页面 2 | EGFR - JAK/STAT 信号通路 - 按“信号通路”分类

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PD153035 盐酸盐

规格或纯度 :

≥98%(HPLC)

CAS号: 183322-45-4

分子式: C₁₆H₁₄BrN₃O₂·HCl 分子量: 396.67

IUPAC Name: N-(3-bromophenyl)-6,7-dimethoxyquinazolin-4-amine;hydrochloride

SMILES: COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Br)OC.Cl

InChIKey: ZJOKWAWPAPMNIM-UHFFFAOYSA-N

InChI: 1S/C16H14BrN3O2.ClH/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11;/h3-9H,1-2H3,(H,18,19,20);1H

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PD168393,细胞渗透性EGFR抑制剂

规格或纯度 :

≥98%

CAS号: 194423-15-9

分子式: C₁₇H₁₃BrN₄O 分子量: 369.22

IUPAC Name: N-[4-(3-bromoanilino)quinazolin-6-yl]prop-2-enamide

SMILES: C=CC(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC(=CC=C3)Br

InChIKey: HTUBKQUPEREOGA-UHFFFAOYSA-N

InChI: 1S/C17H13BrN4O/c1-2-16(23)21-13-6-7-15-14(9-13)17(20-10-19-15)22-12-5-3-4-11(18)8-12/h2-10H,1H2,(H,21,23)(H,19,20,22)

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PD-161570,FGFR抑制剂

规格或纯度 :

≥98%(HPLC)

CAS号: 192705-80-9 Compound CID : 5328135

分子式: C₂₆H₃₅Cl₂N₇O 分子量: 532.51

IUPAC Name: 1-tert-butyl-3-[6-(2,6-dichlorophenyl)-2-[4-(diethylamino)butylamino]pyrido[2,3-d]pyrimidin-7-yl]urea

SMILES: CCN(CC)CCCCNC1=NC2=NC(=C(C=C2C=N1)C3=C(C=CC=C3Cl)Cl)NC(=O)NC(C)(C)C

InChIKey: MKVMEJKNLUWFSQ-UHFFFAOYSA-N

InChI: 1S/C26H35Cl2N7O/c1-6-35(7-2)14-9-8-13-29-24-30-16-17-15-18(21-19(27)11-10-12-20(21)28)23(31-22(17)32-24)33-25(36)34-26(3,4)5/h10-12,15-16H,6-9,13-14H2,1-5H3,(H3,29,30,31,32,33,34,36)

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TAK-285

规格或纯度 :

≥98%

CAS号: 871026-44-7 Compound CID : 11620908

分子式: C₂₆H₂₅ClF₃N₅O₃ 分子量: 547.96

IUPAC Name: N-[2-[4-[3-chloro-4-[3-(trifluoromethyl)phenoxy]anilino]pyrrolo[3,2-d]pyrimidin-5-yl]ethyl]-3-hydroxy-3-methylbutanamide

SMILES: CC(C)(CC(=O)NCCN1C=CC2=C1C(=NC=N2)NC3=CC(=C(C=C3)OC4=CC=CC(=C4)C(F)(F)F)Cl)O

InChIKey: ZYQXEVJIFYIBHZ-UHFFFAOYSA-N

InChI: 1S/C26H25ClF3N5O3/c1-25(2,37)14-22(36)31-9-11-35-10-8-20-23(35)24(33-15-32-20)34-17-6-7-21(19(27)13-17)38-18-5-3-4-16(12-18)26(28,29)30/h3-8,10,12-13,15,37H,9,11,14H2,1-2H3,(H,31,36)(H,32,33,34)

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酪氨酸磷酸化抑制剂A23

规格或纯度 :

≥98%

CAS号: 118409-57-7 Compound CID : 2052

分子式: C₁₀H₆N₂O₂ 分子量: 186.17

IUPAC Name: 2-[(3,4-dihydroxyphenyl)methylidene]propanedinitrile

SMILES: C1=CC(=C(C=C1C=C(C#N)C#N)O)O

InChIKey: VTJXFTPMFYAJJU-UHFFFAOYSA-N

InChI: 1S/C10H6N2O2/c11-5-8(6-12)3-7-1-2-9(13)10(14)4-7/h1-4,13-14H

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Tyrphostin AG 879 酪氨酸激酶的抑制剂

规格或纯度 :

Moligand™

≥98%

CAS号: 148741-30-4 Compound CID : 135419190

分子式: C₁₈H₂₄N₂OS 分子量: 316.46

IUPAC Name: (E)-2-cyano-3-(3,5-ditert-butyl-4-hydroxyphenyl)prop-2-enethioamide

SMILES: CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)C=C(C#N)C(=S)N

InChIKey: XRZYELWZLNAXGE-KPKJPENVSA-N

InChI: 1S/C18H24N2OS/c1-17(2,3)13-8-11(7-12(10-19)16(20)22)9-14(15(13)21)18(4,5)6/h7-9,21H,1-6H3,(H2,20,22)/b12-7+

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WHI-P154,JAK3激酶抑制剂

规格或纯度 :

