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Ferrostatin-1 (Fer-1),雌激素诱导的肥大病抑制剂

有力的选择性选择性雌激素诱导的肥大病抑制剂
42篇引用文献 COA COA
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F129882-5mg
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F129882-500mg
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Anti-infection (2804) Antifungal Ingredients (for Research and Experimental Use) (1) Antioxidant and Free Radical Scavengers [Bioactive Small Molecules] (1) Apoptosis (7108) Ferroptosis (624) Ferroptosis inhibitors (1) Fungal (1689)
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基本描述

别名 铁抑制剂-1 | 3-氨基-4-(环己基氨基)苯甲酸乙酯 | 3-氨基-4-环己基氨基苯甲酸乙酯
英文别名 Ethyl 3-amino-4-(cyclohexylamino)benzoate | 3-Amino-4-cyclohexylaminobenzoic Acid Ethyl Ester
规格或纯度 Moligand™, ≥99%
英文名称 Ferrostatin-1 (Fer-1)
生化机理 铁抑制剂-1是一种活性自由基捕获抗氧化剂，能够捕获过氧自由基，可用作铁死亡的潜在抑制剂。铁死亡被认为是调节性坏死，和细胞凋亡和自吞噬不同。铁抑制剂-1能够保护人们免于亨廷顿病，还能在细胞模型中防止谷氨酸诱导的神经毒性。 铁抑制剂-1是一种高效的非凋亡的，erastin诱导铁死亡细胞死亡抑制剂。铁抑制剂-1能够防止癌症细胞中铁死亡细胞死亡和器官型大鼠脑切片中谷氨酸诱导毒性。铁抑制剂-1控制脂溶解ROS。
储存温度 2-8°C储存,避光,充氩
运输条件 冰袋运输
备注 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍

Ferrostatin-1 (Fer-1) 是一种有效的、选择性的 ferroptosis 抑制剂，抑制 Erastin 诱导的 HT-1080 细胞铁死亡 (EC50=60 nM)。Ferrostatin-1 是一种人工合成的抗氧化剂，通过还原机制来防止膜脂的损伤，从而抑制细胞死亡。Ferrostatin-1 具有抗真菌活性。

Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of ferroptosis with EC50 of 60 nM.
A potent inhibitor of non-apoptotic cell death induced by erastin call ferroptosis

Ferrostatin-1 (Fer-1), a potent and selective ferroptosis inhibitor, suppresses Erastin-induced ferroptosis in HT-1080 cells (EC50=60 nM). Ferrostatin-1, a synthetic antioxidant, acts via a reductive mechanism to prevent damage to membrane lipids and thereby inhibits cell death. Ferrostatin-1 exhibits antifungal activity.

纯度 ≥99%

关联靶点（人）

HT-1080 (3966 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HT-29 (80576 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
IMR-32 (1082 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
T-24 (2342 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

Hdac6 Histone deacetylase 6 (222 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Leishmania major (2877 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mus musculus (284745 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
LLC-MK2 (227 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
RAW264.7 (28094 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NIH3T3 (5395 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HT-22 (3261 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Plasma (328 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Liver microsome (341 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

PubChem SID 504762826
分子类型 小分子
IIUPAC Name ethyl 3-amino-4-(cyclohexylamino)benzoate
INCHI 1S/C15H22N2O2/c1-2-19-15(18)11-8-9-14(13(16)10-11)17-12-6-4-3-5-7-12/h8-10,12,17H,2-7,16H2,1H3
InChi Key UJHBVMHOBZBWMX-UHFFFAOYSA-N
Smiles CCOC(=O)C1=CC(=C(C=C1)NC2CCCCC2)N
Isomeric SMILES CCOC(=O)C1=CC(=C(C=C1)NC2CCCCC2)N
分子量 262.35
Reaxy-Rn 9413226
Reaxys-RN link address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=9413226&ln=

