This is a demo store. No orders will be fulfilled.

首页   400-620-6333
  • 登录
  • 注册
  • 英文站
切换导航
我的购物车
搜索
高级搜索
菜单
登录
设置
྾

盐酸氯丙嗪（CPZ）

62篇引用文献 COA COA
有货

库存信息

关闭

库存信息

关闭

库存信息

关闭

库存信息

关闭
货号 (SKU) 包装规格 是否现货 价格 数量
C131611-1g
 1g 现货 Stock Image
C131611-5g
 5g 现货 Stock Image
C131611-25g
 25g 现货 Stock Image
C131611-100g
 100g 现货 Stock Image
大包装询价 收藏夹 比较  SDS下载  DATASHEET  质量标准
查看相关系列
Autophagy (2848) Class A GPCR (8201) 六元杂环化合物 (1701) 脂质代谢 (4331) 药物成分 (367)
main product photo

基本描述

别名 氯普马嗪 | 氯丙嗪盐酸盐 | 2-氯-10-[3-(二甲氨基)-1-丙基]吩噻嗪盐酸盐 | 氯丙嗪 盐酸盐 | 2-氯-10-(3-二甲氨基丙基)吩噻嗪 盐酸盐 | Chlorpromazine 盐酸盐
英文别名 CPZ | Chlorpromazine.HCl | Largaktyl | Marazine | NC00552 | Chloropromazine monohydrochloride | Chlorpromazin-d6 hydrochloride | NSC 17479 | DTXSID7024827 | HY-B0407A | Tranzine | UNII-9WP59609J6 | AMINAZIN HYDROCHLORIDE | CCRIS 6221 | Klorpromex | Plegom
规格或纯度 Moligand™, ≥98%(HPLC)
英文名称 Chlorpromazine hydrochloride（CPZ）
生化机理 吩噻嗪类抗精神病药;D2 多巴胺受体拮抗剂，H1 组胺受体拮抗剂;抑制钙调蛋白依赖性环核苷酸磷酸二酯?酶和一氧化氮合成酶的活化。氯丙嗪表现出对白血病细胞的细胞毒性和抗增殖活性，但?是不会影响正常淋巴细胞的活力。
应用 在血红蛋白和过氧化物酶的微量测定中替代联苯胺、邻联?茴香胺和邻联甲苯胺。
储存温度 避光,室温
运输条件 常规运输
产品介绍

盐酸氯丙嗪是一种口服有效的、可透过血脑屏障的抗精神病剂，能有效拮抗 D2 多巴胺受体和 5-HT2A，已广泛用于精神分裂症和其他精神疾病。盐酸氯丙嗪可通过多种途径发挥抗癌活性，包括抗增殖、诱导自噬和周期停滞 (G2-M 期)、抑制细胞色素 c 氧化酶 (CcO)、抑制肿瘤生长和转移以及抑制肿瘤免疫逃逸等。盐酸氯丙嗪还能阻断 hNav1.7 通道 (IC50=25.9 μM; 浓度依赖的方式) 和 HERG 钾通道 (IC50=21.6 μM) ，其在止痛以及心律失常方面也具有较好的研究潜力。盐酸氯丙嗪也能抑制网格蛋白介导的内吞作用。

Chlorpromazine hydrochloride is an orally active, blood-brain barrier-transparent antipsychotic agent that effectively antagonises D2 dopamine receptors and 5-HT2A, which is widely used in schizophrenia and other psychiatric disorders. Chlorpromazine hydrochloride exerts anti-cancer activity through a variety of pathways, including anti-proliferation, induction of autophagy and cycle arrest (G2-M phase), inhibition of cytochrome c oxidase (CcO), inhibition of tumour growth and metastasis, and inhibition of tumour immune escape. Chlorpromazine hydrochloride also blocks hNav1.7 channels (IC50=25.9 μM; concentration-dependent) and HERG potassium channels (IC50=21.6 μM), which has potential for analgesic and cardiac arrhythmic studies. Chlorpromazine hydrochloride also can inhibit clathrin-mediated endocytosis。
纯度 ≥98%(HPLC)

