基本描述

别名	铁抑制剂-1 \| 3-氨基-4-(环己基氨基)苯甲酸乙酯 \| 3-氨基-4-环己基氨基苯甲酸乙酯 \| 铁抑素-1 (Fer-1)
英文别名	Ethyl 3-Amino-4-(cyclohexylamino)benzoate \| 3-Amino-4-cyclohexylaminobenzoic Acid Ethyl Ester \| Benzoic acid, 3-amino-4-(cyclohexylamino)-, ethyl ester
规格或纯度	10mM in DMSO
英文名称	Ferrostatin-1 (Fer-1)
生化机理	铁前列素-1（Fer-1）是一种强效的铁突变选择性抑制剂，EC50 为 60 nM。
储存温度	充氩,-80℃储存
运输条件	超低温冰袋运输
产品介绍	Ferrostatin-1 (Fer-1) 是一种有效的、选择性的 ferroptosis 抑制剂，抑制 Erastin 诱导的 HT-1080 细胞铁死亡 (EC50=60 nM)。Ferrostatin-1 是一种人工合成的抗氧化剂，通过还原机制来防止膜脂的损伤，从而抑制细胞死亡。Ferrostatin-1 具有抗真菌活性。 Information Ferrostatin-1 (Fer-1) Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of ferroptosis with EC50 of 60 nM. In vitro Ferrostatin-1 (2 μM) prevents erastin-induced ferroptosis in cancer cells, as well as glutamate-induced cell death in postnatal rat brain slices. Ferrostatin-1 is a lipid ROS scavenger, with the N-cyclohexyl moiety serving as a lipo-philic anchor within biological membranes. Ferrostatin-1 does not inhibit extracellular signal -regulated kinase (ERK) phos-phorylation or arrest the proliferation of HT-1080 cells, suggesting that it does not inhibit the MEK/ERK pathway, chelate iron, or inhibit protein synthesis. Ferrostatin-1 does, however, prevent erastin-induced accumulation of cytosolic and lipid ROS. Ferrostatin-1 readily oxidizes the stable radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) under cell-free conditions. In vivo Cell Data cell lines： Concentrations： Incubation Time： Powder Purity:≥99%

名称和识别符

Isomeric SMILES	CCOC(=O)C1=CC(=C(C=C1)NC2CCCCC2)N
分子量	262.35
Reaxy-Rn	9413226
Reaxys-RN link address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=9413226&ln=