化学和物理性质

溶解性 DMSO 52 mg/mL Water <1 mg/mL Ethanol 52 mg/mL
敏感性 对光线、空气、热敏感
熔点 106 °C
分子量 262.350 g/mol
XLogP3 3.300
氢键供体数Hydrogen Bond Donor Count 2
氢键受体数Hydrogen Bond Acceptor Count 4
可旋转键计数Rotatable Bond Count 5
精确质量Exact Mass 262.168 Da
单同位素质量Monoisotopic Mass 262.168 Da
拓扑极表面积Topological Polar Surface Area 64.400 Ų
重原子数Heavy Atom Count 19
形式电荷Formal Charge 0
复杂度Complexity 290.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 0
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

象形图 GHS07
信号词 警告
危险声明

H315: 引起皮肤刺激

H319: 引起严重眼睛刺激

H335: 可能引起呼吸道刺激
预防措施声明

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾

P264: 处理后要彻底洗手。

P271: 仅在室外或通风良好的地方使用。

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P321: 特殊处理（请参阅此标签上的...）。

P302+P352: 如皮肤沾染：用水充分清洗。

P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。

P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。

P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。

P405: 密闭存放

P403+P233: 存放在通风良好的地方。保持容器密闭。

P501: 将内容物/容器处理到。。。

P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。

P337+P317: 如果眼睛刺激持续：寻求医疗帮助。

P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。

P319: 如果你感到不适，请寻求医疗帮助。

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批号(Lot Number) 证书类型 货号
J2323606 分析证书 F129882
J2323607 分析证书 F129882
J2227381 分析证书 F129882
C2503245 分析证书 F129882
C2503257 分析证书 F129882
C2503258 分析证书 F129882
C2503259 分析证书 F129882
I2504098 分析证书 F129882
L2412567 分析证书 F129882
L2412621 分析证书 F129882
L2412622 分析证书 F129882
L2412627 分析证书 F129882
H2405444 分析证书 F129882
H2405447 分析证书 F129882
H2405445 分析证书 F129882
H2405446 分析证书 F129882
F2406190 分析证书 F129882
F2406191 分析证书 F129882
F2406192 分析证书 F129882
C2406141 分析证书 F129882
C2406139 分析证书 F129882
C2406140 分析证书 F129882
C2406138 分析证书 F129882
J2323608 分析证书 F129882
I2206738 分析证书 F129882
I2206792 分析证书 F129882
I2206793 分析证书 F129882
I2206794 分析证书 F129882
J2227331 分析证书 F129882
J2227336 分析证书 F129882
J2227339 分析证书 F129882
F2301028 分析证书 F129882
G2320169 分析证书 F129882
I2308179 分析证书 F129882
J2307033 分析证书 F129882

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  1. Ferrostatin-1 (Fer-1)
    Ferrostatin-1 (Fer-1)
    • 10mM in DMSO

