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多烯紫杉醇, 微管蛋白 beta I 类抑制剂

强大的细胞毒剂
51篇引用文献 COA COA
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货号 (SKU) 包装规格 是否现货 价格 数量
D107320-10mg
 10mg 现货 Stock Image
D107320-20mg
 20mg 现货 Stock Image
D107320-50mg
 50mg 现货 Stock Image
D107320-100mg
 100mg 现货 Stock Image
D107320-250mg
 250mg 现货 Stock Image
D107320-500mg
 500mg 现货 Stock Image
D107320-1g
 1g 现货 Stock Image
D107320-5g
 5g 现货 Stock Image
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Apoptosis (7108) Cell Cycle (7376) Cell Cycle/DNA Damage (2603) Cytoskeleton (497) Endogenous Metabolite (978) Metabolic Enzyme/Protease (4889) Microtubule/Tubulin (197) tubulin beta class I Inhibitor (5) 代谢物 (8911)
main product photo

基本描述

别名 多西他赛
英文别名 Docetaxel [INN] | D07866 | NSC 759850 | Lead di(acetate) | NCGC00242509-01 | DOCETAXEL MYLAN | Ethanol, 2,2'-iminodi-, 3,5-diiodo-4-oxo-1(4H)-pyridineacetate (salt) | KS-1452 | NCGC00181306-01 | DB12492 | Docetaxel anhydrous | Docetaxol | EmDOC | Q-100074
规格或纯度 Moligand™, ≥98%
英文名称 Docetaxel
生化机理 多西紫杉醇是与紫杉醇有关联的紫杉烷的抗癌剂。它结合并稳定微管的β-微管蛋白亚基，阻止导致细胞周期阻滞和凋亡的有丝分裂纺锤体的解聚.体外有效的细胞毒性剂（IC 50 = 2 nM）。破坏微管装配并在G 2 / M期阻止细胞分裂。诱导细胞凋亡。抗肿瘤剂。在体内和体外具有活性。
应用 多西紫杉醇可用于研究抗生素，细胞生物学，细胞信号传导，神经科学,细胞凋亡和细胞周期。
储存温度 2-8°C储存
运输条件 冰袋运输
作用类型 抑制剂
作用机制 微管蛋白 beta I 类抑制剂
备注 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍

Docetaxel(Taxotere), an analog of taxol, is an inhibitor of depolymerisation of microtubules throμgh binding to stabilized microtubules.多西紫杉醇可用于研究抗生素，细胞生物学，细胞信号传导，神经科学,细胞凋亡和细胞周期。

Docetaxel(Taxotere), an analog of taxol, is an inhibitor of depolymerisation of microtubules through binding to stabilized microtubules.
Docetaxel can be used to study antibiotics, cell biology, cell signaling, neuroscience and apoptosis and the cell cycle.
纯度 ≥98%