关联靶点（人）

CYP2D6 Tclin 细胞色素 P450 2D6(Cytochrome P450 2D6) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
DRD2 Tclin D（2）多巴胺受体(D(2) dopamine receptor) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
ABL1 Tclin Tyrosine-protein kinase ABL (18331 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DRD2 Tclin Dopamine D2 receptor (23596 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR2C Tclin Serotonin 2c (5-HT2c) receptor (11471 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
KCNH2 Tclin HERG (29587 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GSK3B Tclin Glycogen synthase kinase-3 beta (11785 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
POLB Tchem DNA polymerase beta (23632 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CSNK1D Tchem Casein kinase I delta (4546 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GBA1 Tclin Beta-glucocerebrosidase (14647 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ALOX15B Tchem Arachidonate 15-lipoxygenase, type II (7244 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GAA Tclin Lysosomal alpha-glucosidase (35701 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NR1H4 Tclin Bile acid receptor FXR (6228 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NFKB1 Tclin Nuclear factor NF-kappa-B p105 subunit (1459 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CDK2 Tchem Cyclin-dependent kinase 2 (9050 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GLP1R Tclin Glucagon-like peptide 1 receptor (111429 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PIN1 Tchem Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (36611 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AURKA Tchem Serine/threonine-protein kinase Aurora-A (10240 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
U2OS (164939 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HEK293 (82097 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HepG2 (196354 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
FEN1 Tchem Flap endonuclease 1 (12055 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
POLH Tchem DNA polymerase eta (21678 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
KDM4A Tchem Lysine-specific demethylase 4A (52245 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
BRD4 Tchem Bromodomain-containing protein 4 (13122 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
KDM4E Tchem Lysine-specific demethylase 4D-like (40243 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SMN1 Tchem Survival motor neuron protein (34246 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
LMNA Tbio Prelamin-A/C (36751 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SMAD3 Tchem Mothers against decapentaplegic homolog 3 (68039 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GMNN Tbio Geminin (128009 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PMP22 Tbio Peripheral myelin protein 22 (699 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GFER Tchem FAD-linked sulfhydryl oxidase ALR (1466 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CBX1 Tbio Chromobox protein homolog 1 (92434 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MPHOSPH8 Tbio M-phase phosphoprotein 8 (656 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
BAZ2B Tchem Bromodomain adjacent to zinc finger domain protein 2B (56204 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ATXN2 Tbio Ataxin-2 (54410 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic (40980 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GLS Tchem Glutaminase kidney isoform, mitochondrial (16997 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
RAD52 Tchem DNA repair protein RAD52 homolog (856 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

Cruzipain (33337 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mapk1 MAP kinase ERK2 (650 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Fgfr3 Fibroblast growth factor receptor 3 (21 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Pseudomonas aeruginosa (123386 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Klebsiella pneumoniae (43867 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Staphylococcus aureus (210822 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Acinetobacter baumannii (41033 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Escherichia coli (133304 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mycobacterium tuberculosis (203094 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Plasmodium falciparum (966862 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Cryptococcus neoformans (21258 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Candida albicans (78123 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mus musculus (284745 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NIH3T3 (5395 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Npsr1 Neuropeptide S receptor (260 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Plasma (328 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mapt Microtubule-associated protein tau (6 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
fba Putative fructose-1,6-bisphosphate aldolase (15559 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Impa1 Inositol monophosphatase 1 (16203 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ffp 4'-phosphopantetheinyl transferase ffp (24982 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
nfo Endonuclease 4 (425 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Nr1i2 Nuclear receptor subfamily 1 group I member 2 (14 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SARS-CoV (424 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Vero C1008 (1716 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

PubChem SID 504751036
EC号 200-701-3
分子类型 小分子
IIUPAC Name 3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine;hydrochloride
INCHI 1S/C17H19ClN2S.ClH/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H
InChi Key FBSMERQALIEGJT-UHFFFAOYSA-N
Smiles CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl.Cl
Isomeric SMILES CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl.Cl
关联CAS 50-53-3
PubChem CID 6240
UN Number 2811
Packing Group I
分子量 355.33
Beilstein号 3779989
Reaxy-Rn 3779989

化学和物理性质

溶解性 DMSO 71 mg/mL Water 71 mg/mL Ethanol 71 mg/mL
敏感性 对光及湿度敏感
熔点 196°C
分子量 355.300 g/mol
XLogP3
氢键供体数Hydrogen Bond Donor Count 1
氢键受体数Hydrogen Bond Acceptor Count 3
可旋转键计数Rotatable Bond Count 4
精确质量Exact Mass 354.072 Da
单同位素质量Monoisotopic Mass 354.072 Da
拓扑极表面积Topological Polar Surface Area 31.800 Ų
重原子数Heavy Atom Count 22
形式电荷Formal Charge 0
复杂度Complexity 339.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 0
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 2

安全和危险性（GHS）

象形图 GHS06
信号词 危险
WGK Germany 3
RTECS SO1750000
Class 6.1
Merck Index 2185
个人防护装备 Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到19个结果

