| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| C425287-1ml |
1ml |
现货  |
|
| 别名 | 秋水仙素 |
|---|---|
| 英文别名 | COLBENEMID COMPONENT COLCHICINE | Colchicin | COLCHICINE [MI] | EINECS 200-598-5 | HSDB 3044 | COLCHICINE [HSDB] | COLCIGEL | 7JX9WZ3SJ5 | COLCHICINE [EP IMPURITY] | Colchicine Tablets 0.5 mg | Condylon | Kolkicin | N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]h |
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Colchicine |
| 生化机理 | 秋水仙碱是一种微管蛋白抑制剂，通过与微管蛋白结合（IC50 = 3.2 μM）可阻断微管的聚合。研究表明，秋水仙碱还能通过作用于组织纤溶酶原激活剂（tPA）和破坏细胞的细胞骨架来导致细胞凋亡。还有报告称，细胞暴露于秋水仙碱会导致细胞中 Ca2+ 浓度的改变，这也可能导致细胞凋亡。由于有丝分裂的速度加快与癌细胞增殖有关，用秋水仙碱阻断微管功能已被用作抗癌治疗的一种方法。例如，秋水仙碱可阻断 MCF-7 人类乳腺癌细胞的生长，其 IC50 值为 13 nM。秋水仙碱通过抑制中性粒细胞的运动和活性（在痛风性关节炎小鼠模型中为 5 μmol/kg）产生抗炎作用，并抑制尿酸沉积，这是治疗痛风的一个关键方面。 |
| 储存温度 | 避光,-80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 作用机制 | 含溴结构域 4 的抑制剂;甘氨酸受体 α1 亚基拮抗剂;甘氨酸受体 α2 亚基拮抗剂;TAS2R46 的激动剂;TAS2R4 的激动剂;微管蛋白 beta I 类的抑制剂 |
| 产品介绍 |
遇光变暗。易溶于乙醇、氯仿，溶于水、乙醚、苯，不溶于石油醚；溶解度:45g/L (20°C)、1g/220ml 乙醚、1g/100ml 苯。pK（20℃）=12.35，pH值5.9。因其氮原子在侧链上是酰胺结构，故不呈碱性。 Colchicine, a tubulin Inhibitor, has been shown to block polymerization of microtubules by binding to tubulin. Studies indicate that this reagent also causes apoptosis of cells by acting on tissue plasminogen activators (tPA) and disrupting the cytoskeleton of cells. Exposure of cells to Colchicine has also been reported to result in alterations of Ca2+ concentrations in cells which may also result in apoptosis. |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| EC号 | 200-598-5 |
|---|---|
| 分子类型 | 小分子 |
| IIUPAC Name | N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide |
| INCHI | 1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1 |
| InChi Key | IAKHMKGGTNLKSZ-INIZCTEOSA-N |
| Smiles | CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC |
| Isomeric SMILES | CC(=O)N[C@H]1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC |
| UN Number | 1544 |
| Packing Group | I |
| 分子量 | 399.44 |
| Beilstein号 | 2228813 |
| Reaxy-Rn | 2228812 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2228812&ln= |
| 敏感性 | 对光敏感 |
|---|---|
| 比旋光度 | -238° (C=1,EtOH) |
| 熔点 | 150-160°C |
| 分子量 | 399.400 g/mol |
| XLogP3 | 1.000 |
| 氢键供体数Hydrogen Bond Donor Count | 1 |
| 氢键受体数Hydrogen Bond Acceptor Count | 6 |
| 可旋转键计数Rotatable Bond Count | 5 |
| 精确质量Exact Mass | 399.168 Da |
| 单同位素质量Monoisotopic Mass | 399.168 Da |
| 拓扑极表面积Topological Polar Surface Area | 83.100 Ų |
| 重原子数Heavy Atom Count | 29 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 740.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 1 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS06, GHS08 |
|---|---|
| 信号词 | 危险 |
| 危险声明 |
H300: 吞咽致命 H340: 可能导致遗传缺陷 |
| 预防措施声明 |
P201: 使用前获取特殊说明 P202: 在阅读并理解所有安全预防措施之前，不要进行操作。 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P330: 漱口 P301+P310: 如误吞咽：立即呼叫急救中心/医生。 P308+P313: 如接触到或有疑虑：求医/就诊。 P501: 将内容物/容器处理到。。。 |
| WGK Germany | 3 |
| RTECS | GH0700000 |
| Class | 6.1 |
| Merck Index | 2471 |
| 个人防护装备 | Eyeshields,Faceshields,full-face particle respirator type N100 (US),Gloves,respirator cartridge type N100 (US),type P1 (EN143) respirator filter,type P3 (EN 143) respirator cartridges |
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