关联靶点（人）

TUBB Tclin 微管蛋白β链(Tubulin beta chain) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
ESR1 Tclin Estrogen receptor alpha (17718 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NR3C1 Tclin Glucocorticoid receptor (14987 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PGR Tclin Progesterone receptor (8562 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRB2 Tclin Beta-2 adrenergic receptor (11824 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRB1 Tclin Beta-1 adrenergic receptor (6630 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AR Tclin Androgen Receptor (11781 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DRD2 Tclin Dopamine D2 receptor (23596 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GABRA1 Tclin GABA receptor alpha-1 subunit (399 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CNR1 Tclin Cannabinoid CB1 receptor (20913 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HRH2 Tclin Histamine H2 receptor (5428 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR2C Tclin Serotonin 2c (5-HT2c) receptor (11471 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AVPR2 Tclin Vasopressin V2 receptor (2912 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADORA1 Tclin Adenosine A1 receptor (17603 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AGTR1 Tclin Type-1 angiotensin II receptor (5176 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PTGS2 Tclin Cyclooxygenase-2 (13999 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HRH1 Tclin Histamine H1 receptor (7573 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AVPR1A Tclin Vasopressin V1a receptor (5412 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
OPRD1 Tclin Delta opioid receptor (15096 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
OPRK1 Tclin Kappa opioid receptor (16155 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR3A Tclin Serotonin 3a (5-HT3a) receptor (3366 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GRIN1 Tclin Glutamate (NMDA) receptor subunit zeta 1 (122 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
KCNH2 Tclin HERG (29587 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CACNA1C Tclin Voltage-gated L-type calcium channel alpha-1C subunit (766 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PDE3A Tclin Phosphodiesterase 3A (3309 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC29A1 Tclin Equilibrative nucleoside transporter 1 (1711 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRA2B Tclin Alpha-2b adrenergic receptor (4412 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRA2C Tclin Alpha-2c adrenergic receptor (4876 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CHRM3 Tclin Muscarinic acetylcholine receptor M3 (7750 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TBXA2R Tclin Thromboxane A2 receptor (5717 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADORA2A Tclin Adenosine A2a receptor (16305 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADORA3 Tchem Adenosine A3 receptor (15931 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
BDKRB2 Tclin Bradykinin B2 receptor (3970 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HRH3 Tclin Histamine H3 receptor (10389 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CHRNA4 Tclin Neuronal acetylcholine receptor protein alpha-4 subunit (1265 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MC3R Tchem Melanocortin receptor 3 (5659 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

Mc4r Melanocortin receptor 4 (1205 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Npy1r Neuropeptide Y receptor type 1 (8 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Cckar Cholecystokinin A receptor (90 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Pde4d Phosphodiesterase 4D (4 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mapk1 MAP kinase ERK2 (650 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mus musculus (284745 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Vero (26788 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
4T1 (1737 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Plasma (328 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TUBB2B Tubulin (2175 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Liver microsome (341 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

PubChem SID 504757314
分子类型 小分子
IIUPAC Name [(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-acetyloxy-1,9,12-trihydroxy-15-[(2R,3S)-2-hydroxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoyl]oxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate
INCHI 1S/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,52)/t26-,27-,28+,30-,31+,32+,33-,35-,41+,42-,43+/m0/s1
InChi Key ZDZOTLJHXYCWBA-VCVYQWHSSA-N
Smiles CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O
Isomeric SMILES CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O
分子量 807.88
Reaxy-Rn 24720578
Reaxys-RN link address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24720578&ln=

化学和物理性质

密度 1.37
熔点 186-191°C
分子量 807.900 g/mol
XLogP3 1.600
氢键供体数Hydrogen Bond Donor Count 5
氢键受体数Hydrogen Bond Acceptor Count 14
可旋转键计数Rotatable Bond Count 13
精确质量Exact Mass 807.347 Da
单同位素质量Monoisotopic Mass 807.347 Da
拓扑极表面积Topological Polar Surface Area 224.000 Ų
重原子数Heavy Atom Count 58
形式电荷Formal Charge 0
复杂度Complexity 1660.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 11
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

象形图 GHS07,   GHS08
信号词 Danger
WGK Germany 3
RTECS DA4172750
个人防护装备 Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

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批号(Lot Number) 证书类型 货号
C2205397 分析证书 D107320
C2205403 分析证书 D107320
F1828013 分析证书 D107320
I2306353 分析证书 D107320
I2306354 分析证书 D107320
I2306355 分析证书 D107320
I2306356 分析证书 D107320
I2306357 分析证书 D107320
I2306381 分析证书 D107320
I2306403 分析证书 D107320
I2306404 分析证书 D107320
H2409335 分析证书 D107320
H2409336 分析证书 D107320
B2506088 分析证书 D107320
K2111810 分析证书 D107320
C2205575 分析证书 D107320
I2304603 分析证书 D107320
I2306352 分析证书 D107320
I2306402 分析证书 D107320
I2306382 分析证书 D107320
D2525054 分析证书 D107320
I1924081 分析证书 D107320
B2306919 分析证书 D107320
D2122188 分析证书 D107320
I2219402 分析证书 D107320
G2227730 分析证书 D107320
K1820062 分析证书 D107320
K1820061 分析证书 D107320
B2306918 分析证书 D107320
C2205402 分析证书 D107320
C2205404 分析证书 D107320
D2313829 分析证书 D107320

