页面 2 | JAK - JAK/STAT 信号通路 - 按“信号通路”分类

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Fedratinib(SAR302503,TG101348)

规格或纯度 :

Moligand™

≥98%

CAS号: 936091-26-8 Compound CID : 16722836

分子式: C₂₇H₃₆N₆O₃S 分子量: 524.68

IUPAC Name: N-tert-butyl-3-[[5-methyl-2-[4-(2-pyrrolidin-1-ylethoxy)anilino]pyrimidin-4-yl]amino]benzenesulfonamide

SMILES: CC1=CN=C(N=C1NC2=CC(=CC=C2)S(=O)(=O)NC(C)(C)C)NC3=CC=C(C=C3)OCCN4CCCC4

InChIKey: JOOXLOJCABQBSG-UHFFFAOYSA-N

InChI: 1S/C27H36N6O3S/c1-20-19-28-26(30-21-10-12-23(13-11-21)36-17-16-33-14-5-6-15-33)31-25(20)29-22-8-7-9-24(18-22)37(34,35)32-27(2,3)4/h7-13,18-19,32H,5-6,14-17H2,1-4H3,(H2,28,29,30,31)

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(3S,4S)-托法替尼

规格或纯度 :

≥96%

CAS号: 1092578-47-6 Compound CID : 20111936

分子式: C₁₆H₂₀N₆O 分子量: 312.37

IUPAC Name: 3-[(3S,4S)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]-3-oxopropanenitrile

SMILES: CC1CCN(CC1N(C)C2=NC=NC3=C2C=CN3)C(=O)CC#N

InChIKey: UJLAWZDWDVHWOW-WCQYABFASA-N

InChI: 1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m0/s1

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(3S,4R)-托法替尼

规格或纯度 :

≥96%

CAS号: 1092578-48-7 Compound CID : 9966538

分子式: C₁₆H₂₀N₆O 分子量: 312.37

IUPAC Name: 3-[(3S,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]-3-oxopropanenitrile

SMILES: CC1CCN(CC1N(C)C2=NC=NC3=C2C=CN3)C(=O)CC#N

InChIKey: UJLAWZDWDVHWOW-DGCLKSJQSA-N

InChI: 1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13-/m1/s1

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WHI-P154,JAK3激酶抑制剂

规格或纯度 :

Moligand™

≥98%

CAS号: 211555-04-3 Compound CID : 3795

分子式: C₁₆H₁₄BrN₃O₃ 分子量: 376.2

IUPAC Name: 2-bromo-4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol

SMILES: COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)O)Br)OC

InChIKey: CBIAKDAYHRWZCU-UHFFFAOYSA-N

InChI: 1S/C16H14BrN3O3/c1-22-14-6-10-12(7-15(14)23-2)18-8-19-16(10)20-9-3-4-13(21)11(17)5-9/h3-8,21H,1-2H3,(H,18,19,20)

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WP1066,JAK / STAT3抑制剂

规格或纯度 :

Moligand™

≥98%

CAS号: 857064-38-1 Compound CID : 11210478

分子式: C₁₇H₁₄BrN₃O 分子量: 356.22

IUPAC Name: (E)-3-(6-bromopyridin-2-yl)-2-cyano-N-[(1S)-1-phenylethyl]prop-2-enamide

SMILES: CC(C1=CC=CC=C1)NC(=O)C(=CC2=NC(=CC=C2)Br)C#N

InChIKey: VFUAJMPDXIRPKO-LQELWAHVSA-N

InChI: 1S/C17H14BrN3O/c1-12(13-6-3-2-4-7-13)20-17(22)14(11-19)10-15-8-5-9-16(18)21-15/h2-10,12H,1H3,(H,20,22)/b14-10+/t12-/m0/s1

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WHI-P97,JAK-3抑制剂

规格或纯度 :

≥98%

CAS号: 211555-05-4 Compound CID : 3796

分子式: C₁₆H₁₃Br₂N₃O₃ 分子量: 455.11

IUPAC Name: 2,6-dibromo-4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol

SMILES: COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C(=C3)Br)O)Br)OC

InChIKey: YVCXQRVVNQMZEI-UHFFFAOYSA-N

InChI: 1S/C16H13Br2N3O3/c1-23-13-5-9-12(6-14(13)24-2)19-7-20-16(9)21-8-3-10(17)15(22)11(18)4-8/h3-7,22H,1-2H3,(H,19,20,21)

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XL019,JAK2抑制剂

规格或纯度 :

Moligand™

≥98%

CAS号: 945755-56-6 Compound CID : 57990869

分子式: C₂₅H₂₈N₆O₂ 分子量: 444.53

IUPAC Name: (2S)-N-[4-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]phenyl]pyrrolidine-2-carboxamide