批号(Lot Number) 证书类型 货号
H2513314 分析证书 C131611
H2513315 分析证书 C131611
H2513316 分析证书 C131611
H2513317 分析证书 C131611
D2508776 分析证书 C131611
E2515222 分析证书 C131611
E2515221 分析证书 C131611
E2529032 分析证书 C131611
H2217182 分析证书 C131611
H2217183 分析证书 C131611
H2217184 分析证书 C131611
H2217185 分析证书 C131611
D2313858 分析证书 C131611
H2303086 分析证书 C131611
I2402450 分析证书 C131611
J2422033 分析证书 C131611
B2525061 分析证书 C131611
K2415464 分析证书 C131611
E2529034 分析证书 C131611

显示更多⌵

此产品的引用文献

如何在您的发表作品中引用阿拉丁的产品和网站? 引用文献检索

引用文献

1. Li Meng, Panpan Zhao, Yucheng Jiang, Jiawen You, Zhiyan Xu, Kui Yu, Aldo R. Boccaccini, Kai Zheng, Junqing Ma.  (2023)  Extracellular and intracellular effects of bioactive glass nanoparticles on osteogenic differentiation of bone marrow mesenchymal stem cells and bone regeneration in zebrafish osteoporosis model.  Acta Biomaterialia,  [PMID:38040077] [10.1016/j.actbio.2023.11.037]
2. Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia.  (2024)  Lipid-like gemcitabine diester-loaded liposomes for improved chemotherapy of pancreatic cancer.  JOURNAL OF CONTROLLED RELEASE,  365  (112).  [PMID:37981050] [10.1016/j.jconrel.2023.11.028]
3. Tao Wanjun, Xie Pei, Huang Chengyuan, Wang Ying, Huang Yu, Yin Zongning.  (2023)  Construction of PLGA nanoparticles modified with RWrNM and DLPC and their application in acute rhinosinusitis.  Drug Delivery and Translational Research,  (1-14).  [PMID:37966678] [10.1007/s13346-023-01450-4]
4. Xiaowei Wang, Mengyan Wang, Meilian Cai, Rongguang Shao, Guimin Xia, Wuli Zhao.  (2023)  Miriplatin-loaded liposome, as a novel mitophagy inducer, suppresses pancreatic cancer proliferation through blocking POLG and TFAM-mediated mtDNA replication.  Acta Pharmaceutica Sinica B,  [PMID:37969736] [10.1016/j.apsb.2023.07.009]
5. Jinhui Lu, Xiaomeng Zhu, Meng Zhang, Xunchan Jiang, Wei Guo, Feng Jiang, Feng Cao.  (2023)  In vitro and in vivo assessment of structural integrity for HPCD complex@Liposome nanocomposites from ocular surface to the posterior segment of the eye.  CARBOHYDRATE POLYMERS,  315  (120960).  [PMID:37230631] [10.1016/j.carbpol.2023.120960]
6. Chang Ni, Zijun Zhang, Yuling Wang, Zhenhai Zhang, Xueping Guo, Huixia Lv.  (2023)  Hyaluronic acid and HA-modified cationic liposomes for promoting skin penetration and retention.  JOURNAL OF CONTROLLED RELEASE,  357  (432).  [PMID:37004799] [10.1016/j.jconrel.2023.03.049]
7. Fulong Man, Yinqian Yang, Haisheng He, Jianping Qi, Wei Wu, Yi Lu.  (2023)  Establishment of In Vitro Dissolution Based on Similarity with In Vivo Dissolution: A Case Study on Aripiprazole.  MOLECULAR PHARMACEUTICS,  20  (5): (2579–2588).  [PMID:37046179] [10.1021/acs.molpharmaceut.3c00014]
8. Shengnan Ma, Lei Song, Yueyue Bai, Shihao Wang, Jiao Wang, Haohao Zhang, Fazhan Wang, Yiyan He, Chuntao Tian, Guijun Qin.  (2023)  Improved intracellular delivery of exosomes by surface modification with fluorinated peptide dendrimers for promoting angiogenesis and migration of HUVECs.  RSC Advances,  13  (17): (11269-11277).  [PMID:37057265] [10.1039/D3RA00300K]
9. Honghui Wu, Xinchi Jiang, Yaosheng Li, Yunfei Dong, Juanjuan Zheng, Lu Li, Ying Li, Jinqiang Wang, Xianming Lin, Xiangnan Zhang, Tianyuan Zhang, Zhen Gu, Jianqing Gao.  (2023)  Hybrid stem cell-derived bioresponsive vesicles for effective inflamed blood-brain barrier targeting delivery.  Nano Today,  49  (101800).  [10.1016/j.nantod.2023.101800]