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技术文档和文章

紫杉醇（Paclitaxel）
Categories: 技术文章
探索主题:
治疗肿瘤 抗癌化合物
Paclitaxel
Categories: 技术文章
探索主题:
treat tumors Anticancer Compound

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引用文献

1. Purba TS et al..  (2019)  CDK4/6 inhibition mitigates stem cell damage in a novel model for taxane-induced alopecia..  EMBO Mol Med,  11  (10): (e11031).  [PMID:31512803]
2. Zeng J et al..  (2018)  PrLZ increases prostate cancer docetaxel resistance by inhibiting LKB1/AMPK-mediated autophagy..  Theranostics,  8  (109-123).  [PMID:29290796]
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6. Zhuang Yu, Wang Yuxiao, Li Ning, Meng Haitao, Li Zhiyu, Luo Jianguang, Qiu Zhixia.  (2023)  Hydrolytic Metabolism of Withangulatin A Mediated by Serum Albumin Instead of Common Esterases in Plasma.  EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS,  48  (4): (363-376).  [PMID:37344636] [10.1007/s13318-023-00834-8]
7. Jiawei Li, Chunmei Fan, Zhongyang Lv, Ziying Sun, Jie Han, Maochun Wang, Huiming Jiang, Kuoyang Sun, Guihua Tan, Hu Guo, Anlong Liu, Heng Sun, Xingquan Xu, Rui Wu, Wenjin Yan, Qing Jiang, Shiro Ikegawa, Xiao Chen, Dongquan Shi.  (2023)  Microtubule stabilization targeting regenerative chondrocyte cluster for cartilage regeneration.  Theranostics,  13  (10): ( 3480–3496).  [PMID:37351173] [10.7150/thno.85077]
8. Rengui Xu, Honglian Guo, Xiuli Chen, Jiarong Xu, Yusheng Gong, Peng Cao, Chunyu Wei, Fei Xiao, Di Wu, Wei Chen, Lin Wang, Zheng Wang.  (2023)  Smart hydrothermally responsive microneedle for topical tumor treatment.  JOURNAL OF CONTROLLED RELEASE,  358  (566).  [PMID:37182803] [10.1016/j.jconrel.2023.05.008]
9. Qinhui Ren, Yufu Ma, Fuhua Wei, Lan Qin, Hongliang Chen, Zhao Liang, Siyuan Wang.  (2023)  Preparation of Zr-MOFs for the adsorption of doxycycline hydrochloride from wastewater.  Green Processing and Synthesis,  12  (1): [10.1515/gps-2022-8127]
10. Tan Hu, Yang Xu, Gang Xu.  (2023)  Dipeptide-polysaccharides hydrogels through co-assembly.  FOOD CHEMISTRY,  422  (136272).  [PMID:37141751] [10.1016/j.foodchem.2023.136272]
11. Fang Fang, Shaohua Zhang, Chaofan Chen, Xueying Wang, Chuannan Luo, Qin Wei.  (2023)  A fluorescent nanoprobe based on N/S co-doped carbon dots coupled with molecularly imprinted polymers for the detection of curcumin.  OPTICAL MATERIALS,  139  (113800).  [10.1016/j.optmat.2023.113800]
12. Zhen Yu, Xundou Li, Jinhong Duan, Xian-Da Yang.  (2023)  Targeted Treatment of Colon Cancer with Aptamer-Guided Albumin Nanoparticles Loaded with Docetaxel.  International Journal of Nanomedicine,  [PMID:32982230] [10.2147/IJN.S267177]
13. Tong Le, Zhou ZeYang, Wang Gang, Wu Chao.  (2023)  A self-microemulsion enhances oral absorption of docetaxel by inhibiting P-glycoprotein and CYP metabolism.  Drug Delivery and Translational Research,  13  (4): (983-993).  [PMID:36515864] [10.1007/s13346-022-01255-x]
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