2017)  SVCT-2 determines the sensitivity to ascorbate-induced cell death in cholangiocarcinoma cell lines and patient derived xenografts.  CANCER LETTERS,  398  (1).  [PMID:28385602] [10.1016/j.canlet.2017.03.039]
8. Xie Xiaoyun, Han Chaofei, Zeng Weiqi, Chen Chen, Lu Lixia, Liu Queping, Peng Cong, Zhao Shuang, Su Juan, Chen Xiang.  (2017)  Possible Involvement of F1F0-ATP synthase and Intracellular ATP in Keratinocyte Differentiation in normal skin and skin lesions.  Scientific Reports,  7  (42672).  [PMID:28209970] [10.1038/srep42672]
9. Weihua Tian, Yu Wang, Yan Xu, Xiangpeng Guo, Bo Wang, Li Sun, Longqi Liu, Fenggong Cui, Qiang Zhuang, Xichen Bao, Gunnar Schley, Tung-Liang Chung, Andrew L. Laslett, Carsten Willam, Baoming Qin, Patrick H. Maxwell, Miguel A. Esteban.  (2013)  The Hypoxia-inducible Factor Renders Cancer Cells More Sensitive to Vitamin C-induced Toxicity *.  JOURNAL OF BIOLOGICAL CHEMISTRY,  289  (6): (3339-3351).  [PMID:24371136] [10.1074/jbc.M113.538157]
10. Xiangfeng Meng, Yue Zhou, Lei Xu, Limu Hu, Changjiang Wang, Xiao Tian, Xiang Zhang, Yi Hao, Bo Cheng, Jing Ma, Lei Wang, Jialin Liu, Ran Xie.  (2024)  O-GlcNAcylation Facilitates the Interaction between Keratin 18 and Isocitrate Dehydrogenases and Potentially Influencing Cholangiocarcinoma Progression.  ACS Central Science,  10  (5): (1065-1083).  [PMID:38799671] [10.1021/acscentsci.4c00163]

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