10. Liping Zhang, Yuan Xu, Wenjuan Cao, Shibao Xie, Lu Wen, Gang Chen.  (2023)  Understanding the translocation mechanism of PLGA nanoparticles across round window membrane into the inner ear: a guideline for inner ear drug delivery based on nanomedicine.  International Journal of Nanomedicine,  [PMID:29403277] [10.2147/IJN.S154968]
11. Lan Tang, Kaijuan Huang, Wenhui Jiang, Lulu Fu, Ran Zhang, Liting Shen, Zhimin Ou, Ye Huang, Zhenhai Zhang.  (2023)  Exploration of the inhibition action of TPGS on tumor cells and its combined use with chemotherapy drugs.  DRUG DELIVERY,  30  (1): (2183830).  [PMID:36852689] [10.1080/10717544.2023.2183830]
12. Yuan Gao, Yingxi Zhang, Hong Xia, Yuqing Ren, Haibin Zhang, Siwen Huang, Meiju Li, Yongjun Wang, Heran Li, Hongzhuo Liu.  (2023)  Biomimetic virus-like mesoporous silica nanoparticles improved cellular internalization for co-delivery of antigen and agonist to enhance Tumor immunotherapy.  DRUG DELIVERY,  30  (1): (2183814).  [PMID:36843529] [10.1080/10717544.2023.2183814]
13. Zhong Wenzhao, Guo Feng, Chen Fangman, Law Man-Kay, Lu Jun, Shao Dan, Yu Hua, Chan Ging, Chen Meiwan.  (2022)  A multifunctional oxidative stress nanoamplifier with ROS amplification and GSH exhaustion for enhanced chemodynamic therapy.  Frontiers in Pharmacology,  13  [PMID:36438812] [10.3389/fphar.2022.1044083]
14. Guo Yuxin, Wang Shao-Zhe, Zhang Xinping, Jia Hao-Ran, Zhu Ya-Xuan, Zhang Xiaodong, Gao Ge, Jiang Yao-Wen, Li Chengcheng, Chen Xiaokai, Wu Shun-Yu, Liu Yi, Wu Fu-Gen.  (2022)  In situ generation of micrometer-sized tumor cell-derived vesicles as autologous cancer vaccines for boosting systemic immune responses.  Nature Communications,  13  (1): (1-20).  [PMID:36319625] [10.1038/s41467-022-33831-7]
15. Zhimei Wang, Yuehuan Zhang, Qing Chen, Xin Xiao, Carl Redshaw.  (2023)  Preparation of pelargonic acid vesicles and sustained drug release.  Canadian Journal of Chemistry,  101  (2): [10.1139/cjc-2022-0075]
16. Yuhan Yang, Yangyi Chen, Dianpeng Li, Shiyuan Lin, Hui Chen, Wei Wu, Wei Zhang.  (2023)  Linolenic acid conjugated chitosan micelles for improving the oral absorption of doxorubicin via fatty acid transporter.  CARBOHYDRATE POLYMERS,  300  (120233).  [PMID:36372473] [10.1016/j.carbpol.2022.120233]
17. Yanyan Wang, Hai Gao, Xinya Huang, Zhaoan Chen, Pengyu Kang, Yunyi Zhou, Danhua Qin, Wenli Zhang, Jianping Liu.  (2022)  Cyclodextrin boostered-high density lipoprotein for antiatherosclerosis by regulating cholesterol efflux and efferocytosis.  CARBOHYDRATE POLYMERS,  292  (119632).  [PMID:35725197] [10.1016/j.carbpol.2022.119632]
18. Mingming Song, Shuqi Dong, Xiaofei An, Wenxiang Zhang, Ning Shen, Yanbo Li, Caixia Guo, Chang Liu, Xiao Li, Siyu Chen.  (2022)  Erythrocyte-biomimetic nanosystems to improve antitumor effects of paclitaxel on epithelial cancers.  JOURNAL OF CONTROLLED RELEASE,  345  (744).  [PMID:35381274] [10.1016/j.jconrel.2022.03.060]
19. Wenjie Feng, Wanrui Shi, Shuwei Liu, Huiwen Liu, Yi Liu, Pengfei Ge, Hao Zhang.  (2021)  Fe(III)-Shikonin Supramolecular Nanomedicine for Combined Therapy of Tumor via Ferroptosis and Necroptosis.  Advanced Healthcare Materials,  11  (2): (2101926).  [PMID:34738742] [10.1002/adhm.202101926]
20. Yiwei Liu, Xiaopeng Hu, Yide Xia, Faqiong Zhao, Baizhao Zeng.  (2022)  A novel ratiometric electrochemical sensor based on dual-monomer molecularly imprinted polymer and Pt/Co3O4 for sensitive detection of chlorpromazine hydrochloride.  ANALYTICA CHIMICA ACTA,  1190  (339245).  [PMID:34857150] [10.1016/j.aca.2021.339245]