    ¥299.90

此产品的引用文献

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引用文献

1. Henning Y et al..  (2022)  Hypoxia aggravates ferroptosis in RPE cells by promoting the Fenton reaction..  Cell Death Dis,  13  (7): (662).  [PMID:35906211]
2. Wenzel SE et al..  (2017)  PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals..  Cell,  171  (3): (628-641.e26).  [PMID:29053969]
3. Xiaosi Lin , Le Dong, Qing Miao, Zhaobin Huang, Fang Wang.  (2024)  Cycloheptylprodigiosin from marine bacterium Spartinivicinus ruber MCCC 1K03745T induces a novel form of cell death characterized by Golgi disruption and enhanced secretion of cathepsin D in non-small cell lung cancer cell lines.  European Journal of Pharmacology,  无  (974): (176608).  [PMID:38663542] [10.1016/j.ejphar.2024.176608]
4. Haoze Song, Jing Liang, Yuanyuan Guo, Yang Liu, Kuiru Sa, Guohong Yan, Wen Xu, Wei Xu, Lixia Chen, Hua Li.  (2024)  A potent GPX4 degrader to induce ferroptosis in HT1080 cells.  EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,  265  (116110).  [PMID:38194774] [10.1016/j.ejmech.2023.116110]
5. Tianxiang Wang, Changmei Yang, Zhiqiang Li, Ting Li, Ran Zhang, Yujiao Zhao, Tianyi Cheng, Zhaoyun Zong, Yingying Ma, Dongyuan Zhang, Haiteng Deng.  (2024)  Flavonoid 4,4′-dimethoxychalcone selectively eliminates senescent cells via activating ferritinophagy.  Redox Biology,  69  (103017).  [PMID:38176315] [10.1016/j.redox.2023.103017]
6. Yijing Yang, Ying Wang, Ying Deng, Jing Lu, Li Xiao, Jie Li, Yasha Zhou, Fujiao Nie, Xiangdong Chen, Jun Peng, Hanyu Tan, Yuhui Qin, Qinghua Peng.  (2023)  Fructus Lycii and Salvia miltiorrhiza Bunge extract attenuate oxidative stress-induced photoreceptor ferroptosis in retinitis pigmentosa.  BIOMEDICINE & PHARMACOTHERAPY,  167  (115547).  [PMID:37741257] [10.1016/j.biopha.2023.115547]
7. Xi Wang, Wenjing Zhu, Miao Xing, Haiyan Zhu, Enqing Chen, Jie Zhou.  (2023)  Matrine disrupts Nrf2/GPX4 antioxidant system and promotes hepatocyte ferroptosis.  CHEMICO-BIOLOGICAL INTERACTIONS,  384  (110713).  [PMID:37716422] [10.1016/j.cbi.2023.110713]
8. Suleixin Yang, Yi Wu, Wenzhao Zhong, Ruie Chen, Meilin Wang, Meiwan Chen.  (2023)  GSH/Ph Dual Activatable Crosslinked And Fluorinated Pei for Cancer Gene Therapy Through Endogenous Iron De-Hijacking And in Situ Ros Amplification.  ADVANCED MATERIALS,  (2304098).  [PMID:37689975] [10.1002/adma.202304098]
9. Wei Li, Chang Liu, Sichuan Wang, Naifeng Liu.  (2023)  Neutrophil membrane biomimetic delivery system (Ptdser-NM-Lipo/Fer-1) designed for targeting atherosclerosis therapy.  IET Nanobiotechnology,  17  (4): (387-395).  [PMID:37183611] [10.1049/nbt2.12137]
10. Zhao Hongting, Zhang Meng, Zhang Jinghua, Sun Zichen, Zhang Wenxin, Dong Weichen, Cheng Chen, Yao Yongzhong, Li Kuanyu.  (2023)  Hinokitiol-iron complex is a ferroptosis inducer to inhibit triple-negative breast tumor growth.  Cell and Bioscience,  13  (1): (1-15).  [PMID:37179385] [10.1186/s13578-023-01044-0]
11. Yu-Chen Chen, Qiong Zheng, Hui Lu, Yi-Xin Zhuang, Ting-Ting Gong, Lie-Feng Ma, Zha-Jun Zhan.  (2023)  Neuroprotective flavonoids from Epimedium brevicornu by inhibition of ferroptosis.  Phytochemistry Letters,  55  (80).  [10.1016/j.phytol.2023.04.003]
