基本信息

产品名称	MDX-1105 (anti-PD-L1)
别名	PD-L1抗体 \| PD-L1单克隆抗体 \| PD-L1药靶抗体 \| CD274抗体 \| CD274单克隆抗体 \| CD274药靶抗体 \| B7H1抗体 \| B7H1单克隆抗体 \| B7H1药靶抗体
英文别名	B7 H antibody \| B7 H1 antibody \| B7 homolog 1 antibody \| B7-H1 antibody \| B7H antibody \| B7H1 antibody \| CD 274 antibody \| CD-274 antibody \| CD274 antibody \| CD274 antigen antibody \| CD274 molecule antibody \| MGC142294 antibody \| MGC142296 antibody \| OTTH
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
生化机理	Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.
宿主种属	人(Human)
特异性	CD274
种属反应性	人(Human),食蟹猴(Cynomolgus monkey)
偶联	Unconjugated

产品属性

克隆类型	重组抗体
Format	Whole IgG
亚型	Human IgG4SP
轻链亚型	kappa
SDS-PAGE	150 kDa
纯化方法	Protein A purified
储存缓冲液	Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
分子类型	抗体

关联靶点（人）

CD274 Tclin 程序性细胞死亡 1 配体 1(Programmed cell death 1 ligand 1) (0 活性数据)

点击查看靶蛋白信息： CD274

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

图片

Flow Cytometry: MDX-1105 (anti-PD-L1) (Ab190151)

MDX-1105 (anti-PD-L1) (Ab190151) - Flow Cytometry
Flow Cytometry analysis of unstimulated (left) or 500 ng/mL Ionomycin (I139530) and 10 ng/mL PMA (P408905) co-stimulated (right) Jurkat cells labelling PD-L1 (red) with MDX-1105 (anti-PD-L1) (Ab190151) at 0.1 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

ELISA: MDX-1105 (anti-PD-L1) (Ab190151)

MDX-1105 (anti-PD-L1) (Ab190151) - ELISA
Immobilized Recombinant Human PD-L1 protein (rp169666) at 1.0 μg/mL can bind MDX-1105 (anti-PD-L1) (Ab190151) with the EC50 of 158.5 ng/mL.