E1/E2/E3酶 - 代谢酶/蛋白酶 - 按“信号通路”分类 - 小分子和化合物库

Nutlin-3b

规格或纯度 :

≥98%

CAS号: 675576-97-3

分子式: C₃₀H₃₀Cl₂N₄O₄ 分子量: 581.49

IUPAC Name: 4-[(4R,5S)-4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one

SMILES: CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl

InChIKey: BDUHCSBCVGXTJM-IZLXSDGUSA-N

InChI: 1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)/t27-,28+/mSee more

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Nutlin-3,MDM2拮抗剂

规格或纯度 :

≥98%

CAS号: 548472-68-0

分子式: C₃₀H₃₀Cl₂N₄O₄ 分子量: 581.49

IUPAC Name: 4-[4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one

SMILES: CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl

InChIKey: BDUHCSBCVGXTJM-UHFFFAOYSA-N

InChI: 1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)

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RG7112,有效的MDM2抑制剂

规格或纯度 :

Moligand™

≥98%

CAS号: 939981-39-2 Compound CID : 57406853

分子式: C₃₈H₄₈Cl₂N₄O₄S 分子量: 727.78

IUPAC Name: [(4S,5R)-2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethylimidazol-1-yl]-[4-(3-methylsulfonylpropyl)piperazin-1-yl]methanone

SMILES: CCOC1=C(C=CC(=C1)C(C)(C)C)C2=NC(C(N2C(=O)N3CCN(CC3)CCCS(=O)(=O)C)(C)C4=CC=C(C=C4)Cl)(C)C5=CC=C(C=C5)Cl

InChIKey: QBGKPEROWUKSBK-QPPIDDCLSA-N

InChI: 1S/C38H48Cl2N4O4S/c1-8-48-33-26-29(36(2,3)4)14-19-32(33)34-41-37(5,27-10-15-30(39)16-11-27)38(6,28-12-17-31(40)18-13-28)44(34)35(45)43-23-21-42(22-24-43)20-9-25-49(7,46)47/h10-19,26H,8-9,20-25H2,1-7H3See more

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SMIP004,SKP2 E3 Ligase 抑制剂

规格或纯度 :

≥98%

CAS号: 143360-00-3 Compound CID : 2747581

分子式: C₁₃H₁₉NO 分子量: 205.3

IUPAC Name: N-(4-butyl-2-methylphenyl)acetamide

SMILES: CCCCC1=CC(=C(C=C1)NC(=O)C)C

InChIKey: ZFVMECVBUGMWIX-UHFFFAOYSA-N

InChI: 1S/C13H19NO/c1-4-5-6-12-7-8-13(10(2)9-12)14-11(3)15/h7-9H,4-6H2,1-3H3,(H,14,15)

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5-氨基-2,4-二甲基吡啶

规格或纯度 :

≥98%

CAS号: 1193-71-1

分子式: C₇H₁₀N₂ 分子量: 122.17

IUPAC Name: 4,6-dimethylpyridin-3-amine

SMILES: CC1=CC(=NC=C1N)C

InChIKey: SHSQTJRJQHPJRQ-UHFFFAOYSA-N

InChI: 1S/C7H10N2/c1-5-3-6(2)9-4-7(5)8/h3-4H,8H2,1-2H3

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PRT 4165,Bmi1 / Ring1A抑制剂

规格或纯度 :

≥98%

CAS号: 31083-55-3 Compound CID : 207893

分子式: C₁₅H₉NO₂ 分子量: 235.24

IUPAC Name: 2-(pyridin-3-ylmethylidene)indene-1,3-dione

SMILES: C1=CC=C2C(=C1)C(=O)C(=CC3=CN=CC=C3)C2=O

InChIKey: OMHZFEWYVFWVLI-UHFFFAOYSA-N

InChI: 1S/C15H9NO2/c17-14-11-5-1-2-6-12(11)15(18)13(14)8-10-4-3-7-16-9-10/h1-9H

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NSC697923,可透过细胞的UBE2N抑制剂

规格或纯度 :

≥98%

CAS号: 343351-67-7

分子式: C₁₁H₉NO₅S 分子量: 267.26

IUPAC Name: 2-(4-methylphenyl)sulfonyl-5-nitrofuran

SMILES: CC1=CC=C(C=C1)S(=O)(=O)C2=CC=C(O2)[N+](=O)[O-]

InChIKey: GAUHIPWCDXOLCZ-UHFFFAOYSA-N

InChI: 1S/C11H9NO5S/c1-8-2-4-9(5-3-8)18(15,16)11-7-6-10(17-11)12(13)14/h2-7H,1H3

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9H-茚并[1,2-b][1,2,5]恶二唑并[3,4-e]吡嗪-9-酮

