基本信息

产品名称	CC-90002 (anti-CD47)
英文别名	Antigen identified by monoclonal antibody 1D8 antibody \| Antigenic surface determinant protein OA3 antibody \| CD 47 antibody \| CD47 antibody \| CD47 antigen (Rh-related antigen, integrin-associated signal transducer) antibody \| CD47 antigen antibody \| CD47
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
生化机理	通过充当血小板上 THBS1 的粘附受体，在细胞粘附和调节整合素方面发挥作用。在海马的记忆形成和突触可塑性中发挥重要作用（相似）。SIRPA 的受体，与之结合可阻止未成熟树突状细胞的成熟，并抑制成熟树突状细胞产生细胞因子。与 SIRPG 相互作用可介导细胞-细胞粘附，增强超抗原依赖性 T 细胞介导的增殖，并刺激 T 细胞活化。可能在膜运输和/或依赖整合素的信号转导中发挥作用。可防止红细胞过早消亡。可能参与病毒感染后引起的膜通透性变化。
宿主种属	人(Human)
特异性	CD47
种属反应性	人(Human),食蟹猴(Cynomolgus monkey)
偶联	Unconjugated

产品属性

克隆类型	重组抗体
Format	Whole IgG
亚型	Human IgG4SP
轻链亚型	kappa
SDS-PAGE	150 kDa
纯化方法	Protein A purified
储存缓冲液	Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
分子类型	抗体

关联靶点（人）

CD47 Tchem 白细胞表面抗原 CD47(Leukocyte surface antigen CD47) (0 活性数据)

点击查看靶蛋白信息： CD47

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

图片

Flow Cytometry: CC-90002 (anti-CD47) (Ab209891)

CC-90002 (anti-CD47) (Ab209891) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD47 with CC-90002 (anti-CD47) (Ab209891) conjugated with biotin (right panel) compared with Human IgG (Biotin) (Ab180314) - Isotype Control (left panel) and detected with SA-PE (rp156150).

Flow Cytometry: CC-90002 (anti-CD47) (Ab209891)

CC-90002 (anti-CD47) (Ab209891) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD47 (red) with CC-90002 (anti-CD47) (Ab209891) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, Human IgG (Biotin) (Ab180314). Black - Unlabelled control, cells without incubation with primary antibody.

Flow Cytometry: CC-90002 (anti-CD47) (Ab209891)

CC-90002 (anti-CD47) (Ab209891) - Flow Cytometry
Flow Cytometry analysis of Jurkat cells labelling CD47 (red) with CC-90002 (anti-CD47) (Ab209891) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

ELISA: CC-90002 (anti-CD47) (Ab209891)

CC-90002 (anti-CD47) (Ab209891) - ELISA
Immobilized Recombinant Human CD47 protein (rp144028) at 1.0 μg/mL can bind CC-90002 (anti-CD47) (Ab209891) with the EC50 of 17.78 ng/mL.