Recombinant CD146 Antibody

COA

级别和纯度:

≥95%(SDS-PAGE)
见COA

应用:

ELISA
Flow Cytometry

宿主种属: 大鼠(Rat)
种属反应性: 小鼠(Mouse)
亚型: Rat IgG2a
克隆号: P09B03
偶联: Unconjugated

有货

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货号 (SKU)	包装规格	是否现货
Ab211671-10μg	10μg	期货
Ab211671-50μg	50μg	期货
Ab211671-100μg	100μg	期货
Ab211671-1mg	1mg	期货

查看相关系列

点击查看靶蛋白信息: MCAM

Accession#: Q8R2Y2 (4) CD146 (4) Gene ID: 84004 (4) MCAM (5)

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基本信息

产品名称	Recombinant CD146 Antibody
别名	CD146抗体 \| 细胞表面糖蛋白Muc18抗体
英文别名	A32 antigen antibody \| CD 146 antibody \| CD146 antibody \| CD146 antigen antibody \| Cell surface glycoprotein MUC18 antibody \| Cell surface glycoprotein P1H12 antibody \| Gicerin antibody \| Mcam antibody \| Melanoma adhesion molecule antibody \| Melanoma asso
规格或纯度	无动物源, 无载体, 重组, ExactAb™, 无叠氮钠, 已验证, 高性能, ≥95%(SDS-PAGE), 见COA
生化机理	Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as a surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration (By similarity).
宿主种属	大鼠(Rat)
特异性	Mouse CD146
种属反应性	小鼠(Mouse)
免疫原	Endothelial cell line TME-3H3
阳性对照	Flow Cytometry: C57BL/6 splenocytes
偶联	Unconjugated

产品属性

克隆类型	重组抗体
Format	Whole IgG
轻链亚型	kappa
SDS-PAGE	150 kDa
纯化方法	Protein A purified
储存缓冲液	PBS, pH 7.4
浓度	见COA
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	Store at 4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
分子类型	抗体

关联靶点（人）

MCAM Tbio 细胞表面糖蛋白 MUC18(Cell surface glycoprotein MUC18) (0 活性数据)

点击查看靶蛋白信息： MCAM

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

图片

Flow Cytometry: Recombinant CD146 Antibody (Ab211671)

Recombinant CD146 Antibody (Ab211671) - Flow Cytometry
Flow Cytometry analysis of bEnd.3 labelling CD146 with Recombinant CD146 Antibody (Ab211671) conjugated with biotin (right panel) at 0.2 μg/mL for 1 hour at 4°C, compared with Rat IgG (Ab180310) conjugated with biotin - Isotype Control (left panel) and detected with SA-PE (rp156150).

Flow Cytometry: Recombinant CD146 Antibody (Ab211671)

Recombinant CD146 Antibody (Ab211671) - Flow Cytometry
Flow Cytometry analysis of bEnd.3 labelling CD146 (red) with Recombinant CD146 Antibody (Ab211671) conjugated with biotin at 0.2 μg/mL for 1 hour at 4°C, and detected with SA-PE (rp156150). Blue - Isotype control, Rat IgG (Ab180310) conjugated with biotin. Black - Unlabelled control, cells without incubation with primary antibody.

Flow Cytometry: Recombinant CD146 Antibody (Ab211671)

Recombinant CD146 Antibody (Ab211671) - Flow Cytometry
Two-color flow cytometric analysis of CD146 expression on mouse splenocytes. C57BL/6 mouse splenocytes were stained with NKG2A/C/E Rat mAb (FITC) (Ab191686) and either Rat IgG Isotype Control Antibody (Biotin) (Ab180310; Left panel) or Recombinant CD146 Antibody (Ab211671; Right panel) at 0.2 μg/mL. Two-color flow cytometric dot plots showing the correlated expression of NKG2A/C/E versus CD146 (or Isotype control staining) were derived from gated events with the forward and side light-scatter characteristics of viable mononuclear cells.