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Ianalumab (anti-TNFRSF13C), 肿瘤坏死因子受体超家族成员 13C 结合剂的结合剂

Ianalumab (anti-TNFRSF13C), 肿瘤坏死因子受体超家族成员 13C 结合剂的结合剂

级别和纯度:

≥95%(SDS-PAGE&SEC-HPLC)
见COA

应用:

Animal Model
ELISA
Flow Cytometry
Functional Assay

宿主种属: 人(Human)
种属反应性: 人(Human), 食蟹猴(Cynomolgus monkey)
亚型: Human IgG1
偶联: Unconjugated

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货号 (SKU)	包装规格	是否现货
Ab176090-100μg	100μg	现货
Ab176090-1mg	1mg	现货
Ab176090-5mg	5mg	现货
Ab176090-10mg	10mg	期货

查看相关系列

点击查看靶蛋白信息: TNFRSF13C

Accession#:Q96RJ3 (2) BAFFR (2) Extrinsic Pathway (1228) Gene ID:115650 (2) TNFRSF13C (2)

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基本信息

产品名称	Ianalumab (anti-TNFRSF13C), 肿瘤坏死因子受体超家族成员 13C 结合剂的结合剂
别名	伊利尤单抗 \| 伊那鲁单抗（抗肿瘤坏死因子生长因子受体13C）
英文别名	B cell activating factor receptor antibody \| B-cell-activating factor receptor antibody \| BAFF R antibody \| BAFF receptor antibody \| BAFF-R antibody \| BAFFR antibody \| BLyS receptor 3 antibody \| BlySR3 antibody \| BR 3 antibody \| BR3 antibody \| BROMIX anti
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属	人(Human)
特异性	TNFRSF13C
种属反应性	人(Human),食蟹猴(Cynomolgus monkey)
偶联	Unconjugated
作用类型	结合剂
作用机制	肿瘤坏死因子受体超家族成员 13C 结合剂的结合剂

产品属性

克隆类型	重组抗体
Format	Whole IgG
亚型	Human IgG1
轻链亚型	kappa
SDS-PAGE	26.8 kDa (Light Chain) & 52.1 kDa (Heavy Chain), under reducing conditions; 182.4 kDa, under non-reducing conditions.
纯化方法	Protein A purified
纯度	>95%
物理外观	Liquid
储存缓冲液	Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息	1929549-92-7
分子类型	抗体

关联靶点（人）

TNFRSF13C Tbio 肿瘤坏死因子受体超家族成员 13C(Tumor necrosis factor receptor superfamily member 13C) (0 活性数据)

点击查看靶蛋白信息： TNFRSF13C

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

图片

Flow Cytometry: Ianalumab (anti-TNFRSF13C) (Ab176090)

Ianalumab (anti-TNFRSF13C) (Ab176090) - Flow Cytometry
Flow Cytometry analysis of Raji cells labelling TNFRSF13C (red) with Ianalumab (anti-TNFRSF13C) (Ab176090). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

SEC: Ianalumab (anti-TNFRSF13C) (Ab176090)

Ianalumab (anti-TNFRSF13C) (Ab176090) - SEC
The purity of Ianalumab (anti-TNFRSF13C) (Ab176090) is more than 95% verified by HPLC.

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

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通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到5个结果

批号(Lot Number)	证书类型	货号
ZJ23F1001438	分析证书	Ab176090
ZJ23F1001439	分析证书	Ab176090
ZJ24F0911552	分析证书	Ab176090
ZJ24F0911551	分析证书	Ab176090
ZJ24F0911550	分析证书	Ab176090

引用文献

1. Dunham, I I and 24 more authors.. (1999) The DNA sequence of human chromosome 22.. Nature, (2): [PMID:10591208]
2. Thompson, J S JS and 15 more authors.. (2001) BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF.. Science (New York, N.Y.), (14): [PMID:11509692]
3. Yan, M M and 8 more authors.. (2001) Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency.. Current biology : CB, (2): [PMID:11591325]
4. Kayagaki, Nobuhiko N and 11 more authors.. (2002) BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2.. Immunity, [PMID:12387744]
5. Kim, Ho Min HM and 8 more authors.. (2003) Crystal structure of the BAFF-BAFF-R complex and its implications for receptor activation.. Nature structural biology, [PMID:12715002]
6. Liu, Yingfang Y and 11 more authors.. (2003) Ligand-receptor binding revealed by the TNF family member TALL-1.. Nature, (1): [PMID:12721620]
7. Gordon, Nathaniel C NC and 9 more authors.. (2003) BAFF/BLyS receptor 3 comprises a minimal TNF receptor-like module that encodes a highly focused ligand-binding site.. Biochemistry, (27): [PMID:12755599]
8. Losi, Claretta Gioia CG and 8 more authors.. (2005) Mutational analysis of human BAFF receptor TNFRSF13C (BAFF-R) in patients with common variable immunodeficiency.. Journal of clinical immunology, [PMID:16160919]
9. Lee, Chingwei V CV and 13 more authors.. (2006) Synthetic anti-BR3 antibodies that mimic BAFF binding and target both human and murine B cells.. Blood, (1): [PMID:16840730]
10. Warnatz, Klaus K and 13 more authors.. (2009) B-cell activating factor receptor deficiency is associated with an adult-onset antibody deficiency syndrome in humans.. Proceedings of the National Academy of Sciences of the United States of America, (18): [PMID:19666484]

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Ianalumab (anti-TNFRSF13C), 肿瘤坏死因子受体超家族成员 13C 结合剂的结合剂

库存信息

库存信息

库存信息

库存信息

基本信息

产品属性

关联靶点（人）

作用机制

图片

质检证书（CoA,COO,BSE/TSE 和分析图谱)

相关产品

引用文献

溶液计算器

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复溶计算器