FOR46 (anti-CD46)

COA

级别和纯度:

≥95%(SDS-PAGE&SEC-HPLC)
见COA

应用:

Animal Model
ELISA
Flow Cytometry
Functional Assay

宿主种属: 人(Human)
种属反应性: 人(Human), 食蟹猴(Cynomolgus monkey)
亚型: Human IgG1
偶联: Unconjugated

有货

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库存信息

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库存信息

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货号 (SKU)	包装规格	是否现货
Ab176224-100μg	100μg	现货
Ab176224-1mg	1mg	现货
Ab176224-5mg	5mg	现货
Ab176224-10mg	10mg	期货

查看相关系列

点击查看靶蛋白信息: CD46

Accession#:P15529 (6) CD46 (6) Gene ID:4179 (6)

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基本信息

产品名称	FOR46 (anti-CD46)
英文别名	TLX \| Trophoblast leukocyte common antigen
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属	人(Human)
特异性	CD46
种属反应性	人(Human),食蟹猴(Cynomolgus monkey)
偶联	Unconjugated

产品属性

克隆类型	重组抗体
Format	Whole IgG
亚型	Human IgG1
轻链亚型	lambda
SDS-PAGE	26.5 kDa (Light Chain) & 50.6 kDa (Heavy Chain), under reducing conditions; 180.0 kDa, under non-reducing conditions.
纯化方法	Protein A purified
纯度	>95%
物理外观	Liquid
储存缓冲液	Supplied as a 0.22 μm filtered solution in 50mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
分子类型	抗体

关联靶点（人）

CD46 Tbio 膜辅因子蛋白(Membrane cofactor protein) (0 活性数据)

点击查看靶蛋白信息： CD46

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

图片

ELISA: FOR46 (anti-CD46) (Ab176224)

FOR46 (anti-CD46) (Ab176224) - ELISA
Immobilized Human CD46-his at 2.0 μg/mL can bind FOR46 (anti-CD46) (Ab176224) with the EC₅₀ of 5.75 ng/mL.

SEC: FOR46 (anti-CD46) (Ab176224)

FOR46 (anti-CD46) (Ab176224) - SEC
The purity of FOR46 (anti-CD46) (Ab176224) is more than 95% verified by HPLC.

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到3个结果

批号(Lot Number)	证书类型	货号
ZJ24F1114520	分析证书	Ab176224
ZJ24F1114519	分析证书	Ab176224
ZJ24F1114518	分析证书	Ab176224

