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Infliximab (anti-TNF-alpha), TNF-α 抑制剂

COA COA
    应用:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • 宿主种属: 人(Human)
  • 种属反应性: 人(Human), 食蟹猴(Cynomolgus monkey)
  • 亚型: Human IgG1
  • 偶联: Unconjugated
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货号 (SKU) 包装规格 是否现货 价格 数量
I412009-100μg
 100μg 现货 Stock Image
I412009-1mg
 1mg 现货 Stock Image
I412009-5mg
 5mg 现货 Stock Image
I412009-10mg
 10mg 期货 Stock Image
大包装询价 收藏夹 比较  SDS下载  DATASHEET  质量标准
查看相关系列
点击查看靶蛋白信息: TNF
Accession#:P01375 (17) Anti-infection (2804) Apoptosis (7108) Bacterial (5911) Extrinsic Pathway (1228) Gene ID:7124 (17) Tnf (22) TNF Receptor (121) TNF-alpha (11)
main product photo

基本信息

产品名称 Infliximab (anti-TNF-alpha), TNF-α 抑制剂
别名 英夫利昔单抗 | TNFSF2抗体 | TNFSF2单克隆抗体 | TNFSF2药靶抗体 | TNFa抗体 | TNFa单克隆抗体 | TNFa药靶抗体 | TNF抗体 | TNF单克隆抗体 | TNF药靶抗体
英文别名 Infliximab | Remicade | Remsima | Inflectra | Avakine | CT-P13 | APC1 antibody | APC1 protein antibody | Cachectin antibody | DIF antibody | Differentiation inducing factor antibody | Macrophage cytotoxic factor antibody | Tnf antibody | TNF superfamily m
规格或纯度 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
生化机理 Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.
宿主种属 人(Human)
特异性 TNFSF2/TNFa
应用 ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
种属反应性 人(Human),食蟹猴(Cynomolgus monkey)
偶联 Unconjugated
作用类型 抑制剂
作用机制 TNF-α 抑制剂

产品属性

抗体类型 Primary antibody
克隆类型 重组抗体
Format Whole IgG
亚型 Human IgG1
轻链亚型 kappa
SDS-PAGE 27.6 kDa (Light Chain) & 52.7 kDa (Heavy Chain), under reducing conditions; 186.7 kDa, under non-reducing conditions.
纯化方法 Protein A purified
纯度 >95%
来源 CHO supernatant
物理外观 Liquid
储存缓冲液 Supplied as a 0.22 μm filtered solution in 100mM Pro-AC, 20mM Arg, pH 5.0
防腐剂 No
浓度 见COA
储存温度 -80℃储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 长期储存-20℃（24个月）；收货后建议分装，避免反复冻融。
CAS编号和信息 170277-31-3
分子类型 抗体

关联靶点（人）

TNF Tclin 肿瘤坏死因子(Tumor necrosis factor) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

图片

Infliximab (anti-TNF-alpha) (I412009) - ELISA
Immobilized Recombinant Human TNF-α protein (rp156007) at 1.0 μg/mL can bind Infliximab (anti-TNF-alpha) (I412009) with the EC50 of 22.22 ng/mL.

Infliximab (anti-TNF-alpha) (I412009) - ELISA
Immobilized Recombinant huTNF-alpha- ECD-His protein at 2.0 μg/mL can bind Infliximab (anti-TNF-alpha) (I412009) with the EC50 of 26.34 ng/mL.

Infliximab (anti-TNF-alpha) (I412009) - SEC
The purity of Infliximab (anti-TNF-alpha) (I412009) is more than 95% verified by HPLC.

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找到10个结果

批号(Lot Number) 证书类型 货号
ZJ25F0723749 分析证书 I412009
ZJ25F0723748 分析证书 I412009
ZJ25F0723747 分析证书 I412009
ZJ23F0900976 分析证书 I412009
ZJ25F0420198 分析证书 I412009
ZJ25F0420197 分析证书 I412009
ZJ25F0420196 分析证书 I412009
ZJ24F0911299 分析证书 I412009
ZJ24F0911298 分析证书 I412009
ZJ23F0900975 分析证书 I412009

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引用文献

1. Rutgeerts P, D'Haens G, Targan S, Vasiliauskas E, Hanauer SB, Present DH, Mayer L, Van Hogezand RA, Braakman T, DeWoody KL et al..  (1999)  Efficacy and safety of retreatment with anti-tumor necrosis factor antibody (infliximab) to maintain remission in Crohn's disease..  Gastroenterology,  117  (4): (761-9).  [PMID:10500056]
2. Blair HA, Deeks ED.  (2016)  Infliximab Biosimilar (CT-P13; Infliximab-dyyb): A Review in Autoimmune Inflammatory Diseases..  BioDrugs,  30  (5): (469-480).  [PMID:27650650]
3. Yoo DH, Prodanovic N, Jaworski J, Miranda P, Ramiterre E, Lanzon A, Baranauskaite A, Wiland P, Abud-Mendoza C, Oparanov B et al..  (2017)  Efficacy and safety of CT-P13 (biosimilar infliximab) in patients with rheumatoid arthritis: comparison between switching from reference infliximab to CT-P13 and continuing CT-P13 in the PLANETRA extension study..  Ann Rheum Dis,  76  (2): (355-363).  [PMID:27130908]
4. Derzi M, Johnson TR, Shoieb AM, Conlon HD, Sharpe P, Saati A, Koob S, Bolt MW, Lorello LG, McNally J et al..  (2016)  Nonclinical Evaluation of PF-06438179: A Potential Biosimilar to Remicade(®) (Infliximab)..  Adv Ther,  33  (11): (1964-1982).  [PMID:27585978]
5. van Dullemen HM, van Deventer SJ, Hommes DW, Bijl HA, Jansen J, Tytgat GN, Woody J.  (1995)  Treatment of Crohn's disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2)..  Gastroenterology,  109  (1): (129-35).  [PMID:7797011]
6. A-González N, Castrillo A.  (2011)  Liver X receptors as regulators of macrophage inflammatory and metabolic pathways..  Biochim Biophys Acta,  1812  (8): (982-94).  [PMID:21193033]

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