12. Xia Chen, Rong Wu, Lei Li, Yunong Zeng, Jingrui Chen, Mingyuan Wei, Yinglin Feng, Guiming Chen, Yuhang Wang, Lizhen Lin, Haihua Luo, Ali Chen, Zhenhua Zeng, Fangjie He, Yang Bai, Siyou Zhang, Yubing Han, Zhang Wang, Xiaoshan Zhao, Wei Xiao, Yong Jiang, Shenhai Gong.  (2023)  Pregnancy-induced changes to the gut microbiota drive macrophage pyroptosis and exacerbate septic inflammation.  IMMUNITY,  56  (336-352.e9).  [PMID:36792573] [10.1016/j.immuni.2023.01.015]
13. Wenhua Wang, Wenhao Wang, Shiwei Jin, Fangqin Fu, Zhengwei Huang, Ying Huang, Chuanbin Wu, Xin Pan.  (2023)  Open pocket and tighten holes: Inhalable lung cancer-targeted nanocomposite for enhanced ferroptosis-apoptosis synergetic therapy.  CHEMICAL ENGINEERING JOURNAL,  458  (141487).  [10.1016/j.cej.2023.141487]
14. Huiyi Li, Qiqing Weng, Shuai Gong, Weixian Zhang, Jiaqi Wang, Yuqiao Huang, Yuanjun Li, Jiao Guo, Tian Lan.  (2023)  Kaempferol prevents acetaminophen-induced liver injury by suppressing hepatocyte ferroptosis via Nrf2 pathway activation.  Food & Function,  14  (4): (1884-1896).  [PMID:36723004] [10.1039/D2FO02716J]
15. Mingbo Wu, Wenwu Ling, Jiaojun Wei, Ran Liao, Haiyue Sun, Dongqiu Li, Ye Zhao, Long Zhao.  (2022)  Biomimetic photosensitizer nanocrystals trigger enhanced ferroptosis for improving cancer treatment.  JOURNAL OF CONTROLLED RELEASE,  352  (1116).  [PMID:36402233] [10.1016/j.jconrel.2022.11.026]
16. Huan Huang, Yuling Chen, Na Yin, Gaojie Li, Shanshan Ye, Ling Guo, Min Feng.  (2023)  Unsaturated Fatty Acid Liposomes Selectively Regulate Glutathione Peroxidase 4 to Exacerbate Lipid Peroxidation as an Adaptable Liposome Platform for Anti-Tumor Therapy.  MOLECULAR PHARMACEUTICS,  20  (1): (290–302).  [PMID:36368878] [10.1021/acs.molpharmaceut.2c00642]
17. Li Xie, Wenjie Chen, Qifang Chen, Yang Jiang, Erqun Song, Xiaokang Zhu, Yang Song.  (2022)  Synergistic hydroxyl radical formation, system XC- inhibition and heat shock protein crosslinking tango in ferrotherapy: A prove-of-concept study of “sword and shield” theory.  Materials Today Bio,  16  (100353).  [PMID:35865409] [10.1016/j.mtbio.2022.100353]
18. Shuwei Qiao, Baosheng Li, Qing Cai, Zhen Li, Zhaoyi Yin, Jie He, Yuyang Li, Weiyan Meng.  (2022)  Involvement of ferroptosis in Porphyromonas gingivalis lipopolysaccharide-stimulated periodontitis in vitro and in vivo.  ORAL DISEASES,  [PMID:35765229] [10.1111/odi.14292]
19. Hao Chi, Guang Zhu, Yalin Yin, He Diao, Zicheng Liu, Shibo Sun, Zhaoming Guo, Weiping Xu, Jianqiang Xu, Changhao Cui, Xiao-Jin Xing, Kun Ma.  (2022)  Dual-Responsive multifunctional “core–shell” magnetic nanoparticles promoting Fenton reaction for tumor ferroptosis therapy.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,  622  (121898).  [PMID:35688287] [10.1016/j.ijpharm.2022.121898]
20. Feng-guo Zhai, Qi-chao Liang, Yi-yan Wu, Jia-qi Liu, Jia-wei Liu.  (2022)  Red ginseng polysaccharide exhibits anticancer activity through GPX4 downregulation-induced ferroptosis.  PHARMACEUTICAL BIOLOGY,  60  (1): (909-914).  [PMID:35575436] [10.1080/13880209.2022.2066139]
21. Wenhao Wang, Fangqin Fu, Zhengwei Huang, Wenhua Wang, Minglong Chen, Xiao Yue, Jintao Fu, Xiaoqian Feng, Ying Huang, Chuanbin Wu, Xin Pan.  (2022)  Inhalable Biomimetic Protein Corona-Mediated Nanoreactor for Self-Amplified Lung Adenocarcinoma Ferroptosis Therapy.  ACS Nano,  16  (5): (8370–8387).  [PMID:35575209] [10.1021/acsnano.2c02634]
