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Lumretuzumab (anti-ERBB3), 受体酪氨酸蛋白激酶 erbB-3 抑制剂

    应用:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • 宿主种属: 人(Human)
  • 种属反应性: 人(Human)
  • 亚型: Human IgG1
  • 偶联: Unconjugated
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货号 (SKU) 包装规格 是否现货 价格 数量
Ab182754-100μg
100μg 现货 Stock Image
Ab182754-1mg
1mg 现货 Stock Image
Ab182754-5mg
5mg 现货 Stock Image
Ab182754-10mg
10mg 期货 Stock Image

基本信息

产品名称 Lumretuzumab (anti-ERBB3), 受体酪氨酸蛋白激酶 erbB-3 抑制剂
别名 鲁妥珠单抗 | 鲁米妥珠单抗(抗ERBB3)
英文别名 c erbB 3 antibody | c erbB3 antibody | Erb b2 receptor tyrosine kinase 3 antibody | ErbB 3 antibody | ERBB3 antibody | ERBB3 protein antibody | erbB3 S antibody | ERBB3_HUMAN antibody | Glial growth factor receptor antibody | HER 3 antibody | HER3 antibod
规格或纯度 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属 人(Human)
特异性 ERBB3
种属反应性 人(Human)
偶联 Unconjugated
作用类型 抑制剂
作用机制 受体酪氨酸蛋白激酶 erbB-3 抑制剂

产品属性

克隆类型 重组抗体
Format Whole IgG
亚型 Human IgG1
轻链亚型 kappa
SDS-PAGE 147.16 kDa
纯化方法 Protein A purified
纯度 >95% (SDS-PAGE&SEC)
物理外观 Liquid
储存缓冲液 Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂 No
浓度 见COA
储存温度 -80℃储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息 1000000-13-4
分子类型 抗体

关联靶点(人)

ERBB3 Tclin 受体酪氨酸蛋白激酶 erbB-3(Receptor tyrosine-protein kinase erbB-3) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

图片

Lumretuzumab (anti-ERBB3) (Ab182754) - Flow Cytometry
Flow Cytometry analysis of MCF-7 cells labelling ERBB3 (red) with Lumretuzumab (anti-ERBB3) (Ab182754). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Lumretuzumab (anti-ERBB3) (Ab182754) - Flow Cytometry
Flow Cytometry analysis of A431 cells labelling ERBB3 (red) with Lumretuzumab (anti-ERBB3) (Ab182754). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Lumretuzumab (anti-ERBB3) (Ab182754) - ELISA
Immobilized Recombinant Human ErbB3/HER3 protein (rp170123) at 1.0 μg/mL can bind Lumretuzumab (anti-ERBB3) (Ab182754) with the EC50 of 31.62 ng/mL.

Lumretuzumab (anti-ERBB3) (Ab182754) - SEC
The purity of Lumretuzumab (anti-ERBB3) (Ab182754) is more than 95% verified by HPLC.

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批号(Lot Number) 证书类型 货号
ZJ24F0505708 分析证书 Ab182754
ZJ24F0505709 分析证书 Ab182754
ZJ24F0505710 分析证书 Ab182754

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此产品的引用文献

引用文献

1. Fujiwara Y, Nelson DL, Kashihara K, Varga E, Roeske WR, Yamamura HI.  (1990)  The cloning and sequence analysis of the rat serotonin-1A receptor gene..  Life Sci,  47  (22): (PL127-32).  [PMID:2273937]

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