| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| F409163-1ml |
1ml |
现货  |
|
| 英文别名 | 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3,7-dihydroxy- |
|---|---|
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Fisetin |
| 生化机理 | 菲赛汀（Fustel）是一种强效的 sirtuin 激活化合物（STAC），也是一种调节 sirtuin 的药剂。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
溶于乙醇、丙酮、乙酸、氢氧化物碱溶液，不溶于水、乙醚、苯、氯仿和石油醚。在稀氢氧化钠乙醇溶液中呈现暗绿色荧光。 Information Fisetin Fisetin (Fustel) is a potent sirtuin activating compound (STAC) and an agent that modulates sirtuins . In vivo
cell lines： Concentrations： Incubation Time： Powder Purity:≥95% |
| 分子类型 | 小分子 |
|---|---|
| Isomeric SMILES | C1=CC(=C(C=C1C2=C(C(=O)C3=C(O2)C=C(C=C3)O)O)O)O |
| 分子量 | 286.24 |
| Beilstein号 | 18221 |
| Reaxy-Rn | 292829 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=292829&ln= |
| 熔点 | 330°C |
|---|
| 象形图 | GHS07 |
|---|---|
| 信号词 | Warning |
| 危险声明 |
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P403+P233: 存放在通风良好的地方。保持容器密闭。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。 |
| RTECS | LK9250000 |
| Merck Index | 4088 |
| 1. Nayun Kim, Junhye Kwon, Ui Sup Shin, Joohee Jung. (2023) Fisetin induces the upregulation of AKAP12 mRNA and anti-angiogenesis in a patient-derived organoid xenograft model. BIOMEDICINE & PHARMACOTHERAPY, 167 (115613). [PMID:37801904] [10.1016/j.biopha.2023.115613] |
| 2. Fangjie Han, Shulin Luo, Zhifang Wu, Zhishan Liang, Wenxin Yang, Dongxue Han, Zhonghui Sun, Zhenbang Liu, Li Niu. (2023) A label-free photoelectrochemical sensor based on BiVO4@graphene oxide hybrid for analysis of the antioxidant capacity in food. JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 946 (117713). [10.1016/j.jelechem.2023.117713] |
| 3. Yufeng Chen, Guobin Xia, Chunfeng Wang, Huawei Wu, Xiaogang Xu, Genxiang Mao, Jiong Wu, Zhenlei Zhao. (2023) Impact of dietary plant flavonoids on 7,8-dihydroxyflavone transepithelial transport in human intestinal Caco-2 cells. Food Science & Nutrition, [PMID:37970375] [10.1002/fsn3.3581] |
| 4. Xiao-Hua Zhang, Xiang-Dong Qing, Jing-Jing Zheng, Yan Yu, Jiaojiao Huang, Chao Kang, Zhi Liu. (2023) Aqueous two-phase systems coupled with chemometrics-enhanced HPLC-DAD for simultaneous extraction and determination of flavonoids in honey. Food Chemistry-X, 19 (100766). [PMID:37780266] [10.1016/j.fochx.2023.100766] |
| 5. Sichao Gu, Xuefeng Zhou, Xingshi Yuan, Yunliang Zhu, Hui Zhang, Lei Xu, Li Li. (2023) Photocurable fisetin silk fibroin hydrogel accelerates infected diabetic wounds healing through biofilm inhibition and macrophage immunomodulation. MATERIALS LETTERS, 341 (134154). [10.1016/j.matlet.2023.134154] |
| 6. Ruiyi Fan, Congyi Zhu, Diyang Qiu, Genlin Mao, Bernd Mueller-Roeber, Jiwu Zeng. (2023) Integrated transcriptomic and metabolomic analyses reveal key genes controlling flavonoid biosynthesis in Citrus grandis ‘Tomentosa’ fruits. PLANT PHYSIOLOGY AND BIOCHEMISTRY, 196 (210). [PMID:36724705] [10.1016/j.plaphy.2023.01.050] |
| 7. Chun Xiao Li, Fu Rong Wang, Bing Zhang, Ze Yuan Deng, Hong Yan Li. (2023) Stability and antioxidant activity of phenolic compounds during in vitro digestion. JOURNAL OF FOOD SCIENCE, 88 (2): (696-716). [PMID:36617678] [10.1111/1750-3841.16440] |
| 8. Hongting Deng, Yuanju He, Hui Cao, Lei Chen, Hui Teng. (2022) New insight into the effect of hydroxyl substituted flavonoids on the cytotoxicity of 2-amino-3-methylimidazo[4,5-f]quinoline. Food Frontiers, 4 (1): (289-296). [10.1002/fft2.194] |
| 9. Wenjie Yu, Fengjie Sun, Ruixin Xu, Meng Cui, Yongquan Liu, Quanyuan Xie, Limin Guo, Chenxian Kong, Xin Li, Xiali Guo, Liping Luo. (2023) Chemical composition and anti-inflammatory activities of Castanopsis honey. Food & Function, 14 (1): (250-261). [PMID:36484340] [10.1039/D2FO02233H] |
| 10. Xiaochong Song, Qing Luo, Xiaojia Huang. (2022) Speciation of organotin compounds in water and seafood samples by online hyphenation of porous polymer-based magnetism-enhanced in-tube solid phase microextraction and HPLC. ANALYTICA CHIMICA ACTA, 1223 (340175). [PMID:35998999] [10.1016/j.aca.2022.340175] |