22. Fengfan Liu, Xiang Cheng, Shuang Wu, Bei Hu, Chen Yang, Shufen Deng, Qiwen Shi.  (2022)  Nickel oxide nanoparticles induce apoptosis and ferroptosis in airway epithelial cells via ATF3.  ENVIRONMENTAL TOXICOLOGY,  37  (5): (1093-1103).  [PMID:35061333] [10.1002/tox.23467]
23. Haibao Peng, Xingcai Zhang, Peng Yang, Jiaxu Zhao, Wei Zhang, Nianping Feng, Wuli Yang, Jing Tang.  (2023)  Defect self-assembly of metal-organic framework triggers ferroptosis to overcome resistance.  Bioactive Materials,  19  (1).  [PMID:35415315] [10.1016/j.bioactmat.2021.12.018]
24. Zhiwei Wang, Mingxing Li, Yuanfeng Liu, Zhentao Qiao, Tao Bai, Ling Yang, Bo Liu.  (2021)  Dihydroartemisinin triggers ferroptosis in primary liver cancer cells by promoting and unfolded protein response‑induced upregulation of CHAC1 expression.  ONCOLOGY REPORTS,  46  (5): (1-14).  [PMID:34558645] [10.3892/or.2021.8191]
25. Rong Fan, Jidong Sui, Xuepeng Dong, Biao Jing, Zhenming Gao.  (2021)  Wedelolactone alleviates acute pancreatitis and associated lung injury via GPX4 mediated suppression of pyroptosis and ferroptosis.  FREE RADICAL BIOLOGY AND MEDICINE,  173  (29).  [PMID:34246777] [10.1016/j.freeradbiomed.2021.07.009]
26. Xiazhen Bao, Xuehui Cao, Yong Yuan, Bo Zhou, Congde Huo.  (2021)  A water-soluble, highly sensitive and ultrafast fluorescence probe for imaging of mitochondrial hypochlorous acid.  SENSORS AND ACTUATORS B-CHEMICAL,  344  (130210).  [10.1016/j.snb.2021.130210]
27. Wenjun Liu, Jieyuan Zhang, Liang Ding, Weifeng Ni, Junjie Yuan, Haijun Xiao, Jingwei Zhang.  (2021)  RBC-derived nanosystem with enhanced ferroptosis triggered by oxygen-boosted phototherapy for synergized tumor treatment.  Biomaterials Science,  9  (21): (7228-7236).  [PMID:34585181] [10.1039/D1BM00175B]
28. Tao Bai, Ruopeng Liang, Rongtao Zhu, Weijie Wang, Lin Zhou, Yuling Sun.  (2020)  MicroRNA-214-3p enhances erastin-induced ferroptosis by targeting ATF4 in hepatoma cells.  JOURNAL OF CELLULAR PHYSIOLOGY,  235  (7-8): (5637-5648).  [PMID:31960438] [10.1002/jcp.29496]
29. Guo Lin, Zhang Jia, Li Yuqiang, Gao Yuehong, Huang Jiali, Liu Mengru, Li Jing, Chai Wenshu, Li Yubin.  (2025)  3,3′-diindolylmethane induces ferroptosis and inhibits proliferation in non-small-cell lung cancer through the AHR/NRF2/GPX4 axis.  Discover Oncology,  16  (1): (1-18).  [PMID:40100489] [10.1007/s12672-025-02096-z]
30. Shanshan Guo, Lang Zhou, Xueqi Liu, Li Gao, Yuanyuan Li, Yonggui Wu.  (2024)  Baicalein alleviates cisplatin-induced acute kidney injury by inhibiting ALOX12-dependent ferroptosis.  PHYTOMEDICINE,  130  (155757).  [PMID:38805781] [10.1016/j.phymed.2024.155757]
31. Xiaosi Lin, Le Dong, Qing Miao, Zhaobin Huang, Fang Wang.  (2024)  Cycloheptylprodigiosin from marine bacterium Spartinivicinus ruber MCCC 1K03745T induces a novel form of cell death characterized by Golgi disruption and enhanced secretion of cathepsin D in Non-small cell lung cancer cell lines.  EUROPEAN JOURNAL OF PHARMACOLOGY,  (176608).  [PMID:38663542] [10.1016/j.ejphar.2024.176608]
32. Zi-Han Xu, Ming-Min Xie, Chun-Lan Xie, Xian-Wen Yang, Jun-Song Wang.  (2025)  Deep-Sea-Derived Isobisvertinol Targets TLR4 to Exhibit Neuroprotective Activity via Anti-Inflammatory and Ferroptosis-Inhibitory Effects.  Marine Drugs,  23  (1): (49).  [PMID:39852551] [10.3390/md23010049]
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