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Feladilimab (anti-ICOS), 诱导性 T 细胞成本刺激激动剂的激动剂

    应用:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • 宿主种属: 人(Human)
  • 种属反应性: 人(Human), 食蟹猴(Cynomolgus monkey)
  • 亚型: Human IgG4PE
  • 偶联: Unconjugated
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货号 (SKU) 包装规格 是否现货 价格 数量
Ab176561-100μg
100μg 现货 Stock Image
Ab176561-1mg
1mg 现货 Stock Image
Ab176561-5mg
5mg 现货 Stock Image
Ab176561-10mg
10mg 期货 Stock Image

基本信息

产品名称 Feladilimab (anti-ICOS), 诱导性 T 细胞成本刺激激动剂的激动剂
别名 非拉迪利单抗(抗 ICOS)
英文别名 Activation-inducible lymphocyte immunomediatory molecule
规格或纯度 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属 人(Human)
特异性 ICOS
种属反应性 人(Human),食蟹猴(Cynomolgus monkey)
偶联 Unconjugated
作用类型 激动剂
作用机制 诱导性 T 细胞成本刺激激动剂的激动剂

产品属性

克隆类型 重组抗体
Format Whole IgG
亚型 Human IgG4PE
轻链亚型 kappa
SDS-PAGE 27.0 kDa (Light Chain) & 53.2 kDa (Heavy Chain), under reducing conditions; 180.0 kDa, under non-reducing conditions.
纯化方法 Protein A purified
纯度 >95%
物理外观 Liquid
储存缓冲液 Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂 No
浓度 见COA
储存温度 -80℃储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息 2252518-85-5
分子类型 抗体

关联靶点(人)

ICOS Tbio 诱导性T细胞共刺激分子(Inducible T-cell costimulator) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

图片

Feladilimab (anti-ICOS) (Ab176561) - Flow Cytometry
Flow Cytometry analysis of 500 ng/mL Ionomycin (I139530) and 10 ng/mL PMA (P408905) co-stimulated Jurkat cells (24h) labelling ICOS (red) with Feladilimab (anti-ICOS) (Ab176561). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Feladilimab (anti-ICOS) (Ab176561) - SEC
The purity of Feladilimab (anti-ICOS) (Ab176561) is more than 95% verified by HPLC.

Feladilimab (anti-ICOS) (Ab176561) - ELISA
Immobilized hu-ICOS ECD-21-140-Fc at 2.0 μg/mL can bind Feladilimab (anti-ICOS) (Ab176561) with the EC₅₀ of 33.30 ng/mL.

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找到6个结果

批号(Lot Number) 证书类型 货号
ZJ24F1114502 分析证书 Ab176561
ZJ24F1114501 分析证书 Ab176561
ZJ24F1114500 分析证书 Ab176561
ZJ24F0404319 分析证书 Ab176561
ZJ24F0404318 分析证书 Ab176561
ZJ24F0404317 分析证书 Ab176561

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引用文献

1. Hutloff A, Dittrich AM, Beier KC, Eljaschewitsch B, Kraft R, Anagnostopoulos I, Kroczek RA.  (1999)  ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28..  Nature,  397  (6716): (263-6).  [PMID:9930702]
2. Beier KC, Hutloff A, Dittrich AM, Heuck C, Rauch A, Büchner K, Ludewig B, Ochs HD, Mages HW, Kroczek RA.  (2000)  Induction, binding specificity and function of human ICOS..  Eur J Immunol,  30  (12): (3707-17).  [PMID:11169414]
3. Grimbacher B, Hutloff A, Schlesier M, Glocker E, Warnatz K, Dräger R, Eibel H, Fischer B, Schäffer AA, Mages HW et al..  (2003)  Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency..  Nat Immunol,  (3): (261-8).  [PMID:12577056]
4. Aicher, A A and 8 more authors..  (2000)  Characterization of human inducible costimulator ligand expression and function..  Journal of immunology (Baltimore, Md. : 1950),  (1): [PMID:10779774]
5. Tezuka, K K and 6 more authors..  (2000)  Identification and characterization of rat AILIM/ICOS, a novel T-cell costimulatory molecule, related to the CD28/CTLA4 family..  Biochemical and biophysical research communications,  (16): [PMID:11006126]
6. Ling, V V and 9 more authors..  (2001)  Assembly and annotation of human chromosome 2q33 sequence containing the CD28, CTLA4, and ICOS gene cluster: analysis by computational, comparative, and microarray approaches..  Genomics,  [PMID:11735222]
7. Haaning Andersen, A D AD, Lange, M M and Lillevang, S T ST..  (2003)  Allelic variation of the inducible costimulator (ICOS) gene: detection of polymorphisms, analysis of the promoter region, and extended haplotype estimation..  Tissue antigens,  [PMID:12753665]

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