21. Cuiping Jiang, Yuan Wang, Peiyi Liang, Yao Chen, Ziming Zhuang, Lu Zhang, Yankui Yi, Li Liu, Qiang Liu.  (2021)  ATP-Responsive Multifunctional Supramolecular Polymer as a Nonviral Vector for Boosting Cholesterol Removal from Lipid-Laden Macrophages.  ACS Biomaterials Science & Engineering,  7  (11): (5048–5063).  [PMID:34648280] [10.1021/acsbiomaterials.1c00919]
22. Jia Wen, Xiuge Gao, Qian Zhang, Benazir Sahito, Hongbin Si, Gonghe Li, Qi Ding, Wenda Wu, Eugenie Nepovimova, Shanxiang Jiang, Liping Wang, Kamil Kuca, Dawei Guo.  (2021)  Optimization of Tilmicosin-Loaded Nanostructured Lipid Carriers Using Orthogonal Design for Overcoming Oral Administration Obstacle.  Pharmaceutics,  13  (3): (303).  [PMID:33669090] [10.3390/pharmaceutics13030303]
23. Chen Xu, Jinhui Lu, Li Zhou, Jie Liang, Lei Fang, Feng Cao.  (2021)  Multifunctional nanocomposite eye drops of cyclodextrin complex@layered double hydroxides for relay drug delivery to the posterior segment of the eye.  CARBOHYDRATE POLYMERS,  260  (117800).  [PMID:33712148] [10.1016/j.carbpol.2021.117800]
24. Guo Shiqi, Liang Yanzi, Liu Lanze, Yin Miaomiao, Wang Aiping, Sun Kaoxiang, Li Youxin, Shi Yanan.  (2021)  Research on the fate of polymeric nanoparticles in the process of the intestinal absorption based on model nanoparticles with various characteristics: size, surface charge and pro-hydrophobics.  JOURNAL OF NANOBIOTECHNOLOGY,  19  (1): (1-21).  [PMID:33499885] [10.1186/s12951-021-00770-2]
25. Zitong Qi, Cuiping Jiang, Hai Gao, Yanyan Wang, Qiqi Zhang, Wenli Zhang, Jianping Liu.  (2021)  Endocytic recycling as cellular trafficking fate of simvastatin-loaded discoidal reconstituted high-density lipoprotein to coordinate cholesterol efflux and drug influx.  Nanomedicine-Nanotechnology Biology and Medicine,  32  (102323).  [PMID:33186693] [10.1016/j.nano.2020.102323]
26. Yihua Yang, Lina Guo, Zhe Wang, Peng Liu, Xuanjun Liu, Jinsong Ding, Wenhu Zhou.  (2021)  Targeted silver nanoparticles for rheumatoid arthritis therapy via macrophage apoptosis and Re-polarization.  BIOMATERIALS,  264  (120390).  [PMID:32980634] [10.1016/j.biomaterials.2020.120390]
27. Honghui Wu, Xinchi Jiang, Yaosheng Li, Yi Zhou, Tianyuan Zhang, Pei Zhi, Jianqing Gao.  (2020)  Engineering Stem Cell Derived Biomimetic Vesicles for Versatility and Effective Targeted Delivery.  ADVANCED FUNCTIONAL MATERIALS,  30  (49): (2006169).  [10.1002/adfm.202006169]
28. Li Jun, Wang Man, Fan Yao-Yao, Duan Hui-Ling, Deng Xu, Zhang Zhi-Qi.  (2020)  Ligand-RNA interaction assay based on size-selective fluorescence core-shell nanocomposite.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  412  (26): (7349-7356).  [PMID:32783126] [10.1007/s00216-020-02869-1]
29. Ying Zhang, Xie-an Yu, Yiting Hu, Xuefei Bai, Ran Zhang, Mi Lu, Jianhui Sun, Jiangwei Tian, Bo-Yang Yu.  (2020)  A polydopamine-polyethyleneimine/quantum dot sensor for instantaneous readout of cell surface charge to reflect cell states.  SENSORS AND ACTUATORS B-CHEMICAL,  324  (128696).  [10.1016/j.snb.2020.128696]
30. Venkata Narayana Palakollu, Rajshekhar Karpoormath, Lei Wang, Jiao-Ning Tang, Chen Liu.  (2020)  A Versatile and Ultrasensitive Electrochemical Sensing Platform for Detection of Chlorpromazine Based on Nitrogen-Doped Carbon Dots/Cuprous Oxide Composite.  Nanomaterials,  10  (8): (1513).  [PMID:32752281] [10.3390/nano10081513]