化学和物理性质

敏感性	对光线敏感；对加热敏感；
熔点	106 °C

安全和危险性（GHS）

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此产品的引用文献

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引用文献

1. Xiaosi Lin , Le Dong, Qing Miao, Zhaobin Huang, Fang Wang. (2024) Cycloheptylprodigiosin from marine bacterium Spartinivicinus ruber MCCC 1K03745T induces a novel form of cell death characterized by Golgi disruption and enhanced secretion of cathepsin D in non-small cell lung cancer cell lines. European Journal of Pharmacology, 无 (974): (176608). [PMID:38663542] [10.1016/j.ejphar.2024.176608]
2. Haoze Song, Jing Liang, Yuanyuan Guo, Yang Liu, Kuiru Sa, Guohong Yan, Wen Xu, Wei Xu, Lixia Chen, Hua Li. (2024) A potent GPX4 degrader to induce ferroptosis in HT1080 cells. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 265 (116110). [PMID:38194774] [10.1016/j.ejmech.2023.116110]
3. Xi Wang, Wenjing Zhu, Miao Xing, Haiyan Zhu, Enqing Chen, Jie Zhou. (2023) Matrine disrupts Nrf2/GPX4 antioxidant system and promotes hepatocyte ferroptosis. CHEMICO-BIOLOGICAL INTERACTIONS, 384 (110713). [PMID:37716422] [10.1016/j.cbi.2023.110713]
4. Yu-Chen Chen, Qiong Zheng, Hui Lu, Yi-Xin Zhuang, Ting-Ting Gong, Lie-Feng Ma, Zha-Jun Zhan. (2023) Neuroprotective flavonoids from Epimedium brevicornu by inhibition of ferroptosis. Phytochemistry Letters, 55 (80). [10.1016/j.phytol.2023.04.003]
5. Wenhua Wang, Wenhao Wang, Shiwei Jin, Fangqin Fu, Zhengwei Huang, Ying Huang, Chuanbin Wu, Xin Pan. (2023) Open pocket and tighten holes: Inhalable lung cancer-targeted nanocomposite for enhanced ferroptosis-apoptosis synergetic therapy. CHEMICAL ENGINEERING JOURNAL, 458 (141487). [10.1016/j.cej.2023.141487]
6. Huiyi Li, Qiqing Weng, Shuai Gong, Weixian Zhang, Jiaqi Wang, Yuqiao Huang, Yuanjun Li, Jiao Guo, Tian Lan. (2023) Kaempferol prevents acetaminophen-induced liver injury by suppressing hepatocyte ferroptosis via Nrf2 pathway activation. Food & Function, 14 (4): (1884-1896). [PMID:36723004] [10.1039/D2FO02716J]
7. Mingbo Wu, Wenwu Ling, Jiaojun Wei, Ran Liao, Haiyue Sun, Dongqiu Li, Ye Zhao, Long Zhao. (2022) Biomimetic photosensitizer nanocrystals trigger enhanced ferroptosis for improving cancer treatment. JOURNAL OF CONTROLLED RELEASE, 352 (1116). [PMID:36402233] [10.1016/j.jconrel.2022.11.026]
8. Huan Huang, Yuling Chen, Na Yin, Gaojie Li, Shanshan Ye, Ling Guo, Min Feng. (2023) Unsaturated Fatty Acid Liposomes Selectively Regulate Glutathione Peroxidase 4 to Exacerbate Lipid Peroxidation as an Adaptable Liposome Platform for Anti-Tumor Therapy. MOLECULAR PHARMACEUTICS, 20 (1): (290–302). [PMID:36368878] [10.1021/acs.molpharmaceut.2c00642]
9. Li Xie, Wenjie Chen, Qifang Chen, Yang Jiang, Erqun Song, Xiaokang Zhu, Yang Song. (2022) Synergistic hydroxyl radical formation, system XC- inhibition and heat shock protein crosslinking tango in ferrotherapy: A prove-of-concept study of “sword and shield” theory. Materials Today Bio, 16 (100353). [PMID:35865409] [10.1016/j.mtbio.2022.100353]
10. Shuwei Qiao, Baosheng Li, Qing Cai, Zhen Li, Zhaoyi Yin, Jie He, Yuyang Li, Weiyan Meng. (2022) Involvement of ferroptosis in Porphyromonas gingivalis lipopolysaccharide-stimulated periodontitis in vitro and in vivo. ORAL DISEASES, [PMID:35765229] [10.1111/odi.14292]
11. Hao Chi, Guang Zhu, Yalin Yin, He Diao, Zicheng Liu, Shibo Sun, Zhaoming Guo, Weiping Xu, Jianqiang Xu, Changhao Cui, Xiao-Jin Xing, Kun Ma. (2022) Dual-Responsive multifunctional “core–shell” magnetic nanoparticles promoting Fenton reaction for tumor ferroptosis therapy. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 622 (121898). [PMID:35688287] [10.1016/j.ijpharm.2022.121898]
