| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| D424096-1ml |
1ml |
现货  |
|
| 别名 | 氯化二亚苯基碘鎓 | 二苯基氯化碘盐 | 二亚苯基碘鎓氯化物 |
|---|---|
| 英文别名 | 8-iodoniatricyclo[7.4.0.02,7]trideca-1(13),2,4,6,9,11-hexaene;chloride | 8-iodoniatricyclo[7.4.0.0^{2,7]trideca-1(13),2,4,6,9,11-hexaene;chloride | AKOS015903219 | EU-0100367 | DTXSID00196932 | dibenzo[b,d]iodolium chloride | Diphenyleneiodonium Chloride |
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Diphenyleneiodonium chloride |
| 生化机理 | 一种从巨噬细胞和内皮细胞中提取的一氧化氮合成酶的有效且可逆的抑制剂。也抑制其他黄酮酶，如中性粒细胞NADPH氧化酶.强大的NO合酶，NADPH氧化酶和NADPH细胞色素P450氧化还原酶抑制剂（IC 50 = 30 nM，不产生NO）。抑制时钟和DNA修复基因的光依赖性诱导。在体内抑制血小板聚集。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 激动剂 |
| 作用机制 | GPR3 激动剂 |
| 产品介绍 |
有效并具可逆性的氧化氮合成酶抑制剂，来自于巨噬细胞和内皮细胞。该抑制剂也抑制其它的黄素酶（flavoenzymes）， 如中性粒细胞NADPH氧化酶。 Diphenyleneiodonium chloride (DPI) is an inhibitor of NADPH oxidase and also a potent, irreversible, and time-, temperature-dependent iNOS/eNOS inhibitor. Diphenyleneiodonium chloride (DPI) also functions as a TRPA1 activator and selectively inhibits intracellular reactive oxygen species (ROS). Diphenyleneiodonium chloride (DPI) is an inhibitor of NADPH oxidase and also a potent, irreversible, and time-, temperature-dependent iNOS/eNOS inhibitor. Diphenyleneiodonium chloride (DPI) also functions as a TRPA1 activator and selectively inhibits intracellular reactive oxygen species (ROS). |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| EC号 | MFCD00214165 |
|---|---|
| 分子类型 | 小分子 |
| IIUPAC Name | 8-iodoniatricyclo[7.4.0.02,7]trideca-1(13),2,4,6,9,11-hexaene;chloride |
| INCHI | 1S/C12H8I.ClH/c1-3-7-11-9(5-1)10-6-2-4-8-12(10)13-11;/h1-8H;1H/q+1;/p-1 |
| InChi Key | FCFZKAVCDNTYID-UHFFFAOYSA-M |
| Smiles | C1=CC=C2C(=C1)C3=CC=CC=C3[I+]2.[Cl-] |
| Isomeric SMILES | C1=CC=C2C(=C1)C3=CC=CC=C3[I+]2.[Cl-] |
| PubChem CID | 2733504 |
| 分子量 | 314.55 |
| 熔点 | 312-322°C |
|---|---|
| 分子量 | 314.550 g/mol |
| XLogP3 | |
| 氢键供体数Hydrogen Bond Donor Count | 0 |
| 氢键受体数Hydrogen Bond Acceptor Count | 1 |
| 可旋转键计数Rotatable Bond Count | 0 |
| 精确质量Exact Mass | 313.936 Da |
| 单同位素质量Monoisotopic Mass | 313.936 Da |
| 拓扑极表面积Topological Polar Surface Area | 0.000 Ų |
| 重原子数Heavy Atom Count | 14 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 170.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 2 |
| 象形图 | GHS07 |
|---|---|
| 信号词 | 警告 |
| 危险声明 |
H361: 怀疑破坏生育力或未出生的孩子 |
| 预防措施声明 |
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 |
| WGK Germany | 3 |
| 个人防护装备 | Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter |
| 1. Denan Mu, Jinfeng Xing. (2023) The preparation of double network hydrogel with high mechanical properties by photopolymerization under the green LED irradiation and enhancement of wet adhesion by tannic acid. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 671 (131656). [10.1016/j.colsurfa.2023.131656] |
| 2. Shujie Liu, Zhen Wang, Jinfeng Xing. (2022) A tunable multifunctional hydrogel with balanced adhesion, toughness and self-healing ability prepared by photopolymerization under green LED irradiation for wound dressing. EUROPEAN POLYMER JOURNAL, 168 (111119). [10.1016/j.eurpolymj.2022.111119] |
| 3. Shuang Guo, Yue Ma, Hao Liang, Xiaoyan Zhao, Dan Wang. (2021) The effect of diphenyliodonium iodide treatment on bisdemethoxycurcumin accumulation in fresh-cut yam. INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 57 (1): (566-575). [10.1111/ijfs.15452] |
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