SMILES: C1CC(NC1)C(=O)NC2=CC=C(C=C2)C3=NC(=NC=C3)NC4=CC=C(C=C4)N5CCOCC5

InChIKey: ISOCDPQFIXDIMS-QHCPKHFHSA-N

InChI: 1S/C25H28N6O2/c32-24(23-2-1-12-26-23)28-19-5-3-18(4-6-19)22-11-13-27-25(30-22)29-20-7-9-21(10-8-20)31-14-16-33-17-15-31/h3-11,13,23,26H,1-2,12,14-17H2,(H,28,32)(H,27,29,30)/t23-/m0/s1

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ZM 39923 盐酸盐

规格或纯度 :

Moligand™

≥98%

CAS号: 1021868-92-7

分子式: C₂₃H₂₅NO.HCl 分子量: 367.91

IUPAC Name: 3-[benzyl(propan-2-yl)amino]-1-naphthalen-2-ylpropan-1-one;hydrochloride

SMILES: CC(C)N(CCC(=O)C1=CC2=CC=CC=C2C=C1)CC3=CC=CC=C3.Cl

InChIKey: NJTUORMLOPXPBY-UHFFFAOYSA-N

InChI: 1S/C23H25NO.ClH/c1-18(2)24(17-19-8-4-3-5-9-19)15-14-23(25)22-13-12-20-10-6-7-11-21(20)16-22;/h3-13,16,18H,14-15,17H2,1-2H3;1H

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巴瑞克替尼

规格或纯度 :

Moligand™

≥99%

CAS号: 1187594-09-7

分子式: C₁₆H₁₇N₇O₂S 分子量: 371.42

IUPAC Name: 2-[1-ethylsulfonyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]azetidin-3-yl]acetonitrile

SMILES: CCS(=O)(=O)N1CC(C1)(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3

InChIKey: XUZMWHLSFXCVMG-UHFFFAOYSA-N

InChI: 1S/C16H17N7O2S/c1-2-26(24,25)22-9-16(10-22,4-5-17)23-8-12(7-21-23)14-13-3-6-18-15(13)20-11-19-14/h3,6-8,11H,2,4,9-10H2,1H3,(H,18,19,20)

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α-藏花素

规格或纯度 :

分析标准品

≥98%

CAS号: 42553-65-1 EC号: 255-881-6

分子式: C₄₄H₆₄O₂₄ 分子量: 976.96

IUPAC Name: bis[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl] (2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethylhexadeca-2,4,6,8,10,12,14-hepSee more

SMILES: CC(=CC=CC=C(C)C=CC=C(C)C(=O)OC1C(C(C(C(O1)COC2C(C(C(C(O2)CO)O)O)O)O)O)O)C=CC=C(C)C(=O)OC3C(C(C(C(O3)COC4C(C(C(C(O4)CO)O)O)O)O)O)O

InChIKey: SEBIKDIMAPSUBY-RTJKDTQDSA-N

InChI: 1S/C44H64O24/c1-19(11-7-13-21(3)39(59)67-43-37(57)33(53)29(49)25(65-43)17-61-41-35(55)31(51)27(47)23(15-45)63-41)9-5-6-10-20(2)12-8-14-22(4)40(60)68-44-38(58)34(54)30(50)26(66-44)18-62-42-36(56)32(52)See more

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CYT387,JAK 1/2抑制剂

规格或纯度 :

Moligand™

≥98%

CAS号: 1056634-68-4

分子式: C₂₃H₂₂N₆O₂ 分子量: 414.47

IUPAC Name: N-(cyanomethyl)-4-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]benzamide

SMILES: C1COCCN1C2=CC=C(C=C2)NC3=NC=CC(=N3)C4=CC=C(C=C4)C(=O)NCC#N

InChIKey: ZVHNDZWQTBEVRY-UHFFFAOYSA-N

InChI: 1S/C23H22N6O2/c24-10-12-25-22(30)18-3-1-17(2-4-18)21-9-11-26-23(28-21)27-19-5-7-20(8-6-19)29-13-15-31-16-14-29/h1-9,11H,12-16H2,(H,25,30)(H,26,27,28)

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CEP-33779

规格或纯度 :

Moligand™

≥98%

CAS号: 1257704-57-6

分子式: C₂₄H₂₆N₆O₂S 分子量: 462.57

IUPAC Name: N-[3-(4-methylpiperazin-1-yl)phenyl]-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine

SMILES: CN1CCN(CC1)C2=CC=CC(=C2)NC3=NN4C=CC=C(C4=N3)C5=CC=C(C=C5)S(=O)(=O)C

InChIKey: RFZKSQIFOZZIAQ-UHFFFAOYSA-N

InChI: 1S/C24H26N6O2S/c1-28-13-15-29(16-14-28)20-6-3-5-19(17-20)25-24-26-23-22(7-4-12-30(23)27-24)18-8-10-21(11-9-18)33(2,31)32/h3-12,17H,13-16H2,1-2H3,(H,25,27)

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