31. Hu Hang, Wang Chong, Zhang Rong, Xiao Chen, Lai Chao, Li Zifu, Xu Defeng.  (2020)  Branched worm-like nanoparticles featured with programmed drug release for synergistic castration-resistant prostate cancer therapy.  JOURNAL OF MATERIALS SCIENCE,  55  (16): (6992-7008).  [10.1007/s10853-020-04495-9]
32. Qian Zhang, Haifeng Yang, Benazir Sahito, Xinyu Li, Lin Peng, Xiuge Gao, Hui Ji, Liping Wang, Shanxiang Jiang, Dawei Guo.  (2020)  Nanostructured lipid carriers with exceptional gastrointestinal stability and inhibition of P-gp efflux for improved oral delivery of tilmicosin.  COLLOIDS AND SURFACES B-BIOINTERFACES,  187  (110649).  [PMID:31767412] [10.1016/j.colsurfb.2019.110649]
33. Ying Li, Jing Luo, Meng-Ting Lin, Pei Zhi, Wang-Wei Guo, Min Han, Jian You, Jian-Qing Gao.  (2019)  Co-Delivery of Metformin Enhances the Antimultidrug Resistant Tumor Effect of Doxorubicin by Improving Hypoxic Tumor Microenvironment.  MOLECULAR PHARMACEUTICS,  16  (7): (2966–2979).  [PMID:31095914] [10.1021/acs.molpharmaceut.9b00199]
34. Xiaojie Zhu, Ying Kong, Qi Liu, Yayuan Lu, Han Xing, Xiaoyu Lu, Yue Yang, Jiaqiu Xu, Ning Li, Di Zhao, Xijing Chen, Yang Lu.  (2019)  Inhalable dry powder prepared from folic acid-conjugated docetaxel liposomes alters pharmacodynamic and pharmacokinetic properties relevant to lung cancer chemotherapy.  PULMONARY PHARMACOLOGY & THERAPEUTICS,  55  (50).  [PMID:30738974] [10.1016/j.pupt.2019.02.001]
35. Cuiping Jiang, Zitong Qi, Hengbo Jia, Yilei Huang, Yunbo Wang, Wenli Zhang, Zimei Wu, Hu Yang, Jianping Liu.  (2019)  ATP-Responsive Low-Molecular-Weight Polyethylenimine-Based Supramolecular Assembly via Host–Guest Interaction for Gene Delivery.  BIOMACROMOLECULES,  20  (1): (478–489).  [PMID:30516950] [10.1021/acs.biomac.8b01395]
36. Guang-Yu Pan, Hao-Ran Jia, Ya-Xuan Zhu, Fu-Gen Wu.  (2018)  Turning double hydrophilic into amphiphilic: IR825-conjugated polymeric nanomicelles for near-infrared fluorescence imaging-guided photothermal cancer therapy.  Nanoscale,  10  (4): (2115-2127).  [PMID:29326993] [10.1039/C7NR07495F]
37. Ying Li, Meng Wang, Bu-Wei Huang, Yuan Ping, Jian You, Jian-Qing Gao.  (2017)  Transcriptome-wide elucidation of liposomal formulations for anticancer drug delivery.  International Journal of Nanomedicine,  12  ( 8557–8572).  [PMID:29238192] [10.2147/IJN.S148975]
38. Danyi Lu, Qian Xie, Baojian Wu.  (2017)  N-glucuronidation catalyzed by UGT1A4 and UGT2B10 in human liver microsomes: Assay optimization and substrate identification.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,  145  (692).  [PMID:28803208] [10.1016/j.jpba.2017.07.037]
39. Jing Lu, Yi Zhao, Xiaoju Zhou, Jian Hua He, Yun Yang, Cuiping Jiang, Zitong Qi, Wenli Zhang, Jianping Liu.  (2017)  Biofunctional Polymer–Lipid Hybrid High-Density Lipoprotein-Mimicking Nanoparticles Loading Anti-miR155 for Combined Antiatherogenic Effects on Macrophages.  BIOMACROMOLECULES,  18  (8): (2286–2295).  [PMID:28738148] [10.1021/acs.biomac.7b00436]
40. Qi Liu, Di Zhao, Xiaojie Zhu, Huili Chen, Yue Yang, Jiaqiu Xu, Qing Zhang, Ali Fan, Ning Li, Chaorui Guo, Ying Kong, Yang Lu, Xijing Chen.  (2017)  Coloaded Nanoparticles of Paclitaxel and Piperlongumine for Enhancing Synergistic Antitumor Activities and Reducing Toxicity.  JOURNAL OF PHARMACEUTICAL SCIENCES,  106  (3066).  [PMID:28552690] [10.1016/j.xphs.2017.05.027]
41. Peng Zhang, Bangbang Li, Jianwei Du, Youxiang Wang.  (2017)  Regulation the morphology of cationized gold nanoparticles for effective gene delivery.  COLLOIDS AND SURFACES B-BIOINTERFACES,  157  (18).  [PMID:28558339] [10.1016/j.colsurfb.2017.04.056]