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引用文献

1. Russell, S M SM, Sparrow, R L RL, McKenzie, I F IF and Purcell, D F DF.. (1992) Tissue-specific and allelic expression of the complement regulator CD46 is controlled by alternative splicing.. European journal of immunology, [PMID:1601037]
2. Post, T W TW and 5 more authors.. (1991) Membrane cofactor protein of the complement system: alternative splicing of serine/threonine/proline-rich exons and cytoplasmic tails produces multiple isoforms that correlate with protein phenotype.. The Journal of experimental medicine, (1): [PMID:1711570]
3. Adams, E M EM, Brown, M C MC, Nunge, M M, Krych, M M and Atkinson, J P JP.. (1991) Contribution of the repeating domains of membrane cofactor protein (CD46) of the complement system to ligand binding and cofactor activity.. Journal of immunology (Baltimore, Md. : 1950), (1): [PMID:1717583]
4. Purcell, D F DF and 5 more authors.. (1991) Alternatively spliced RNAs encode several isoforms of CD46 (MCP), a regulator of complement activation.. Immunogenetics, [PMID:2050389]
5. Purcell, D F DF, Deacon, N J NJ, Andrew, S M SM and McKenzie, I F IF.. (1990) Human non-lineage antigen, CD46 (HuLy-m5): purification and partial sequencing demonstrates structural homology with complement-regulating glycoproteins.. Immunogenetics, [PMID:2298462]
6. Lublin, D M DM and 8 more authors.. (1988) Molecular cloning and chromosomal localization of human membrane cofactor protein (MCP). Evidence for inclusion in the multigene family of complement-regulatory proteins.. The Journal of experimental medicine, (1): [PMID:3260937]
7. Manchester, M M and 7 more authors.. (1995) Measles virus and C3 binding sites are distinct on membrane cofactor protein (CD46).. Proceedings of the National Academy of Sciences of the United States of America, (14): [PMID:7534417]
8. Cui, W W and 5 more authors.. (1993) Characterization of the promoter region of the membrane cofactor protein (CD46) gene of the human complement system and comparison to a membrane cofactor protein-like genetic element.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:7691939]
9. Okada, N N, Liszewski, M K MK, Atkinson, J P JP and Caparon, M M.. (1995) Membrane cofactor protein (CD46) is a keratinocyte receptor for the M protein of the group A streptococcus.. Proceedings of the National Academy of Sciences of the United States of America, (28): [PMID:7708671]
10. Schneider-Schaulies, J J, Dunster, L M LM, Schwartz-Albiez, R R, Krohne, G G and ter Meulen, V V.. (1995) Physical association of moesin and CD46 as a receptor complex for measles virus.. Journal of virology, [PMID:7884872]
11. Naniche, D D and 6 more authors.. (1993) Human membrane cofactor protein (CD46) acts as a cellular receptor for measles virus.. Journal of virology, [PMID:8371352]
12. Dörig, R E RE, Marcil, A A, Chopra, A A and Richardson, C D CD.. (1993) The human CD46 molecule is a receptor for measles virus (Edmonston strain).. Cell, (22): [PMID:8402913]
13. Cervoni, F F, Fenichel, P P, Akhoundi, C C, Hsi, B L BL and Rossi, B B.. (1993) Characterization of a cDNA clone coding for human testis membrane cofactor protein (MCP, CD46).. Molecular reproduction and development, [PMID:8418811]
14. Maisner, A A and 5 more authors.. (1996) The N-glycan of the SCR 2 region is essential for membrane cofactor protein (CD46) to function as a measles virus receptor.. Journal of virology, [PMID:8764003]
15. Källström, H H, Liszewski, M K MK, Atkinson, J P JP and Jonsson, A B AB.. (1997) Membrane cofactor protein (MCP or CD46) is a cellular pilus receptor for pathogenic Neisseria.. Molecular microbiology, [PMID:9379894]
16. Hara, T T and 9 more authors.. (1998) Post-translational modification and intracellular localization of a splice product of CD46 cloned from human testis: role of the intracellular domains in O-glycosylation.. Immunology, [PMID:9659228]
17. Liszewski, M K MK, Leung, M K MK and Atkinson, J P JP.. (1998) Membrane cofactor protein: importance of N- and O-glycosylation for complement regulatory function.. Journal of immunology (Baltimore, Md. : 1950), (1): [PMID:9759896]
18. Casasnovas, J M JM, Larvie, M M and Stehle, T T.. (1999) Crystal structure of two CD46 domains reveals an extended measles virus-binding surface.. The EMBO journal, (1): [PMID:10357804]
19. Santoro, F F and 5 more authors.. (1999) CD46 is a cellular receptor for human herpesvirus 6.. Cell, (23): [PMID:10619434]
20. Wang, G G, Liszewski, M K MK, Chan, A C AC and Atkinson, J P JP.. (2000) Membrane cofactor protein (MCP; CD46): isoform-specific tyrosine phosphorylation.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:10657632]
21. Kusuhara, K K and 10 more authors.. (2000) Analysis of measles virus binding sites of the CD46 gene in patients with subacute sclerosing panencephalitis.. The Journal of infectious diseases, [PMID:10751138]