Moligand™

≥98%

CAS号: 211555-04-3 Compound CID : 3795

分子式: C₁₆H₁₄BrN₃O₃ 分子量: 376.2

IUPAC Name: 2-bromo-4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol

SMILES: COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)O)Br)OC

InChIKey: CBIAKDAYHRWZCU-UHFFFAOYSA-N

InChI: 1S/C16H14BrN3O3/c1-22-14-6-10-12(7-15(14)23-2)18-8-19-16(10)20-9-3-4-13(21)11(17)5-9/h3-8,21H,1-2H3,(H,18,19,20)

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WZ8040

规格或纯度 :

≥98%

CAS号: 1214265-57-2 Compound CID : 44607531

分子式: C₂₄H₂₅ClN₆OS 分子量: 481.02

IUPAC Name: N-[3-[5-chloro-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]sulfanylphenyl]prop-2-enamide

SMILES: CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(=N3)SC4=CC=CC(=C4)NC(=O)C=C)Cl

InChIKey: KIISCIGBPUVZBF-UHFFFAOYSA-N

InChI: 1S/C24H25ClN6OS/c1-3-22(32)27-18-5-4-6-20(15-18)33-23-21(25)16-26-24(29-23)28-17-7-9-19(10-8-17)31-13-11-30(2)12-14-31/h3-10,15-16H,1,11-14H2,2H3,(H,27,32)(H,26,28,29)

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WZ4002

规格或纯度 :

Moligand™

≥98%

CAS号: 1213269-23-8 Compound CID : 44607530

分子式: C₂₅H₂₇ClN₆O₃ 分子量: 494.97

IUPAC Name: N-[3-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]prop-2-enamide

SMILES: CN1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=C(C(=N3)OC4=CC=CC(=C4)NC(=O)C=C)Cl)OC

InChIKey: ITTRLTNMFYIYPA-UHFFFAOYSA-N

InChI: 1S/C25H27ClN6O3/c1-4-23(33)28-17-6-5-7-19(14-17)35-24-20(26)16-27-25(30-24)29-21-9-8-18(15-22(21)34-3)32-12-10-31(2)11-13-32/h4-9,14-16H,1,10-13H2,2-3H3,(H,28,33)(H,27,29,30)

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WZ3146

规格或纯度 :

≥98%

CAS号: 1214265-56-1 Compound CID : 44607360

分子式: C₂₄H₂₅ClN₆O₂ 分子量: 464.96

IUPAC Name: N-[3-[5-chloro-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]prop-2-enamide

SMILES: CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(=N3)OC4=CC=CC(=C4)NC(=O)C=C)Cl

InChIKey: APHGZZPEOCCYNO-UHFFFAOYSA-N

InChI: 1S/C24H25ClN6O2/c1-3-22(32)27-18-5-4-6-20(15-18)33-23-21(25)16-26-24(29-23)28-17-7-9-19(10-8-17)31-13-11-30(2)12-14-31/h3-10,15-16H,1,11-14H2,2H3,(H,27,32)(H,26,28,29)

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Varlitinib,小分子抑制剂

规格或纯度 :

Moligand™

≥96%

CAS号: 845272-21-1 Compound CID : 42642648

分子式: C₂₂H₁₉ClN₆O₂S 分子量: 466.94

IUPAC Name: 4-N-[3-chloro-4-(1,3-thiazol-2-ylmethoxy)phenyl]-6-N-[(4R)-4-methyl-4,5-dihydro-1,3-oxazol-2-yl]quinazoline-4,6-diamine

SMILES: CC1COC(=N1)NC2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=NC=CS5)Cl

InChIKey: UWXSAYUXVSFDBQ-CYBMUJFWSA-N

InChI: 1S/C22H19ClN6O2S/c1-13-10-31-22(27-13)29-14-2-4-18-16(8-14)21(26-12-25-18)28-15-3-5-19(17(23)9-15)30-11-20-24-6-7-32-20/h2-9,12-13H,10-11H2,1H3,(H,27,29)(H,25,26,28)/t13-/m1/s1

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AC480 (BMS-599626),HER1和HER2抑制剂

规格或纯度 :

Moligand™

≥98%

CAS号: 714971-09-2

分子式: C₂₇H₂₇FN₈O₃ 分子量: 530.55

IUPAC Name: [(3S)-morpholin-3-yl]methyl N-[4-[[1-[(3-fluorophenyl)methyl]indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamate

SMILES: CC1=C2C(=NC=NN2C=C1NC(=O)OCC3COCCN3)NC4=CC5=C(C=C4)N(N=C5)CC6=CC(=CC=C6)F

InChIKey: LUJZZYWHBDHDQX-QFIPXVFZSA-N

InChI: 1S/C27H27FN8O3/c1-17-23(34-27(37)39-15-22-14-38-8-7-29-22)13-36-25(17)26(30-16-32-36)33-21-5-6-24-19(10-21)11-31-35(24)12-18-3-2-4-20(28)9-18/h2-6,9-11,13,16,22,29H,7-8,12,14-15H2,1H3,(H,34,37)(H,30,3See more

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