42. Quan-Xing Mao, Shuang E, Jun-Mei Xia, Ru-Sheng Song, Yang Shu, Xu-Wei Chen, Jian-Hua Wang.  (2016)  Hydrophobic Carbon Nanodots with Rapid Cell Penetrability and Tunable Photoluminescence Behavior for in Vitro and in Vivo Imaging.  LANGMUIR,  32  (46): (12221–12229).  [PMID:27805819] [10.1021/acs.langmuir.6b03331]
43. Guo Teng, Zhang Yongtai, Zhao Jihui, Zhu Chunyun, Feng Nianping.  (2015)  Nanostructured lipid carriers for percutaneous administration of alkaloids isolated from Aconitum sinomontanum.  JOURNAL OF NANOBIOTECHNOLOGY,  13  (1): (1-14).  [PMID:26156035] [10.1186/s12951-015-0107-3]
44. Lili Wu, Wanping Zhong, Junjin Liu, Weichao Han, Shilong Zhong, Qiang Wei, Shuwen Liu, Lan Tang.  (2015)  Human microsomal cyttrochrome P450-mediated reduction of oxysophocarpine, an active and highly toxic constituent derived from Sophora flavescens species, and its intestinal absorption and metabolism in rat.  FITOTERAPIA,  105  (26).  [PMID:26045316] [10.1016/j.fitote.2015.05.021]
45. Yongtai Zhang, Kai Zhang, Zhonghua Wu, Teng Guo, Beini Ye, Mingyun Lu, Jihui Zhao, Chunyun Zhu, Nianping Feng.  (2015)  Evaluation of transdermal salidroside delivery using niosomes via in vitro cellular uptake.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,  478  (138).  [PMID:25448576] [10.1016/j.ijpharm.2014.11.018]
46. Chi H, Gu Y, Xu T, Cao F.  (2017)  Multifunctional organic-inorganic hybrid nanoparticles and nanosheets based on chitosan derivative and layered double hydroxide: cellular uptake mechanism and application for topical ocular drug delivery..  Int J Nanomedicine,  12  (1607-1620).  [PMID:28280329]
47. Xu T, Xu X, Gu Y, Fang L, Cao F.  (2018)  Functional intercalated nanocomposites with chitosan-glutathione-glycylsarcosine and layered double hydroxides for topical ocular drug delivery..  Int J Nanomedicine,  13  (917-937).  [PMID:29491707]
48. Wang Y, Zhou L, Fang L, Cao F.  (2020)  Multifunctional carboxymethyl chitosan derivatives-layered double hydroxide hybrid nanocomposites for efficient drug delivery to the posterior segment of the eye..  Acta Biomater,  104  (104-114).  [PMID:31931169]
49. Xiao-Lin Hou, Bin Zhang, Kai Cheng, Fang Zhang, Xiao-Ting Xie, Wei Chen, Lin-Fang Tan, Jin-Xuan Fan, Bo Liu, Qiu-Ran Xu.  (2024)  Engineering Phage Nanocarriers Integrated with Bio-Intelligent Plasmids for Personalized and Tunable Enzyme Delivery to Enhance Chemodynamic Therapy.  Advanced Science,  (2308349).  [PMID:38582522] [10.1002/advs.202308349]
50. Dan Wang, Xiaobo Wang, Yan Li, Xiaowei Wang, Xuelei Wang, Jiayi Su, Apeng Wang, Kai Lv, Mingliang Liu, Guimin Xia.  (2024)  Improved Antitumor Efficiency of N4-Tetradecyloxycarbonyl Gemcitabine-Loaded Liposomes for Pancreatic Cancer Chemotherapy.  International Journal of Nanomedicine,  [PMID:39679246] [10.2147/IJN.S485861]
51. Ye Lusha, Gao Yanan, Mok Simon Wing Fai, Liao Wucan, Wang Yazhou, Chen Changjiang, Yang Lijun, Zhang Junfeng, Shi Liyun.  (2024)  Modulation of alveolar macrophage and mitochondrial fitness by medicinal plant-derived nanovesicles to mitigate acute lung injury and viral pneumonia.  JOURNAL OF NANOBIOTECHNOLOGY,  22  (1): (1-20).  [PMID:38637808] [10.1186/s12951-024-02473-w]