22. Astier, A A, Trescol-Biémont, M C MC, Azocar, O O, Lamouille, B B and Rabourdin-Combe, C C.. (2000) Cutting edge: CD46, a new costimulatory molecule for T cells, that induces p120CBL and LAT phosphorylation.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:10843656]
23. Tatsuo, H H, Ono, N N, Tanaka, K K and Yanagi, Y Y.. (2000) SLAM (CDw150) is a cellular receptor for measles virus.. Nature, (24): [PMID:10972291]
24. Källström, H H and 5 more authors.. (2001) Attachment of Neisseria gonorrhoeae to the cellular pilus receptor CD46: identification of domains important for bacterial adherence.. Cellular microbiology, [PMID:11260136]
25. Lee, Shaun W SW and 5 more authors.. (2002) CD46 is phosphorylated at tyrosine 354 upon infection of epithelial cells by Neisseria gonorrhoeae.. The Journal of cell biology, (18): [PMID:11901164]
26. Giannakis, Eleni E and 9 more authors.. (2002) Identification of the streptococcal M protein binding site on membrane cofactor protein (CD46).. Journal of immunology (Baltimore, Md. : 1950), (1): [PMID:11971006]
27. Riley, Rebecca C RC, Kemper, Claudia C, Leung, Marilyn M and Atkinson, John P JP.. (2002) Characterization of human membrane cofactor protein (MCP; CD46) on spermatozoa.. Molecular reproduction and development, [PMID:12112588]
28. Greenstone, Heather L HL, Santoro, Fabio F, Lusso, Paolo P and Berger, Edward A EA.. (2002) Human Herpesvirus 6 and Measles Virus Employ Distinct CD46 Domains for Receptor Function.. The Journal of biological chemistry, (18): [PMID:12171934]
29. Kemper, Claudia C and 5 more authors.. (2003) Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype.. Nature, (23): [PMID:12540904]
30. Mori, Yasuko Y, Yang, Xuwei X, Akkapaiboon, Pilailuk P, Okuno, Toshiomi T and Yamanishi, Koichi K.. (2003) Human herpesvirus 6 variant A glycoprotein H-glycoprotein L-glycoprotein Q complex associates with human CD46.. Journal of virology, [PMID:12663806]
31. Santoro, Fabio F and 6 more authors.. (2003) Interaction of glycoprotein H of human herpesvirus 6 with the cellular receptor CD46.. The Journal of biological chemistry, (11): [PMID:12724329]
32. Segerman, Anna A and 5 more authors.. (2003) Adenovirus type 11 uses CD46 as a cellular receptor.. Journal of virology, [PMID:12915534]
33. Richards, Anna A and 12 more authors.. (2003) Mutations in human complement regulator, membrane cofactor protein (CD46), predispose to development of familial hemolytic uremic syndrome.. Proceedings of the National Academy of Sciences of the United States of America, (28): [PMID:14566051]
34. Gaggar, Anuj A, Shayakhmetov, Dmitry M DM and Lieber, André A.. (2003) CD46 is a cellular receptor for group B adenoviruses.. Nature medicine, [PMID:14566335]
35. Gill, Darcy B DB, Koomey, Michael M, Cannon, Janne G JG and Atkinson, John P JP.. (2003) Down-regulation of CD46 by piliated Neisseria gonorrhoeae.. The Journal of experimental medicine, (3): [PMID:14597734]
36. Noris, Marina M and 8 more authors.. (2003) Familial haemolytic uraemic syndrome and an MCP mutation.. Lancet (London, England), (8): [PMID:14615110]
37. Wu, Eugene E and 6 more authors.. (2004) Membrane cofactor protein is a receptor for adenoviruses associated with epidemic keratoconjunctivitis.. Journal of virology, [PMID:15047806]
38. Sirena, Dominique D and 10 more authors.. (2004) The human membrane cofactor CD46 is a receptor for species B adenovirus serotype 3.. Journal of virology, [PMID:15078926]
39. Hakulinen, Juha J, Junnikkala, Sami S, Sorsa, Timo T and Meri, Seppo S.. (2004) Complement inhibitor membrane cofactor protein (MCP; CD46) is constitutively shed from cancer cell membranes in vesicles and converted by a metalloproteinase to a functionally active soluble form.. European journal of immunology, [PMID:15307194]
40. Gaggar, Anuj A, Shayakhmetov, Dmitry M DM, Liszewski, M Kathryn MK, Atkinson, John P JP and Lieber, André A.. (2005) Localization of regions in CD46 that interact with adenovirus.. Journal of virology, [PMID:15919905]
41. Marttila, Marko M and 6 more authors.. (2005) CD46 is a cellular receptor for all species B adenoviruses except types 3 and 7.. Journal of virology, [PMID:16254377]
42. Esparza-Gordillo, Jorge J and 6 more authors.. (2006) Insights into hemolytic uremic syndrome: segregation of three independent predisposition factors in a large, multiple affected pedigree.. Molecular immunology, [PMID:16386793]
43. Caprioli, Jessica J and 18 more authors.. (2006) Genetics of HUS: the impact of MCP, CFH, and IF mutations on clinical presentation, response to treatment, and outcome.. Blood, (15): [PMID:16621965]
44. Maga, Tara K TK, Nishimura, Carla J CJ, Weaver, Amy E AE, Frees, Kathy L KL and Smith, Richard J H RJ.. (2010) Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome.. Human mutation, [PMID:20513133]

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所需的复溶浓度

FOR46 (anti-CD46)

库存信息

库存信息

库存信息

库存信息

基本信息

产品属性

关联靶点（人）

图片

质检证书（CoA,COO,BSE/TSE 和分析图谱)

相关产品

可替换产品

引用文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器