12. Haibao Peng, Xingcai Zhang, Peng Yang, Jiaxu Zhao, Wei Zhang, Nianping Feng, Wuli Yang, Jing Tang. (2023) Defect self-assembly of metal-organic framework triggers ferroptosis to overcome resistance. Bioactive Materials, 19 (1). [PMID:35415315] [10.1016/j.bioactmat.2021.12.018]
13. Xiazhen Bao, Xuehui Cao, Yong Yuan, Bo Zhou, Congde Huo. (2021) A water-soluble, highly sensitive and ultrafast fluorescence probe for imaging of mitochondrial hypochlorous acid. SENSORS AND ACTUATORS B-CHEMICAL, 344 (130210). [10.1016/j.snb.2021.130210]
14. Guo Lin, Zhang Jia, Li Yuqiang, Gao Yuehong, Huang Jiali, Liu Mengru, Li Jing, Chai Wenshu, Li Yubin. (2025) 3,3′-diindolylmethane induces ferroptosis and inhibits proliferation in non-small-cell lung cancer through the AHR/NRF2/GPX4 axis. Discover Oncology, 16 (1): (1-18). [PMID:40100489] [10.1007/s12672-025-02096-z]
15. Qingchen Bai, Miao Wang, Kai Wang, Jingwei Liu, Fengyu Qu, Huiming Lin. (2024) CuPc-Fe@BSA nanocomposite: Intracellular acid-sensitive aggregation for enhanced sonodynamic and chemo-therapy. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 671 (577). [PMID:38820842] [10.1016/j.jcis.2024.05.113]
16. Xinyu Zhang, Hui Liu, Chenyu Wang, Yuan Gao, Shiqi Zhao, Mengyao Mu, Ke Ren, Yufang Gong, Qing Fan, Xiao Sun. (2025) Dimeric PD-L1 specific affibody grafted Fe-based nanosheets for tumor-targeting dual-mode magnet resonance imaging and enhancement of Photothermal-Immunotherapy. CHEMICAL ENGINEERING JOURNAL, (159400). [10.1016/j.cej.2025.159400]
17. Xiaoyu Wang, Chunzhe Xu, Hantao Tian, Yu Pang, Jie Lv, Meng Li. (2025) FeS embedded bioreactor collaborate with artesunate for cascade-catalytic tumor ferroptosis. JOURNAL OF COLLOID AND INTERFACE SCIENCE, (137479). [PMID:40184656] [10.1016/j.jcis.2025.137479]
18. Yu Fu, Guiqin Huang, Yawen Cai, Menghui Ren, Run Cheng, Yuhui Chai, Yingdi Wang, Yunqi An, Tianhua Yan, Lingpeng Zhu, Xinxin Liu. (2025) Integrated network pharmacology, bioinformatics, and experiment analysis to decipher the molecular mechanism of Salidroside on Gastric cancer via targeting NCOA4-mediated ferritinophagy. CHEMICO-BIOLOGICAL INTERACTIONS, (111368). [PMID:39746501] [10.1016/j.cbi.2024.111368]
19. Xin Zheng, Xinyi Tang, Yinan Xu, Haiyan Zhu, Lianwei Zhong, Chen Chen, Jiajun Cui, Jie Zhou. (2025) Sodium aescinate induces hepatotoxicity through apoptosis and ferroptosis by inhibiting the Nrf2/CTH pathway. JOURNAL OF ETHNOPHARMACOLOGY, 345 (119608). [PMID:40064321] [10.1016/j.jep.2025.119608]
20. Lin Shuai, Cai Hui, Song Xuemei. (2024) Synergy between isobavachalcone and doxorubicin suppressed the progression of anaplastic thyroid cancer through ferroptosis activation. BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 57 (e13679). [PMID:39166605] [10.1590/1414-431X2024e13679]
21. Ningjun Shao, Kedan Cai, Yue Hong, Lingping Wu, Qun Luo. (2025) USP9X suppresses ferroptosis in diabetic kidney disease by deubiquitinating Nrf2 in vitro. RENAL FAILURE, [PMID:39967230] [10.1080/0886022X.2025.2458761]
22. Tianfeng Yang, Suyu Zhang, Kun Nie, Xiuhong Peng, Jian Huo, Xiao Fu, Yanmin Zhang. (2025) WWOX-mediated p53/SAT1 and NRF2/FPN1 axis contribute to toosendanin-induced ferroptosis in hepatocellular carcinoma. BIOCHEMICAL PHARMACOLOGY, (116790). [PMID:39894307] [10.1016/j.bcp.2025.116790]

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