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Denintuzumab (anti-CD19), B 淋巴细胞抗原的结合剂 CD19 结合剂

Denintuzumab (anti-CD19), B 淋巴细胞抗原的结合剂 CD19 结合剂

级别和纯度:

≥95%(SDS-PAGE&SEC-HPLC)
见COA

应用:

Animal Model
ELISA
Flow Cytometry
Functional Assay

宿主种属: 人(Human)
种属反应性: 人(Human)
亚型: Human IgG1
偶联: Unconjugated

有货

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货号 (SKU)	包装规格	是否现货
Ab170852-100μg	100μg	期货
Ab170852-1mg	1mg	现货
Ab170852-5mg	5mg	现货
Ab170852-10mg	10mg	期货

查看相关系列

点击查看靶蛋白信息: CD19

Accession#:P15391 (62) CD19 (76) Gene ID:930 (62)

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基本信息

产品名称	Denintuzumab (anti-CD19), B 淋巴细胞抗原的结合剂 CD19 结合剂
别名	地宁妥珠单抗 \| 地尼妥珠单抗(抗 CD19)
英文别名	hBU 12 \| Antibody deficiency due to defect in CD19 antibody \| Antibody deficiency due to defect in CD19, included antibody \| AW495831 antibody \| B lymphocyte antigen CD19 antibody \| B lymphocyte surface antigen B4 antibody \| B-lymphocyte antigen CD19 anti
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属	人(Human)
特异性	CD19
种属反应性	人(Human)
偶联	Unconjugated
作用类型	结合剂
作用机制	B 淋巴细胞抗原的结合剂 CD19 结合剂

产品属性

克隆类型	重组抗体
Format	Whole IgG
亚型	Human IgG1
轻链亚型	kappa
SDS-PAGE	145.96 kDa
纯化方法	Protein A purified
纯度	>95%
物理外观	Liquid
储存缓冲液	Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息	1630074-14-4
分子类型	抗体

关联靶点（人）

CD19 Tclin B淋巴细胞抗原CD19(B-lymphocyte antigen CD19) (0 活性数据)

点击查看靶蛋白信息： CD19

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

图片

Flow Cytometry: Denintuzumab (anti-CD19) (Ab170852)

Denintuzumab (anti-CD19) (Ab170852) - Flow Cytometry
Flow Cytometry analysis of Raji cells labelling CD19 (red) with Denintuzumab (anti-CD19) (Ab170852). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

SEC: Denintuzumab (anti-CD19) (Ab170852)

Denintuzumab (anti-CD19) (Ab170852) - SEC
The purity of Denintuzumab (anti-CD19) (Ab170852) is more than 95% verified by HPLC.

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

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找到2个结果

批号(Lot Number)	证书类型	货号
ZJ23F0900971	分析证书	Ab170852
ZJ23F0900972	分析证书	Ab170852

技术文档和文章

流式细胞术实验方案

Categories: 实验方案（Protocols）

探索主题:

