| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| E425045-1ml |
1ml |
现货  |
|
| 别名 | 2-苯基-1,2-苯并异硒唑-3(2H)-酮 |
|---|---|
| 英文别名 | ebselen | 60940-34-3 | 2-Phenyl-1,2-benzisoselenazol-3(2H)-one | 2-phenylbenzo[d][1,2]selenazol-3(2H)-one | Ebselenum | 2-phenyl-1,2-benzoselenazol-3-one | SPI-1005 | Ebselene | Ebseleno | Ebselen [INN] | Ebselene [French] | Ebselenum [Latin] | Harmokisane | Ebseleno [Spanish] | C13 |
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Ebselen |
| 生化机理 | 一种具有抗氧化特性的有机硒化合物。在没有硫醇基团的情况下，它能抑制哺乳动物的脂氧合酶，还能通过与半胱氨酸残基的相互作用抑制谷胱甘肽 S 转移酶和木瓜蛋白酶。硒-有机化合物，抗氧化剂，谷胱甘肽过氧化物酶的模拟物。抑制脂氧合酶、NO 合酶、NADPH 氧化酶、蛋白激酶 C 和 H+/K(+)-ATP 酶，产生抗炎作用。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用机制 | 抗氧化剂 |
| 产品介绍 |
Ebselen is an interesting organoselenium compound displaying antiinflammatory and antioxidant properties. Ebselen is shown to inhibit the 5-lipoxygenase (5-LO) and 15-lipoxygenase (15-LO) enzymes in the absence of glutathione. Ebselen also inhibits Cox (cyclooxygenase), PKC (protein kinase C), DECR1 (NADPH), and Mox-1 (NADPH oxidase). The oxidation of low density lipoproteins by free radicals is suppressed by the antioxidant action of Ebselen. Ebselen is an inhibitor of Cox-1, Cox-2, NOS, GST and IDO. Ebselen is an interesting organoselenium compound displaying antiinflammatory and antioxidant properties. Ebselen is shown to inhibit the 5-lipoxygenase (5-LO) and 15-lipoxygenase (15-LO) enzymes in the absence of glutathione. Ebselen also inhibits Cox (cyclooxygenase), PKC (protein kinase C), DECR1 (NADPH), and Mox-1 (NADPH oxidase). The oxidation of low density lipoproteins by free radicals is suppressed by the antioxidant action of Ebselen. Ebselen is an inhibitor of Cox-1, Cox-2, NOS, GST and IDO. application： Ebselen has been used as a:voltage-dependent calcium channels (VDCCs) blocker；glutathione peroxidase mimetic to test its inhibitory effect on contraction-mediated deoxy glucose (2-DG) uptake in mouse；extensor digitorum longus (fast-twitch) muscle glucocerebrosidase inhibitor；hepatitis C virus helicase inhibitor |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | 2-phenyl-1,2-benzoselenazol-3-one |
| INCHI | 1S/C13H9NOSe/c15-13-11-8-4-5-9-12(11)16-14(13)10-6-2-1-3-7-10/h1-9H |
| InChi Key | DYEFUKCXAQOFHX-UHFFFAOYSA-N |
| Smiles | C1=CC=C(C=C1)N2C(=O)C3=CC=CC=C3[Se]2 |
| Isomeric SMILES | C1=CC=C(C=C1)N2C(=O)C3=CC=CC=C3[Se]2 |
| 分子量 | 274.18 |
| Reaxy-Rn | 164926 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=164926&ln= |
| 敏感性 | 对热敏感 |
|---|---|
| 熔点 | 183 °C |
| 分子量 | 274.190 g/mol |
| XLogP3 | |
| 氢键供体数Hydrogen Bond Donor Count | 0 |
| 氢键受体数Hydrogen Bond Acceptor Count | 1 |
| 可旋转键计数Rotatable Bond Count | 1 |
| 精确质量Exact Mass | 274.985 Da |
| 单同位素质量Monoisotopic Mass | 274.985 Da |
| 拓扑极表面积Topological Polar Surface Area | 20.300 Ų |
| 重原子数Heavy Atom Count | 16 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 275.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS06, GHS08, GHS09 |
|---|---|
| 信号词 | 危险 |
| 危险声明 |
H301: 吞咽会中毒 H331: 吸入会中毒 H373: 通过长时间或反复暴露对器官造成损害 H400: 对水生生物有剧毒 H410: 对水生生物有剧毒并具有长期持续影响 |
| 预防措施声明 |
P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P271: 仅在室外或通风良好的地方使用。 P273: 避免释放到环境中。 P321: 特殊处理（请参阅此标签上的...）。 P330: 漱口 P391: 收集溢出物 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P405: 密闭存放 P403+P233: 存放在通风良好的地方。保持容器密闭。 P501: 将内容物/容器处理到。。。 P301+P316: 如果吞咽：立即寻求紧急医疗救助。 P316: 立即寻求紧急医疗救助。 P319: 如果你感到不适，请寻求医疗帮助。 |
| WGK Germany | 3 |
| Merck Index | 3486 |
| 1. Minglu Li, Hui Han, Shengmei Song, Shaomin Shuang, Chuan Dong. (2021) AIE-based fluorescent boronate probe and its application in peroxynitrite imaging. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 261 (120044). [PMID:34118522] [10.1016/j.saa.2021.120044] |
| 2. Yiming Li, Guanhui Chen, Yi He, Xiliu Zhang, Binghui Zeng, Chao Wang, Chen Yi, Dongsheng Yu. (2019) Ebselen rescues oxidative-stress-suppressed osteogenic differentiation of bone-marrow-derived mesenchymal stem cells via an antioxidant effect and the PI3K/Akt pathway. JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, 55 (64). [PMID:31345368] [10.1016/j.jtemb.2019.06.002] |
| 3. Yongqin Fan, Junxia Feng, Xudong Yang, Ruike Chen, Dongjie Cui, Chunli Liu, Hangbo Xu, Qisen Xiang, Zhen Jiao, Ruonan Ma. (2024) Cold atmospheric plasma degradation of deoxynivalenol in solid and liquid phases and its effect on whole wheat flour quality. LWT-FOOD SCIENCE AND TECHNOLOGY, 211 (116920). [10.1016/j.lwt.2024.116920] |
| 4. Xionghua Sun, Xuelei Wan, Li Chen, Yadong Cui, Xihua Chen, Jian Zhang, Xiaogang Jiang. (2025) Mitomycin induced the senescence of alveolar epithelial cells by targeting peroxiredoxin I. BIOCHEMICAL PHARMACOLOGY, 236 (116890). [PMID:40139326] [10.1016/j.bcp.2025.116890] |
| 5. Chang Liu, Linhua Li, Li Li, Qingyin Li, Jing Liu, Chunle Zhang, Zhengjiang Cao, Liang Ma, Xiaoxi Zeng, Ping Fu. (2024) Ultrasmall Magnolol/Ebselen Nanomicelles for Preventing Renal Ischemia/Reperfusion Injury. Biomaterials Science, [PMID:39034872] [10.1039/D4BM00614C] |
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