52. Hairong Chen, Guichun Wang, Xiaoliang Li, Jingjing Wang, Xinrui Wang, Yuxiao Wang, Zhenzhen Liu, Jiajia Liu, Yang Ding, Jian Guo, Shuangying Gui.  (2024)  Multi-functional D-alpha-tocopheryl polyethylene glycol succinate surface modified nanocrystals improve the stability and oral bioavailability of pueraria flavonoids.  JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,  95  (105623).  [10.1016/j.jddst.2024.105623]
53. Chunmei Jiang, Fangping Li, Pei Song, Mengyao Wen, Saixue Yang, Geng Tian, Dongyan Shao, Junling Shi, Li Shang.  (2024)  Multifunctional Gold Nanozyme-Engineered Amphotericin B for Enhanced Antifungal Infection Therapy.  Small,  (2312253).  [PMID:38501846] [10.1002/smll.202312253]
54. Yuhan Yang, Yangyi Chen, Yue Wei, Wei Wu, Qing Wang, Tianyun Xue, Xiaoyan Zhang, Wei Chen, Wei Zhang.  (2024)  Novel Silybin-Conjugated Chitosan Polymeric Micelles for Improving the Oral Absorption of Doxorubicin Based on the Inhibition of P-gp and CYP3A4.  BIOMACROMOLECULES,  [PMID:39418531] [10.1021/acs.biomac.4c00628]
55. Yang Chen, Wenzhe Xu, Hao Jin, Mengsi Zhang, Shuwei Liu, Yi Liu, Hao Zhang.  (2024)  Nutritional Glutamine-Modified Iron-Delivery System with Enhanced Endocytosis for Ferroptosis Therapy of Pancreatic Tumors.  ACS Nano,  18  (46): (31846-31868).  [PMID:39512234] [10.1021/acsnano.4c08083]
56. Xiao-Lin Hou, Lin-Fang Tan, Xiao-Ting Xie, Bin Zhang, Qiong Wang, Kai Cheng, Jin-Xuan Fan, Tian-Cai Liu, Bo Liu.  (2024)  Peroxisome-inspired T4 phage hybrid enzyme nanoreactors for photodynamic therapy of breast cancer.  CHEMICAL ENGINEERING JOURNAL,  (159138).  [10.1016/j.cej.2024.159138]
57. Xia Lei, Jie Meng, Tianyu Gao, Mengxue Zhang, Zhanlin Zhang, Shuang Xie, Yupeng Su, Xiaohong Li.  (2025)  pH-Responsive photothermal effect and heterojunction formation for tumor-specific pyroelectrodynamic and nanozyme-catalyzed starvation therapy.  Acta Biomaterialia,  [PMID:40113022] [10.1016/j.actbio.2025.03.031]
58. Yanhao Xu, Ziyi Zhong, Pinle Zhang, Huancheng Huang, Kuan Cai, Xinliang Liu.  (2025)  Recognition-enrichment-in-situ degradation of p-chlorophenol by Fe-IL@UIO-66.  JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY,  (116347).  [10.1016/j.jphotochem.2025.116347]
59. Qiang Hou, Yali Wang, Jian Hu, Jianxiong Zhang, Caihua Zhang, Wang Song, Xuesong Wang, Baiqin Zheng, Xin Zhou.  (2025)  Simultaneous determination of phenothiazine drugs and their metabolites residues in animal derived foods by high performance liquid chromatography tandem mass spectrometry.  FOOD CONTROL,  167  (110799).  [10.1016/j.foodcont.2024.110799]
60. Shanshan Zhan, Hongying Liu, Lihua Li, Zhengzhi Yin, Chunchuan Gu.  (2024)  Simultaneously determining dopamine, acetaminophen and chlorpromazine with high performance on coordinated functional acupuncture needle electrode.  MICROCHEMICAL JOURNAL,  204  (111085).  [10.1016/j.microc.2024.111085]
61. Lin Liu, Kaiyan Huang, Xia Sun, Junpeng Shi, Xianggui Yin, Wenpeng Zhao, Peng Lin, Yutong Han, Fangrong Zhang, Weibing Miao, Yun Zhang.  (2025)  Tunable ion-release biodegradable nanoparticles enhanced pyroptosis for tumor immunotherapy.  BIOMATERIALS,  317  (123111).  [PMID:39827512] [10.1016/j.biomaterials.2025.123111]
62. Shuiling Qin, Zhiwei Wen, Huajie Huang, Wei Wu.  (2024)  Use of novel taurine-chitosan mediated liposomes for enhancing the oral absorption of doxorubicin via the TAUT transporter.  CARBOHYDRATE POLYMERS,  329  (121780).  [PMID:38286550] [10.1016/j.carbpol.2024.121780]

溶液计算器

上海阿拉丁生化科技股份有限公司
© 2016 ALADDIN-E.COM . 版权所有,未经授权禁止拷贝本站资料,如有违反,将追究法律责任

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用。

上海工商 危险品化学品经营许可证（带存储）营业执照(三证合一)