抗体流式细胞术流式抗体活性染料间接抗体标记

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引用文献

1. Tedder TF, Isaacs CM. (1989) Isolation of cDNAs encoding the CD19 antigen of human and mouse B lymphocytes. A new member of the immunoglobulin superfamily.. J Immunol, 143 (2): (712-7). [PMID:2472450]
2. Herbst R, Wang Y, Gallagher S, Mittereder N, Kuta E, Damschroder M, Woods R, Rowe DC, Cheng L, Cook K et al.. (2010) B-cell depletion in vitro and in vivo with an afucosylated anti-CD19 antibody.. J Pharmacol Exp Ther, 335 (1): (213-22). [PMID:20605905]
3. Horton HM, Bernett MJ, Pong E, Peipp M, Karki S, Chu SY, Richards JO, Vostiar I, Joyce PF, Repp R et al.. (2008) Potent in vitro and in vivo activity of an Fc-engineered anti-CD19 monoclonal antibody against lymphoma and leukemia.. Cancer Res, 68 (19): (8049-57). [PMID:18829563]
4. Zammarchi F, Corbett S, Adams L, Tyrer PC, Kiakos K, Janghra N, Marafioti T, Britten CE, Havenith CEG, Chivers S et al.. (2018) ADCT-402, a PBD dimer-containing antibody drug conjugate targeting CD19-expressing malignancies.. Blood, 131 (10): (1094-1105). [PMID:29298756]
5. Zhou, L J LJ, Ord, D C DC, Omori, S A SA and Tedder, T F TF.. (1992) Structure of the genes encoding the CD19 antigen of human and mouse B lymphocytes.. Immunogenetics, [PMID:1370948]
6. Carter, R H RH and Fearon, D T DT.. (1992) CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes.. Science (New York, N.Y.), (3): [PMID:1373518]
7. Kozmik, Z Z, Wang, S S, Dörfler, P P, Adams, B B and Busslinger, M M.. (1992) The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP.. Molecular and cellular biology, [PMID:1375324]
8. Bradbury, L E LE, Kansas, G S GS, Levy, S S, Evans, R L RL and Tedder, T F TF.. (1992) The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules.. Journal of immunology (Baltimore, Md. : 1950), (1): [PMID:1383329]
9. Matsumoto, A K AK and 5 more authors.. (1991) Intersection of the complement and immune systems: a signal transduction complex of the B lymphocyte-containing complement receptor type 2 and CD19.. The Journal of experimental medicine, (1): [PMID:1702139]
10. Stamenkovic, I I and Seed, B B.. (1988) CD19, the earliest differentiation antigen of the B cell lineage, bears three extracellular immunoglobulin-like domains and an Epstein-Barr virus-related cytoplasmic tail.. The Journal of experimental medicine, (1): [PMID:2459292]
11. Buhl, A M AM, Pleiman, C M CM, Rickert, R C RC and Cambier, J C JC.. (1997) Qualitative regulation of B cell antigen receptor signaling by CD19: selective requirement for PI3-kinase activation, inositol-1,4,5-trisphosphate production and Ca2+ mobilization.. The Journal of experimental medicine, (1): [PMID:9382888]
12. Brooks, S R SR, Li, X X, Volanakis, E J EJ and Carter, R H RH.. (2000) Systematic analysis of the role of CD19 cytoplasmic tyrosines in enhancement of activation in Daudi human B cells: clustering of phospholipase C and Vav and of Grb2 and Sos with different CD19 tyrosines.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:10706702]
13. Kuroki, K K and 10 more authors.. (2002) Polymorphisms of human CD19 gene: possible association with susceptibility to systemic lupus erythematosus in Japanese.. Genes and immunity, [PMID:12215898]
14. Wang, Yue Y and 5 more authors.. (2002) The physiologic role of CD19 cytoplasmic tyrosines.. Immunity, [PMID:12387743]
15. Martin, Joel J and 121 more authors.. (2004) The sequence and analysis of duplication-rich human chromosome 16.. Nature, (23): [PMID:15616553]
16. Shoham, Tsipi T, Rajapaksa, Ranjani R, Kuo, Chiung-Chi CC, Haimovich, Joseph J and Levy, Shoshana S.. (2006) Building of the tetraspanin web: distinct structural domains of CD81 function in different cellular compartments.. Molecular and cellular biology, [PMID:16449649]
17. van Zelm, Menno C MC and 10 more authors.. (2006) An antibody-deficiency syndrome due to mutations in the CD19 gene.. The New England journal of medicine, (4): [PMID:16672701]
18. Zugmaier, Gerhard G, Klinger, Matthias M, Schmidt, Margit M and Subklewe, Marion M.. (2015) Clinical overview of anti-CD19 BiTE(®) and ex vivo data from anti-CD33 BiTE(®) as examples for retargeting T cells in hematologic malignancies.. Molecular immunology, [PMID:25883042]
19. Gallagher, Sandra S and 7 more authors.. (2016) MEDI-551 Treatment Effectively Depletes B Cells and Reduces Serum Titers of Autoantibodies in Mice Transgenic for Sle1 and Human CD19.. Arthritis & rheumatology (Hoboken, N.J.), [PMID:26606525]
20. Gallagher, Sandra S and 7 more authors.. (2016) Pharmacological profile of MEDI-551, a novel anti-CD19 antibody, in human CD19 transgenic mice.. International immunopharmacology, [PMID:27163209]
21. Teplyakov, Alexey A, Obmolova, Galina G, Luo, Jinquan J and Gilliland, Gary L GL.. (2018) Crystal structure of B-cell co-receptor CD19 in complex with antibody B43 reveals an unexpected fold.. Proteins, [PMID:29490423]
22. Wang, Michael and 24 more authors.. (2020) KTE-X19 CAR T-Cell Therapy in Relapsed or Refractory Mantle-Cell Lymphoma.. The New England journal of medicine, (2): [PMID:32242358]

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Denintuzumab (anti-CD19), B 淋巴细胞抗原的结合剂 CD19 结合剂

库存信息

库存信息

库存信息

库存信息

基本信息

产品属性

关联靶点（人）

作用机制

图片

质检证书（CoA,COO,BSE/TSE 和分析图谱)

技术文档和文章

相关产品

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引用文献

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