规格或纯度 :

≥98%

CAS号: 67200-34-4 Compound CID : 568763

分子式: C₁₁H₄N₄O₂ 分子量: 224.18

IUPAC Name: 13-oxa-10,12,14,16-tetrazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(16),2,4,6,9,11,14-heptaen-8-one

SMILES: C1=CC=C2C(=C1)C3=NC4=NON=C4N=C3C2=O

InChIKey: SFSSAKVWCKFRHE-UHFFFAOYSA-N

InChI: 1S/C11H4N4O2/c16-9-6-4-2-1-3-5(6)7-8(9)13-11-10(12-7)14-17-15-11/h1-4H

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RO8994

规格或纯度 :

≥98%

CAS号: 1309684-94-3 Compound CID : 53238217

分子式: C₃₁H₃₁Cl₂FN₄O₄ 分子量: 613.51

IUPAC Name: (2'R,3R,3'S,5'S)-N-(4-carbamoyl-2-methoxyphenyl)-6-chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide

SMILES: CC(C)(C)CC1C2(C(C(N1)C(=O)NC3=C(C=C(C=C3)C(=O)N)OC)C4=C(C(=CC=C4)Cl)F)C5=C(C=C(C=C5)Cl)NC2=O

InChIKey: MURAVORBGFDSMA-ISKXDESKSA-N

InChI: 1S/C31H31Cl2FN4O4/c1-30(2,3)14-23-31(18-10-9-16(32)13-21(18)37-29(31)41)24(17-6-5-7-19(33)25(17)34)26(38-23)28(40)36-20-11-8-15(27(35)39)12-22(20)42-4/h5-13,23-24,26,38H,14H2,1-4H3,(H2,35,39)(H,36,40)See more

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C25-140

规格或纯度 :

≥98%

CAS号: 1358099-18-9

分子式: C₂₆H₃₁N₇O 分子量: 457.57

IUPAC Name: 1-(4-benzylpiperidin-1-yl)-3-[3,5-dimethyl-1-(3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)pyrazol-4-yl]propan-1-one

SMILES: CC1=C(C(=NN1C2=NN3C(=NN=C3C=C2)C)C)CCC(=O)N4CCC(CC4)CC5=CC=CC=C5

InChIKey: HFKVRXVHZGBRKF-UHFFFAOYSA-N

InChI: 1S/C26H31N7O/c1-18-23(19(2)32(29-18)25-11-10-24-28-27-20(3)33(24)30-25)9-12-26(34)31-15-13-22(14-16-31)17-21-7-5-4-6-8-21/h4-8,10-11,22H,9,12-17H2,1-3H3

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Auxinole

规格或纯度 :

≥98%

CAS号: 86445-22-9

分子式: C₂₀H₁₉NO₃ 分子量: 321.37

IUPAC Name: 4-(2,4-dimethylphenyl)-2-(1H-indol-3-yl)-4-oxobutanoic acid

SMILES: CC1=CC(=C(C=C1)C(=O)CC(C2=CNC3=CC=CC=C32)C(=O)O)C

InChIKey: HGUYAIJBXSQXGV-UHFFFAOYSA-N

InChI: 1S/C20H19NO3/c1-12-7-8-14(13(2)9-12)19(22)10-16(20(23)24)17-11-21-18-6-4-3-5-15(17)18/h3-9,11,16,21H,10H2,1-2H3,(H,23,24)

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NVP-CGM097

规格或纯度 :

≥98%

CAS号: 1313363-54-0

分子式: C₃₈H₄₇ClN₄O₄ 分子量: 659.26

IUPAC Name: (1S)-1-(4-chlorophenyl)-6-methoxy-2-[4-[methyl-[[4-(4-methyl-3-oxopiperazin-1-yl)cyclohexyl]methyl]amino]phenyl]-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one

SMILES: CC(C)OC1=C(C=C2CC(=O)N(C(C2=C1)C3=CC=C(C=C3)Cl)C4=CC=C(C=C4)N(C)CC5CCC(CC5)N6CCN(C(=O)C6)C)OC

InChIKey: CLRSLRWKONPSRQ-CPOWQTMSSA-N

InChI: 1S/C38H47ClN4O4/c1-25(2)47-35-22-33-28(20-34(35)46-5)21-36(44)43(38(33)27-8-10-29(39)11-9-27)32-16-14-30(15-17-32)41(4)23-26-6-12-31(13-7-26)42-19-18-40(3)37(45)24-42/h8-11,14-17,20,22,25-26,31,38H,6-See more

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