| 11. Zhang Xiao-Hua, Ma Yi-Xin, Yi Chong, Qing Xiang-Dong, Liu Zhi, Zheng Jing-Jing, Lin Fang, Lv Tian-Feng. (2020) Chemometrics-enhanced HPLC–DAD as a rapid and interference-free strategy for simultaneous quantitative analysis of flavonoids in Chinese propolis. EUROPEAN FOOD RESEARCH AND TECHNOLOGY, 246 (10): (1909-1918). [10.1007/s00217-020-03543-7] |
| 12. Wei Yang, Zhi-Kai Tian, Hui-Xin Yang, Zhao-Jun Feng, Jian-Mei Sun, Hong Jiang, Chao Cheng, Qing-Lei Ming, Chan-Min Liu. (2019) Fisetin improves lead-induced neuroinflammation, apoptosis and synaptic dysfunction in mice associated with the AMPK/SIRT1 and autophagy pathway. FOOD AND CHEMICAL TOXICOLOGY, 134 (110824). [PMID:31539617] [10.1016/j.fct.2019.110824] |
| 13. Chengyun He, Xiaoling Liu, Zhaojing Jiang, Sheng Geng, Hanjun Ma, Benguo Liu. (2019) Interaction Mechanism of Flavonoids and α-Glucosidase: Experimental and Molecular Modelling Studies. Foods, 8 (9): (355). [PMID:31438605] [10.3390/foods8090355] |
| 14. Ni Zeng, Guowen Zhang, Xing Hu, Junhui Pan, Deming Gong. (2019) Mechanism of fisetin suppressing superoxide anion and xanthine oxidase activity. Journal of Functional Foods, 58 (1). [10.1016/j.jff.2019.04.044] |
| 15. Yike Yue, Yongsheng Chen, Sheng Geng, Guizhao Liang, Benguo Liu. (2018) Antioxidant and α-Glucosidase Inhibitory Activities of Fisetin. Natural Product Communications, [10.1177/1934578X1801301119] |
| 16. Hui Wang, Wenxi Zhang, Yatao Cheng, Xinyu Zhang, Nannan Xue, Gaorong Wu, Meng Chen, Kang Fang, Wenbo Guo, Fei Zhou, Herong Cui, Tao Ma, Penglong Wang, Haimin Lei. (2018) Design, Synthesis and Biological Evaluation of Ligustrazine-Flavonoid Derivatives as Potential Anti-Tumor Agents. MOLECULES, 23 (9): (2187). [PMID:30200208] [10.3390/molecules23092187] |
| 17. Tingting Wang, Huajuan Lin, Qian Tu, Jingjing Liu, Xican Li. (2016) Fisetin Protects DNA Against Oxidative Damage and Its Possible Mechanism. Advanced Pharmaceutical Bulletin, 6 (2): ( 267–270). [PMID:27478791] [10.15171/apb.2016.037] |
| 18. Xiaodan Liu, Xia Wu. (2014) Fluorescence enhancement of fisetin by silver nanoparticles with cetyltrimethyl ammonium bromide micelles. RSC Advances, 5 (10): (7433-7439). [10.1039/C4RA12726A] |
| 19. Zhenning Xu, Mo Wang, Tingting Zhou, Huanshun Yin, Shiyun Ai. (2013) Electrochemical biosensing method for the detection of DNA methylation and assay of the methyltransferase activity. SENSORS AND ACTUATORS B-CHEMICAL, 178 (412). [10.1016/j.snb.2012.12.124] |
| 20. Huanshun Yin, Zhenning Xu, Mo Wang, Xueping Zhang, Shiyun Ai. (2013) An electrochemical biosensor for assay of DNA methyltransferase activity and screening of inhibitor. ELECTROCHIMICA ACTA, 89 (530). [10.1016/j.electacta.2012.11.093] |
| 21. Huanshun Yin, Yunlei Zhou, Zhenning Xu, Lijian Chen, Di Zhang, Shiyun Ai. (2013) An electrochemical assay for DNA methylation, methyltransferase activity and inhibitor screening based on methyl binding domain protein. BIOSENSORS & BIOELECTRONICS, 41 (492). [PMID:23021851] [10.1016/j.bios.2012.09.010] |
| 22. Shujuan Xu, Yong Shao, Kun Ma, Qinghua Cui, Guiying Liu, Fei Wu, Minjie Li. (2011) Fluorescence light-up recognition of DNA nucleotide based on selective abasic site binding of an excited-state intramolecular proton transfer probe. ANALYST, 136 (21): (4480-4485). [PMID:21946800] [10.1039/C1AN15652G] |
| 23. Li-Feng Li, Meng-Di Wang, Chen-Yang Zhang, Meng-Yao Jin, Hua-Lei Chen, Huan Luo, Tian-Yu Hou, Zhi-Jun Zhang, He Li. (2025) Influence of hydroxyl substitution on the inhibition of flavonoids in advanced glycation end-products formation in glucose-lysine-arginine Maillard reaction models. FOOD RESEARCH INTERNATIONAL, 207 (116068). [PMID:40086959] [10.1016/j.foodres.2025.116068] |
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